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Development and validation of a machine learning-based early prediction model for massive intraoperative bleeding in patients with primary hepatic malignancies

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World Journal of Gastrointestinal Oncology 2024年第1期16卷 90-101页

作者： Jin Li Yu-Ming Jia Zhi-Lei Zhang Cheng-Yu Liu Zhan-Wu Jiang Zhi-Wei Hao Li Peng department of Hepatological Surgery The Fourth Hospital of Hebei Medical UniversityShijiazhuang 050011Hebei ProvinceChina department of General Surgery II Baoding First Central HospitalBaoding 071000Hebei ProvinceChina

BACKGROUND Surgical resection remains the primary treatment for hepatic malignancies,and intraoperative bleeding is associated with a significantly increased risk of ***,accurate prediction of intraoperative bleeding risk in patients with hepatic malignancies is essential to preventing bleeding in advance and providing safer and more effective *** To develop a predictive model for intraoperative bleeding in primary hepatic malignancy patients for improving surgical planning and *** The retrospective analysis enrolled patients diagnosed with primary hepatic malignancies who underwent surgery at the Hepatobiliary Surgery department of the Fourth hospital of hebei Medical University between 2010 and *** regression analysis was performed to identify potential risk factors for intraoperative bleeding.A prediction model was developed using Python programming language,and its accuracy was evaluated using receiver operating characteristic(ROC)curve *** Among 406 primary liver cancer patients,16.0%(65/406)suffered massive intraoperative *** regression analysis identified four variables as associated with intraoperative bleeding in these patients:ascites[odds ratio(OR):22.839;P<0.05],history of alcohol consumption(OR:2.950;P<0.015),TNM staging(OR:2.441;P<0.001),and albumin-bilirubin score(OR:2.361;P<0.001).These variables were used to construct the prediction *** 406 patients were randomly assigned to a training set(70%)and a prediction set(30%).The area under the ROC curve values for the model’s ability to predict intraoperative bleeding were 0.844 in the training set and 0.80 in the prediction *** The developed and validated model predicts significant intraoperative blood loss in primary hepatic malignancies using four preoperative clinical factors by considering four preoperative clinical factors:ascites,history of alcohol consumption,TNM staging,and albumin-bilirubin ***

关键词： Primary liver cancer Intraoperative bleeding Machine learning Model

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Urinary exosomal microRNA-145-5p and microRNA-27a-3p act as noninvasive diagnostic biomarkers for diabetic kidney disease

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World Journal of Diabetes 2024年第1期15卷 92-104页

作者： Lu-Lu Han Sheng-Hai Wang Ming-Yan Yao Hong Zhou department of Endocrinology The Second Hospital of Hebei Medical UniversityShijiazhuang 050000Hebei ProvinceChina department of Endocrinology Baoding No.1 Central HospitalBaoding 071000Hebei ProvinceChina department of Critical Care Medicine The Affiliated Hospital of Hebei UniversityBaoding 071000Hebei ProvinceChina

BACKGROUND Diabetic kidney disease(DKD),characterized by increased urinary microalbumin levels and decreased renal function,is the primary cause of end-stage renal *** pathological mechanisms are complicated and multifactorial;Therefore,sensitive and specific biomarkers are *** exosome originate from diverse renal cells in nephron segments and partially mirror the pathological changes in the *** microRNAs(miRNAs)in urinary exosome are remark-ably stable and highly tissue-specific for the *** Type 2 diabetic mellitus(T2DM)patients were recruited from the Second hospital of hebei Medical University and were divided into two groups:DM,diabetic pa-tients without albuminuria[urinary albumin to creatinine ratio(UACR)<30 mg/g]and DKD,diabetic patients with albuminuria(UACR≥30 mg/g).Healthy subjects were the normal control(NC)*** exosomal miR-145-5p,miR-27a-3p,and miR-29c-3p,were detected using real-time quantitative polymerase chain *** correlation between exosomal miRNAs and the clinical in-dexes was *** diagnostic values of exosomal miR-145-5p and miR-27a-3p in DKD were determined using receiver operating characteristic(ROC)*** functions of miR-145-5p were investigated by performing RESULTS Urinary exosomal expression of miR-145-5p and miR-27a-3p was more upregulated in the DKD group than in the DM group(miR-145-5p:4.54±1.45 vs 1.95±0.93,P<0.001;miR-27a-3p:2.33±0.79 vs 1.71±0.76,P<0.05)and the NC group(miR-145-5p:4.54±1.45 vs 1.55±0.83,P<0.001;miR-27a-3p:2.33±0.79 vs 1.10±0.51,P<0.001).The exosomal miR-145-5p and miR-27a-3p positively correlated with albuminuria and serum creatinine and negatively correlated with the estimated glomerular filtration ***-27a-3p was also closely related to blood glucose,gly-cosylated hemoglobin A1c,and low-density lipoprotein *** analysis revealed that miR-145-5p had a better area under the curve of 0.88[95%confidence interval(CI):0.784-0.985

关键词： Urinary exosome MicroRNA-145-5p MicroRNA-27a-3p Diabetic kidney disease Diagnostic biomarkers

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Gradient inflammation in the pancreatic stump after pancreaticoduodenectomy:Two case reports and review of literature

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World Journal of Clinical Cases 2024年第9期12卷 1649-1659页

作者： Tie-Gong Wang Liang Tian Xiao-Ling Zhang Lei Zhang Xiu-Lei Zhao De-Shuai Kong department of Surgery Cangzhou Central HospitalCangzhou 061000Hebei ProvinceChina department of pathology Cangzhou Central HospitalCangzhou 061000Hebei ProvinceChina

BACKGROUND Postoperative pancreatic fistula(POPF)contributes significantly to morbidity and mortality after pancreaticoduodenectomy(PD).However,the underlying mechanisms remain *** study explored this pathology in the pancreatic stumps and elucidated the mechanisms of POPF following *** SUMMARY Pathological analysis and 16S rRNA gene sequencing were performed on specimens obtained from two patients who underwent complete pancreatectomy for grade C POPF after *** inflammation is present in the pancreatic *** apoptosis was lower than that in the normal ***,neu-trophildominated inflammatory cells are concentrated in the ductal ***-tably,neutrophils migrated through the ductal wall in acinar duct metaplasia-formed ***,evidence indicates that gut microbes migrate from the digestive *** inflammation occurs in pancreatic stumps after *** The mechanisms underlying POPF include high biochemical activity in the pancreas,mechanical injury,and digestive *** prevent POPF and address pancreatic inflammation and reflux,breaking the link with anastomotic dehi-scence is practical.

关键词： Pancreaticoduodenectomy Postoperative pancreatic fistula Inflammation Digestive reflux Case report

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Sustained remission of Cronkhite-Canada syndrome after corticosteroid and mesalazine treatment: A case report

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World Journal of Clinical Cases 2024年第14期12卷 2431-2437页

作者： Ya-Lan Chen Rui-Yao Wang Ling Mei Ran Duan department of Gastroenterology The Affiliated Hospital of Hebei UniversityBaoding 071000Hebei ProvinceChina department of Thoracic Surgery The Affiliated Hospital of Hebei UniversityBaoding 071000Hebei ProvinceChina department of Medical Imageology The Affiliated Hospital of Hebei UniversityBaoding 071000Hebei ProvinceChina

BACKGROUND Cronkhite-Canada syndrome(CCS)is a rare disease of unknown *** optimal treatment for CCS remains *** with corticosteroids is considered the mainstay treatment because of its high efficacy,but the therapeutic strategy for steroid-resistant CCS is not yet *** SUMMARY This is the case of an 81-year-old woman who was diagnosed with *** her severe diarrhea,nausea,vomiting,and hypoproteinemia,hormone therapy(40 mg/d)was administered,and the symptoms improved within 1 *** 3 mo,the patient had no obvious *** polyps were significantly reduced on review gastroscopy and colonoscopy,thus hormone reduction gradually *** hormone level was maintained at 10 mg/d after 6 *** the age of the patient and the side effects of hormones,the patient had no obvious ***,hormone drugs were discontinued,and mesalazine was administered orally at 3 g/*** patient's symptoms continued to improve after a follow-up of 5 *** Corticosteroids and mesalazine are potential treatment options for CCS.

关键词： Cronkhite-Canada syndrome Corticosteroids Mesalazine Gastrointestinal polyposis Case report

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Comprehensive understanding of glioblastoma molecular phenotypes:classification,characteristics,and transition

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Cancer Biology & Medicine 2024年第5期21卷 363-381页

作者： Can Xu Pengyu Hou Xiang Li Menglin Xiao Ziqi Zhang Ziru Li Jianglong Xu Guoming Liu Yanli Tan Chuan Fang School of Clinical Medicine Hebei UniversityDepartment of NeurosurgeryAffiliated Hospital of Hebei UniversityBaoding 07100China hebei Key Laboratory of Precise Diagnosis and Treatment of Glioma Baoding 071000China School of Basic Medical Sciences Hebei UniversityBaoding 07100China department of pathology Affiliated Hospital of Hebei UniversityBaoding 07100China

Among central nervous system-associated malignancies,glioblastoma(GBM)is the most common and has the highest mortality *** high heterogeneity of GBM cell types and the complex tumor microenvironment frequently lead to tumor recurrence and sudden relapse in patients treated with *** precision medicine,research on GBM treatment is increasingly focusing on molecular subtyping to precisely characterize the cellular and molecular heterogeneity,as well as the refractory nature of GBM toward *** understanding of the different molecular expression patterns of GBM subtypes is *** have recently proposed tetra fractional or tripartite methods for detecting GBM molecular *** various molecular subtypes of GBM show significant differences in gene expression patterns and biological *** subtypes also exhibit high plasticity in their regulatory pathways,oncogene expression,tumor microenvironment alterations,and differential responses to standard ***,we summarize the current molecular typing scheme of GBM and the major molecular/genetic characteristics of each ***,we review the mesenchymal transition mechanisms of GBM under various regulators.

关键词： Glioblastoma molecular phenotype classification characteristic mesenchymal transition

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Endobronchial metastasis secondary to renal clear cell carcinoma:A case report

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World Journal of Clinical Cases 2024年第23期12卷 5416-5421页

作者： Tian-Hao Xie Yan Fu Si-Ning Ha Qing-Xu Meng Qian Sun Pan Wang department of General Surgery The Affiliated Hospital of Hebei UniversityBaoding 071000Hebei ProvinceChina department of Ophthalmology Baoding First Central HospitalBaoding 071000Hebei ProvinceChina department of pathology The Affiliated Hospital of Hebei UniversityBaoding 071000Hebei ProvinceChina

BACKGROUND Endobronchial metastases(EBMs)are tumours that metastasise from a malignant tumour outside the lungs to the central and subsegmental bronchi,and are visible under a *** EBMs are formed by direct invasion or metastasis of intrathoracic malignant tumours,such as lung cancer,oesophageal cancer or mediastinum *** cell carcinoma(RCC),accounting for 2%to 3%of all tumours,is a common malignant tumour of the urinary *** clear cell carcinoma(RCCC)constitutes the predominant pathological subtype of RCC,comprising approximately 70%to 80%of all RCC *** can spread and metastasise through arterial,venous and lymphatic circulation to almost all organs of the ***,lung,bone,liver,brain and local recurrence are the most common metastatic neoplasms of ***,EBM from RCCC has a low complication rate and is often misdiagnosed as primary lung *** SUMMARY A 71-year-old male patient who had undergone radical left nephrectomy 7 years prior due to RCCC was referred to our hospital due to a 1-mo history of productive *** results of an enhanced chest CT scan indicated the presence of a soft tissue nodule in the upper lobe of the left lung,and flexible bronchoscopy revealed a hypervascular lesion in the bronchus of the left lung's superior ***,the patient underwent thoracoscopic left superior lobe wedge resection,and pathology confirmed EBM from the *** EBM from RCCC has a low incidence and no characteristic clinical manifestations in the early *** a bronchial tumour is found in a patient with RCCC,the possibility of bronchial metastatic cancer should be considered.

关键词： Endobronchial metastases Clear renal cell carcinoma Renal cell carcinoma diagnosis Treatment Case report

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Waist subcutaneous soft tissue metastasis of rectal mucinous adenocarcinoma: A case report

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World Journal of Clinical Cases 2024年第14期12卷 2412-2419页

作者： Zi-Xing Gong Guo-Lei Li Wen-Min Dong Zhao Xu Rui Li Wen-Xia Lv Jing Yang Zhong-Xin Li Wei Xing department of General Surgery Hebei Provincial Hospital of Chinese MedicineShijiazhuang 050011Hebei ProvinceChina department of Medical Imaging Hebei Provincial Hospital of Chinese MedicineShijiazhuang 050011Hebei ProvinceChina department of pathology Hebei Provincial Hospital of Chinese MedicineShijiazhuang 050011Hebei ProvinceChina department of Gastroendoscopy Hebei Provincial Hospital of Chinese MedicineShijiazhuang 050011Hebei ProvinceChina Gastrointestinal Disease Diagnosis and Treatment Center The First Hospital of Hebei Medical UniversityShijiazhuang 050000Hebei ProvinceChina

BACKGROUND Rectal mucinous adenocarcinoma(MAC)is a rare pathological type of rectal can-cer with unique pathological features and a poor *** is difficult to diag-nose and treat early because of the lack of specific manifestations in some aspects of the *** common metastatic organs of rectal cancer are the liver and lung;however,rectal carcinoma with metastasis to subcutaneous soft tissue is a rare *** SUMMARY In this report,the clinical data,diagnosis and treatment process,and postope-rative pathological features of a patient with left waist subcutaneous soft tissue masses were retrospectively *** patient underwent surgical treatment after admission and recovered well after *** final pathological diagnosis was rectal MAC with left waist subcutaneous soft tissue *** Subcutaneous soft tissue metastasis of rectal MAC is rare,and it can suggest that the tumor is disseminated,and it can appear even earlier than the primary ma-lignant tumor,which is occult and leads to a missed diagnosis and misdiagnosis *** a subcutaneous soft tissue mass of unknown origin appears in a patient with rectal cancer,a ma-lignant tumor should be considered.

关键词： Colorectal cancer Rectal mucinous adenocarcinoma Cancer metastasis Subcutaneous soft tissue Hematogenous Case report

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The roles of macrophage migration inhibitory factor in retinal diseases

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Neural Regeneration Research 2024年第2期19卷 309-315页

作者： Hongbing Zhang Xianjiao Zhang Hongsong Li Bing Wang Pei Chen Jiamin Meng Shaanxi Institute of Ophthalmology Xi’anShaanxi ProvinceChina department of Ophthalmology First Affiliated Hospital of Northwest UniversityXi’anShaanxi ProvinceChina department of pathology First Affiliated Hospital of Northwest UniversityXi’anShaanxi ProvinceChina

Macrophage migration inhibitory factor(MIF),a multifunctional cytokine,is secreted by various cells and participates in inflammatory reactions,including innate and adaptive *** are some evidences that MIF is involved in many vitreoretinal *** example,MIF can exacerbate many types of uveitis;measurements of MIF levels can be used to monitor the effectiveness of uveitis *** also alleviates trauma-induced and glaucoma-induced optic nerve ***,MIF is critical for retinal/choroidal neovascularization,especially complex *** exacerbates retinal degeneration;thus,anti-MIF therapy may help to mitigate retinal *** protects uveal melanoma from attacks by natural killer *** mechanism underlying the effects of MIF in these diseases has been demonstrated:it binds to cluster of differentiation 74,inhibits the c-Jun N-terminal kinase pathway,and triggers mitogen-activated protein kinases,extracellular signal-regulated kinase-1/2,and the phosphoinositide-3-kinase/Akt *** also upregulates Toll-like receptor 4 and activates the nuclear factor kappa-B signaling *** review focuses on the structure and function of MIF and its receptors,including the effects of MIF on uveal inflammation,retinal degeneration,optic neuropathy,retinal/choroidal neovascularization,and uveal melanoma.

关键词： diabetic retinopathy glaucoma macrophage migration inhibitory factor migration inhibitory factor receptor optic neuropathy retinal degeneration retinal neovascular uveal melanoma uveitis

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Clinical experience sharing on gastric microneuroendocrine tumors: A case report

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World Journal of Clinical Cases 2024年第4期12卷 795-800页

作者： You-Jun Wang Da-Ming Fan Yu-Shuang Xu Qi Zhao Zhen-Fang Li department of Gastroenterology Central Hospital Affiliated to Shandong First Medical UniversityJinan 250000Shandong ProvinceChina department of pathology Central Hospital Affiliated to Shandong First Medical UniversityJinan 250000Shandong ProvinceChina department of Gastroenterology The Affiliated Hospital of Qingdao UniversityQingdao 266000Shandong ProvinceChina

BACKGROUND The majority of gastric neuroendocrine tumors(G-NENs)are present in various lesions under endoscopy,and they can be polypoid uplifts,submucosal tumors or papules,erosions,and *** lesions are mostly confined to the mucosal or submucosal layer,usually less than 2 cm,and exclusively localized to the gastric body or *** type 1 G-NENs,about 22%of cases have no visible lesions under an endoscope,and such lesions can only be detected via biopsies(microcar-cinoids).CONCLUSION In the case under study,the patient did not have any visible raised lesions under a gastroscope,and the lesions were found only after a random *** article combines the endoscopic manifestations and clinical features of the lesions in this case to improve the diagnosis of G-NENs.

关键词： Neuroendocrine tumor Micro carcinoids Endoscopy Case report

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Analysis of the Clinical Value of Immunohistochemical Testing in the Pathological Diagnosis of Breast Cancer

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Proceedings of Anticancer Research 2024年第4期8卷 1-6页

作者： Qiushuang Ma Jirui Sun Haizhi Qiao Xueli Wang Jinku Zhang baoding No.1 central hospital Baoding 071000Hebei ProvinceChina Key Laboratory of Molecular pathology and Early Diagnosis of Tumor in hebei province Baoding 071000Hebei ProvinceChina

Objective:To investigate the clinical value of immunohistochemistry(IHC)detection in the pathological diagnosis of breast ***:Eighty breast cancer patients admitted to baoding No.1 central hospital from June 2022 to June 2023 were selected as study *** samples were divided into a positive group(40 cases)and a negative group(40 cases)according to ER and PR test *** was performed on all patients to compare the differences between the two groups in C-erbB-2 positive expression and axillary lymph node ***:The positive expression rate of C-erbB-2 in the positive group(35.00%)was significantly lower than that in the negative group(80.00%),with a highly significant difference(Ppathology enhances diagnostic accuracy,predicts prognosis,and supports personalized treatment by identifying ER,PR,and *** is worth being widely adopted in clinical practice.

关键词： Breast cancer Pathological diagnosis Immunohistochemical detection

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