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Advances in the treatment of autism spectrum disorder:Wharton jelly mesenchymal stem cell transplantation

World Journal of Methodology 2025年第1期15卷 72-79页

作者： Serdar Kabatas ErdinçCivelek Eyüp Can Savrunlu Umut Karaaslan Özlem Yıldız Erdal Karaöz Department of Neurosurgery University of Health Sciences TurkeyGaziosmanpaşa Training and Research HospitalIstanbul 34255Türkiye Department of Pediatric Allergy-Immunology Institute of Health Sciences Marmara UniversityIstanbul 34865Türkiye Center for Stem Cell&Gene Therapy Research and Practice University of Health Sciences TurkeyIstanbul 34255Türkiye Department of child and adolescent Psychiatry University of Health SciencesGaziosmanpaşa Training and Research HospitalIstanbul 34255Türkiye Department of child and adolescent Psychiatry Kocaeli University Faculty of MedicineKocaeli 41001Türkiye Center for Regenerative Medicine and Stem Cell Research&Manufacturing Liv HospitalIstanbul 34340Türkiye Department of Histology and Embryology Istinye UniversityFaculty of MedicineIstanbul 34010Türkiye Center for Stem Cell and Tissue Engineering Research and Practice Istinye UniversityIstanbul 34340Türkiye

BACKGROUND Autism spectrum disorder(ASD)is a complex neurodevelopmental disorder with multifaceted *** recent studies,neuroinflammation and immune dysregulation have come to the forefront in its *** are studies suggesting that stem cell therapy may be effective in the treatment of *** To evolve the landscape of ASD treatment,focusing on the potential benefits and safety of stem cell *** A detailed case report is presented,displaying the positive outcomes observed in a child who underwent intrathecal and intravenous Wharton’s jelly-derived mesenchymal stem cells(WJ-MSCs)transplantation combined with *** The study demonstrates a significant improvement in the child’s functional outcomes(childhood Autism Rating Scale,Denver 2 Developmental Screening Test),especially in language and gross motor *** serious side effects were encountered during the 2-year *** The findings support the safety and effectiveness of WJ-MSC transplantation in managing ASD.

关键词： Autism spectrum disorder Neurorehabilitation Stem cell transplantation Wharton jelly mesenchymal stem cells Inflammation

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The Mediating Effect of Body Dissatisfaction in Association between Obesity and Dietary Behavior Changes for Weight Loss in Chinese children

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Biomedical and Environmental Sciences 2019年第9期32卷 639-646页

作者： GAO Huai Quan WANG Bang Xuan SUN Li Li LI Ting WU Lu FU Lian Guo MA Jun Department of child and adolescent health School of Public HealthBengbu Medical CollegeBengbu 233030AnhuiChina institute of child and adolescent health School of Public HealthPeking University Health Science CenterBeijing 100191China

Objective The aim of this study was to analyze the mediating effect of body dissatisfaction in correlation between obesity and dietary behavior changes for weight loss(DBCWL).Methods A total of 680 primary and middle school students were included in this study. Their body height, weight, and waistline were effectively measured, and they were also evaluated to assess their body dissatisfaction, perception of dietary behaviors, and DBCWL. The correlation among these factors was analyzed using mediating effect *** The prevalence of overweight/obesity and abdominal obesity was significantly higher in males than in females(P children to correctly recognize their body might be more conducive than promoting obese children toward weight loss through dietary behavior changes.

关键词： children and adolescents Obesity Body dissatisfaction Dietary behavior changes for weight loss

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Association of the Common Genetic Variant Upstream of INSIG2 Gene with Obesity Related Phenotypes in Chinese children and adolescents

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Biomedical and Environmental Sciences 2008年第6期21卷 528-536页

作者： HAI-JUN WANG HENG ZHANG SHI-WEI ZHANG YONG-PING PAN JUN MA Department of Maternal and child health School of Public Health Peking University Beijing 100191 China institute of child and adolescent health Peking University Beijing 100191 China Key Laboratory of Epidemiology Ministry of Education China Dongcheng School health Care institute Beijing 100005 China

Objective To study the association between the rs7566605 variant of INSIG2 and obesity-related phenotypes in Chinese children and adolescents. Methods The study sample consisted of two independent cohorts of Chinese children and adolescents. Anthropometric indices, lipids, blood pressure, fasting glucose, insulin and percentage of fat mass were determined. PCR with restriction fragment length polymorphism analysis was performed for genotyping the rs7566605 variant. Results In each of the two independent cohorts, no significant association was observed between rs7566605 and obesity under additive, dominant or recessive model. We also did not detect any difference in the genotype frequency between all the obese children and controls. Furthermore, we did not find evidence of an association between body composition indices and metabolic phenotypes in all children. However, the triglyceride level of CC homozygotes was significantly higher than that of GG＋GC genotypes in obese children （P=0.022）. Additionally, we observed a non-significant trend of severe obesity in a post-hoc test. Conclusion INSIG2 rs7566605 variant is not associated Chinese childhood obesity in two independent cohorts. Further study is needed to verify the effect of rs7566605 on triglyceride in obese children.

关键词： INSIG2 gene Obesity-related phenotypes children and adolescents

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Secular trends and urban–rural disparities in the median age at menarche among Chinese han girls from 1985 to 2019

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World Journal of Pediatrics 2023年第12期19卷 1162-1168页

作者： Ning Ma Di Shi Jia-Jia Dang Pan-Liang Zhong Yun-Fei Liu Shan Cai Yan-Hui Dong Pei-Jin Hu Jun Ma Yi Song institute of child and adolescent health School of Public HealthPeking UniversityNo.38 Xueyuan RoadHaidian DistrictBeijing100191China National health Commission Key Laboratory of Reproductive health Beijing100191China

Background Menarche is a substantial milestone of female *** of age at menarche is considered the key to understanding the potential linkages with women’s health outcomes later in *** study aimed to explore the secular trends and urban‒rural disparities in the median age at menarche among Chinese Han girls from 1985 to *** Data were extracted from the 1985,1995,2005,2014,and 2019 Chinese National Surveys on Students’Constitution and health,which were nationally representative cross-sectional studies,and a total of 173,535 Han girls aged 9–18 years were *** were asked whether menarche had *** median age at menarche was estimated by probit analysis.Z tests were used to compare the differences between survey years and between urban and rural *** The median age at menarche among Chinese Han girls decreased from 13.37 years in 1985 to 12.00 years in 2019,and the overall decrease was more significant in rural areas(1.77 years)than in urban areas(0.99 years).The average five-year change in the decrease in the median age at menarche showed an accelerating and then slowing pace;and it was observed similarly in both urban and rural *** urban‒rural disparities shrank from 0.64 years in 1985 to 0.44 years in 1995,then to 0.27 years in 2005,0.24 years in 2014,and finally to−0.14 years in *** The median age at menarche among Chinese Han girls continued to decline from 1985 to 2019 but at a slowing pace in the last five ***‒rural disparities gradually *** and reproductive health education and interventions to prevent the decline in the age of menarche are needed,especially in rural areas.

关键词： Menarche Puberty Sexual development Trends Urban-rural inequality

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Association Between Combinations of 24-Hour Movement Behaviors and Depression Among adolescents—Inner Mongolia Autonomous Region,China,2019–2021

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China CDC weekly 2023年第40期5卷 889-893,I0001-I0004页

作者： Wen Yuan Yihang Zhang Tian Yang Shan Cai Ziyue Chen Xinli Song Yanhui Dong Jun Ma Xiuhong Zhang Yi Song institute of child and adolescent health School of Public HealthPeking UniversityBeijingChina Inner Mongolia Autonomous Region Comprehensive Disease Prevention and Control Center Inner Mongolia Autonomous RegionChina

Summary What is already known about this topic?In recent years,there has been growing concern regarding the escalating rates of depression among *** certain individual behaviors have been suggested as potential protective factors for mental health,there is a scarcity of research examining the collective influence of 24-hour movement behaviors.

关键词： protective collective movement

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Vulnerability to HIV Infection and Related health Risk Behaviors of the Out of School adolescents Migrated with Their Parents to Beijing

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Biomedical and Environmental Sciences 2008年第5期21卷 404-410页

作者： YING-HUA MA Su-QIN DINC AND CHAO WANG institute of child and adolescent health Peking University Beijing 100083 China

Objective To explore the vulnerability to HIV infection and related risk behaviors of the out-of-school adolescents who migrated with their parents from rural areas to cities. Methods From September to October 2005, 260 out-of-school adolescents aged 14-20 years were interviewed through a questionnaire. Results Out-of-school adolescents lacked HIV/AIDS knowledge and related life skills, and their psychosocial competency was relatively low. The interviewed adolescents were open in their sexuality, showing a low rate of condom use. Their attitudes towards people living with HIV/AIDS and HIV/AIDS prevention competency were positively correlated with family well-being, harmonious relations between their parents, a stable job, knowledge, life skill, and psychosocial competency for emotion control and empathy. Conclusion Out-of-school adolescents are highly vulnerable to HIV/AIDS infection and transmission. Practical and feasible health and life skill education and psychosocial competency are the keys to effective HIV/AIDS prevention among out-of-school adolescent migrants.

关键词： Migrant people Out-of-school adolescent Vulnerability Life skill Psychosocial competency HIV/AIDS

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Secular Changes of Stature in Rural children and adolescents in China, 1985-2010

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Biomedical and Environmental Sciences 2014年第8期27卷 573-581页

作者： CHEN Tian Jiao JI Cheng Ye institute of child and adolescent health School of Public Health Peking University Health Science Center

Objective To analyze and assess secular change in stature in rural children and adolescents in China from 1985 to 2010. Methods Data were obtained from the 6 rounds of the Chinese National Survey on Student＇s Constitution and health. The subjects enrolled in the study were children and adolescents aged 7-18 years in rural areas of provincial capitals. Results An overall positive secular trend in stature occurred in rural areas of provincial capitals in China from 1985 to 2010. The overall average increase rates were 3.1 and 2.4 cm/decade for boys and girls, respectively. The total body height increases for grown up boys and girls were 3.6 and 2.3 cm and the increase rates were 1.4 and 0.9 cm/decade, respectively. There were differences in body height increase among eastern, central and western regions. The average body height of the children or adolescents in eastern region was highest, followed by central region and western region. The overall increase rates in central region were highest among the three regions. The difference between eastern/central region and western region was obvious. 〈br〉 Conclusion Positive secular trend in stature of children or adolescents has occurred in rural area of China, and rural boys and girls showed a great potential for continuous growth. More attention should be paid to the differences in children＇s body height between western region and eastern/central region.

关键词： Secular change Stature Rural population Regional difference child and adolescent

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Secular Changes on the Distribution of Body Mass Index among Chinese children and adolescents, 1985-2010

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Biomedical and Environmental Sciences 2013年第7期26卷 520-530页

作者： JI Cheng Ye CHEN Tian Jiao SUN Xiao institute of child and adolescent health School of Public Health Peking University Health Science Center

Objective To analyze the change in Body Mass Index （BMI） distribution among Chinese children and adolescents for the development of more effective intervention for childhood obesity. Methods Data on the national students＇ constitution and health survey between 1985 and 2010 was used for this study. Subjects were students aged 7-18 randomly selected from 30 provinces in China. BMI for-age curves were developed by LMS method, and the trend of BMI distribution was determined by comparing the upper BMI percentiles and analyzing the skew shift of distribution between 2985 and 2010. Results An overall positive swift trend of BMI between 1985 and 2010 was observed among the Chinese school-age children and adolescents. The average median of the BMI increased from 16.8 and 17.0 ks/m2 to 18.2 and 17.9 kg/m2 in 25 years, with increments 0.56 and 0.36 kg/m2 per decade for males and females, respectively. The more obvious increments were found at the high BMI. The total increments of BMI in this period were 4.03 and 2.20 kg/m2 at the 85th, 6.24 and 3.57 kg/m2 at the 95th, and 6.99 and 4.27 kg/m2 at the 97th percentiles, for males and females, respectively. Conclusion Obvious increments were observed at high BMI of the Chinese children and adolescents. More effective interventions should be taken for control and prevention of obesity and its health consequence for these subgroups. It is necessary to establish a risk-complex system consisting of the identification of BMI scope, the screen of the disease risk factors and the assessment of excessive adiposity.

关键词： Body mass index Obesity Chinese School-age children Secular growth changes

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Periconceptional Folic Acid Only Versus Multiple Micronutrients Containing Folic Acid and Association with Gestational Diabetes Mellitus-Beijing Municipality,China,2017-2021

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China CDC weekly 2023年第23期5卷 505-510页

作者： Shuangbo Xia Yushan Du Ziyang Ren Jinjuan Zhang Suhong Gao Jiamei Wang Zhiwen Li Xiaohong Liu Jufen Liu Department of Epidemiology and Biostatistics School of Public HealthPeking UniversityBeijingChina institute of Reproductive and child health/National health Commission Key Laboratory of Reproductive health Peking UniversityBeijingChina Department of child health Beijing Haidian Maternal and Child Health HospitalBeijingChina Department of Gynaecology and Obstetrics Beijing Haidian Maternal and Child Health HospitalBeijingChina

Summary What is already known about this topic?Inconsistent results have been reported on the association between periconceptional folic acid only(FAO)or multiple micronutrients containing folic acid(MMFA)supplementation and the risk of gestational diabetes mellitus(GDM)in previous *** is added by this report?In a prospective cohort study conducted among pregnant women in Haidian District,Beijing Municipality,it was observed that those who took MMFA demonstrated a higher likelihood of developing GDM in comparison to those who consumed FAO ***,the increased risk for GDM in pregnant women supplemented with MMFA compared to FAO was primarily due to changes in fasting plasma *** are the implications for public health practice?It is highly recommended that women prioritize the use of FAO in order to yield potential benefits in the prevention of GDM.

关键词： prevention Diabetes conception

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Secular Change in Stature of Urban Chinese children and adolescents, 1985-2010

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Biomedical and Environmental Sciences 2013年第1期26卷 13-22页

作者： CHEN Tian Jiao JI Cheng Ye institute of child and adolescent health School of Public HealthPeking University Health Science Center

Objective Research evidence shows a secular trend in Chinese physical growth in recent *** aim of this study was to analyze and assess changes in stature of children and adolescents during the 25 years from 1985‐2010,using national *** Data came from successive cycles of the Chinese National Survey on Students＇ Constitution and health（CNSSCH）.Subjects were 7‐ to 18‐year‐old children and *** An overall positive secular trend occurred in urban China during 1985‐*** overall average rates of increment were 2.4 and 1.7 cm/decade for boys and girls,*** increases in adult stature for boys and girls were 2.6 and 1.7 cm,yielding rates of 1.0 and 0.7 cm/decade,*** with different socioeconomic levels had different characteristic *** stature increases in big cities were larger than those in moderate and small cities,and boys and girls in moderate and small cities showed greater potential for growth in *** An overall positive secular growth trend was associated with socioeconomic progress and differed with area socioeconomic *** policies and strategies should be developed based on increased stature,and should continue narrowing the inequity between different socioeconomic populations.

关键词： Secular change Stature Growth Socioeconomic disparity children and adolescents

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