检索结果-南通市图书馆

m^(6)A reader YTHDF1 promotes cardiac fibrosis by enhancing AXL translation

Frontiers of Medicine 2024年第3期18卷 499-515页

作者： Han Wu Weitao Jiang Ping Pang Wei Si Xue Kong Xinyue Zhang Yuting Xiong Chunlei Wang Feng Zhang Jinglun Song Yang Yang Linghua Zeng Kuiwu Liu Yingqiong Jia Zhuo Wang Jiaming Ju Hongtao Diao Yu Bian Baofeng Yang Department of Pharmacology(National Key Laboratory of Frigid Zone Cardiovascular Diseases the State-Province Key Laboratories of Biomedicine-Pharmaceutics of ChinaKey Laboratory of Cardiovascular ResearchMinistry of Education)College of PharmacyHarbin Medical UniversityHarbin150081China

Cardiac fibrosis caused by ventricular remodeling and dysfunction such as post-myocardial infarction(MI)can lead to heart *** N6-methyladenosine(m^(6)A)methylation has been shown to play a pivotal role in the occurrence and development of many *** investigating the biological function of the m^(6)A reader YTHDF1 in cardiac fibrosis,adeno-associated virus 9 was used to knock down or overexpress the YTHDF1 gene in mouse hearts,and MI surgery in vivo and transforming growth factor-β(TGF-β)-activated cardiac fibroblasts in vitro were performed to establish fibrosis *** results demonstrated that silencing YTHDF1 in mouse hearts can significantly restore impaired cardiac function and attenuate myocardial fibrosis,whereas YTHDF1 overexpression could further enhance cardiac dysfunction and aggravate the occurrence of ventricular pathological remodeling and fibrotic ***,zinc finger BED-type containing 6 mediated the transcriptional function of the YTHDF1 gene ***1 augmented AXL translation and activated the TGF-β-Smad2/3 signaling pathway,thereby aggravating the occurrence and development of cardiac dysfunction and myocardial ***,our data indicated that YTHDF1 was involved in activation,proliferation,and migration to participate in cardiac fibrosis in *** results revealed that YTHDF1 could serve as a potential therapeutic target for myocardial fibrosis.

关键词： cardiac fibrosis YTHDF1 AXL ZBED6 heart failure

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A numerical simulation strategy for a compressor’s underlying axisymmetric characteristic and its application in body force model

引用

Chinese Journal of Aeronautics 2024年第8期37卷 79-90页

作者： Shijie LIU Tianyu PAN Qiushi LI ` School of Energy and Power Engineering Beihang UniversityBeijing 100191China research Institute of Aero-Engine Beihang UniversityBeijing 100191China Key Laboratory of Fluid and Power Machinery Ministry of EducationXihua UniversityChengdu 610039China

Accurate prediction of the aerodynamic response of a compressor under inlet distortion is crucial for next-generation civil aircraft,such as Boundary Layer Ingestion(BLI)silent ***,research on the Body Force(BF)model plays a significant role in achieving this ***,distorted inlet airflow can lead to varying operating conditions across different spatial locations of the compressor,which may cause some regions to operate outside the stability ***,the accuracy of BF model simulations might be *** address this issue,this paper proposes a numerical simulation strategy for acquiring the steady axisymmetric three-dimensional flow field of a compressor operating at low mass flow rates,which is known as the Underlying Axisymmetric Pressure Rise Characteristic(UAPRC).The proposed simulation accounts for two different rotor speeds of a transonic compressor and identifies initial positions in the flow field where deterioration occurs based on prior experimental ***,simulation results are incorporated into the BF model to replicate hub instability observed in *** results demonstrate that this strategy provides valid predictions of the UAPRC of the compressor,thereby addressing the limitations associated with the BF model.

关键词： Compressor partial instability Performance at low mass flow rates Underlying axisymmetric pressure rise characteristic Novel simulation strategy Body force model

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Unidirectional propagation of water waves near ancient Luoyang Bridge

引用

Frontiers of physics 2024年第3期19卷 167-174页

作者： Linkang Han Qilin Duan Junliang Duan Shan Zhu Shiming Chen Yuhang Yin Huanyang Chen Shenzhen research Institute of Xiamen University Shenzhen 518000China Department of Physics Xiamen UniversityXiamen 361005China Key Laboratory of Underwater Acoustic Communication and Marine Information Technology of the Ministry of education Xiamen UniversityXiamen 361005China

Metasurfaces and metagratings offer new platforms for electromagnetic wave control with significant ***,metasurfaces based on abrupt phase change and resonant structures suffer from the drawback of high loss and face challenges when applied in water ***,the application of metasurfaces in water wave control is not ideal due to the limitations associated with high loss and other *** have discovered that non-resonant metagratings exhibit promising effects in water wave *** the similarity between bridges and metagratings,we have successfully developed a water wave metagrating model inspired by the ancient Luoyang Bridge in *** conduct theoretical calculations and simulations on the metagrating and derive the equivalent anisotropic model of the *** model provides evidence that the metagrating has the capability to control water waves and achieve unidirectional surface water *** accuracy of our theory is strongly supported by the clear observation of the unidirectional propagation phenomenon during simulation and experiments conducted using a reduced version of the *** is the first time that the unidirectional propagation of water waves has been seen in water wave metagrating *** all,we realize the water wave metagrating experiment for the first *** combining complex gratings with real bridges,we explore the physics embedded in the ancient building—Luoyang Bridge,which are of great significance for the water wave metagrating design and provide a new method for analyzing the effects of water waves on *** the same time,this discovery also provides a new idea for ocean cargo transportation,ocean garbage cleaning,and the development and protection of ancient bridges.

关键词： Luoyang Bridge unidirectional propagation water wave metagratings equivalent anisotropic model

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A Review on the Security of the Ethereum-Based DeFi Ecosystem

引用

Computer Modeling in Engineering & Sciences 2024年第4期139卷 69-101页

作者： Yue Xue Dunqiu Fan Shen Su Jialu Fu Ning Hu Wenmao Liu Zhihong Tian Cyberspace Institute of Advanced Technology Guangzhou UniversityGuanzhou510000China Innovation Center NSFOCUS Inc.Beijing100089China Engineering research Center of Integration and Application of Digital Learning Technology Ministry of EducationBeijing100816China

Decentralized finance(DeFi)is a general term for a series of financial products and *** is based on blockchain technology and has attracted people’s attention because of its open,transparent,and intermediary *** them,the DeFi ecosystem based on Ethereum-based blockchains attracts the most ***,the current decentralized financial system built on the Ethereum architecture has been exposed to many smart contract vulnerabilities during the last few ***,we believe it is time to improve the understanding of the prevailing Ethereum-based DeFi ecosystem security *** that end,we investigate the Ethereum-based DeFi security issues:1)inherited from the real-world financial system,which can be solved by macro-control;2)induced by the problems of blockchain architecture,which require a better blockchain platform;3)caused by DeFi invented applications,which should be focused on during the project *** on that,we further discuss the current solutions and potential directions ofDeFi *** to our research,we could provide a comprehensive vision to the research community for the improvement of Ethereum-basedDeFi ecosystem security.

关键词： Blockchain smart contract decentralized finance DeFi security

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Corrigendum to“Nitrosamines crisis in pharmaceuticals-Insights on toxicological implications,root causes and risk assessment:A systematic review”[***.14(2024)100919]

引用

Journal of Pharmaceutical Analysis 2024年第6期14卷 934-936页

作者： Hemanth P.R.Vikram Tegginamath Pramod Kumar Gunjan Kumar Narasimha M.Beeraka Rajashree Deka Sheik Mohammed Suhail Sandeep Jat Namitha Bannimath Gayatiri Padmanabhan Ravandur S.Chandan Pramod Kumar Bannimath Gurupadayya Department of Pharmaceutical Chemistry JSS College of Pharmacy MysuruJSS Academy of Higher Education and Research(JSSAHER)Mysuru570015India Xenone Healthcare Pvt.Ltd. New Delhi110076India Department of Pharmaceutics JSS College of Pharmacy MysuruJSS Academy of Higher Education and Research(JSSAHER)Mysuru570015India Department of Human Anatomy I.M.Sechenov First Moscow State Medical University(Sechenov University)Moscow119991Russian Federation Department of Pharmacology Raghavendra Institute of Pharmaceutical Education and Research(RIPER)Ananthapuramu515721India Herman B.Wells Center for Pediatric research Department of PediatricsIndiana University School of MedicineIndianapolisIN46202USA Animal Physiology and Biochemistry Laboratory Department of ZoologyGauhati UniversityGuwahati781014India Department of Pharmacology JSS College of Pharmacy MysuruJSS Academy of Higher Education and Research(JSSAHER)Mysuru570015India Department of Pharmaceutical Analysis National Institute of Pharmaceutical Education and Research(NIPER)-GuwahatiChangsari781101India Department of Pharmacology University of GalwayGalwayH91 TK33Ireland

Original statement in the Section 2:*** search Our primary screening of 180 articles yielded the relevant data for this *** selection A total of 180 articles spanning from 1960 to the present day,including original research,reviews,case reports and studies reporting nitrosamine impurities above the no-observed-adverse-effect levels(NOAEL)established by regulatory agencies,were initially *** the primary screening,we considered factors such as relevance,publication date,access to the full article text,and content.

关键词： statement initially spanning

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The Coarse l^(p)-Novikov Conjecture and Banach Spaces with Property(H)

引用

Chinese Annals of Mathematics,Series B 2024年第2期45卷 193-220页

作者： Huan WANG Qin WANG research Center for Operator Algebras School of Mathematical SciencesEast China Normal UniversityShanghai 200241China Key Laboratory of MEA Ministry of Educationand Shanghai Key Laboratory of PMMPEast China Normal UniversityShanghai 200241China

In this paper,for 1

关键词： The coarse l^(p)-Novikov conjecture Banach spaces with Property(H) Coarse geometry K-Theory

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Artificial Self-Recovery Opens up a New Journey of Autonomous Health of Mechanical Equipments

引用

Engineering 2024年第6期37卷 22-26页

作者： Xin Pan Haoyu Zhang Jinji Gao Weimin Wang Zhinong Jiang Lidong He Beijing Key Laboratory of Health Monitoring and Self-recovery for High-end Mechanical Equipment Beijing University of Chemical TechnologyBeijing 100029China Engineering research Center of Chemical Safety Ministry of education Beijing University of Chemical TechnologyBeijing 100029China

*** With the implementation of modern production strategies,such as“Industry 4.0”and“Made in China 2025,”the development of high-end mechanical equipment is gradually reaching a high degree of parameterization,digitalization,networking,and intelligence[1].High-end mechanical equipment no longer consists of traditional single devices,but is closely linked to the overall production process;that is,a variety of devices interact with each other and collectively form a complex ***,faults can lead to production delays throughout the system and even seriously threaten the safety of workers[2].In addition,equipment operating in unmanned air or space vehicles(including space robots)cannot be repaired by humans if they break down[3].Until recently,the typical method of addressing machine faults was primarily the“fault cure”method,which involves manually shutting down,inspecting,and repairing the equipment to restore normal ***,the maintenance cycle of the traditional“fault cure”method is time-consuming,and the quality of the maintenance depends on the skills of the technician[4].

关键词： collective consuming Open

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The origin of two divergent ovine β-globin haplotypes and their potential association with environmental adaptation

引用

Journal of Genetics and Genomics 2024年第8期51卷 877-879页

作者： Yuxin Kang Yilin Liang Fengting Fan Hojjat Asadollahpour Nanaei Chunna Cao Yu Jiang Xianyong Lan Chuanying Pan Ran Li College of Animal Science and Technology Northwest A&F UniversityYanglingShaanxi 712100China Key Laboratory of Livestock Biology Northwest A&F UniversityYanglingShaanxi 712100China Department of Animal Science Fars Agricultural and Natural Resources Research and Education CenterAgricultural ResearchEducation&Extension Organization(AREEO)FarsIran Author links open overlay panel

Hemoglobin is responsible for transporting oxygen from the lungs to body ***,this protein is a tetramer composed of two a-globin chains and twoβ-globin *** sheep,the β-globin locus is of particular interest because it contains two different haplotypes,namely haplotype A(hap A)and hap B,which differ in length by more than 30 kb and do not undergo recombination with each other due to low sequence similarity(Bauer and Jung,1975;Jiang et al.,2015).The two haplotypes also differ in gene content with hap A possessing two clusters of hemoglobin gene families and hap B possessing only one(Aguiletam et al.,2004),which implies differentiation in their functional *** A was speculated to be associated with high-altitude adaptation in sheep(Hu et al.,2019).

关键词： chains altitude similarity

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Electron-beam-driven anomalous Doppler effects in Smith–Purcell radiation

引用

Photonics research 2024年第1期12卷 78-84页

作者： XIAOQIUYAN ZHANG TIANYU ZHANG ZHUOCHENG ZHANG XINGXING XU DIWEI LIU ZHAOYUN DUAN YANYU WEI YUBIN GONG LIANG JIE WONG MIN HU Terahertz research Center School of Electronic Science and EngineeringUniversity of Electronic Science and Technology of ChinaChengdu 610054China Key Laboratory of Terahertz Technology Ministry of EducationChengdu 610054China School of Electrical and Electronic Engineering Nanyang Technological UniversitySingapore 639798Singapore

The interaction between electrons and matter is an effective means of light emission,through mechanisms including Cherenkov radiation and Smith–Purcell radiation(SPR).In this study,we show that the superlight inverse Doppler effects can be realized in reverse Smith–Purcell radiation excited by a free electron beam with a homogeneous *** particular,we find that two types of anomalous SPR exist in the homogenous substrate:special SPR and reverse *** results reveal that the electron velocity can be tuned to simultaneously excite different combinations of normal SPR,special SPR,and reverse *** proposed manifold light radiation mechanism can offer greater versatility in controlling and shaping SPR.

关键词： anomalous beam Electron

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Coordination-environment regulation of atomic Co-Mn dual-sites for efficient oxygen reduction reaction

引用

Nano research 2024年第8期17卷 6841-6848页

作者： Caiting Sun Yarong Liu Zunhang Lv Rui Liu Changli Wang Liuhua Li Jinming Wang Yu Zhang Wenxiu Yang Bo Wang Key Laboratory of Cluster Science(Ministry of education) Beijing Key Laboratory of Photoelectronic/Electrophotonic Conversion MaterialsAdvanced Technology Research Institute(Jinan)Advanced Research Institute of Multidisciplinary ScienceSchool of Chemistry and Chemical EngineeringBeijing Institute of TechnologyBeijing 100081China Beijing Institute of Technology Library Beijing Institute of TechnologyBeijing 100081China

Precisely designing atomic metal-nitrogen-carbon(M-N-C)catalysts with asymmetric diatomic configurations and studying their structure–activity relationships for oxygen reduction reaction(ORR)are important for zinc-air batteries(ZABs).Herein,a dualatomic-site catalyst(DASC)with CoN_(3)S-MnN_(2)S_(2) configuration was prepared for the cathodes of *** with Co-N-C(Mn-free)and CoMn-N-C(S-free doping),CoMn-N/S-C exhibits excellent half-wave potential(0.883 V)and turnover frequency(1.54 e·s^(−1)·site^(−1)),surpassing most of the reported state-of-the-art Pt-free ORR *** CoMn-N/S-C-based ZABs achieve extremely high specific capacity(959 mAh·g^(−1))and good stability(350 h@5 mA·cm^(−2)).Density functional theory(DFT)calculation shows that the introduction of Mn and S can break the electron configuration symmetry of the original Co 3d orbital,lower the dband center of the Co site,and optimize the desorption behavior of*OH intermediate,thereby increasing the ORR activity.

关键词： metal organic frameworks oxygen reduction reaction dual-atom catalyst coordination-environment regulation zinc-air batteries

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：