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Prevalence of Helicobacter pylori infection in Chinese military personnel:A cross-sectional,multicenter-based study

World Journal of Gastroenterology 2025年第3期31卷 42-49页

作者： Han-Chen Min Chun-Yan Zhang Fang-Yu Wang Xiao-Hui Yu shan-Hong Tang Hong-Wu Zhu Ya-Gang Zhao Ji-Luo Liu Jian Wang Jing-Han Guo Xiao-Mei Zhang Yun-sheng Yang Chinese people’s liberation army medical school Chinese People’s Liberation Army General HospitalBeijing 100853China Department of Gastroenterology and Hepatology The First Medical CenterChinese People’s Liberation Army General HospitalBeijing 100853China sixth Healthcare Department The Second Medical CenterChinese People’s Liberation Army General HospitalBeijing 100853China Department of Gastroenterology The 940th Hospital of Joint Logistic Support Force of Chinese People’s Liberation ArmyLanzhou 730050Gansu ProvinceChina Department of Gastroenterology General Hospital of Western Theater CommandChengdu 610011Sichuan ProvinceChina Department of Gastroenterology General Hospital of Southern Theater CommandGuangzhou 510010Guangdong ProvinceChina Department of Epidemiology Naval Medical UniversityShanghai 200433China school of Medicine Nankai UniversityTianjin 300071China National Clinical Research Center for Geriatric Diseases Chinese People’s Liberation Army General HospitalBeijing 100853China

BACKGROUND Helicobacter pylori(***)infection is a prevalent disease encountered in military internal medicine and recognized as the main cause of dyspepsia,gastritis,and peptic ulcer,which are common diseases in military *** guidelines in China state all patients with evidence of active infection with *** are offered ***,the prevalence of *** infection and its regional distribution in the military population remain unclear,which hinders effective prevention and treatment *** the prevalence of *** infection in the military population will aid in the development of customized strategies to better manage this infectious *** To investigate the prevalence of *** infection in the Chinese military population in different geographic *** This multicenter,retrospective study included 22421 individuals from five tertiary hospitals located in north,east,southwest,and northwest cities of *** infection was identified using the urea breath test,which had been performed between January 2020 and December *** Of the 22421 military service members,7416(33.1%)were urea breath *** highest prevalence of *** was in the 30-39 years age group for military personnel,with an infection rate of 34.9%.The majority of infected subjects were younger than 40-years-old,accounting for 70.4%of the infected *** individuals serviced in Lanzhou and Chengdu showed a higher infection prevalence than those in Beijing,Nanjing,and Guangzhou,with prevalence rates of 44.3%,37.9%,29.0%,31.1%,and 32.3%,*** *** infection remains a common infectious disease among military personnel in China and has a relatively high prevalence rate in northwest China.

关键词： Helicobacter pylori Prevalence Military personnel Urea breath test Multicenter study

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Role of neurogenic inflammation in intervertebral disc degeneration

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World Journal of Orthopedics 2025年第1期16卷 24-39页

作者： Bao-Gan Peng Yong-Chao Li Liang Yang Department of Orthopaedics The Third Medical CenterGeneral Hospital of the Chinese People’s Liberation ArmyBeijing 100039China Department of Orthopeadics Featured Medical Center of Chinese People’s Armed Police ForcesTianjin 300000China

In healthy intervertebral discs(IVDs),nerves and blood vessels are present only in the outer annulus fibrosus,while in degenerative IVDs,a large amount of nerve and blood vessel tissue grows *** supports that neurogenic inflammation produced by neuropeptides such as substance P and calcitonin gene related peptide released by the nociceptive nerve fibers innervating the IVDs plays a crucial role in the process of IVD ***,non-neuronal cells,including IVD cells and infiltrating immune cells,have emerged as important players in neurogenic *** cells and infiltrating immune cells express functional receptors for neuropeptides through which they receive signals from the nervous *** return,IVD cells and immune cells produce neuropeptides and nerve growth factor,which stimulate nerve *** communication generates a positive bidirectional feedback loop that can enhance the inflammatory response of the *** emerging transient receptor potential channels have been recognized as contributors to neurogenic inflammation in the degenerative *** findings suggest that neurogenic inflammation involves complex pathophysiological interactions between sensory nerves and multiple cell types in the degenerative *** the mechanism of neurogenic inflammation in IVD degeneration may provide in-depth understanding of the pathology of discogenic low back pain.

关键词： Intervertebral disc degeneration Discogenic low back pain Neurogenic inflammation Neuropeptides Neurotrophins Transient receptor potential channels

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Experimental and numerical simulation of the attenuation effect of blast shock waves in tunnels at different altitudes

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Defence Technology(防务技术) 2025年第1期43卷 120-141页

作者： Changjiang Liu Hujun Li Zhen Wang Yong He Guokai Zhang Mingyang Wang school of Mechanical Engineering Nanjing University of Science and TechnologyNanjing 210094China state Key Laboratory of Disaster Prevention and Mitigation of Explosion and Impact People's Liberation Army Engineering UniversityNanjing 210014China

Traffic engineering such as tunnels in various altitudinal gradient zone are at risk of accidental explosion,which can damage personnel and *** prediction of the distribution pattern of explosive loads and shock wave propagation process in semi-enclosed structures at various altitude environment is key research focus in the fields of explosion shock and fluid *** effect of altitude on the propagation of shock waves in tunnels was investigated by conducting explosion test and numerical *** on the experimental and numerical simulation results,a prediction model for the attenuation of the peak overpressure of tunnel shock waves at different altitudes was *** results showed that the peak overpressure decreased at the same measurement points in the tunnel entrance under the high altitude *** contrast,an increase in altitude accelerated the propagation speed of the shock wave in the *** average error between the peak shock wave overpressure obtained using the overpressure prediction formula and the measured test data was less than15%,the average error between the propagation velocity of shock waves predicted values and the test data is less than 10%.The method can effectively predict the overpressure attenuation of blast wave in tunnel at various altitudes.

关键词： shock wave propagation Tunnel Altitude effect Peak overpressure shock waves velocity Engineering safety

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Comparative study of a rabbit model of spinal tuberculosis using different concentrations of Mycobacterium tuberculosis

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World Journal of Orthopedics 2025年第1期16卷 46-56页

作者： Yong-Jie Qiao Xiao-Yang song Lv-Dan Zhang Feng Li Hao-Qiang Zhang sheng-Hu Zhou Department of Joint surgery The Second Hospital&Clinical Medical SchoolLanzhou UniversityLanzhou 730050Gansu ProvinceChina Department of Orthopedics The 940th Hospital of Joint Logistic Support Force of Chinese People’s Liberation ArmyLanzhou 730000Gansu ProvinceChina Department of Respiratory Medicine The 940th Hospital of Joint Logistic Support Force of Chinese People’s Liberation ArmyLanzhou 730050Gansu ProvinceChina Department of Orthopaedics The 943rd Hospital of Joint Logistic Support Force of Chinese People’s Liberation ArmyWuwei 733099Gansu ProvinceChina

BACKGROUND Tuberculosis is among the most devastating infectious diseases *** tuberculosis is not easy to detect at an early stage,which without effective treatment often leads to spinal deformity and spinal cord damage which in turn cause complications such as paraplegia and *** this study,we established a model using three concentrations of bacteria and carried out a comprehensive evaluation of the model by imaging,general observations,and histopathological and bacteriological *** To establish a rabbit model of spinal tuberculosis and examine the effect on the model’s efficacy using different concentrations of Mycobacterium tuberculosis(***)*** New Zealand rabbits were randomly divided into experimental,control and blank *** experimental and control animals were sensitized with complete Freund′s adjuvant,a hole was drilled beneath the upper endplate of the L6 vertebral body and filled with gelfoam *** experimental group was divided into three subgroups(experimental 1,experimental 2,experimental 3)and infused with *** suspension at various *** control group was inoculated with saline and the blank group received no *** 12-week post-operative survival rates were 100%,80%and 30%in the experimental groups inoculated with concentrations of 106,107 and 108 CFU/mL bacteria,*** The survival rate of the control and blank groups was 100%.Vertebral body destruction at 8 weeks in the three experimental groups as determined by X-ray analysis was 33.3%,62.5%and 66.7%,and by computed tomography(CT)and 3-dimensional CT 44.4%,75%and 100%,*** 12 weeks,the figures were 44.4%,75%and 100%by X-ray analysis and 44.4%,100%and 100%by CT and 3-dimensional CT,*** surviving rabbits of the experimental groups had vertebral *** positive bacterial culture rates were 22.2%,75%and 66.7%,respectively,in the experimental *** being

关键词： spinal tuberculosis Animal model H37RV Mycobacterium tuberculosis New Zealand rabbits

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Fundamentals of intervertebral disc degeneration and related discogenic pain

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World Journal of Orthopedics 2025年第1期16卷 18-23页

作者： Bao-Gan Peng Department of Orthopedics The Third Medical CenterGeneral Hospital of the Chinese People’s Liberation ArmyBeijing 100039China

Lumbar intervertebral disc degeneration is thought to be the main cause of low back pain,although the mechanisms by which it occurs and leads to pain remain *** healthy adult discs,vessels and nerves are present only in the outer layer of the annulus fibrosus and in the bony *** models,and histological and biomechanical studies have shown that annulus tear or endplate injury is the initiating factor for painful disc *** to the disc triggers a local inflammatory repair response that activates nociceptors and promotes the synthesis of neuropeptides such as substance P and calcitonin generelated peptide,by dorsal root ganglion *** neuropeptides are transported to injured discs and act as pro-inflammatory molecules,promoting the production of an“inflammatory soup”by inducing vasodilatation and plasma extravasation as well as by promoting the release of chemical mediators from disc cells and infiltrating immune cells,causing neurogenic inflammation that leads to progressive disc degeneration and discogenic pain.

关键词： Intervertebral disc degeneration Discogenic low back pain Neurogenic inflammation Neuropeptides substance P Calcitonin gene-related peptide

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Metastatic lymph node distribution and pathology correlations in upper and lower gastric cancer patients:A multicenter retrospective study

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World Journal of Gastrointestinal Oncology 2025年第2期17卷 56-66页

作者： Xian-Bei Yuan Gang sun Jun Niu Lei Dong Yi sui Yong-Zhu Lv Department of General surgery No.967 Hospital of the People's Liberation Army Joint Logistics Support ForceDalian 116000Liaoning ProvinceChina Department of Trauma surgery The No.967 Hospital of People's Liberation Army Joint Logistics Support ForceDalian 116000Liaoning ProvinceChina Department of General surgery The First Affiliated Hospital of Dalian Medical UniversityDalian 116000Liaoning ProvinceChina Department of General surgery The Fifth People's Hospital of ShenyangShenyang 110000Liaoning ProvinceChina Department of General surgery The Fifth People's Hospital of DalianDalian 116000Liaoning ProvinceChina

BACKGROUND Gastric cancer(GC)poses a significant threat to public ***,the clinicopathological features and tumor biological behaviors vary among the GC patients,leading to individual variations in lymph node ***,the stratification of lymph node dissection according to the specific type,particularly upper GC,has emerged as a prominent area of *** To investigate the distribution of metastatic lymph nodes in patients with upper and lower GC and to analyze the differences in related pathological elements and *** Differential analysis between upper and lower GC patients with various clinicopathological factors was performed using the chi-square test and rank-sum regression models were used to analyze risk factors affecting patient *** Kaplan-Meier method was used to construct survival curves associated with prognostic risk factors for *** significant differences were observed between the two GC populations regarding tumor diameter,histological grade,pT stage,pN stage,tumor-node-metastasis(pTNM)stage,vascular invasion,and adjuvant chemotherapy usage(all Pstasis rates were highest for siewert type II patients in groups Nos.1,3,2 and 7;for siewert type III patients in groups Nos.3,1,2 and 7;and for other/unclassified patients in groups Nos.1,3,7,*** the lower GC samples,the sequences were Nos.3,6,7,*** type,pT stage,pTNM stage,and positive vascular invasion were independent risk factors for development of lymph node ***,pathological type,pT stage,pN stage,pTNM stage,vascular invasion,and absence of adjuvant chemotherapy were identified as independent prognostic *** Upper GC showed a significantly higher malignancy grade and different lymph node metastasis pattern than lower GC.

关键词： Upper gastric cancer Lower gastric cancer Metastatic lymph nodes Prognosis Retrospective study

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TRIPLET combined with microwave ablation:A novel treatment for advanced hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 10-12页

作者： Fei-Yu Zhao Guo-Wei si Nian-song Qian Department of Thoracic Oncology Respiratory and Critical Care MedicineThe Eighth Medical Center of People’s Liberation Army General HospitalBeijing 100853China Department of Gastroenterology Fourth Medical CentreGeneral Hospital of the People's Liberation ArmyBeijing 100142China senior Department of Thoracic Oncology Respiratory and Critical Care MedicineThe Eighth Medical Center of People’s Liberation Army General HospitalBeijing 100091China

This editorial comments on a study by Zuo et *** focus is on the efficacy of he-patic arterial infusion chemotherapy combined with camrelizumab and apatinib(the TRIPLET regimen),alongside microwave ablation therapy,in treating advanced hepatocellular carcinoma(HCC).The potential application of this combination therapy for patients with advanced HCC is evaluated.

关键词： Microwave ablation Hepatic arterial infusion chemotherapy Apatinib Camrelizumab Hepatocellular carcinoma

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Retraction note to:shugan Jieyu capsule effects on peripheral blood micro-124,micro-132,and brain-derived neurotrophic factor in patients with mild to moderate depression

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World Journal of Psychiatry 2025年第2期15卷 283-284页

作者： Xian Zhang Yang Liu Hua-Fei Tang Feng Jiang Chun-Liang Chen Ting-Ting Wang Hui-Zhong Gu QiangZhao Rui Ma Department of Pharmacy The 305 Hospital of People’s Liberation ArmyBeijing 100017China

In this retraction note,we have decided to retract an article published in World Journal of Psychiatry due to disagreement among the authors.

关键词： World Journal of Psychiatry Retraction note

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Two treatment methods for hepatocellular carcinoma:Lenvatinib or bevacizumab combined with sintilimab and interventional therapy

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World Journal of Gastroenterology 2025年第10期31卷 164-167页

作者： Fei-Yu Zhao Xiao-Ming Zhang Nian-song Qian Department of Thoracic Oncology Respiratory and Critical Care MedicineThe Eighth Medical Center of People’s Liberation Army General HospitalBeijing 100853China

In their study,Han et al compared the efficacy of bevacizumab plus sindilizumab plus interventional therapy with that of lenvatinib plus sindilizumab plus interventional therapy for patients with intermediate and advanced hepatocellular *** triple therapy,which integrates interventional therapy,targeted therapy,and immunotherapy,has emerged as a promising research focus in the treatment of liver ***,it is of utmost significance to select an appropriate combination of interventional therapy,targeted therapy,and immunotherapy for patients suffering from intermediate and advanced liver cancer.

关键词： Hepatocellular carcinoma Bevacizumab Lenvatinib sintilimab Interventional treatment

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Multicenter analysis on the correlation between the anatomical characteristics of hepatic veins and hepatic venous wedge pressure

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World Journal of Gastroenterology 2025年第9期31卷 43-53页

作者： Qiu-Xia Ye Ming-Ming Meng Yi-Fan Wu Cheng-Bin Dong Yu Zhang Bo-Wen Liu Yi-Fan Lv shao-Li You sa Lv Hui-Guo Ding Ying Han Yong-Ping Yang Bing Zhu Fu-Quan Liu Liver Disease Minimally Invasive Diagnosis and Treatment Center Beijing Shijitan HospitalCapital Medical UniversityBeijing 100038China Liver Vascular Disease Diagnosis and Treatment Center The Fifth Medical Center of Chinese People's Liberation Army General HospitalBeijing 100039China Department of Gastroenterology and Hepatology Beijing You’an HospitalCapital Medical UniversityBeijing 100069China

BACKGROUND Wedged hepatic venous pressure(WHVP)is a crucial variable for accurately assessing the hepatic venous pressure gradient(HVPG)and is vital for the diagnosis and prognostic evaluation of patients with portal hypertension(PH).AIM To investigate the anatomical characteristics of balloon-occluded hepatic venous angiography in patients with PH and analyze the relationship between the WHVP and portal venous pressure(PVP).METHODs This retrospective study included 877 patients with PH who met the inclusion criteria from January 2020 to June *** and innovative hepatic venous angiography was performed during transjugular intrahepatic portosystemic shunt procedures to measure hepatic venous and *** patients'angiographic images were collected for *** associations between WHVP and PVP in each group were analyzed via linear regression analysis,and a predictive model was *** The 877 patients had a mean age of 52.6±13.0 years,with 582 males and 295 *** were categorized into four groups on the basis of their anatomical *** groups showed strong correlations between WHVP and *** regression coefficient between the WHVP and PVP in the hepatic right vein-portal venous angiography group was 0.884(Pssory hepatic venous angiography group,it was 0.721(Ps angiography group,it was 0.344(Ps 0.293(PsION The presence and anatomical classification of hepatic venous collaterals are key factors influencing the relationship between WHVP with and *** on the different anatomical classifications of hepatic veins,WHVP can be used to estimate PVP,improving the accuracy of PVP prediction.

关键词： Wedged hepatic venous pressure Portal venous pressure Portal hypertension Collateral branches of the hepatic vein Transjugular intrahepatic portosystemic shunt

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