检索结果-南通市图书馆

Comprehensive review into the challenges of gastrointestinal tumors in the Gulf and Levant countries

World Journal of Clinical Cases 2020年第3期8卷 487-503页

作者： Rare Tumors GI Group Fadi Farhat Abdulaziz Al Farsi Ahmed Mohieldin Bassim Al Bahrani Eman Sbaity Hassan Jaffar Joseph Kattan Kakil Rasul Khairallah Saad Tarek Assi Waleed El Morsi Rafid A Abood 不详 Hammoud Hospital UMC Saida PO Box 652Lebanon Medical oncology Department Royal HospitalMuscat PO Box 1331Oman Medical oncology Department Kuwait Cancer Control CenterKuwait PO Box 42262Kuwait Division of General Surgery American University of BeirutBeirut 11072180Lebanon oncology Department Tawam HospitalAl Ain PO Box 15258United Arab Emirates Hemato-oncology Department Hotel Dieu de FranceBeirutLebanon Hemato-oncology Department National Center for Cancer Care and ResearchDohaQatar Pathology Department Institute National de PathologicBeirutLebanon oncology Department Faculty of MedicineSaint-Joseph UniversityBeirutLebanon pfizer oncology-emerging markets Dubai Media CityDubaiUnited Arab Emirates oncology Department Basra College of MedicineBasraIraq

Although gastrointestinal stromal tumors(GISTs)are rare,with an incidence of 1/100000 per year,they are the most common sarcomas in the peritoneal *** considerable progress in the diagnosis and treatment of GIST,about half of all patients are estimated to experience *** only two drugs,sunitinib and regorafenib,approved by the Food and Drug Administration,selecting treatment options after imatinib failure and coordinating multidisciplinary care remain *** addition,physicians across the Middle East face some additional and unique challenges such as lack of published local data from clinical trials,national disease registries and regional scientific research,limited access to treatment,lack of standardization of care,and limited access to mutational *** global guidelines set a framework for the management of GIST,there are no standard local guidelines to guide clinical practice in a resource-limited ***,a group of 11 experienced medical oncologists from across the Gulf and Levant region,part of the Rare Tumors Gastrointestinal Group,met over a period of one year to conduct a narrative review of the management of GIST and to describe regional challenges and gaps in patient management as an essential step to proposing local clinical practice recommendations.

关键词： Gastrointestinal stromal tumors Diagnosis Disease management Treatment Challenges Middle East

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Breakthrough cancer medicine and its impact on novel drug development in China: report of the US Chinese Anti-Cancer Association (USCACA) and Chinese Society of Clinical oncology (CSCO) Joint Session at the 17th CSCO Annual Meeting

引用

Chinese Journal of Cancer 2014年第12期33卷 620-624页

作者： Feng Roger Luo Jian Ding Helen X. Chen Hao Liu Man-Cheong Fung Maria Koehler Jean Pierre Armand Lei Jiang Xiao Xu Ge Zhang Li Xu Pascal Qian Li Yan The US Chinese Anti-Cancer Association MartinezCA 94553 USA Department of oncology Janssen Research & Development LLC RaritanNJ 08869 USA Shanghai Institute of Materia Medica Chinese Academy of Sciences Cancer Therapy Evaluation Program National Cancer Institute Novartis Pharmaceuticals (China) oncology pfizer oncology New YorkNY 10017 USA Institut Gustave Roussy Cancer Campus Grand Paris ACEA Biosciences Inc. Jiangsu Hengrui Medicine Co. Ltd. Beijing Cancer Hospital and Institute Peking University School of Oncology

The US Chinese Anti-Cancer Association(USCACA)teamed up with Chinese Society of Clinical oncology(CSCO)to host a joint session at the17th CSCO Annual Meeting on September 20th,2014in Xiamen,*** a focus on breakthrough cancer medicines,the session featured innovative approaches to evaluate breakthrough agents and established a platform to interactively share successful experiences from case studies of 6 novel agents from both the United States and *** goal of the session is to inspire scientific and practical considerations for clinical trial design and strategy to expedite cancer drug development in China.A panel discussion further provided in-depth advice on advancing both early and full development of novel cancer medicines in China.

关键词：抗癌药物中国临床美国学会肿瘤协会新药

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Combined gemcitabine and CHK1 inhibitor treatment induces apoptosis resistance in cancer stem cell-like cells enriched with tumor spheroids from a non-small cell lung cancer cell line

引用

Frontiers of Medicine 2013年第4期7卷 462-476页

作者： Douglas D.Fang Joan Cao Jitesh P.Jani Konstantinos Tsaparikos Alessandra Blasina Jill Kornmann Maruja E.Lira Jianying Wang Zuzana Jirout Justin Bingham Zhou Zhu Yin Gu Gerrit Los Zdenek Hostomsky Todd VanArsdale oncology Research Unit PfizerInc.10777 Science Center DriveSan DiegoCA 92121USA WuXi AppTec(Shanghai)Co. Ltd.288 Fute Zhong RdWaigaoqiao Free Trade ZoneShanghai 200131China

Evaluating the effects of novel drugs on appropriate tumor models has become crucial for developing more effective therapies that target highly tumorigenic and drug-resistant cancer stem cell(CSC)*** this study,we demonstrate that a subset of cancer cells with CSC properties may be enriched into tumor spheroids under stem cell conditions from a non-small cell lung cancer cell *** these CSC-like cells with gemcitabine alone and a combination of gemcitabine and the novel CHK1 inhibitor PF-00477736 revealed that PF-00477736 enhances the anti-proliferative effect of gemcitabine against both the parental and the CSC-like cell ***,the CSC-like cells exhibited resistance to gemcitabine-induced ***,the spheroid-forming CSC-like cells may serve as a model system for understanding the mechanism underlying the drug resistance of CSCs and for guiding the development of better therapies that can inhibit tumor growth and eradicate CSCs.

关键词： drug resistance cancer stem cell checkpoint kinase 1(CHK1) PF-00477736 lung cancer tumorigenicity

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The USCACA hosted symposiums at the 7th CACA annual meeting and the 15th CSCO annual meeting in Beijing

引用

Chinese Journal of Cancer 2012年第11期31卷 505-506页

作者： Michael Shi Wancai Yang Pascal Qian Li Yan Novartis oncology One Health PlazaEast HanoverNJ 07936USA Department of Pathology Xinxiang Medical UniversityXinxiangHenan 453003P.R.China Department of Pathology University of Illinois at ChicagoIL 60612USA CDMA Pfizer OncologyShanghai 200041P.R.China USCACA 939 S Highland AveLos AngelesCA 90036USA.

In September 2012,the US Chinese Anti-Cancer Association(USCACA) hosted two symposiums in *** USCACA hosted the first joint session at the 7th annual meetings of the Chinese Anti-Cancer Association(CACA),themed on "Collaboration between the US and China in Cancer Research." Six experts from the United States and China presented their latest work on basic and translational cancer *** this symposium,5 young Chinese scholars,returnees after their training in the United States,were honored the"AFCR-USCACA Scholarships Award." The USCACA hosted a second symposium during the 15th annual meeting of the Chinese Society of Clinical oncology(CSCO),focused on the "US-China Collaboration in Cancer Drug Clinical Development." An international delegation of oncology experts presented the innovative clinical trial strategies and discussed the biomarkers for cancer early detection and clinical trials,targeted therapy,and new drug *** oncology Drug Clinical Development and Safety Evaluation Committee was also launched to promote an innovative environment and to provide a collaborative platform for anti-cancer drug development in China.

关键词：协会北京年会中国学者临床试验抗癌药物邪教开发过程

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Critical questions in development of targeted nanoparticle therapeutics

引用

Regenerative Biomaterials 2016年第2期3卷 143-147页

作者： Richard Korsmeyer Pharmaceutical Sciences Pfizer Worldwide R&DGrotonCT 06340USA

One of the fourteen Grand Challenges for Engineering articulated by the US National Academy of Engineering is‘Engineer Better Medicines’.Although there are many ways that better medicines could be engineered,one of the most promising ideas is to improve our ability to deliver the therapeutic molecule more precisely to the desired *** conventional drug delivery methods(oral absorption,intravenous infusion etc.)result in systemic exposure to the therapeutic molecule,which places severe constraints on the types of molecules that can be used.A molecule administered by systemic delivery must be effective at low concentrations in the target tissue,yet safe everywhere else in the *** drug carriers could be developed to deliver therapeutic molecules selectively to the desired target,it should be possible to greatly improve safety and efficacy of ***(and related nanostructures,such as liposomes,nanoemulsions,micelles and dendrimers)are an attractive drug carrier concept because they can be made from a variety of materials engineered to have properties that allow loading and precise delivery of bound therapeutic *** field of targeted nanoparticles has been extraordinarily active in the academic realm,with thousands of articles published over the last few *** of these publications seem to demonstrate very promising results in in vitro studies and even in animal *** addition,a handful of human clinical trials are in ***,the biopharmaceutical industry has been relatively slow to make major investments in targeted nanoparticle development programs,despite a clear desire to introduce innovative new therapies to the *** is the reason for such caution?Some degree of caution is no doubt due to the use of novel materials and the unproven nature of targeted nanoparticle technology,but many other unproven technologies have generated intense interest at various *** believe that the major barrier to the exploration

关键词： nanoparticles targeting biodistribution manufacturing

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

East meets West:ethnic differences in epidemiology and clinical behaviors of lung cancer between East Asians and Caucasians

引用

Chinese Journal of Cancer 2011年第5期30卷 287-292页

作者： Wei Zhou David C. Christiani Molecular Epidemiology Research Global Outcomes Research Pfizer Oncology Collegeville PA 19426 USA Departments of Epidemiology and Environmental Health Harvard School of Public Health Boston MA 02115 USA Department of Medicine Massachusetts General Hospital Harvard Medical School Boston MA 02115 USA

Lung cancer is the leading cause of cancer death worldwide,with large variation of the incidence and mortality across *** the mortality of lung cancer has been decreasing,or steady in the US,it has been increasing in Asia for the past two *** is the leading cause of lung cancer,and other risk factors such as indoor coal burning,cooking fumes,and infections may play important roles in the development of lung cancer among Asian never smoking *** median age of diagnosis in Asian patients with lung cancer is generally younger than Caucasian patients,particularly among *** and Caucasians may have different genetic susceptibilities to lung cancer,as evidenced from candidate polymorphisms and genome-wide association *** epidemiologic studies and clinical trials have shown consistently that Asian ethnicity is a favorable prognostic factor for overall survival in non-small cell lung cancer(NSCLC),independent of smoking *** with Caucasian patients with NSCLC,East Asian patients have a much higher prevalence of epidermal growth factor receptor(EGFR) mutation(approximately 30% vs.7%,predominantly among patients with adenocarcinoma and never-smokers),a lower prevalence of K-Ras mutation(less than 10% vs.18%,predominantly among patients with adenocarcinoma and smokers),and higher proportion of patients who are responsive to EGFR tyrosine kinase *** ethnic differences in epidemiology and clinical behaviors should be taken into account when conducting global clinical trials that include different ethnic populations.

关键词：非小细胞肺癌临床试验种族差异流行病学亚洲人中西文化行为白种人

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Nondestructive Quantitative Analysis of Cofrel Medicines by Double ANN-NIR Spectroscopy

引用

Chinese Chemical Letters 2006年第9期17卷 1209-1212页

作者： Ming Yang LIU Yu MENG Jun Feng LI Hai Tao ZHANG Hong Yan WANG College of Chemistry Jilin University Changchun 130012 pfizer Pharmaceuticals Limited Co. Dalian 116600

In this paper, a double artificial neural network （DANN） algorithm was used to parse near infrared （NIR） reflectance spectrum of Cofrel medicines. The contents of benproperine phosphate, which is the effective ingredient in Cofrel medicines, were accurately nondestructive quantitatively predicted. Compared the results with those of HPLC, the relative errors （RE %） were less than 0.18%. The analytical results could be applied to qualitative control of Cofrel medicines.

关键词： Double ANN NIR spectroscopy nondestructive quantitative analysis Cofrel.

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Targeted therapies in metastatic gastric cancer: Current knowledge and future perspectives

引用

World Journal of Gastroenterology 2019年第38期25卷 5773-5788页

作者： Antonio Pellino Erika Riello Floriana Nappo Stefano Brignola Sabina Murgioni Selma Ahcene Djaballah Sara Lonardi Vittorina Zagonel Massimo Rugge Fotios Loupakis Matteo Fassan Department of oncology Veneto Institute of Oncology IOV-IRCCSPadua 35100Italy Department of Surgery Oncology and GastroenterologyUniversity of PaduaPadua 35100Italy Surgical Pathology&Cytopathology Unit Department of MedicineUniversity of PaduaPadua 35100Italy Veneto Cancer Registry Padua 35100Italy

Gastric cancer(GC)represents a leading cause of cancer related morbidity and mortality worldwide accounting for more than 1 million of newly diagnosed cases and thousands of deaths every *** the last decade,the development of targeted therapies and the optimization of already available chemotherapeutic drugs has expanded the available treatment options for advanced GC and granted better survival expectations to the *** the same time,global efforts have been undertaken to investigate in detail the genomic and epigenomic heterogeneity of this disease,resulting in the identification of new specific and sensitive predictive and prognostic biomarkers and in innovative molecular classifications based on gene expression ***,several randomized studies aimed at exploring new innovative agents,such as immune checkpoint inhibitors,failed to demonstrate clinically meaningful survival ***,it is essential to further improve the molecular characterization of GC subgroups in order to provide researchers and medical oncologists with new tools for patients’selection and stratification in future clinical development programs and subsequent *** aim of the present manuscript is to provide a global overview of the recent molecular classifications from The Cancer Genome Atlas and the Asian Cancer Research Group and to present key promising developments in the field of immunotherapy and targeted therapies in metastatic GC.

关键词： Gastric cancer Personalized medicine Predictive biomarkers Molecular diagnostic The Cancer Genome Atlas Asian Cancer Research Group

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hepatotoxicity reports in the FDA adverse event reporting system database:A comparison of drugs that cause injury via mitochondrial or other mechanisms

引用

Acta Pharmaceutica Sinica B 2021年第12期11卷 3857-3868页

作者： Payal Rana Michael D.Aleo Xuerong Wen Stephen Kogut Drug Safety Research&Development PfizerGrotonCT 06340USA University of Rhode Island College of PharmacyKingstonRI 02881USA

Drug-induced liver injury(DILI) is a leading reason for preclinical safety attrition and postmarket drug ***-induced mitochondrial toxicity has been shown to play an essential role in various forms of DILI,especially in idiosyncratic liver *** study examined liver injury reports submitted to the Food and Drug Administration(FDA) Adverse Event Reporting System(FAERS) for drugs associated with hepatotoxicity via mitochondrial mechanisms compared with non-mitochondrial mechanisms of *** frequency of hepatotoxicity was determined at a group level and individual drug level.A reporting odds ratio(ROR) was calculated as the measure of *** the two DILI groups,reports for DILI involving mitochondrial mechanisms of toxicity had a 1.43(95% CI 1.42-1.45;P 18:benzbromarone,troglitazone,isoniazid,rifampin) were associated with mitochondrial mechanisms of *** major demographic influence for DILI risk was also *** was a higher mean patient age among reports for drugs that were associated with mitochondrial mechanisms of toxicity [56.1±18.33(SD)] compared to non-mitochondrial mechanisms [48±19.53(SD)](P <0.0001),suggesting that age may play a role in susceptibility to DILI via mitochondrial mechanisms of *** logistic regression analysis showed that reports of liver injury were 2.2(odds ratio:2.2,95% CI 2.12-2.26) times more likely to be associated with older patient age,as compared with reports involving patients less than 65 years of *** to males,female patients were 37% less likely(odds ratio:0.63,95% CI

关键词： Mitochondrial toxicity FAERS database Adverse event reporting Drug-induced liver injury Hepatotoxicity

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The Prevalence of Methicillin-Resistant Staphylococcus aureus Colonization in Patients with Complicated Skin and Skin Structure Infections after Treatment with Linezolid or Vancomycin

引用

Advances in Infectious Diseases 2014年第4期4卷 186-193页

作者： Laura A. Puzniak Kimbal D. Ford David B. Huang formerly pfizer Inc. Collegeville USA pfizer Inc. Collegeville USA

Background: Complicated skin and skin structure infections (cSSSIs) due to Staphylococcus aureus, including methicillin-resistant S. aureus (MRSA), are associated with significant morbidity. Re-ducing MRSA carriage has been a focus of infection control interventions. The prevalence of MRSA colonization after successful treatment of a MRSA cSSSI is unknown. Methods: Secondary analysis of a randomized controlled trial comparing linezolid and vancomycin for the treatment of MRSA cSSSI. Adult patients that had a colonization culture, confirmed MRSA cSSSI, received at least one dose of study treatment, and had an outcome recorded at end of study. Patient, clinical characteristics and prevalence of colonization were compared by treatment regimens. A multivariate regression model identified predictors of MRSA colonization at EOS. Results: There were 456 patients evaluated. The prevalence of MRSA colonization was higher for vancomycin treated patients compared to linezolid treated patients at end of treatment (EOT) (28% vs. 5%, p < 0.001) and EOS (34% vs. 22%, p < 0.01). Independent predictors of colonization at EOS after treatment for a MRSA cSSSI included diagnosis, primarily driven by abscess, black race, treatment with vancomycin, MRSA mixed infection and male gender. Conclusion: Patients treated with linezolid for a cSSSI had less MRSA colonization at EOT and EOS compared to those treated with vancomycin. Multiple independent predictors of MRSA colonization were identified. Additional studies evaluating the relationship of MRSA colonization after treatment of cSSSI are needed.

关键词： Staphylococcus aureus Complicated Skin and Skin Structure Infection Colonization Linezolid

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：