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Causal roles of gut microbiota in cholangiocarcinoma etiology suggested by genetic study

World Journal of Gastrointestinal Oncology 2024年第4期16卷 1319-1333页

作者： Zhi-Tao Chen Chen-Chen Ding Kai-Lei Chen Yang-Jun Gu Chi-Cheng Lu Qi-Yong Li Division of Hepatobiliary and Pancreatic Surgery Shulan(Hangzhou)Hospital Affiliated to Zhejiang Shuren University Shulan International Medical CollegeHangzhou 310000Zhejiang ProvinceChina pediatric psychology The Affiliated Mental Health Centre&Hangzhou Seventh People’s HospitalZhejiang University School of MedicineHangzhou 310000Zhejiang ProvinceChina School of Medicine Zhejiang Shuren UniversityHangzhou 310000Zhejiang ProvinceChina School of Medicine Zhejiang Chinese Medical University Zhejiang Shuren CollegeHangzhou 310000Zhejiang ProvinceChina

BACKGROUND Cholangiocarcinoma(CCA)is a highly malignant biliary tract cancer with poor *** studies have implicated the gut microbiota in CCA,but evidence for causal mechanisms is *** To investigate the causal relationship between gut microbiota and CCA *** We performed a two-sample mendelian randomization study to evaluate potential causal associations between gut microbiota and CCA risk using genome-wide association study summary statistics for 196 gut microbial taxa and *** variants were used as instrumental *** sensitivity analyses assessed result *** Fifteen gut microbial taxa showed significant causal associations with CCA *** genetically predicted abundance of genus Eubacteriumnodatum group,genus Ruminococcustorques group,genus Coprococcus,genus Dorea,and phylum Actinobacteria were associated with reduced risk of gallbladder cancer and extrahepatic *** intrahepatic CCA risk was associated with higher abundance of family Veillonellaceae,genus Alistipes,order Enterobacteriales,and phylum *** effects against CCA were suggested for genus Collinsella,genus Eisenbergiella,genus Anaerostipes,genus Paraprevotella,genus Parasutterella,and phylum *** analyses indicated these findings were reliable without *** This pioneering study provides novel evidence that specific gut microbiota may play causal roles in CCA *** experimental validation of these candidate microbes is warranted to consolidate causality and mechanisms.

关键词： Cholangiocarcinoma Mendelian randomization Gut microbiota Instrumental variables Sensitivity analyses

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Neurodevelopmental in Relation to Breastfeeding–Experiences among Hungarian Preterm Infants at 12 Months of Corrected Age:Empirical Study

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International Journal of Mental Health Promotion 2022年第5期24卷 699-709页

作者： Anna Szabina Szele Beáta Erika Nagy Department of pediatrics Faculty of MedicinePediatric Psychology and Psychosomatic UnitKálmán Laki Doctoral SchoolUniversity of DebrecenDebrecen4032Hungary Department of pediatrics Faculty of MedicinePediatric Psychology and Psychosomatic UnitUniversity of DebrecenDebrecen4032Hungary

Preterm and low birth weight infants are at higher risk of neurodevelopmental outcomes;breastfeeding offers sev-eral beneﬁcial aspects for *** study aimed to describe the average neurodevelopmental outcomes of pre-term infants and examine the associations between neurodevelopment and breastfeeding among Hungarian preterm infants at 12 months of corrected age.154 preterm infants with low birth weight(<2500 g)and their mothers were participated in this ***-III Screening Test(Bayley Scales of Infant and Toddler Develop-ment Screening Test,Third Edition)was administered to measure the cognitive,language and motor skills of infants;breastfeeding data was obtained through parental *** analyze data,independent sample t-test or the Welch t-test,Mann-Whitney tests,Chi-square tests of independence and Spearman’s rank correlation test were used *** the risk of developmental delay,Receptive and Expressive language and Fine motor subscales were the *** of the associations between breastfeeding and neurodevelopmental per-formance identiﬁed signiﬁcantly higher cognitive(U=2047.5;P=0.023)andﬁne motor(U=2096.0;P=0.037)skills in infants who were *** found signiﬁcant positive correlations between the duration of breastfeeding and cognitive,expressive language andﬁne motor *** study draws the attention to the importance of breastfeeding and early *** research is required to examine the casual relationship between neurodevelopmental outcomes and breastfeeding.

关键词： Preterm infants low birth weight breastfeeding duration of breastfeeding neurodevelopmental outcomes

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Des-Arg(9)bradykinin as a causal metabolite for autism spectrum disorder

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World Journal of Psychiatry 2024年第1期14卷 88-101页

作者： Zhong-Yu Huang Zi-Pan Lyu Hong-Gui Li Hua-Zhi You Xiang-Na Yang Cai-Hui Cha Center for Medical Research on Innovation and Translation Institute of Clinical MedicineGuangzhou First People’s HospitalSchool of MedicineSouth China University of TechnologyGuangzhou 510000Guangdong ProvinceChina School of Biological Sciences Nanyang Technological UniversityNanyang Ave 639798Singapore Department of pediatrics First Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510405Guangdong ProvinceChina Department of Nutrition First Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510405Guangdong ProvinceChina Department of pediatric Traditional Chinese Medicine Clinic Guangzhou Women and Children's Medical CenterGuangzhou 510632Guangdong ProvinceChina Department of psychology Guangzhou Women and Children's Medical CenterGuangzhou 510632Guangdong ProvinceChina

BACKGROUND Early diagnosis and therapeutic interventions can greatly enhance the developmental trajectory of children with autism spectrum disorder(ASD).However,the etiology of ASD is not completely *** presence of confounding factors from environment and genetics has increased the difficulty of the identification of diagnostic biomarkers for *** To estimate and interpret the causal relationship between ASD and metabolite profile,taking into consideration both genetic and environmental *** A two-sample Mendelian randomization(MR)analysis was conducted using summarized data from large-scale genome-wide association studies(GWAS)including a metabolite GWAS dataset covering 453 metabolites from 7824 European and an ASD GWAS dataset comprising 18381 ASD cases and 27969 healthy *** in plasma were set as exposures with ASD as the main *** causal relationships were estimated using the inverse variant weight(IVW)*** also performed leave-one-out sensitivity tests to validate the robustness of the *** on the drafted metabolites,enrichment analysis was conducted to interpret the association via constructing a protein-protein interaction network with multi-scale evidence from databases including Infinome,SwissTargetPrediction,STRING,and *** Des-Arg(9)-bradykinin was identified as a causal metabolite that increases the risk of ASD(β=0.262,SE=0.064,P_(IVW)=4.64×10^(-5)).The association was robust,with no significant heterogeneity among instrument variables(P_(MR Egger)=0.663,P_(IVW)=0.906)and no evidence of pleiotropy(P=0.949).Neuroinflammation and the response to stimulus were suggested as potential biological processes mediating the association between Des-Arg(9)bradykinin and *** Through the application of MR,this study provides practical insights into the potential causal association between plasma metabolites and *** findings offer perspectives for the discovery of diagnos

关键词： Des-Arg(9)bradykinin Autism spectrum disorder Mendelian randomization Metabolite Enrichment analysis

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Outcomes of critically ill children with pre-existing mental health conditions

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pediatric Investigation 2024年第2期8卷 108-116页

作者： Conrad Krawiec Morgan Cash Gary Ceneviva Zizhong Tian Shouhao Zhou Neal J.Thomas Department of pediatrics Pediatric Critical Care MedicinePenn State Hershey Children's HospitalPennsylvaniaUSA Department of Public Health Sciences Division of Biostatistics and BioinformaticsPennsylvania State University College of MedicinePennsylvaniaUSA Department of Public Health_Sciences Pennsylvania State University College of MedicinePennsylvaniaUSA

Importance:Critically ill children with pre-existing mental health conditions may have an increased risk of poor health ***:We aimed to evaluate if pre-existing mental health conditions in critically ill pediatric patients would be associated with worse clinical outcomes,compared to children with no documented mental health ***:This retrospective observational cohort study utilized the TriNetX electronic health record database of critically ill subjects aged 12-18 *** were analyzed for demographics,pre-existing conditions,diagnostic,medication,procedural codes,and ***:From a dataset of 102027 critically ill children,we analyzed 1999 subjects(284[14.2%]with a pre-existing mental health condition and 1715[85.8%]with no pre-existing mental health condition).Multivariable analysis demonstrated that death within one year was associated with the presence of pre-existing mental health conditions(odds ratio 8.97[3.48-23.15],P<0.001),even after controlling for the presence of a complex chronic ***:The present study demonstrates that the presence of pre-existing mental health conditions was associated with higher odds of death within 1 year after receiving critical ***,the confidence interval was wide and hence,the findings are *** studies with a larger sample size may be necessary to evaluate the true long-term impact of children with pre-existing mental health conditions who require critical care services.

关键词： Critical care Psychiatry psychology Public health

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Examination of the Illness Representations among Children with T1DM in Relation to Mental Health Factors

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International Journal of Mental Health Promotion 2023年第8期25卷 961-969页

作者： Brigitta Munkácsi EnikőFelszeghy Flóra Kenyhercz Beáta Erika Nagy Faculty of Medicine Department of pediatrics Pediatric Psychology and Psychosomatic UnitKálmán Laki Doctoral SchoolUniversity of DebrecenDebrecen4032Hungary Department of Behavioural Sciences University of DebrecenDebrecen4032Hungary

The most common comorbid psychiatric disorders in children with type 1 diabetes mellitus(T1DM)are depression,anxiety and behavioral *** with comorbid psychopathology are less capable of psychically adjusting to the new life situation resulting from T1DM,which may negatively affect glycemic control and adherence related to the *** aimed to investigate the association between mental health and type 1 diabetes including illness representation.115 children and adolescents with T1DM were recruited through the outpatient clinic in Debrecen,***:PRISM-D,Child Depression Inventory(CDI),Cantril Ladder and Self-Rated Health,Glycosylaeted haemoglobin(HbA1C)were *** having depressive symptoms drew fewer circles with less *** not drawing any important relationships possessed more depressive *** diagnosed at a younger age displayed smaller distance between the Self-and *** PRISM-D test can be a promising tool to analyse emotional and cognitive representations and the psychological burden of T1DM.

关键词： T1DM illness representation mental health depression children and adolescents

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Social skills and psychopathology are associated with autonomic function in children:a cross-sectional observational study

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Neural Regeneration Research 2022年第4期17卷 920-928页

作者： Elisa Cainelli Luca Vedovelli Daniele Bottigliengo Dario Boschiero Agnese Suppiej Child Neurology and Clinical Neurophysiology University Hospital of PadovaPadovaItaly Department of General psychology University of PadovaPadovaItaly unit of Biostatistics Epidemiology and Public HealthDepartment of CardiacThoracicVascular Sciencesand Public HealthUniversity of PadovaPadovaItaly BioTekna Biomedical Technologies Marcon(VE)Italy Department of Medical Sciences Pediatric SectionUniversity of FerraraFerraraItaly

In recent years,the increase of psychopathological disorders in the population has become a health emergency,leading to a great effort to understand psychological vulnerability *** this scenario,the role of the autonomic nervous system(ANS)has become increasingly *** study investigated the association between ANS,social skills,and psychopathological functioning in *** an ANS status proxy,we measured heart rate variability(HRV).Infants admitted to the neonatal intensive care unit of the University Hospital of Padova because of preterm birth or neonatal hypoxic-ischemic encephalopathy were sequentially recruited from January 2011 to June 2013 and followed long-term up to school age in this cross-sectional observational *** recorded 5 minutes of HRV immediately before measuring performance in social abilities tasks(affect recognition and theory of mind,NEPSY-II)in 50 children(mean age 7.4±1.4 years)with and without risk factors for developing neuropsychiatric disorders due to pre-/perinatal insults without major *** also completed extensive cognitive,neuropsychological,and psychosocial *** were assessed with psychopathological interviews and a questionnaire(CBCL 6-18).Analysis in a robust Bayesian framework was used to unearth dependencies between HRV,social skills,and psychopathological *** task scores were associated with HRV components,with high frequency the most *** bands were also associated with the psychopathological *** normalized HRV high frequency was able to distinguish impaired children in the affect recognition *** data suggest that ANS may be implicated in social cognition both in typical and atypical developmental conditions and that HRV has cross-disease *** suggest that HRV parameters may reflect a neurobiological vulnerability to *** study was approved by the Ethics Committee of the University Hospital of Padova(Comi

关键词： affect recognition autonomic nervous system children hypoxic-ischemic encephalopathy impairment neonatal prematurity psychopathology recovery theory of mind

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Growth retardation and severe anemia in children with Trichuris dysenteric syndrome

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Asian Pacific Journal of Tropical Biomedicine 2015年第7期5卷 581-586页

作者： Rina Girard Kaminsky Renato Valenzuela Castillo Coralia Abrego Flores pediatric Department School of Medicine National Autonomous University of Honduras and Service of Parasitology University Hospital Honduras.P.O.Box 1547Tegucigalpa Honduras pediatric Department School of Medicine National Autonomous University of Honduras pediatric psychology unit University HospitalHonduras

Objective: To document epidemiologic data, clinical manifestations and treatment in hospitalized children with Trichuris dysenteric syndrome from Honduras during 2010-2012. Methods: Severe trichuriasis cases were identified by routine stool examinations from hospitalized patients(12 years old or less). Relevant epidemiologic, clinical and management data were obtained from review of clinical histories in the ward. Results: Of 122 Trichuris infections diagnosed in 11 528(1.0%) stool samples for all ages, 81(66.4%) were identified in the age group 2-12 years old, 21(25.9%) of which were severe(≥ 100 eggs in 2 mg of feces). Thirteen of those 21 patients collaborated in this study. Patients(9 males and 4 females) were of rural precedence, from large poor or very poor families, chronically parasitized, and between 2 and 12 years old. Dysentery of months duration, severe anemia and stunting were common complaints; clinical characteristics associated with heavy Trichuris infections included egg counts from 232-3 520 eggs per direct smear, hemoglobin from 3.4-10.8 g/d L, eosinophilia up to 43%, severe malnutrition and growth stunting. Orally administered drugs mebendazole, albendazole, metronidazole, nitaxozanide, and piperazine were prescribed at different dosages and duration other than recommended; no cure or egg excretion control was exercised before patient release. A range of 340 to about 10 000 worms were recovered after treatment from 8 patients. Conclusions: This report underlines the need for detailed community studies in trichuriasis morbidity, effective treatment assessment and clinical response in severely malnourished parasitized children.

关键词： Anemia Honduras Stunting Trichuris dysentery syndrome

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The Doppelgänger phenomenon and death:a peculiar case of homicide by a subject with first-episode psychosis

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Forensic Sciences Research 2022年第4期7卷 798-802页

作者： Cristiano Barbieri Gabriele Rocca Caterina Bosco Lucia Tattoli Ignazio Grattagliano Giancarlo Di Vella Section of Forensic Medicine and Forensic Sciences University of PaviaPaviaItaly Department of Health Sciences University of GenoaGenoaItaly S.C.Medicina Legale U A.O.U.Cittàdella Salute e della Scienza di TorinoTurinItaly Department of Education PsychologyCommunication University Aldo Moro of BariBariItaly Department of Public Health and pediatric Sciences Legal Medicine UnitUniversity of TurinTurinItaly

The Doppelgänger phenomenon refers to the experience of a direct encounter with one’s self,characteriswed by:(i)the perception of a figure with one’s own identical physical features;or(ii)the apprehension that the perceived figure shares the same personality and *** Doppelgänger does not only look like the same person,it is his/her *** perceptual element is usually a hallucination,although occasionally a false perception of an actual figure may be *** phenomenon has been described in individuals suffering from overwhelming fear,severe anxiety or intoxication,epilepsy,as well as in the sleep-wakefulness *** has also been reported in major *** fear of imminent death often precedes the Doppelgänger *** report presents the case of a 30-year-old man,Mr.Y,who was stabbed to death by Mr.X,his“double”.The aggressor and his victim,although not related,were truly doubles;remarkably,they shared the same name and surname,age,professional activity and place of ***,they attended the same sports center but barely knew each *** forensic psychiatric evaluations in Mr.X,subsequent to the crime committed,were suggestive of a psychotic *** case is unique in the scientific *** the most serious psychotic forms,the issue of the“double”calls into question not only the dissociative processes involved in the etiopathogenesis of the disorder,but also bio-psycho-social elements,as well as personal data in this case,which made the victim and the aggressor“identical”.In the context of psychopathological functioning,the delusional mood(Wahnstimmung)that precedes the development of delirium is a sort of gateway to an impending psychotic illness,involving delusional awareness or mood(atmosphere).In psychosis,splitting is the main issue and this influence is seen as an evil,foreign,apocalyptic and unknown side no longer recognised as belonging to the self even in a physical *** such a situation,it is

关键词： Forensic sciences forensic psychiatry homicide first-episode psychosis Doppelgänger delusional disorder criminal responsibility

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An Open-label, Self-control, Prospective Study on Cognitive Function, Academic Performance, and Tolerability of Osmotic-release Oral System Methylphenidate in Children with Attention-deficit Hyperactivity Disorder

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Chinese Medical Journal 2015年第22期128卷 2988-2997页

作者： Yi Zheng Jian-Min Liang Hong-Yun Gao Zhi-Wei Yang Fu-Jun Jia Yue-Zhu Liang Fang Fang Rong Li Sheng-Nan Xie Jian-Min Zhuo Department of pediatrics Beijing Anding Hospital Capital Medical University Beijing 100088 China Department of pediatric Neurology The First Hospital Jilin University Changchun Jilin 130021 China Department of psychology Children's Hospital of Fudan University Shanghai 201102 China Department of pediatric psychology Shenzhen Kangning Hospital shenzhen Guangdong 518003 China Guangdong Mental Health Center Guangdong General Hospital Guangzhou Guangdong 510120 China Department of Neurology Beijing Children's Hospital Capital Medical University Beijing 100053 China Department of pediatric psychology Children's Hospital Zhejiang University School of Medicine Hangzhou Zhejiang 310003 China Janssen Research and Development Departmeni Xi'an Janssen Pharmaceutical Ltd Beijing 100025 China

Background： Attention-deficit hyperactivity disorder （ADHD） is the most common mental and behavioral disorder in school-aged children. This study evaluated the effect of osmotic-release oral system （OROS） methylphenidate （MPH） on cognitive function and academic performance of Chinese school-aged children with ADHD. Methods： This 12-week, prospective, multicenter, open-label, self-controlled study enrolled 153 Chinese school-aged children with ADHD and 41 non-ADHD children. Children with ADHD were treated with once-daily OROS-MPH （18 mg, 36 mg, or 54 mg）. The primary endpoints were Inattention/Overactivity （I/O） with Aggression Conners Behavior Rating Scale （IOWA） and Digit Span Test at week 12 compared with baseline. Secondary endpoints included opposition/defiant （O/D） subscale of IOWA, Clinical Global Impression （CGI）, Coding Test, Stroop Color-word Test, Wisconsin Card Sorting Test （WCST）, academic performance on teacher-rated school examinations, and safety at week 12 compared with baseline. Both non-ADHD and ADHD children received the same frequency of cognitive operational test to avoid the possible bias caused by training. Results： A total of 128 patients were evaluated with cognitive assessments. The OROS-MPH treatment significantly improved IOWA Conners I/O subscale scores at week 12 （3.8 ± 2.3） versus baseline （10.0 ± 2.4; P 〈 0.0001）. Digit Span Test scores improved significantly （P 〈 0.0001 ） with a high remission rate （81.1%） at week 12 versus baseline. A significant （P 〈 0.0001 ） improvement was observed in O/D subscale of IOWA, CGI, Coding Test, Stroop Color-word Test, WCST, and academic performance at week 12 versus baseline. Very few practice-related improvements were noticed in the non-ADHD group at week 12 compared with baseline. No serious adverse events and deaths were reported during the study. Conclusions： The OROS-MPH treatment effectively controlled symptoms of ADHD and significantly improved academic performance and cognitive fimction of Ch

关键词： Academic Performance Attention-deficit Hyperactivity Disorder: Cognitive Function Osmotic-release Oral System-methylphenidate

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Neurocognitive outcomes in pediatric brain tumors after treatment with proton versus photon radiation:a systematic review and meta-analysis

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世界儿科杂志:英文版 2023年第8期19卷 727-740页

作者： Álvaro Lassaletta Javier S.Morales Pedro L.Valenzuela Borja Esteso Lisa S.Kahalley Donald J.Mabbott Soumya Unnikrishnan Elena Panizo Felipe Calvo Radiation Oncology Department Clínica Universidad de NavarraCalle Marquesado de Santa Marta 128027 MadridSpain pediatric Neuro-Oncology unit Hospital Infantil Universitario Niño JesúsMadridSpain MOVE-IT Research Group Department of Physical EducationFaculty of Education SciencesUniversity of CadizCádizSpain Biomedical Research and Innovation Institute of Cádiz(INiBICA)Research unit Puerta del Mar University HospitalUniversity of CádizCádizSpain Physical Activity and Health Research Group(PaHerg) Research Institute of the Hospital 12 de Octubre(‘imas12’)MadridSpain Systems Biology Department University of AlcaláMadridSpain Clinical Neuropsychology unit Psychiatry and Clinical Psychology DepartmentHospital Infantil Universitario Niño JesúsMadridSpain Baylor College of Medicine HoustonTXUSA Texas Children’s Hospital HoustonTXUSA The Hospital for Sick Children TorontoONCanada The University of Toronto TorontoONCanada University of California School of Medicine San DiegoLa JollaCAUSA

Background Advances in cancer treatments,particularly the development of radiation therapy,have led to improvements in survival outcomes in children with brain ***,radiation therapy is associated with significant long-term neurocognitive *** present systematic review and meta-analysis aimed to compare the neurocognitive outcomes of children and adolescents with brain tumors treated with photon radiation(XRT)or proton therapy(PBRT).Methods A systematic search was conducted(PubMed,Embase,Cochrane,and Web of Science from inception until 02/01/2022)for studies comparing the neurocognitive outcomes of children and adolescents with brain tumors treated with XRT *** pooled mean differences(expressed as Z scores)were calculated using a random effects method for those endpoints analyzed by a minimum of three *** Totally 10 studies(n=630 patients,average age range:1–20 years)met the inclusion *** who had received PBRT achieved significantly higher scores(difference in Z scores ranging from 0.29–0.75,all P0.05 in main analyses or sensitivity analyses)were found for nonverbal memory,verbal working memory and working memory index,processing speed index,or focused *** pediatric brain tumor patients who receive PBRT achieve significantly higher scores on most neurocognitive outcomes than those who receive *** studies with long-term follow-ups are needed to confirm these results.

关键词： Brain health Childhood cancer Intelligence quotient Radiotherapy

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