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Resistin-binding peptide antagonizes role of resistin on white adipose tissue

Acta Pharmacologica Sinica 2007年第2期28卷 221-226页

作者： Nan GU~(2,3,4) Shu-ping HAN~(2,4) Li FEI~3 Xiao-qin PAN~3 Mei GUO~3 Rong-hua CHEN~3 Xi-rong GUO~(2,3,5)2 Department of Pediatrics,Nanjing Maternal and Child Health Hospital of Nanjing Medical University,Nanjing 210029,China 3 Pediatric Research Institute of Nanjing Medical University,Nanjing 210029,China DepartmentofPediatrics NanjingMaternalandChildHealthHospitalofNanjingMedicalUniversityNanjing210029China pediatricresearchinstituteofnanjingmedicaluniversity Nanjing210029China

Aim:To investigate the direct effects of resistin and resistin-binding peptide（RBP）on lipid metabolism and endocrine function in adipose ***:Ratwhite adipose tissue was cultured in vitro and incubated for 24 h with 30 ng/mLrecombinant rat resistin protein（rResistin）or combined with RBP of varyingconcentrations(1×1-12mol/L,1×10-10mol/L,1×10-8mol/L).Free fatty acids（FFA）released into medium was measured by a colorimetric *** levels of proteinsecretion and mRNA expression of TNF-α and adiponectin were detected by ELISAkit and RT-PCR ***:The levels of FFA released into mediumwere significantly increased after 24 h of exposure to rResistin,but significantlydecreased after RBP was applied,although there was no difference between the *** protein level and gene expression of TNF-αin adipose tissuewere significantly increased after 24 h of exposure to rResistin,but only obviouslydecreased after incubated with 1×10-8mol/L *** levels of protein secretionand mRNA expression of adiponectin in adipose tissue were significantly de-creased after 24 h of exposure to rResistin,but increased after incubated with RBPwith the higher ***:RBP can effectively antagonize therole of resistin on the lipid metabolism and endocrine function of adipose tissue.

关键词： resistin resistin-binding peptide white adipose tissue lipid metabolism endocrine function

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