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Enhancing the Photosensitivity of Hypocrellin A by Perylene Diimide Metallacage‑Based Host–Guest Complexation for Photodynamic Therapy

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Nano-Micro Letters 2024年第11期16卷 71-87页

作者： Rongrong Li Tianfeng Yang Xiuhong Peng Qian Feng Yali Hou Jiao Zhu Dake Chu Xianglong Duan Yanming Zhang Mingming Zhang state Key Laboratory for Mechanical Behavior of Materials Shaanxi International Research Center for Soft MatterSchool of Materials Science and EngineeringXi’an Jiaotong UniversityXi’an 710049People’s Republic of China school of Pharmacy Health Science CenterXi’an Jiaotong UniversityXi’an 710061People’s Republic of China Department of Rehabilitation Medicine Shaanxi Provincial People’s HospitalXi’an 710068ShaanxiPeople’s Republic of China Department of Gastroenterology The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061People’s Republic of China

The development of supramolecular hosts which can efficiently encapsulate photosensitizers to improve the photodynamic efficacy holds great promise for cancer ***,we report two perylene diimide-based metallacages that can form stable host–guest complexes with planar conjugated molecules including polycyclic aromatic hydrocarbons and photosensitizers(hypocrellin A).such host–guest complexation not only prevents the aggregation of photosensitizers in aqueous environments,but also offers fluorescence resonance energy transfer(FRET)from the metallacage to the photosensitizers to further improve the singlet oxygen generation(Φ_(Δ)=0.66).The complexes are further assembled with amphiphilic polymers,forming nanoparticles with improved stability for anticancer *** in vitro and in vivo studies indicate that the nanoparticles display excellent anticancer activities upon light irradiation,showing great potential for cancer photodynamic *** study provides a straightforward and effective approach for enhancing the photosensitivity of conventional photosensitizers via host–guest complexation-based FRET,which will open a new avenue for host–guest chemistry-based supramolecular theranostics.

关键词： Metallacages Host-guest interactions Fluorescence resonance energy transfer singlet oxygen Photodynamic therapy

Nanomaterial‑Based Repurposing of Macrophage Metabolism and Its Applications

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Nano-Micro Letters 2024年第11期16卷 494-528页

作者： Tingting Meng Danfeng He Zhuolei Han Rong shi Yuhan Wang Bibo Ren Cheng Zhang Zhengwei Mao Gaoxing Luo Jun Den Institute of Burn Research Southwest HospitalState Key Laboratory of Trauma and Chemical PoisoningArmy Medical UniversityChongqing 400038People’s Republic of China Department of Breast surgery Gansu Provincial HospitalLanzhouGansu 730030People’s Republic of China MOE Key Laboratory of Macromolecular synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China

Macrophage immunotherapy represents an emerging therapeutic approach aimed at modulating the immune response to alleviate disease ***(NMs)have been engineered to monitor macrophage metabolism,enabling the evaluation of disease progression and the replication of intricate physiological signal *** achieve this either directly or by delivering regulatory signals,thereby mapping phenotype to effector functions through metabolic repurposing to customize macrophage fate for ***,a comprehensive summary regarding NM-mediated macrophage visualization and coordinated metabolic rewiring to maintain phenotypic equilibrium is currently *** review aims to address this gap by outlining recent advancements in NM-based metabolic *** initially explore the relationship between metabolism,polarization,and disease,before delving into recent NM innovations that visualize macrophage activity to elucidate disease onset and fine-tune its fate through metabolic remodeling for macrophage-centered ***,we discuss the prospects and challenges of NM-mediated metabolic immunotherapy,aiming to accelerate clinical *** anticipate that this review will serve as a valuable reference for researchers seeking to leverage novel metabolic intervention-matched immunomodulators in macrophages or other fields of immune engineering.

关键词： Immunomodulatory nanomaterial Macrophage polarization Macrophage metabolic reprogramming Immune engineering

High-performance piezoresistive sensors based on transfer-free large-area Pdse_(2) films for human motion and health care monitoring

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InfoMat 2024年第1期6卷 139-149页

作者： Rui Zhang Jie Lin Tao He Jiafang Wu Zhuojun Yang Liwen Liu shaofeng Wen Yimin Gong Haifeng Lv Jing Zhang Yi Yin Fangjia Li Changyong Lan Chun Li state Key Laboratory of Electronic Thin Films and Integrated Devices School of Optoelectronic Science and EngineeringUniversity of Electronic Science and Technology of ChinaChengduthe People's Republic of China school of Physics University of Electronic Science and Technology of ChinaChengduthe People's Republic of China sichuan Academy of Medical sciences and sichuan people's hospital Chengduthe People's Republic of China school of Medicine University of Electronic Science and Technology of ChinaChengduthe People's Republic of China

Two-dimensional transition metal dichalcogenides(TMDs)are needed in highperformance piezoresistive sensors due to their strong strain-induced bandgap modification and thereby large gauge ***,integrating a conventional high-temperature chemical vapor deposition(CVD)-grown TMD with a flexible substrate necessitates a transfer process that inevitably degrades the sensing properties of the TMDs and increases the overall fabrication *** present a high-performance piezoresistive strain sensor that employs largearea Pdse_(2) films grown directly on polyimide(PI)substrates via plasma-assisted selenization of a sputtered Pd *** reliable strain transfer from the substrate to the Pdse_(2) film ensures an outstanding strain-sensing capability of the ***,the sensors have a gauge factor of up to315±2.1,a response time under 25 ms,a detection limit of 8×10^(-6),and an exceptional stability of over 104 loadingunloading *** attaching the sensors to the skin surface,we demonstrate their application for measuring physiological parameters in health care monitoring,including motion,voice,and arterial pulse ***,using the Pdse_(2) film sensor combined with deep learning technology,we achieved intelligent recognition of artery temperature from arterial pulse signals with only a 2%difference between predicted and actual *** excellent sensing performance,together with the advantages of low-temperature fabrication and simple device structure,make the Pdse_(2) film sensor promising for wearable electronics and health care sensing systems.

关键词： layered crystal Pdse_(2) piezoresistive effect strain sensor

Injectable Nanorobot-Hydrogel superstructure for Hemostasis and Anticancer Therapy of spinal Metastasis

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Nano-Micro Letters 2024年第12期16卷 59-80页

作者： Qing Chen Miao Yan Annan Hu Bing Liang Hongwei Lu Lei Zhou Yiqun Ma Chao Jia Dihan su Biao Kong Wei Hong Libo Jiang Jian Dong Department of Orthopaedic surgery Zhongshan HospitalFudan UniversityShanghai 200032People’s Republic of China Department of Chemistry Fudan UniversityShanghai 200438People’s Republic of China Department of surgery Yong Loo Lin School of MedicineNational University of Singapore1E Kent Ridge RoadSingapore 119228Singapore Department of Geriatrics and Gerontology Huadong HospitalFudan UniversityShanghai 200438People’s Republic of China state Key Laboratory of Molecular Engineering of Polymers Fudan UniversityShanghai 200438People’s Republic of China Department of Orthopaedic surgery Zhongshan hospital Wusong Branch Fudan UniversityShanghai 200940People’s Republic of China

surgery remains the standard treatment for spinal ***,uncontrolled intraoperative bleeding poses a significant challenge for adequate surgical resection and compromises surgical *** this study,we develop a thrombin(Thr)-loaded nanorobothydrogel hybrid superstructure by incorporating nanorobots into regenerated silk fibroin nanofibril *** superstructure with superior thixotropic properties is injected percutaneously and dispersed into the spinal metastasis of hepatocellular carcinoma(HCC)with easy bleeding characteristics,before spinal surgery in a mouse *** near-infrared irradiation,the self-motile nanorobots penetrate into the deep spinal tumor,releasing Thr in a controlled ***-induced thrombosis effectively blocks the tumor vasculature and reduces bleeding,inhibiting tumor growth and postoperative recurrence with Au nanorod-mediated photothermal *** minimally invasive treatment platform provides a novel preoperative therapeutic strategy for HCC spinal metastasis effectively controlling intraoperative bleeding and tumor growth,with potentially reduced surgical complications and enhanced operative outcomes.

关键词： silk fibroin Nanofibril hydrogels Nanorobots Thrombin spinal metastasis

Influence of heat treatment on microstructure,mechanical and corrosion behavior of WE43 alloy fabricated by laser-beam powder bed fusion

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International Journal of Extreme Manufacturing 2024年第1期6卷 258-275页

作者： Chenrong Ling Qiang Li Zhe Zhang Youwen Yang Wenhao Zhou Wenlong Chen Zhi Dong Chunrong Pan Cijun shuai College of Mechanical and Electrical Engineering Jiangxi University of Science and TechnologyGanzhou 341000People’s Republic of China school of Mechanical and Electronic Engineering Suzhou UniversitySuzhou 234000People’s Republic of China shaanxi Key Laboratory of Biomedical Metal Materials Northwest Institute for Non-ferrous Metal ResearchXi’an 710016People’s Republic of China Department of Orthopedics First Afffliated Hospital of Gannan Medical CollegeGanzhou 341000People’s Republic of China school of Mechanical and Automotive Engineering South China university of technologyGuangzhou 510641People’s Republic of China state Key Laboratory of High-Performance Complex Manufacturing Central South UniversityChangsha 410083People’s Republic of China Double Medical Technology Inc. Xiamen 361026People’s Republic of China

Magnesium(Mg)alloys are considered to be a new generation of revolutionary medical ***-beam powder bed fusion(PBF-LB)is suitable for fabricating metal implants withpersonalized and complicated ***,the as-built part usually exhibits undesirable microstructure and unsatisfactory *** this work,WE43 parts were firstly fabricated by PBF-LB and then subjected to heat *** a high densification rate of 99.91%was achieved using suitable processes,the as-built parts exhibited anisotropic and layeredmicrostructure with heterogeneously precipitated Nd-rich *** heat treatment,fine and nano-scaled Mg24Y5particles were ***,theα-Mg grainsunderwent recrystallization and turned coarsened slightly,which effectively weakened thetexture intensity and reduced the *** a consequence,the yield strength and ultimate tensile strength were significantly improved to(250.2±3.5)MPa and(312±3.7)MPa,respectively,while the elongation was still maintained at a high level of 15.2%.Furthermore,the homogenized microstructure reduced the tendency of localized corrosion and favoredthe development of uniform passivation ***,the degradation rate of WE43 parts was decreased by an order of ***,in-vitro cell experiments proved their favorable biocompatibility.

关键词： laser-beam powder bed fusion WE43 alloys heat treatment mechanical performance biodegradation behavior

Chemical scissors Tailored Nano‑Tellurium with High‑Entropy Morphology for Efficient Foam‑Hydrogel‑Based solar Photothermal Evaporators

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Nano-Micro Letters 2024年第3期16卷 149-168页

作者： Chenyang Xing Zihao Li Ziao Wang shaohui Zhang Zhongjian Xie Xi Zhu Zhengchun Peng state Key Laboratory of Radio FrequencyHeterogeneous Integration Shenzhen UniversityShenzhen 518060People’s Republic of China Center for stretchable Electronics and Nanosensors College of Physics and Optoelectronic EngineeringShenzhen UniversityShenzhen 518060People’s Republic of China school of science and Engineering The Chinese University of Hong KongShenzhenShenzhen 518172People’s Republic of China Institute of Pediatrics Shenzhen Children’s HospitalShenzhen 518038GuangdongPeople’s Republic of China International Collaborative Laboratory of 2D Materials for Optoelectronics science and Technology of Ministry of Education Institute of Microscale OptoelectronicsShenzhen UniversityShenzhen 518060People’s Republic of China

The development of tellurium(Te)-based semiconductor nanomaterials for efficient light-to-heat conversion may offer an effective means of harvesting sunlight to address global energy ***,the nanosized Te(nano-Te)materials reported to date suffer from a series of drawbacks,including limited light absorption and a lack of surface ***,we report the preparation of nano-Te by electrochemical exfoliation using an electrolyzable room-temperature ionic ***,cations,and their corresponding electrolytic products acting as chemical scissors can precisely intercalate and functionalize bulk *** resulting nano-Te has high morphological entropy,rich surface functional groups,and broad light *** also constructed foam hydrogels based on poly(vinyl alcohol)/nano-Te,which achieved an evaporation rate and energy efficiency of 4.11 kg m^(−2)h^(−1)and 128%,respectively,under 1 sun ***,the evaporation rate was maintained in the range 2.5-3.0 kg m^(−2)h^(−1)outdoors under 0.5-1.0 sun,providing highly efficient evaporation under low light conditions.

关键词： Tellurium High entropy Electrochemical modification solar absorption Evaporation rate

The state-of-the-art of atmospheric pressure plasma for transdermal drug delivery

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Plasma science and Technology 2024年第4期26卷 9-26页

作者：聂兰兰刘大伟程鹤赵峰卢新培 state key laboratory of advanced electromagnetic engineering and technology School of Electrical and Electronic EngineeringHuazhong University of Science and TechnologyWuhan 430074People’s Republic of China school of Chemistry and Chemical Engineering Nanjing University of Science and TechnologyNanjing 210094People’s Republic of China Department of Thoracic surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022People’s Republic of China

Plasma-enhanced transdermal drug delivery(TDD) presents advantages over traditional methods,including painless application, minimal skin damage, and rapid recovery of permeability. To harness its clinical potential, factors related to plasma’s unique properties, such as reactive species and electric fields, must be carefully *** review provides a concise summary of conventional TDD methods and subsequently offers a comprehensive examination of the current state-of-the-art in plasma-enhanced TDD. This includes an analysis of the impact of plasma on HaCaT human keratinocyte cells, ex vivo/in vivo studies, and clinical research on plasma-assisted TDD. Moreover, the review explores the effects of plasma on skin physical characteristics such as microhole formation, transepidermal water loss(TEWL), molecular structure of the stratum corneum(sC), and skin resistance. Additionally, it discusses the involvement of various reactive agents in plasma-enhanced TDD, encompassing electric fields,charged particles, UV/VUV radiation, heat, and reactive species. Lastly, the review briefly addresses the temporal behavior of the skin after plasma treatment, safety considerations, and potential risks associated with plasma-enhanced TDD.

关键词： plasma transdermal drug delivery skin physical characteristics reactive agents

3D printed grafts with gradient structures for organized vascular regeneration

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International Journal of Extreme Manufacturing 2024年第3期6卷 505-520页

作者： Yuewei Chen Zhongfei Zou Tao Fu Zhuang Li Zhaojie Zhang Meng Zhu Qing Gao shaofei Wu Guosheng Fu Yong He Jiayin Fu state Key Laboratory of Fluid Power and Mechatronic systems School of Mechanical EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China school of Mechanical Engineering Guizhou UniversityGuiyang 550025People’s Republic of China Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province Department of CardiologySir Run Run Shaw HospitalZhejiang UniversityHangzhou 310016People’s Republic of China school of Mechanical Engineering Guizhou Institute of TechnologyGuiyang 550003People’s Republic of China Department of Oral and Maxillofacial surgery The Second Affiliated Hospital of Zhejiang University School of MedicineSchool of Stomatologyand Key Laboratory of Oral Biomedical Research of Zhejiang ProvinceHangzhouZhejiang 310006People’s Republic of China

synthetic vascular grafts suitable for small-diameter arteries(<6 mm) are in great ***,there are still no commercially available small-diameter vascular grafts(sDVGs) in clinical practice due to thrombosis and stenosi... 详细信息

synthetic vascular grafts suitable for small-diameter arteries(still no commercially available small-diameter vascular grafts(sDVGs) in clinical practice due to thrombosis and stenosis after in vivo *** designing sDVGs,many studies emphasized reendothelization but ignored the importance of reconstruction of the smooth muscle layer(sML).To facilitate rapid sML regeneration,a high-resolution 3D printing method was used to create a novel bilayer sDVG with structures and mechanical properties mimicking natural *** by the collagen alignment of sML,the inner layer of the grafts had larger pore sizes and high porosity to accelerate the infiltration of cells and their circumferential alignment,which could facilitate sML reconstruction for compliance restoration and spontaneous *** outer layer was designed to induce fibroblast recruitment by low porosity and minor pore size and provide sDVG with sufficient mechanical *** month after implantation,the arteries regenerated by 3D-printed grafts exhibited better pulsatility than electrospun grafts,with a compliance(8.9%) approaching that of natural arteries(11.36%) and significantly higher than that of electrospun ones(1.9%).The 3D-printed vascular demonstrated a three-layer structure more closely resembling natural arteries while electrospun grafts showed incomplete endothelium and immature *** study shows the importance of sML reconstruction during vascular graft regeneration and provides an effective strategy to reconstruct blood vessels through 3D-printed structures rapidly.

关键词： small-diameter vascular graft smooth muscle layer 3D printing endothelialization

Functional analysis of the novel mitochondrial tRNA^(Trp)and tRNA^(ser(AGY))variants associated with type 2 diabetes mellitus

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World Journal of Diabetes 2024年第8期15卷 1753-1763页

作者： Yu Ding Xue-Jiao Yu Qin-Xian Guo Jian-Hang Leng Central Laboratory Hangzhou First People’s HospitalHangzhou 310006Zhejiang ProvinceChina Clinical Laboratory Quzhou People’s HospitalQuzhou 324000Zhejiang ProvinceChina

BACKGROUND Mutations in mitochondrial tRNA(mt-tRNA)genes that result in mitochondrial dysfunction play important roles in type 2 diabetes mellitus(T2DM).We previously reported a large Chinese pedigree with maternally inherited T2DM that harbors novel mt-tRNA^(Trp)A5514G and tRNA^(ser(AGY))C12237T variants,however,the effects of these mt-tRNA variants on T2DM progression are largely *** To assess the potential pathogenicity of T2DM-associated m.A5514G and m.C12237T variants at genetic,molecular,and biochemical *** Cytoplasmic hybrid(cybrid)cells carrying both m.A5514G and m.C12237T variants,and healthy control cells without these mitochondrial DNA(mtDNA)variants were generated using trans-mitochondrial *** features,including mt-tRNA steady-state level,levels of adenosine triphosphate(ATP),mitochondrial membrane potential(MMP),reactive oxygen species(ROs),mtDNA copy number,nicotinamide adenine dinucleotide(NAD+)/NADH ratio,enzymatic activities of respiratory chain complexes(RCCs),8-hydroxy-deoxyguanine(8-OhdG),malondialdehyde(MDA),and superoxide dismutase(sOD)were examined in cell lines with and without these mt-tRNA *** Compared with control cells,the m.A5514G variant caused an approximately 35%reduction in the steady-state level of mt-tRNA^(Trp)(Pser(AGY))steady-state level(P=0.5849).Biochemical analysis revealed that cells with both m.A5514G and m.C12237T variants exhibited more severe mitochondrial dysfunctions and elevated oxidative stress than control cells:ATP,MMP,NAD+/NADH ratio,enzyme activities of RCCs and sOD levels were markedly decreased in mutant cells(Psures).By contrast,the levels of ROs,8-OhdG and MDA were significantly increased(Psures),but mtDNA copy number was not affected by m.A5514G and m.C12237T variants(P=0.5942).CONCLUsION The m.A5514G variant impaired mt-tRNA^(Trp)metabolism,which subsequent

关键词： Type 2 diabetes mellitus Mitochondrial tRNA genes Novel variants Oxidative stress Mitochondrial dysfunctions