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Treatment of spinal cord injury with biomaterials and stem cell therapy in non-human primates and humans

Neural Regeneration Research 2025年第2期20卷 343-353页

作者： Ana Milena Silva Olaya Fernanda Martins Almeida Ana Maria Blanco Martinez Suelen Adriani Marques phd program in Pathological Anatomy Federal University of Rio de JaneiroRio de JaneiroBrazil Biomedical Science Institute Federal University of Rio de JaneiroRio de JaneiroBrazil Graduate program in Pathological Anatomy Federal University of Rio de JaneiroRio de JaneiroBrazil Graduate program in Pathological Anatomy(PPGAP/UFRJ) Department of Neurobiology/Institute of BiologyCampus do GragoatáNiteróiRio de JaneiroBrazil

Spinal cord injury results in the loss of sensory,motor,and autonomic functions,which almost always produces permanent physical ***,in the search for more effective treatments than those already applied for years,which are not entirely efficient,researches have been able to demonstrate the potential of biological strategies using biomaterials to tissue manufacturing through bioengineering and stem cell therapy as a neuroregenerative approach,seeking to promote neuronal recovery after spinal cord *** of these strategies has been developed and meticulously evaluated in several animal models with the aim of analyzing the potential of interventions for neuronal repair and,consequently,boosting functional *** the majority of experimental research has been conducted in rodents,there is increasing recognition of the importance,and need,of evaluating the safety and efficacy of these interventions in non-human primates before moving to clinical trials involving therapies potentially promising in *** article is a literature review from databases(PubMed,Science Direct,Elsevier,Scielo,Redalyc,Cochrane,and NCBI)from 10 years ago to date,using keywords(spinal cord injury,cell therapy,non-human primates,humans,and bioengineering in spinal cord injury).From 110 retrieved articles,after two selection rounds based on inclusion and exclusion criteria,21 articles were ***,this review arises from the need to recognize the experimental therapeutic advances applied in non-human primates and even humans,aimed at deepening these strategies and identifying the advantages and influence of the results on extrapolation for clinical applicability in humans.

关键词： bioengineering biomaterials cell therapy humans non-human primates spinal cord injury stem cell therapy

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Brain-derived neurotrophic factor in main neurodegenerative diseases

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Neural Regeneration Research 2023年第3期18卷 554-555页

作者： Serena Camuso Sonia Canterini Division of Neuroscience Department of PsychologyUniversity La SapienzaRomeItaly phd program in Behavioral Neuroscience Sapienza University of RomeRomeItaly

Discovered in pig brains in 1982,the brain-derived neurotrophic factor(BDNF)is one of the most studied and characterized neurotrophins in the central nervous *** recent years,BDNF has received considerable attention for its importance in the development and maintenance of normal brain *** is because BDNF plays an important role in crucial functions of the nervous system,such as the survival,differentiation,and maturation of neurons and glial cells as well as the actions of neuroprotection in adverse conditions,such as glutamatergic overstimulation,cerebral ischemia,hypoglycemia,and neurotoxicity(Kowiański et al.,2018).

关键词： stimulation diseases

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Beginning from the end:the presynaptic terminal as a pathomechanism hub in frontotemporal dementia and amyotrophic lateral sclerosis

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Neural Regeneration Research 2025年第11期20卷 3217-3218页

作者： Laura Huggon Emma L.Clayton UK Dementia Research Institute at King’s College London LondonUK Department of Basic and Clinical Neuroscience Institute of Psychiatry Psychology&NeuroscienceKing’s College LondonLondonUK

Frontotemporal dementia and amyotrophic lateral sclerosis:Frontotemporal dementia(F T D)and amyo t rophic lateral sclerosis(ALS)are neurodegenerative diseases with significant overlapping *** these neurodegenerative diseases affect different neuronal populations(with FTD affecting neurons of the frontal and temporal lobes,and ALS affecting upper and lower motor neurons),these two diseases are complexly *** and ALS exist on a disease spectrum,with shared genetic causes,clinical presentations,and pathologies.

关键词： diseases amyotrophic sclerosis

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Sex differences in the influence of social context, salient social stimulation and amphetamine on ultrasonic vocalizations in prairie voles

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Integrative Zoology 2014年第3期9卷 280-293页

作者： Sean T.MA Shanna L.RESENDEZ Brandon J.ARAGONA Department of psychology program in Neuroscience University of MichiganAnn ArborMIUSA

Prairie voles(Microtus ochrogaster)are a socially monogamous rodent species and their cooperative behaviors require extensive communication between *** use ultrasonic vocalizations(USVs)to communicate and because a prairie vole breeder pair must engage in extensive cooperation for successful reproduction,auditory communication may be critical for this ***,we sought to characterize USVs in adult male and female prairie voles,and to determine how these calls are influenced by social context,salient social stimuli and the psychostimulant drug of abuse amphetamine(AMPH).Here,we characterize prairie vole USVs by showing the range of frequencies of prairie vole USVs,the proportion of various call types,how these call types compare between males and females,and how they are influenced by social stimulation and *** caused a robust increase in the number of USVs in both males and females and there was a dramatic sex difference in the complexity of call structures of AMPH-induced USVs,with males emitting more elaborate ***,we show that novel(***)social cues evoked differential increases in USVs across sex,with males showing a much more robust increase in USV production,both with respect to the frequency and complexity of USV *** to an estrous female in particular caused an extraordinary increase in USVs in male *** data suggest that USVs may be a useful measure of social motivation in this species,including how social behaviors can be impacted by drugs of abuse.

关键词： amphetamine dopamine mate choice pair bonding ultrasonic vocalization

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Eating as a motivated behavior:modulatory effect of high fat diets on energy homeostasis,reward processing and neuroinflammation

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Integrative Zoology 2018年第6期13卷 673-686页

作者： Michael J.BUTLER Lisa A.ECKEL Department of psychology and program in Neuroscience Florida State UniversityTallahasseeFloridaUSA

Eating is a basic motivated behavior that provides fuel for the body and supports brain *** ensure survival,the brain’s feeding circuits are tuned to monitor peripheral energy balance and promote food-seeking behavior when energy stores are *** brain’s bias toward a positive energy state,which is necessary to ensure adequate nutrition during times of food scarcity,is evolutionarily conserved across mammalian species and is likely to drive overeating in the presence of a palatable,energy-dense *** models of diet-induced overeating have played a vital role in investigating how the drive to consume palatable food may override the homeostatic processes that serve to maintain energy *** animal models have provided valuable insights into the neurobiological mechanisms underlying homeostatic and non-homeostatic eating,motivation and food reward,and the development of obesity and related ***,we provide a brief review of this literature and discuss how diet-induced inflammation in the central nervous system impacts the neural control of food intake and regulation of body *** connection between diet and the immune system provides an exciting new direction for the study of ingestive behavior and the pathophysiology of obesity.

关键词： high fat diet inflammation obesity

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Glial plasticity after hexahydrobenzene exposure

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Neural Regeneration Research 2016年第3期11卷 404-405页

作者： Tania Campos-Ordonez Oscar Gonzalez-Perez Laboratory of Neurobiology School of PsychologyUniversity of Colima Medical Sciences phd program School of MedicineUniversity of Colima

The organic solvents are not only utilized in industrial processes,but also as drugs of *** fact,solvent consumption represents the fourth option for drug users just after alcohol,tobacco and *** humans,intentional in... 详细信息

关键词： intentional tobacco plasticity utilized volatile alcohol exposure abuse morphological microglia

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The History of Chinese Mathematics-the Founding of the IHNS(CAS)-and the True Story of a Wrong Diagram in SCC Volume 3

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Chinese Annals of History of Science and Technology 2018年第2期2卷 86-128页

作者： Joseph W.Dauben phd program in History The Graduate CenterThe City University of New YorkNY 10016US

The Institute for the History of Natural Sciences in Beijing celebrated the sixtieth anniversary of its founding in 1957 with an international symposium devoted to“China and the World in the Global History of Science and Technology.”2 This contribution to that symposium focuses on the roles that historians of mathematics,East and West,have played in bringing the importance of mathematics in China to the attention of the world at *** concludes by discussing a controversy surrounding the diagram and purported“proof”given in the ancient mathematical classic,the Zhoubi suanjing周髀算經(Mathematical classic of Zhou’s gnomon),of the gou-gu theorem that appeared in volume 3 of Joseph Needham’s Science and Civilisation in China,published in 1959.

关键词： Institute for the History of Natural Sciences ⅢICHCS Beijing(1974) Zhu Kezhen Li Yan Qian Baocong Yan Dunjie Joseph Needham ⅧICHS Milan(1956) Zhoubi suanjing

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Potential protective role of ACE-inhibitors and AT1 receptor blockers against levodopa-induced dyskinesias:a retrospective case-control study

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Neural Regeneration Research 2021年第12期16卷 2475-2478页

作者： Elena Contaldi Luca Magistrelli Anna VMilner Marco Cosentino Franca Marino Cristoforo Comi Movement Disorders Centre Neurology UnitDepartment of Translational MedicineUniversity of Piemonte OrientaleNovaraItaly phd program in Medical Sciences and Biotechnology University of Piemonte OrientaleNovaraItaly phd program in Clinical and Experimental Medicine and Medical Humanities University of InsubriaVareseItaly Center of Research in Medical Pharmacology University of InsubriaVareseItaly Center for Research in Neuroscience University of InsubriaVareseItaly

Growing evidence has highlighted that angiotensin-converting enzyme(ACE)-inhibitors(ACEi)/AT1 receptor blockers(ARBs)may influence the complex interplay between dopamine and the renin-angiotensin system in the nigrostriatal pathway,thus affecting the development of levodopa-induced dyskinesia in Parkinson’s disease(PD).In the present study,we analyzed whether the use of this class of medication was associated with a reduced occurrence of levodopa-induced dyskinesia,using electronically-stored information of idiopathic PD patients enrolled at Novara University Hospital“Maggiore della Carità”.We conducted a retrospective case-control study identifying PD patients with dyskinesias(PwD;n=47)as *** each PwD we selected a non-dyskinetic control(NoD),nearly perfectly matched according to sex,Unified Parkinson’s Disease Rating Scale(UPDRS)part III score,and duration of antiparkinsonian *** logistic regression was used to evaluate whether dyskinesias were associated with ACEi/ARBs ***-four PD patients were included,aged 72.18±9 years,with an average disease duration of 10.20±4.8 years and 9.04±4.9 years of antiparkinsonian *** mean UPDRS part III score was 18.87±7.6 and the median HY stage was *** the NoD group,25(53.2%)were users and 22(46.8%)non-users of ACEi/***,in the PwD group,11(23.4%)were users and 36 non-users(76.6%)of this drug class(Pearson chi-square=8.824,P=0.003).Concerning general medication,there were no other statistically significant differences between *** controlling for tremor dominant phenotype,levodopa equivalent daily dose,HY 3-4,and disease duration,ACEi/ARBs use was a significant predictor of a lower occurrence of dyskinesia(OR=0.226,95%CI:0.080-0.636,P=0.005).Therefore,our study suggests that ACEi/ARBs may reduce levodopa-induced dyskinesia occurrence and,thanks to good tolerability and easy management,represent a feasible choice when dealing with the treatment of hypertension in PD patients.

关键词： angiotensin-converting enzyme inhibitors AT1 receptor blockers dyskinesias hypertension levodopa motor complications neuroinflammation Parkinson’s disease renin-angiotensin system

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Therapeutic termination of pregnancy and women’s mental health:Determinants and consequences

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World Journal of Psychiatry 2021年第11期11卷 937-953页

作者： Ester di Giacomo Rodolfo Pessina Mario Santorelli Daniele Rucco Valeria Placenti Francesca Aliberti Fabrizia Colmegna Massimo Clerici School of Medicine and Surgery University Milan BicoccaMonza 20900LombardyItaly Department of Psychiatric ASST MonzaMonza 20900LombardyItaly Psychiatric Residency Training program University Milan BicoccaMonza 20900LombardyItaly phd program in psychology Linguistics and Cognitive NeuroscienceUniversity Milan BicoccaMilano 20126LombardyItaly Psychiatric Residency Training program University of GenovaGenova 16126LiguriaItaly

The therapeutic termination of pregnancy(TToP)is an induced abortion following a diagnosis of medical *** is applied to avoid the risk of substantial harm to the mother or in cases of fetal *** type of induced abortion is provided after the second semester of gestation if fetal illness or the pregnancy cause physical danger or pathological mental distress to the *** and economic determinants could influence the desire for children and family planning in couples,as well as the use of effective contraception and the choice to perform an induced ***,pre-existing mental health problems could affect the decision between carrying on a problematic pregnancy or having ***,the TToP is a reproductive event with an important traumatic burden,but also with an intrinsic therapeutic effect and it can produce different psychological and psychopathological effects on women and *** aim of this review is to evaluate what demographic,reproductive and psychopathological determinants are involved in the choice of undergoing a TToP in ***,we will examine both positive and negative consequences of this procedure on women’s mental health,underlying which factors are related to a worse outcome in order to provide the best clinical support to vulnerable groups.

关键词： Therapeutic abortion Women’s health Depression PostTraumatic stress disorder Perinatal care Psychiatry

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Aging gracefully: social engagement joins exercise and enrichment as a key lifestyle factor in resistance to age-related cognitive decline

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Neural Regeneration Research 2019年第1期14卷 39-42页

作者： Tyler J.Dause Elizabeth D.Kirby Department of psychology The Ohio State University Department of Neuroscience The Ohio State University Chronic Brain Injury program The Ohio State University

Cognitive impairment is a consequence of the normal aging process that effects many species, including humans and rodent models. Decline in hippocampal memory function is especially prominent with age and often reduces quality of life. As the aging population expands, the need for interventional strategies to prevent cognitive decline has become more pressing. Fortunately, several major lifestyle factors have proven effective at combating hippocampal aging, the most well-known of which are environmental enrichment and exercise. While the evidence supporting the beneficial nature of these factors is substantial, a less well-understood factor may also contribute to healthy cognitive aging: social engagement. We review the evidence supporting the role of social engagement in preserving hippocampal function in old age. In elderly humans, high levels of social engagement correlate with better hippocampal function, yet there is a dearth of work to indicate a causative role. Existing rodent literature is also limited but has begun to provide causative evidence and establish candidate mechanisms. Summed together, while many unanswered questions remain, it is clear that social engagement is a viable lifestyle factor for preserving cognitive function in old age. Social integration across the lifespan warrants more investigation and more appreciation when designing living circumstances for the elderly.

关键词： aging age-related cognitive decline social engagement hippocampus cognitive enrichment exercise memory neurogenesis

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