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The chemokine receptor CCR7 is a promising target for rheumatoid arthritis therapy

Cellular & Molecular Immunology 2019年第10期16卷 791-799页

作者： Georgios L.Moschovakis Anja Bubke Michaela Friedrichsen Jasmin Ristenpart Jaap Willem Back Christine S.Falk Elisabeth Kremmer Reinhold Forster Institute of Immunology Hannover Medical SchoolCarl-Neuberg Str.130625 HannoverGermany pepscan therapeutics bv LelystadThe Netherlands Institute of Transplant Immunology Integrated Research and Treatment Center TransplantationIFB.TxHannover Medical SchoolCarl-Neuberg Str.130625 HannoverGermany Helmholtz-Zentrum München Institute of Molecular ImmunologyD-81377 MunichGermany Present address:Biozentrum Martinsried Dept.Bio II.LMU MünchenGrosshaderner Str.2D-82152 MartinsriedGermany

The chemokine receptor CCR7 and its ligands CCL19 and CCL21 guide the homing and positioning of dendritic and T cells in lymphoid organs,thereby contributing to several aspects of adaptive immunity and immune *** the present study,we investigated the role of CCR7 in the pathogenesis of collagen-induced arthritis(CIA).By using a novel anti-human CCR7 antibody and humanized CCR7 mice,we evaluated CCR7 as a target in this autoimmune model of rheumatoid arthritis(RA).Ccr7-deficient mice were completely resistant to CIA and presented severely impaired antibody responses to collagen II(CII).Selective CCR7 expression on dendritic cells restored arthritis severity and anti-CII antibody *** and therapeutic treatment of humanized CCR7 mice with anti-human CCR7 mAb 8H3-16A12 led to complete resistance to CIA and halted CIA progression,*** data demonstrate that CCR7 signaling is essential for the induction of CIA and identify CCR7 as a potential therapeutic target in RA.

关键词： CCR7 impaired immunity

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Gene and cell therapy based treatment strategies for inflammatory bowel diseases

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World Journal of Gastrointestinal Pathophysiology 2011年第6期2卷 114-122页

作者： Sander van der Marel Anna Majowicz Sander van Deventer Harald Petry Daniel W Hommes Valerie Ferreira Department of Research and Development Amsterdam Molecular Therapeutics BV1105 BA AmsterdamThe Netherlands Department of Gastroenterology and Hepatology Leiden University Medical Center2333 ZA LeidenThe Netherlands

Inflammatory bowel diseases(IBD)are a group of chronic inflammatory disorders most commonly affecting young *** available therapies can result in induction and maintenance of remission,but are not curative and have sometimes important side *** in basic research in IBD have provided new therapeutic opportunities to target the inflammatory process *** and cell therapy approaches are suitable to prevent inflammation in the gastrointestinal tract and show therefore potential in the treatment of *** this review,we present the current progress in the field of both gene and cell therapy and future prospects in the context of *** gene therapy,we focus on viral vectors and their applications in preclinical *** focus for cell therapy is on regulatory T lymphocytes and mesenchymal stromal cells,their potential for the treatment of IBD and the progress made in both preclinical models and clinical trials.

关键词： Viral vector Gene therapy Cell therapy Inflammatory bowel diseases Immune tolerance Regulatory T lymphocytes Mesenchymal stromal cells

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