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Impact of early refined nursing program on prognosis of middleaged and elderly patients with cognitive dysfunction combined with cerebral infarction

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World Journal of Psychiatry 2024年第7期14卷 1034-1042页

作者： Hui-Lian Xiong Zhi-Xin Li Xin Lu Yan-Hua Lu Ping Zhong Ganzhou City Central Blood station Ganzhou 341000Jiangxi ProvinceChina Department of Rehabilitation Medicine Ganzhou People's HospitalGanzhou 341000Jiangxi ProvinceChina

BACKGROUND Cerebral infarction is a local or extensive necrosis of brain ***,the corresponding neurological deficits *** incidence of cerebrovascular diseases in China is increasing *** the onset of cerebrovascular disease,the most common sequelae include movement disorders,language disorders,and cognitive *** To investigate the effect of early refined nursing program on the prognosis of middle-aged and elderly patients with cerebral infarction combined with cognitive *** A retrospective study was conducted to divide 60 patients with cerebral infarction and cognitive impairment into an experimental group(n=32)and a control group(n=28).The experimental group received early intensive care every day,and the control group received daily routine *** scores of the Mini-Mental state Examination(MMsE)and the Trail Making Test(TMT),as well as the latency and amplitude of the event-related potential P300,were used as main indicators to evaluate changes in cognitive function,and changes in BDNF,TGF-β,and GDNF expression were used as secondary *** Both groups experienced notable enhancements in MMsE scores,with the experi-mental group demonstrating higher scores than the control group(experimental:28.75±2.31;control:25.84±2.87).Moreover,reductions in TMT-A and TMT-B scores were observed in both groups(experimental:TMT-A 52.36±6.18,TMT-B 98.47±10.23;control:TMT-A 61.48±7.92,TMT-B 112.63±12.55),with the experimental group displaying lower scores.P300 Latency decreased(experimental:270.63 ms±14.28 ms;control:285.72 ms±16.45 ms),while amplitude increased(experimental:7.82μV±1.05μV;control:6.35μV±0.98μV)significantly in both groups,with superior outcomes in the experimental ***,the levels of the growth factors BDNF,TGF-β1,and GDNF surged(experimental:BDNF 48.37 ng/mL±5.62 ng/mL,TGF-β152.14 pg/mL±4.28 pg/mL,GDNF 34.76 ng/mL±3.89 ng/mL;control:BDNF 42.58 ng/mL±4.73 ng/mL,TGF-β146.23 pg/m

关键词： Early refined nursing program Cerebral infraction Cognitive impairment Psychiatry Trajectory test

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Emerging non-antibody‒drug conjugates (non-ADCs) therapeutics of toxins for cancer treatment

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Acta Pharmaceutica sinica B 2024年第4期14卷 1542-1559页

作者： Xiaolan Xu Jiaming Zhang Tao Wang Jing Li Yukang Rong Yanfang Wang Chenxia Bai Qing Yan Xiaohua Ran Yingli Wang Tianhong Zhang Jin sun Qikun Jiang Wuya College of Innovation Shenyang Pharmaceutical UniversityShenyang 110016China school of Education University of NottinghamNottingham NG72RDUK Department of Pharmacy Linyi People's HospitalShandong UniversityLinyi 276000China state Key Laboratory of Natural and Biomimetic Drugs Peking UniversityBeijing 100871China

The non-selective cytotoxicity of toxins limits the clinical relevance of the *** recent years,toxins have been widely used as warheads for antibody-drug conjugates(ADCs)due to their eff-cient killing activity against various cancer *** ADCs confer certain targeting properties to the toxins,low drug loading capacity,possible immunogenicity,and other drawbacks also limit the po-tential application of ***,non-ADC delivery strategies for toxins have been extensively *** further understand the application of toxins in anti-tumor,this paper provided an over-view of prodrugs,nanodrug delivery systems,and biomimetic drug delivery *** addition,toxins and their combination strategies with other therapies were ***,the prospect and challenge of toxins in cancertreatmentwerealso summarized.

关键词： Toxins Non-antibody-drug conjugates Delivery strategies Prodrugs Nano drug delivery systems Biomimetic drugdelivery systems Combination strategies Cancer treatment

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Analysis of the Effect of Problem-Oriented Nursing Intervention on Patients with Lower Extremity Arteriosclerosis Obliterans in Vascular surgery

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Journal of Clinical and Nursing Research 2024年第4期8卷 1-6页

作者： Yang An shanxi Provincial people’s hospital Taiyuan 030012China

Objective: To analyze the effect of problem-oriented nursing intervention on patients with lower extremity arteriosclerosis obliterans (AsO) in vascular surgery. Methods: The clinical data of 128 patients with lower extremity AsO in vascular surgery were selected and randomly divided into groups A and B, with 64 cases each. Group A is the control group, and Group B is the observation group. Group A received the routine nursing intervention, and Group B received the problem-oriented nursing intervention. The compliance, self-care ability, psychological state, quality of life, and nursing satisfaction of the two groups of patients were evaluated based on various indicators. Results: After the intervention, the evaluation of self-care ability (EsCA) score of the patients in Group B was higher than that of Group A, and the symptom checklist-90 (sCL-90) score was lower than that of Group A. The differences were significant (t = 10.019, t = 3.118, P scores of the two groups increased and the increase in Group B was significantly higher than Group A (P s higher than that of Group A (52/ 81.25%), and the difference was extremely significant (χ2 = 8.020, P sion: Problem-oriented nursing intervention for patients with lower extremity AsO in vascular surgery improved the patient’s self-care ability, and quality of life, reduced the patient’s negative emotions, and enhanced their overall satisfaction.

关键词： Problem orientation Nursing intervention Vascular surgery Lower extremity arteriosclerosis obliterans

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Echocardiographic Measurements in Normal Chinese Adults(EMINCA)II focusing on left ventricular and left atrial size and function by three-dimensional echocardiography

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Frontiers of Medicine 2024年第4期18卷 649-663页

作者： Yingbin Wang Yu Zhang Guihua Yao Hong Tang Lixin Chen Lixue Yin Tiangang Zhu Jianjun Yuan Wei Han Jun Yang Xianhong shu Ya Yang Yulin Wei Yanli Guo Weidong Ren Dongmei Gao Guilin Lu Ji Wu Hongning Yin Yuming Mu Jiawei Tian Lijun Yuan Xiaojing Ma Hongyan Dai Yunchuan Ding Mingyan Ding Qing Zhou Hao Wang Di Xu Mei Zhang Yun Zhang state Key Laboratory for Innovation and Transformation of Luobing Theory Key Laboratory of Cardiovascular Remodeling and Function ResearchChinese Ministry of EducationChinese National Health Commission and Chinese Academy of Medical SciencesDepartment of CardiologyQilu Hospital of Shandong UniversityJinan250012China Department of Cardiology Qilu Hospital of Shandong University(Qingdao)Qingdao266000China Department of Ultrasonography West China HospitalSichuan UniversityChengdu610041China Department of Ultrasonography Shenzhen People’s Hospital/The Second Clinical Medical College of Jinan UniversityShenzhen518020China Department of Ultrasonography Electronic Science and Technology University of ChinaThe Affiliated Sichuan Provincial People’s HospitalChengdu610072China Department of Cardiology Peking University People’s HospitalBeijing100044China Department of Ultrasonography Henan Provincial People’s HospitalZhengzhou463599China Department of Cardiology The First Affiliated Hospital of Harbin Medical UniversityHarbin150007China Department of Echocardiology The First Affiliated Hospital of China Medical UniversityShenyang110001China Department of Echocardiology Zhongshan HospitalFudan UniversityShanghai200032China Department of Echocardiology Beijing Anzhen HospitalCapital Medical UniversityBeijing100029China Department of Cardiology Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou510120China Department of Ultrasonography The Southwest Hospital of AMUChongqing400038China Department of Ultrasonography Shengjing Hospital of China Medical UniversityShenyang110136China Department of Ultrasonography China-Japan Union hospital of Jilin UniversityChangchun130033China Department of Ultrasonography First Affiliated HospitalSchool of MedicineShihezi UniversityShihezi832000China Department of Ultrasonography The First Affiliated Hospital of Guangxi Medical UniversityNanning537406China Department of Echocardiology The Second Hospital of Hebei Medical Uni

Current guidelines encourage large studies in a diverse population to establish normal reference ranges for three-dimensional(3D)echocardiography for different ethnic *** study was designed to establish the normal values of 3D-left ventricular(LV)and left atrial(LA)volume and function in a nationwide,population-based cohort of healthy Han Chinese adults.A total of 1117 healthy volunteers aged 18–89 years were enrolled from 28 collaborating laboratories in *** sets of 3D echocardiographic instruments were used,and full-volume echocardiographic images were recorded and transmitted to a core laboratory for image analysis with a vendor-independent off-line ***,866 volunteers(mean age of 48.4 years,402 men)were qualified for final *** parameters exhibited substantial differences between different sex and age groups,even after indexation by body surface *** normal ranges of 3D-LV and 3D-LA volume and function differed from those recommended by the American society of Echocardiography and the European Association of Cardiovascular Imaging guidelines,presented by the World Alliance societies of Echocardiography(WAsE)study,and from the 2D values in the EMINCA *** normal reference values of 3D echocardiography-derived LV and LA volume and function were established for the first time in healthy Han Chinese *** ranges of 3D-LV and 3D-LA echocardiographic measurements stratified with sex,age,and race should be recommended for clinical applications.

关键词： three-dimensional echocardiography left ventricle left atrium normal reference values Chinese adults

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Modeling human gastric cancers in immunocompetent mice

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Cancer Biology & Medicine 2024年第7期21卷 553-570页

作者： Weihong Zhang shilong Wang Hui Zhang Yan Meng shi Jiao Liwei An Zhaocai Zhou Department of stomatology Department of Medical UltrasoundShanghai Tenth People's HospitalTongji University Cancer CenterTongji University School of MedicineShanghai 200072China state Key Laboratory of Genetic Engineering School of Life SciencesZhongshan HospitalFudan UniversityShanghai 200032China Collaborative Innovation Center for Cancer Personalized Medicine School of Public HealthNanjing Medical UniversityNanjing 211166China

Gastric cancer(GC)is a major cause of cancer-related mortality *** is determined by multiple(epi)genetic and environmental factors;can occur at distinct anatomic positions of the stomach;and displays high heterogeneity,with different cellular origins and diverse histological and molecular *** heterogeneity has hindered efforts to fully understand the pathology of GC and develop efficient *** the past decade,great progress has been made in the study of GC,particularly in molecular subtyping,investigation of the immune microenvironment,and defining the evolutionary path and *** mouse models,particularly immunocompetent models that mimic the cellular and molecular features of human GC,in combination with organoid culture and clinical studies,have provided powerful tools for elucidating the molecular and cellular mechanisms underlying GC pathology and immune evasion,and the development of novel therapeutic ***,we first briefly introduce current progress and challenges in GC study and subsequently summarize immunocompetent GC mouse models,emphasizing the potential application of genetically engineered mouse models in antitumor immunity and immunotherapy studies.

关键词： Gastric cancer heterogeneity mouse model GEMM immunocompetent

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Consideration on immunotherapy of liver metastases of malignant tumors

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World Journal of Gastrointestinal surgery 2024年第8期16卷 2374-2381页

作者： Chuang Jiang Zhi-Hong Zhang Jia-Xin Li Division of Liver surgery Department of General Surgery and Laboratory of Liver Surgeryand State Key Laboratory of Biotherapy and Collaborative Innovation Center of BiotherapyWest China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Department of General surgery Dafang County People's HospitalBijie 551600Guizhou ProvinceChina

In this editorial,we comment on the article“Analysis of the impact of immuno-therapy efficacy and safety in patients with gastric cancer and liver metastasis”by Liu et al that was published in the recent issue of the World Journal of Gastroin-testinal *** has prompted us to think and summarize some thoughts on immunotherapy for malignant tumor liver *** plays a crucial role in the treatment of malignant tumors;however,the presence of liver metastases in advanced tumors may impact its *** patients with liver metastases can still benefit from immunotherapy,multiple clinical studies have indicated that,compared to other sites of metastasis,liver metastases may diminish the effectiveness of *** efficacy of immune checkpoint inhibitors in patients with liver metastases often fails to reach the ideal level,primarily due to the liver metastases exploiting the host's peripheral immune to-lerance mechanisms to promote systemic CD8(+)T cell exhaustion,resulting in a systemic immune-tolerant *** article aims to summarize the reasons for the decreased efficacy of immunotherapy following liver metastasis in various malignant tumors and propose potential clinical strategies for manage-ment.

关键词： Liver metastasis Immunotherapy Immune tolerance Cancer Treatment

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Mutations and intron polymorphisms in voltage-gated sodium channel genes of different geographic populations of Culex pipiens pallens/ Culex pipiens quinquefasciatus in China

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贫困所致传染病(英文) 2024年第2期13卷 1-11页

作者： Li Wenyu Ma Delong Mu Qunzheng Zhou Xinxin Hua Dongdong Zhao Chunchun Liu Qiyong Wang Jun Meng Fengxia state Key Laboratory of Infectious Disease Prevention and Control Department of Vector Biology and Control National Institute for Communicable Disease Control and Prevention Chinese Center for Disease Control and Prevention WHO Collaborating Centre for Vector Surveillance and Management Beijing People’s Republic of China Ningxia Center for Disease Prevention and Control YinChuan NingXia People’s Republic of China Jinan shizhong Center for Disease Control and Prevention Jinan Shandong China Vanke school of Public Health Tsinghua University Beijing People’s Republic of China Weifang No. people’s hospital Weifang Shandong People’s Republic of China Beijing Daxing Center for Disease Control and Prevention Beijing People’s Republic of China Jinan second Maternal and Child Health hospital Jinan Shandong China

Background Culex pipiens pallens andCulex pipiens quinquefasciatus are the dominant species ofCulex mosquitoes in China and important disease vectors. Long-term use of insecticides can cause mutations in the voltage-gated sodium channel (vgsc) gene of mosquitoes, but little is known about the current status and evolutionary origins ofvgsc gene in different geographic populations. Therefore, this study aimed to determine the current status ofvgsc genes inCx. p. pallens andCx. p. quinquefasciatus in China and to investigate the evolutionary inheritance of neighboring downstream introns of thevgsc gene to determine the impact of insecticides on long-term *** sampling was conducted from July to september 2021 in representative habitats of 22 provincial-level administrative divisions in China. Genomic DNA was extracted from 1308 mosquitoes, the IIs6 fragment of thevgsc gene on the nerve cell membrane was amplified using polymerase chain reaction, and the sequence was used to evaluate allele frequency and knockdown resistance (kdr) frequency. MEGA 11 was used to construct neighborjoining (NJ) tree. PopART was used to build a TCs *** There were 6 alleles and 6 genotypes at the L1014 locus, which included the wild-type alleles TTA/L and CTA/L and the mutant alleles TTT/F, TTC/F, TCT/s and TCA/s. The geographic populations with akdr frequency less than 20.00% were mainly concentrated in the regions north of 38° N, and the geographic populations with akdr frequency greater than 80.00% were concentrated in the regions south of 30° *** frequency increased with decreasing latitude. And within the same latitude, the frequency ofkdr in large cities is relatively high. Mutations were correlated with the number of introns. The mutant allele TCA/s has only one intron, the mutant allele TTT/F has three introns, and the wild-type allele TTA/L has 17 *** Cx. p. pallens andCx. p. quinquefasciatus have developed resistance to insecticides in mos

关键词： Culex pipiens pallens Culex pipiens quinquefasciatus vgsc gene Mutation Frequency Intron Haplotype China

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Evidence-Based Nursing Practice of Reducing Immune-Related skin Toxicity of Tumor Patients Guided by sensitive Indicators

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Journal of Biosciences and Medicines 2024年第4期12卷 210-215页

作者： Lingling Tang Qiong Wen The First people’ s Hospital of Jingzhou Jingzhou China

Purpose research on nursing sensitive indicators in tumor Patients application effect in immune-related skin toxicity management. Method select our hospital April to June, 202360 cases patients with immune therapy settings as the control group. August-October, 2023 60 cases the patients treated with immune therapy were the experimental group. The control group adopted regular nursing methods, while the experimental group sensitive Indicators, evidence-based give preventive care. The social situation, psychological state, physical function, quality of life score, incidence of skin toxicity caused by immune checkpoint inhibitors, moderate and above of the two groups of patients were compared. Incidence of skin toxicity. Result: experience group sAs score, sDs score higher than the control group, the difference was statistically significant (P skin toxic reactions caused by immune checkpoint inhibitors and the incidence of moderate and above skin toxic reactions in the experimental group are lower than those in the control group, and the difference is statistically significant (P sion: sensitive indicator guidance evidence-based preventive care can reduce the degree of immune-related skin toxicity, improve the psychological state and quality of life of tumor patients treated with immune therapy and reduce the incidence of adverse reactions, improve nursing quality and patient satisfaction.

关键词： sensitive Indicators Immune-Related skin Toxicity Evidence-Based Practice Tumor

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Early and sensitive Detection of Pathogens for Public Health and Biosafety:An Example of surveillance and Genotyping of sARs-CoV-2 in sewage Water by Cas12a-Facilitated Portable Plasmonic Biosensor

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Research 2024年第2期2023卷 259-272页

作者： Tianzhong Li Yuzhi Chen Zhi Chen Yuan Hao Minyi Liang Yingxia Liu Guanyong Ou Huanian Zhang Yuxuan Tang Yabing Hao swelm Wageh Omar AAl-Hartomy Abul Kalam Bin Zhang Xin shi Xuejin Li Han Zhang College of Physics and Optoelectronic Engineering Institute of Translational MedicineDepartment of OtolaryngologyShenzhen Second People's HospitalFirst Affiliated Hospital of Shenzhen UniversityHealth Science CenterShenzhen UniversityShenzhen 518060China shenzhen Key Laboratory of sensor Technology Shenzhen 518060China The sixth Affiliated hospital of Guangzhou Medical University Qingyuan People's HospitalQingyuan 511518China shenzhen Key Laboratory of Pathogen and Immunity National Clinical Research Center for Infectious DiseaseState Key Discipline of Infectious DiseaseShenzhen Third People's HospitalSecond Hospital Affiliated to Southern University of Science and TechnologyShenzhen 518112China school of Medicine Southern University of Science and TechnologyShenzhen 518055China school of Physics and Optoelectronic Engineering Shandong University of TechnologyZibo 255049China Department of Physics Faculty of ScienceKing Abdulaziz University Jeddah 21589Saudi Arabia Research Center for Advanced Materials science(RCAMs) King Khalid UniversityP.0.Box 9004Abha 61413Saudi Arabia Department of Chemistry College of ScienceKing Khalid UniversityP.0.Box9004Abha 61413 Saudi Arabia Health sciences Institute China Medical UniversityShenyang 110000China The Chinese University of Hong Kong Shenzhen 518060China

Infectious diseases severely threaten public health and global *** addition to transmission through the air,pathogenic microorganisms have also been detected in environmental liquid samples,such as sewage *** biochemical detection methodologies are time-consuming and cost-ineffective,and their detection limits hinder early *** the present study,ultrafine plasmonic fiber probes with a diameter of 125μm are fabricated for clustered regularly interspaced short palindromic repeats/CRIsPR-associated protein(CRIsPR/Cas)-12a-mediated sensing of severe acute respiratory syndrome coronavirus 2(sARs-CoV-2).single-stranded DNA exposed on the fiber surface is trans-cleaved by the Cas12a enzyme to release gold nanoparticles that are immobilized onto the fiber surface,causing a sharp reduction in the surface plasmon resonance(sPR)*** proposed fiber probe is virus-specific with the limit of detection of~2,300 copies/ml,and genomic copy numbers can be reflected as shifts in wavelengths.A total of 21 sewage water samples have been examined,and the data obtained are consistent with those of quantitative polymerase chain reaction(qPCR).In addition,the Omicron variant and its mutation sites have been fast detected using s gene-specific *** study provides an accurate and convenient approach for the real-time surveillance of microbial contamination in sewage water.

关键词： fiber consuming hinder

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Roles of cancer-associated fibroblast functional heterogeneity in shaping the lymphatic metastatic landscape:new insights and therapeutic strategies

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Cancer Biology & Medicine 2024年第6期21卷 445-450页

作者： Hanhao Zheng Daiyin Liu Zhicong Liu Mingjie An Yuming Luo Changhao Chen Tianxin Lin Department of Urology Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510003China Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Sun Yat-sen Memorial HospitalState Key Laboratory of Oncology in South ChinaGuangzhou 510003China Department of General surgery Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhou 510003China

Lymph node (LN) metastasis is a process in which cancer cells travel from primary tumors to LNs via the lymphatic system,then proliferate and spread within the LNs. In most cancers,LN metastasis is a major mode of cancer dissemination,and a critical indicator of cancer progression and worsening prognosis1. The occurrence of LN metastasis indicates that the tumor has invaded the lymphatic system.

关键词： metastasis lymphatic landscape

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