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Histopathological findings in cholecystectomies specimens:A single institution study of 20 584 cases

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Hepatobiliary & Pancreatic Diseases International 2018年第4期17卷 345-348页

作者： Slim Charfi Naourez Gouiaa Hela Mnif Lassaad Chtourou Nabil Tahri Bassem Abid Rafik Mzali Tahya Sellami Boudawara department of pathology CHU Habib Bourguiba Sfax Medical School University of Sfax department of Gastroenterology CHU Habib Bourguiba department of Surgery CHU Habib Bourguiba

Background: The histopathological examination of cholecystectomy specimens has not been standardized with a debate concerning the routine and the selective approach. The aim of this study was to assess the information obtained from routine histopathological examination of cholecystectomy ***: All histopathological reports of cholecystectomy specimens between January 2003 and December 2016 were analyzed, including a clinical diagnosis of benign gallstone disease or ***: A total of 20,584 reports were examined. The mean age of patients was 54.2 years. Patients aged more than 60 years represent 37.6% of the study population. Of all patients, 15,973(77.6%) were *** gallbladder cancers(GBC) were present in 155 cholecystectomies specimens(0.8%). 67.1% of GBC are at T2 and T3 stage. Granulomatous cholecystitis was diagnosed in only 19 cases(0.1%). GBC were more prevalent in older patients(P < 10-6) and cholesterolosis was more prevalent in young patients(P < 10-6). There was no gender predilection for GBC(P = 0.739).Conclusions: The rate of incidental gallbladder carcinoma in our study is low, yet, we found a higher proportion of T2 and T3 carcinomas stage. Granulomatous cholecystitis may need further investigations and treatments. When a selective approch of histopathological examination of cholecystectomy specimens is used, it is important to take into account that clinical parameters are significantly associated with gallbladder cancer.

关键词： Cholecystectomy Gallbladder carcinoma Routine Incidental pathology Granulomas

Unexpected discovery of 2 cases of hepatocyte nuclear factor 1α-mutated infracentimetic adenomatosis

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World Journal of Gastroenterology 2008年第30期14卷 4830-4833页

作者： Hervé Laumonier Anne Rullier Jean Saric Charles Balabaud Paulette Bioulac-Sage department of Radiology Hpital Saint André CHU Bordeaux department of pathology Hpital Pellegrin CHU Bordeaux department of Surgery Hpital Saint André CHU Bordeaux department of Hepatology Hpital Saint André CHU Bordeaux

We present 2 cases of hepatocyte nuclear factor 1α (HNF1α)-mutated adenomatosis, discovered for reasons unrelated to this disease, and identified using immunohistochemical methods. These new tools may further our understanding of the link between adenomas/adenomatosis subtypes and their complications, and their association with other abnormalities.

关键词： Hepatocellular adenoma Adenomatosis Hepatocyte nuclear factor 1 Hepatocyte nuclear factor 1α mutation β-catenin mutation Focal nodular hyperplasia

18-Fluoro-deoxyglucose uptake in inflammatory hepatic adenoma:A case report

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World Journal of Hepatology 2017年第11期9卷 562-566页

作者： Willy Liu Jean Delwaide Noella Bletard Philippe Delvenne Paul Meunier Roland Hustinx Olivier Detry department of Abdominal Surgery and Transplantation CHU Liege (CHU-ULg) department of Hepato-gastroenterology CHU Liege (CHU-ULg) department of pathology CHU Liege(CHU-ULg) department of pathology CHU Liege (CHU-ULg) department of Radiology CHU Liege (CHUULg) department of Nuclear Imaging CHU Liege (CHU-ULg)

Positron emission tomography computed tomography (PET-CT) using 18-Fluoro-deoxyglucose (18FDG) is an imaging modality that reflects cellular glucose metabolism. Most cancers show an uptake of 18FDG and benign tumors do not usually behave in such a way. The authors report herein the case of a 38-year-old female patient with a past medical history of cervical intraepithelial neoplasia and pheochromocytoma, in whom a liver lesion had been detected with PET-CT. The tumor was laparoscopically resected and the diagnosis of inflammatory hepatic adenoma was confirmed. This is the first description of an inflammatory hepatic adenoma with an 18FDG up-take.

关键词： Liver surgery Liver tumor Liver cancer Benign tumor Laparoscopy Prognosis

Role of endoscopic ultrasound in the molecular diagnosis of pancreatic cancer

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World Journal of Gastroenterology 2014年第31期20卷 10758-10768页

作者： Barbara Bournet Marion Gayral Jérme Torrisani Janick Selves Pierre Cordelier Louis Buscail department of Gastroenterology CHU Toulouse Rangueil University of Toulouse INSERM UMR 1037 CHU Toulouse Rangueil University of Toulouse department of pathology CHU Toulouse Purpan University of Toulouse

Pancreatic ductal adenocarcinoma remains one of the most deadly types of tumor. Endoscopic ultrasoundguided fine-needle aspiration(EUS-FNA) is a safe, cost-effective, and accurate technique for evaluating and staging pancreatic tumors. However, EUS-FNA may be inconclusive or doubtful in up to 20% of cases. This review underlines the clinical interest of the molecular analysis of samples obtained by EUS-FNA in assessing diagnosis or prognosis of pancreatic cancer, especially in locally advanced tumors. On EUS-FNA materials DNA, mRNA and miRNA can be extracted, amplified, quantified and subjected to methylation assay. Kras mutation assay, improves diagnosis of pancreatic cancer. When facing to clinical and radiological presentations of pseudo-tumorous chronic pancreatitis, wildtype Kras is evocative of benignity. Conversely, in front of a pancreatic mass suspected of malignancy, a mutated Kras is highly evocative of pancreatic adenocarci-noma. This strategy can reduce false-negative diagnoses, avoids the delay of making decisions and reduces loss of surgical resectability. Similar approaches are conducted using analysis of miRNA expression as well as Mucin or markers of invasion(S100P, S100A6, PLAT or PLAU). Beyond the diagnosis approach, the prediction of response to treatment can be also investigated form biomarkers expression within EUS-FNA materials.

关键词： Pancreatic ductal adenocarcinoma Endoscopic ultrasound-guided fine-needle aspiration Solid pancreatic mass KRAS-mutation assay qPCR analysis Micro-RNA Chronic pancreatitis

Prognostic value of ^(18)F-FDG PET/CT in liver transplantation for hepatocarcinoma

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World Journal of Gastroenterology 2015年第10期21卷 3049-3054页

作者： Olivier Detry Laurence Govaerts Arnaud Deroover Morgan Vandermeulen Nicolas Meurisse Serge Malenga Noella Bletard Charles Mbendi Anne Lamproye Pierre Honoré Paul Meunier Jean Delwaide Roland Hustinx department of Abdominal Surgery and Transplantation CHU LiegeB4000 LiegeBelgium department of Nuclear Medicine CHU Liege University of Liege ULg CHU B4000 LiegeBelgium department of Radiology CHU LiegeUniversity of LiegeULg CHUB4000 LiegeBelgium department of pathology CHU LiegeUniversity of LiegeULg CHUB4000 LiegeBelgium department of Hepato-Gastroenterology CHU LiegeUniversity of LiegeULg CHUB4000 LiegeBelgium

AIM:To evaluate the prognostic value of pretreatment F D G p o s i t r o n e m i s s i o n t o m o g ra p h y c o m p u t e d tomography(PET-CT) in patients with hepatocarcinoma treated by liver transplantation(LT).METHODS:The authors retrospectively analyzed the data of 27 patients(mean age 58 ± 9 years) who underwent FDG PET-CT before LT for *** follow-up was 26 ± 18 *** FDG PET/CT was performed according to a standard clinical protocol:4 MBq FDG/kg body weight,uptake 60 min,low-dose non-enhanced *** authors measured the SUVmax and SUVmean of the tumor and the normal *** tumor/liver activity ratios(RSUVmax and RSUVmean) were tested as prognostic factors and compared to the following conventional prognostic factors:MILAN,CLIP,OKUDA,TNM stage,alphafoetoprotein level,portal thrombosis,size of the largest nodule,tumor differentiation,microvascular invasion,underlying cirrhosis and liver ***:Overall and recurrence free survivals were80.7%and 67.4%at 3 years,and 70.6%and 67.4%at 5 years,*** to a multivariate Cox model,only FDG PET/CT RSUVmax predicted recurrence free *** though the MILAN criteria alone were not predictive,it is worth noting that none of the patients outside the MILAN criteria and with RSUVmax<1.15 ***:FDG PET/CT with an RSUVmax cutoff value of 1.15 is a strong prognostic factor for recurrence and death in patients with HCC treated by LT in this retrospective *** prospectivestudies should test whether this metabolic index should be systematically included in the preoperative assessment.

关键词： Cancer Hepatoma Hepatocellular cancer Liver transp

Outcomes of nonresected main-duct intraductal papillary mucinous neoplasms of the pancreas

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World Journal of Gastroenterology 2015年第9期21卷 2658-2667页

作者： Mathieu Daudé Fabrice Muscari Camille Buscail Nicolas Carrère Philippe Otal Janick Selves Louis Buscail Barbara Bournet department of Gastroenterology CHU Toulouse RangueilUniversity of Toulouse31059 ToulouseFrance department of Digestive Surgery CHU Toulouse Rangueil and PurpanUniversity of Toulouse31059 ToulouseFrance department of Public Health and Epidemiology CHU Rennes PontchaillouUniversity of Rennes35033 RennesFrance department of Radiology CHU Toulouse RangueilUniversity of Toulouse31059 ToulouseFrance department of pathology CHU Toulouse PurpanUniversity of Toulouse31300 ToulouseFrance

AIM:To compare characteristics and outcomes of resected and nonresected main-duct and mixed intraductal papillary mucinous neoplasms of the pancreas(IPMN).METHODS:Over a 14-year period,50 patients who did not undergo surgery for resectable main-duct or mixed IPMN,for reasons of precluding comorbidities,age and/or refusal,were compared with 74 patients who underwent resection to assess differences in rates of survival,recurrence/occurrence of malignancy,and prognostic *** study participants had dilatation of the main pancreatic duct by ≥ 5 mm,with or without dilatation of the branch *** of the nonsurgical patients showed evidence of mucus upon perendoscopic retrograde cholangiopancreatography or endoscopic ultrasound and/or after fine needle *** the surgical patients,pathologic analysis of resected specimens confirmed a diagnosis of IPMN with involvement of the main pancreatic duct or of both branch ducts as well as the main pancreatic *** and biologic follow-ups were conducted for all patients at least annually,through hospitalization or consultation every six months during the first year of follow-up,together with abdominal imaging analysis(magnetic resonance cholangiopancreatography or computed tomography) and,if necessary,endoscopic ultrasound with or without fine needle ***:The overall five-year survival rate of patients who underwent resection was significantly greater than that for the nonsurgical patients(74% vs 58%; P =0.019).The parameters of age( 10 mm,branch ductdiameter > 30 mm,or presence of extra pancreatic cancers did not significantly influence the *** the nonsurgical patients,pancreatic malignancy occurred in 36% of cases within a mean time of 33 mo(median:29 mo; range:8-141 mo).Comparison of the nonsurgical patients who experienced disease progression

关键词： Main-duct intraductal papillary mucinous neoplasms

Polymorphisms in oxidative pathway related genes and susceptibility to inflammatory bowel disease

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World Journal of Gastroenterology 2017年第47期23卷 8300-8307页

作者： Nezha Senhaji Sellama Nadifi Younes Zaid Aurora Serrano Daniel Arturo Leon Rodriguez Nadia Serbati Mehdi Karkouri Wafaa Badre Javier Martín Laboratory of Genetic and Molecular pathology Faculty of Medicine and Pharmacy of CasablancaHassanⅡUniversity Mohammed VI University of Health Sciences Instituto de Parasitología y Biomedicina López-Neyra Consejo Superior de Investigaciones Científicas department of pathology CHU Ibn Rochd department of Gastroenterology CHU Ibn Rochd

AIM To investigate whether common variants in the oxidative pathway genes influence inflammatory bowel disease(IBD) risk among Moroccan patients. METHODS The distribution of(TAAA)n_rs12720460 and(CCTTT)n_rs3833912 NOS2 A microsatellite repeats, HIF-1 A_rs11549467 and NFKB1-94 ins/delA TTG_rs28362491 was analyzed in 507 subjects grouped in 199 IBD and 308 healthy controls. Genotyping was performed withpolymerase chain reaction-fluorescent method and the TaqMan~? allelic discrimination *** The allele and genotype frequencies of HIF1 A_ rs11549467, NFKB1_rs28362491 and NOS2 A_(TAAA)n did not differ significantly between patients and controls. Analysis of NOS2 A_(CCTTT)n markers evidenced differences between patients and healthy controls. A preferential presence of the(CCTTT)8(P = 0.02; OR = 1.71, 95%CI: 1.07-2.74),(CCTTT)14(P = 0.02; OR = 1.71, 95%CI: 1.06-2.76) alleles in IBD,(CCTTT)8(P = 0.008; OR = 1.95, 95%CI: 1.17-3.23) in CD and(CCTTT)7(P = 0.009; OR = 7.61, 95%CI: 1.25-46.08),(CCTTT)11(P = 0.05; OR = 0.51, 95%CI: 0.25-1.01),(CCTTT)14(P = 0.02; OR = 2.05, 95%CI: 1.07-3.94),(CCTTT)15(P = 0.01; OR = 2.25, 95%CI: 1.16-4.35) repeats in UC patients indicated its possible association with higher disease risk which need to be confirmed in a larger sample size. CONCLUSION Our results suggest that the NOS2 A_(CCTTT)n gene variations may influence IBD susceptibility in the Moroccan population.

关键词： HIF1A NFKB1 NOS2A Inflammatory bowel disease Moroccan patients

Primary Breast Tuberculosis Mimicking Carcinomatous Mastitis: A Case Report

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Open Journal of pathology 2021年第3期11卷 79-83页

作者： Zo Irène Raivoherivony Lalaina Nomenjanahary Fenohery Nalisoa Rakotondrainibe Nantenaina Soa Randrianjafisamindrakotroka department of pathology Joseph Ravoahangy Andrianavalona University Hospital Antananarivo Madagascar department of pathology Anosiala University Hospital Antananarivo Madagascar department of pathology Medical School of Antananarivo Antananarivo Madagascar

The breast is a rare localization of extra-pulmonary tuberculosis, even in highly endemic countries. It is most often primitive. The clinical and radiological features are sometimes misleading. It poses diagnostic problems especially with cancer. We report a case of breast tuberculosis having clinical and radiological presentations as a breast carcinoma. Through this observation and a review of the literature, we provide an update on the epidemiological characteristics and the means of diagnosis of this lesion. It was a 52-year-old woman with inflammatory lump of the left breast, adherent to the skin. Ultrasonography and mammography revealed a homogeneous, poorly demarcated nodule of approximately 4 cm of diameter, classified ACR4. Surgical excision was performed. The histological diagnosis was breast tuberculosis. The diagnosis of tuberculous mastitis is made on bacteriological and pathological examinations. Histological examination helps for diagnostic confirmation while excluding a malignant lesion of the breast.

关键词： Mastitis Breast Disease Extra-Pulmonary Tuberculosis

Adult Granulosa Cell Tumor in a Young Woman: A Case Report and Literature Review

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Open Journal of pathology 2020年第4期10卷 124-128页

作者： Z. I. Raivoherivony F. N. Rakotondrainibe L. Nomenjanahary N. S. Randrianjafisamindrakotroka department of pathology Joseph Ravoahangy Andrianavalona University Hospital Antananarivo Madagascar department of pathology Anosiala University Hospital Antananarivo Madagascar department of pathology Medical School of Antananarivo Antananarivo Madagascar

Granulosa cell tumors belong to the group of stromal and sex cord tumors of the ovary. The adult type is the most common type and usually occurs during the perimenopausal period while the juvenile type mostly affects young women. This is a report of a 26 years old woman who presented an adult type of granulosa cells tumor, with review of the literature. She complained abdominal pain and distension associated with abundant ascites and underwent a right adnexectomy. The pathology examination diagnosed an adult granulosa cell tumor. The two entities of granulosa cell tumors (juvenile and adult types) are distinguished by their characteristic morphological aspects on histological examination allowing diagnostic orientation.

关键词： Ovary Stromal and Sex Cord Tumors Granulosa Cell Tumors