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Coexistence of papillary thyroid microcarcinoma and mucosa-associated lymphoid tissue lymphoma in a context of Hashimoto's thyroiditis

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Asian Pacific Journal of Tropical Medicine 2016年第8期9卷 789-791页

作者： Saul Levy-Blitchtein Stefany Plasencia-Rebata Domingo Morales Luna Juana del Valle Mendoza School of Medicine Faculty of Health Sciences Universidad Peruana de Ciencias Aplicadas (UPC) Research Center and Innovation of the Health Sciences Faculty Universidad Peruana de Ciencias Aplicadas (UPC) pathologist service Hospital Nacional Edgardo Rebagliati Martins (HNERM)

Papillary thyroid cancer(PTC)represents 80%-85%of thyroid cancer and its prevalence has been rising in the last *** thyroid lymphoma(PTL)accounts for 3%of extranodal lymphomas and about 5%of thyroid malignancies,having a prevalence of one or two cases per million ***-Associated Lymphoid Tissue lymphoma represents approximately30%of *** entities have an indolent course and a very good *** is made by ultrasound and fine needle aspiration(FNA)or surgery specimen *** have also been associated with Hashimoto’s thyroiditis(HT),but pathogenesis and its links remains to be *** remains controversial and surgery is generally accepted in cases of disease limited to thyroid,as the *** with thyroid nodules should be observed and *** there is an enlargement by ultrasound or clinical symptoms,FNA should be performed *** with HT deserve additional surveillance,since this condition is associated with both PTC and *** this case,the management with surgery and radioactive iodine ablation therapy was effective for both *** with thyroid nodules should be properly evaluated with ultrasound and thyroid function *** there is an enlargement of the neck,reported by symptoms or ultrasound,it requires further *** is associated to both PTC and PTL so if the enlargement of the nodules is on this context additional tests such as FNA should be *** this case,the patient was managed with surgery and radioactive iodine ablation therapy and it was effective for both entities.

关键词： Thyroid cancer-clinical Hashimoto’s thyroiditis Pathology-thyroid Thyroid diseases

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Evaluation of cardiac hypertrophy in the setting of sudden cardiac death

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Forensic Sciences Research 2019年第3期4卷 223-240页

作者： Kristopher S.Cunningham Danna A.Spears Melanie Care Department of Laboratory Medicine and Pathobiology Ontario Forensic Pathology ServiceUniversity of TorontoTorontoCanada University Health Network Division of Cardiology-ElectrophysiologyUniversity of TorontoTorontoCanada Fred A.Litwin Family Centre in Genetic Medicine and Inherited Arrhythmia Clinic University Health Network&Mount Sinai HospitalUniversity of TorontoTorontoCanada

Ventricular hypertrophy is a common pathological finding at autopsy that can act as a substrate for *** grapple with the significance of ventricular hypertrophy when assessing the sudden and unexpected deaths of young people and what it could mean for surviving family *** pathological spectrum of left ventricular hypertrophy (LVH) is reviewed *** article is oriented to the practiring autopsy pathologist to help make sense of various patterns of increased heart musde,particularly those that are not clearly cardiomyopathic,yet present in the setting of sudden cardiac *** article also reviews factors influencing arrhythmogenesis as well as genetic mutations most commonly associated with ventricular hypertrophy,especially those associated with hypertrophic cardiomyopathy (HCM).

关键词： Forensic sciences forensic pathology ventricular hypertrophy arrhythmia sudden cardiac death genetics

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Effect of COVID-19 pandemic on blood transfusion service:an experience from a regional blood transfusion center

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Blood Science 2023年第3期5卷 209-217页

作者： Sanjay K.Thakur Anil K.Sinha Dinesh K.Negi Sompal Singh PhD Research Scholar P.G.Department of ZoologyVeer Kunwar Singh UniversityAraBihar 802301India Dean Faculty of Science and Head P.G.Department of Zoology Veer Kunwar Singh UniversityAraBihar 802301India Former CMO In charge Department of RBTCHindu Rao HospitalDelhi 110007India Specialist pathologist Head Department of Regional Blood Transfusion Centre and Department of PathologyHindu Rao HospitalDelhi 110007India

The unforeseen and uncertain life-threatening situation of the COVID-19 pandemic dramatically affected all areas of the human daily work *** study was designed to assess the impact of the COVID-19 pandemic on blood transfusion services and discuss the adopted confrontation measures for uninterrupted blood supply during the pandemic *** data on blood donation,blood component preparation,and issue from January 2019 to December 2022 were collected from the inventory registers of the RBTC,Delhi,*** to the non-pandemic year 2019,during the year 2020,all variables decreased *** observed maximum decrease in variables such as blood collection(–79.16%)in the month of October,blood issue(–71.61%)in the month of August,random donor platelets(RDP)preparation(–98.09%)in the month of October,RDP issue(–86.08%)in the month of September,fresh frozen plasma(FFP)preparation(–100%)in the month of October,and FFP issue(–96.08%)in the month of July with an annual decrease of–45.52%,–42.87%,–33.00%,–59.79%,–40.98%,and–54.48%,respectively,as compared to year *** to year 2020,in year 2021,the annual increase in blood collection,blood issue,FFP preparation,FFP issue,RDP preparation,and RDP issue was+50.20%,+21.68%,+65.31%,+78.52%,+116.23%,and+213.30%,*** study results show that the COVID-19 pandemic has significantly affected blood transfusion services at our blood *** adopted coping strategies to maintain the safe and uninterrupted blood transfusion chain at our blood bank gave us lessons for future preparedness if faced with a similar situation.

关键词： Blood bank inventory Blood components Blood recipients Blood transfusion COVID-19 pandemic

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Inflammatory bowel disease:A proposal to facilitate the achievement of an unequivocal diagnosis

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World Journal of Gastroenterology 2013年第3期19卷 426-428页

作者： Gabriella Canavese Gabrio Bassotti Marco Astegiano Isabella Castellano Paola Cassoni Anna Sapino Vincenzo Villanacci Ⅲ service of Pathology Department of Laboratory DiagnosisAzienda Ospedaliera Cittàdella Salute e della Scienza di TorinoDepartment of Medical SciencesUniversity of Torino10100 TorinoItaly Gastroenterology and Hepatology Section Department of Clinical and Experimental MedicineUniversity of Perugia06100 PerugiaItaly Gastroenterology and Hepatology Section Azienda Ospedaliera Città della Salute e della Scienza di Torino 10100 TorinoItaly Department of Pathology Spedali Civili of Brescia25100 BresciaItaly

Following the international guidelines criteria an adequate"diagnostic conclusion"of inflammatory bowel disease(IBD)can be achieved only if clinical,endoscopic and laboratory findings,together with sample technical adequacy and unequivocal histomorphological signs of the disease are ***,a conclusive diagnosis requires a complex combination of clinical, endoscopic and histological data.A considerable number of endoscopic biopsies obtained from IBD patients do not meet the above-mentioned *** aim of the present proposal is to introduce a binary system of evaluation in the"diagnostic conclusion"of the histopathological report that will help to simplify the clinical decisions and consequent patient *** patients with no history of disease,the pathologist should classify the biopsies in"Diagnostic",when the criteria established by the international guidelines are satisfied and"not diagnostic"when one or more of the above-mentioned criteria are not met. The term"not diagnostic"should replace"highly suggestive"and"probable".This new terminology could avoid ambiguous expressions that encourage the clinician to classify the patient as affected by IBD without fulfilling all of the requirements for an accurate diagnostic approach.

关键词： Inflammatory bowel disease Diagnosis Biopsy

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子宫颈癌筛查中传统子宫颈涂片、单层细胞学及人乳头状瘤病毒DNA检测的横断面研究

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英国医学杂志中文版 2003年第4期6卷 215-219页

作者： Jol Coste Batrix Cochand-Priollet Patricia de Cremoux Catherine Le Gals Isabelle Cartier Vincent Molini Sylvain Labb Marie-Cecile Vacher-Lavenu Philippe Vielh 徐艳峰 Departement de Biostatistique Hopital Cochin Assistance Publique-Hopitaux de ParisFaculte de Medecine Cochin-Port Royal Universite Paris V ParisFrance professor of medical statistics service d Anatomie et Cytologie Pathologiques Hopital Lariboisiere Assistance Publique-Hopitaux de Paris.Paris France assistant professor of pathology Laboratoire de Physiopathol ogi e Departement de Biologie des TumeursInstitut CurieParisFrance assistant professor of pharmacology Centre for Health Economics and Administration Research (CREGAS) INSERM U537-CNRS UPRESA 8052 Le Kremlin-Bicetre Francesenior economist Laboratoire Cartier ParisFrance pathologist

目的比较子宫颈癌筛查中传统子宫颈涂片、单层细胞学,以及人乳头状瘤病毒检测的敏感性、特异性和观察者间的可信性。设计对同时进行了此3项检查并有参考标准(阴道镜和组织学)者进行横断面研究。研究单位法国的公立大学和私人诊所,... 详细信息

目的比较子宫颈癌筛查中传统子宫颈涂片、单层细胞学,以及人乳头状瘤病毒检测的敏感性、特异性和观察者间的可信性。设计对同时进行了此3项检查并有参考标准(阴道镜和组织学)者进行横断面研究。研究单位法国的公立大学和私人诊所,本研究完全独立于病例提供者。研究对象因先前检出的细胞学异常而进行阴道镜检查的828名妇女和参加常规涂片检查的1757名妇女。主要结果判定指标临床读片和最优化解释(为取得一致所进行的双盲读片)。根据诊断异常的不同阈值计算出敏感性、特异性和加权κ值。结果根据Bethesda系统,传统子宫颈涂片检查得到的结果更为满意(91％比87％),比单层细胞学更可靠(加权κ值0.70比0.57),其敏感性和特异性更高。这些结果适用于临床读片和最优化解释,区分高级别和低级别病变,以及有低和高异常发生率的人群。人乳头状瘤病毒检测与单层细胞学检查同时进行,不论是系统性的还是只对于意义不明的非典型细胞,并不比传统涂片检查优越。结论在子宫颈癌筛选中,单层细胞学检查不如传统子宫颈涂片检查可靠,且更容易出现假阳性和假阴性结果。

关键词：子宫颈癌子宫颈涂片单层细胞学人乳头状瘤病毒 DNA检测 HPV

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