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Journal of Traffic and Transportation Engineering 2024年第3期12卷 107-118页

作者： William Robert Spy Pond partners LLCArlingtonMA 02474USA

In 1997 the Michigan Department of Transportation (MDOT) established an ambitious set of condition targets for its pavements and bridges, and the Department received increased revenue from a 4-cent-per-gallon increase in the state motor fuels tax to help meet its targets. However, over time, actual revenue was less than both what was initially estimated as needed to meet the targets and what was projected from the tax increase. Consequently, actual conditions were projected to fall short of the target levels, so the department issued bonds to address the shortfall through 2012. To support deliberations on future funding, in 2013 MDOT performed an analysis of historic conditions to determine what additional fuel tax revenues would have been required beginning in 1997 to: replace bond revenues used to fund pavement and bridge projects from 1997 to 2012;and enable MDOT to meet its condition targets. The analysis was performed using data on actual pavement and bridge funding and conditions;as well as predicted funding and conditions for different hypothetical increases in fuel taxes. The analysis concluded that, in addition to the actual increase of 4 cents per gallon, a fuel tax increase of another 10 cents per gallon would have been required in 1997 to replace bond revenue used for pavement and bridges and allow MDOT to meet its condition targets. The analysis results were used to help inform the discussion of Michigan’s target asset conditions and funding, and demonstrate application of MDOT’s pavement and bridge management systems for performing historic analyses.

关键词： Transportation asset management transportation finance performance measures pavement management bridge management

Do tensile and shear forces exerted on cells influence mechanotransduction through stored energy considerations?

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BIOCELL 2024年第4期48卷 525-540页

作者： FREDERICK H.SILVER TANMAY DESHMUKH Department of Pathology and Laboratory Medicine Robert Wood Johnson Medical SchoolRutgersThe State University of New JerseyPiscatawayNJ 08854USA OptoVibronex LLC.Ben Franklin Tech PartnersBethlehemPA 18015USA

All tissues in the body are subjected externally to gravity and internally by collagenﬁbril and cellular retractive forces that create stress and energy equilibrium required for *** involves mechanical work(force through a distance)and energy storage as kinetic and potential *** leads to changes in cell mitosis or apoptosis and the synthesis or loss of tissue *** involves the application of energy directly to cells through integrin-mediated processes,cell-cell connections,stretching of the cell cytoplasm,and activation of the cell nucleus via yes-associated protein(YAP)and transcriptional coactivator with PDZ-motif(TAZ).These processes involve numerous complexes,intermediate molecules,and multiple *** pathways have been identiﬁed from research studies on vertebrate cell culture and from studies in *** pathways involve mechanosensors and other molecules that activate the *** review discusses the mitogen-activated protein kinase(MAPK)family,Hippo,Hedgehog,and Wingless-related integration site(WNT)/βcatenin signaling *** mediators covered includeβcatenin,ion channels,growth factors,hormone receptors,members of the Ras superfamily,and components of the linker of nucleoskeleton and cytoskeleton(LINC)***,the interrelationship among the different pathways remains to be clariﬁ***-mediated mechanotransduction involves direct tensile loading and energy applied to the cell membrane via collagenﬁbril *** energy is transferred between cells by stretching the cell-cell connections involving cadherins and the WNT/βcatenin *** alterations induce changes in intracellular events in the cytoskeleton and nuclear skeleton caused by the release of YAP and *** coactivators then penetrate through the nuclear pores and inﬂuence nuclear cell *** in the balance of forces and energy applied to cells and tissues is hypothesized to shift th

关键词： MAPK family Hippo Hedgehog WNT pathway βcatenin Ion channels Growth factor receptors Hormone receptors Ras superfamily LINC complex Collagen Cadherins

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2025大阪世博会沙特馆方案

现代装饰 2024年第2期 184-187页

作者：无舒禹(编译) Foster+partners 不详

近期,Foster+partners公布2025年大阪世博会沙特阿拉伯王国馆的设计方案,该展馆创造奇特空间体验,如同探索沙特阿拉伯城镇,给来访者提供身临其境的视听环境。Foster+partners工作室负责人Luke Fox表示:“展馆带领参观者踏上发现和偶遇之... 详细信息

近期,Foster+partners公布2025年大阪世博会沙特阿拉伯王国馆的设计方案,该展馆创造奇特空间体验,如同探索沙特阿拉伯城镇,给来访者提供身临其境的视听环境。Foster+partners工作室负责人Luke Fox表示:“展馆带领参观者踏上发现和偶遇之旅,生动描绘沙特阿拉伯文化图景。我们的设计巧妙利用光线、声音和质感,刺激感官,同时展示该国一些具创新性和令人兴奋的成就。”

关键词：沙特阿拉伯王国视听环境空间体验 Foster 工作室大阪世博会展馆创新性

Prehospital transdermal glyceryl trinitrate for ultra- acute ischaemic stroke: data from the RIGHT- 2 randomised sham- controlled ambulance trial

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Stroke & Vascular Neurology 2024年第1期9卷 38-49,I0035-I0046页

作者： Jason Philip Appleton Lisa J Woodhouse Craig S Anderson Sandeep Ankolekar Lesley Cala Mark Dixon Timothy J England Kailash Krishnan Grant Mair Keith W Muir John Potter Christopher I Price Marc Randall Thompson G Robinson Christine Roffe Else C Sandset Jeffrey L Saver Angela Shone Aloysius Niroshan Siriwardena Joanna M Wardlaw Nikola Sprigg Philip M Bath Stroke University Hospitals Birmingham NHS Foundation TrustBirminghamUK Institute of Applied healthResearch University of Birmingham College of Medical and Dental SciencesBirminghamUK Stroke Trials Unit Mental Health and Clinical NeurosciencesUniversity of NottinghamNottinghamUK Faculty of Medicine The George Institute for Global HealthSydneyNew South WalesAustralia The George Institute China at Peking University health Science Center BeijingChina Neurology Royal Prince Alfred HospitalSydney Health PartnersSydneyNew South WalesAustralia Department of Neurology King's College Hospital NHS Foundation TrustLondonUK Faculty of health and Medical Sciences University of Western AustraliaCrawleyWestern AustraliaAustralia East Midlands Ambulance Service NHS Trust NottinghamUK Stroke Queen's Medical CentreNottingham University Hospitals NHS TrustNottinghamUK Centre for Clinical Brain Sciences Dementia Research InstituteUniveristy of EdinburghEdinburghUK Institute of Neurology and Psychology University of GlasgowGlasgowUK Bob Champion Research and Education Building University of East AngliaNorwichUK Institute of Neuroscience Newcastle UniversityNewcastle upon TyneUK Department of Neurology Leeds Teaching Hospitals NHS TrustLeedsUK Department of Cardiovascular Sciences and NIHR Leicester Biomedical Research Centre University of LeicesterLeicesterUK Stroke Research in Stoke Institute for Science and Technology in MedicineKeele UniversityStoke-on TrentUK Department of Neurology Oslo University HospitalOsloNorway Research and Development Norwegian Air Ambulance FoundationOsloNorway Department of Neurology and Comprehensive Stroke Center David Geffen School of MedicineUCLALos AngelesCaliforniaUSA Research and Graduate Services University of NottinghamNottinghamUK Community and health Research Unit University of LincolnLincolnUK

Background The effect of transdermal glyceryl trinitrate(GTN,a nitrovasodilator)on clinical outcome when administered before hospital admission in suspected stroke patients is ***,we assess the safety and efficacy of GTN in the prespecified subgroup of patients who had an ischaemic stroke within the Rapid Intervention with Glyceryl trinitrate in Hypertensive stroke Trial-2(RIGHT-2).Methods RIGHT-2 was an ambulance-based multicentre sham-controlled blinded-endpoint study with patients randomised within 4hours of *** primary outcome was a shift in scores on the modified Rankin scale(mRS)at day *** outcomes included death;a global analysis(Wei-Lachin test)containing Barthel Index,EuroQol-5D,mRS,telephone interview for cognitive status-modified and Zung depression scale;and neuroimaging-determined‘brain frailty’*** were reported as n(%),mean(SD),median[IQR],adjusted common OR(acOR),mean difference or Mann-Whitney difference(MWD)with 95%*** 597 of 1149(52%)patients had a final diagnosis of ischaemic stroke;age 75(12)years,premorbid mRS>2107(18%),Glasgow Coma Scale 14(2)and time from onset to randomisation 67[45,108]***‘brain frailty’was common:median score 2[2,3](range 0–3).At day 90,GTN did not influence the primary outcome(acOR for increased disability 1.15,95%CI 0.85 to 1.54),death or global analysis(MWD 0.00,95%CI-0.10 to 0.09).In subgroup analyses,there were non-significant interactions suggesting GTN may be associated with more death and dependency in participants randomised within 1hour of symptom onset and in those with more severe *** In patients who had an ischaemic stroke,ultra-acute administration of transdermal GTN in the ambulance did not improve clinical outcomes in a population with more clinical and radiological frailty than seen in previous in-hospital *** IS ALREADY KNOWN ON THIS TOPIC⇒Transdermal glyceryl trinitrate(GTN)was associat-ed with less death and dependency in those w

关键词： Glasgow nitrate random

Disaster Awareness and Preparedness Among Older Adults in Canada Regarding Floods, Wildfires, and Earthquakes

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International Journal of Disaster Risk Science 2024年第2期15卷 198-212页

作者： Evalyna Bogdan Rachel Krueger Julie Wright Kyle Woods Shaieree Cottar School of Administrative Studies Disaster and Emergency Management ProgramYork UniversityTorontoOntario M3J 1P3Canada Department of Geography and Environmental Management University of WaterlooWaterlooOntario N2L 3G1Canada partners for Action Faculty of EnvironmentUniversity of WaterlooWaterlooOntario N2L 3G1Canada

Older adults are significantly impacted by natural hazards and disasters that are exacerbated by climate change. Understanding their awareness and preparedness is essential for enhancing disaster resilience. This study investigated the attitudes, actions, and recommendations of older adults regarding natural hazards that pose risks in their geographic area—specifically floods, wildfires, and/or earthquakes in Canada. Methods for this study included survey and focus groups with older adults(n = 161 and n = 10, respectively) and other high-risk groups from across Canada, that are vulnerable to these natural hazards. The main findings from this study are that current awareness and preparedness among older adults is low, though stronger perceptions of risks are associated with risks specific to geographic locations where respondents live. Several barriers, such as hazard vulnerability misperceptions, cost-related reasons, and lack of hazard awareness have resulted in low awareness and preparedness among these populations. The two main recommendations arising from this research are:(1) improve awareness and preparedness with tailor-made emergency preparedness materials for older adults;and(2) adopt community-based approaches to disaster preparedness through existing community groups to strengthen social connections with a focus on locally specific hazards. The findings from this research can be applied to other hazards, including heatwaves and pandemics.

关键词： Canada Community-based disaster risk management Disaster awareness and preparedness Disaster resilience Natural hazards Older adults

展现中国魅力，讲好中国故事——浅谈公共关系如何在新形势下助力国际友城建设

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国际公关 2024年第11期 84-86页

作者：曹越 FINN partners大中华区

随着中国综合国力的不断提升和国际影响力的日益增强，越来越多的外国游客希望走进中国，领略中华文明的独特魅力。2023年，中国陆续对多个国家实施免签政策，极大地便利了国际人员往来，也为提升中国国家形象提供了新的机遇。在此背景...

随着中国综合国力的不断提升和国际影响力的日益增强，越来越多的外国游客希望走进中国，领略中华文明的独特魅力。2023年，中国陆续对多个国家实施免签政策，极大地便利了国际人员往来，也为提升中国国家形象提供了新的机遇。在此背景下，我们应该充分利用这一契机，在政府、企业和民间多个层面协同发力，全方位、多角度地向世界展现一个开放自信、和谐包容的中国，增进中外人文交流，传播中华优秀文化，让世界更好地了解中国、读懂中国。同时，用有魅力的中国名片，去扩展和建立国际友城关系，这对增强经济活力，为企业走出国门赢得更大海外市场空间，都会产生巨大的积极作用。

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展现中国魅力,讲好中国故事——浅谈公共关系如何在新形势下助力国际友城建设

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国际公关 2024年第3期 87-89页

作者：曹越 FINN partners大中华区

随着中国综合国力的不断提升和国际影响力的日益增强,越来越多的外国游客希望走进中国,领略中华文明的独特魅力。2023年,中国陆续对多个国家实施免签政策,极大地便利了国际人员往来,也为提升中国国家形象提供了新的机遇。在此背景下,我... 详细信息

随着中国综合国力的不断提升和国际影响力的日益增强,越来越多的外国游客希望走进中国,领略中华文明的独特魅力。2023年,中国陆续对多个国家实施免签政策,极大地便利了国际人员往来,也为提升中国国家形象提供了新的机遇。在此背景下,我们应该充分利用这一契机,在政府、企业和民间多个层面协同发力,全方位、多角度地向世界展现一个开放自信、和谐包容的中国,增进中外人文交流,传播中华优秀文化,让世界更好地了解中国、读懂中国。同时,用有魅力的中国名片,去扩展和建立国际友城关系,这对增强经济活力,为企业走出国门赢得更大海外市场空间,都会产生巨大的积极作用。

关键词：中国国家形象公共关系中华优秀文化中外人文交流中国综合国力走出国门经济活力国际影响力

Sedation reversal trends at outpatient ambulatory endoscopic center vs in-hospital ambulatory procedure center using a triage protocol

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World Journal of Gastrointestinal Endoscopy 2024年第7期16卷 413-423页

作者： Saqib Walayat Peter Stadmeyer Azfar Hameed Minahil Sarfaraz Paul Estrada Mark Benson Anurag Soni Patrick Pfau Paul Hayes Brittney Kile Toni Cruz Deepak Gopal Department of Gastroenterology University of IllinoisPeoriaIL 61605United States Department of Gastroenterology University of WisconsinMadisonWI 53792United States Department of Internal Medicine Texas Health DentonDentonTX 76201United States Department of Internal Medicine Allama Iqbal Medical CollegeLahore 042Pakistan Department of Gastroenterology Texas Tech University Health Services CenterEl PasoTX 79911United States Department of Gastroenterology and Hepatology University of WisconsinMadisonWI 53705United States Finance Business partners UW health University of WisconsinMadisonWI 53792United States UW health Digestive health Center Endoscopy University of WisconsinMadisonWI 53792United States Division of Gastroenterology and Hepatology Department of MedicineUniversity of Wisconsin Hospitals and ClinicsMadisonWI 53705United States

BACKGROUND Routine outpatient endoscopy is performed across a variety of outpatient settings.A known risk of performing endoscopy under moderate sedation is the potential for over-sedation,requiring the use of reversal *** needs to be reported on rates of reversal across different outpatient *** academic tertiary care center utilizes a triage tool that directs higher-risk patients to the in-hospital ambulatory procedure center(APC)for their ***,we report data on outpatient sedation reversal rates for endoscopy performed at an inhospital APC vs at a free-standing ambulatory endoscopy digestive health center(AEC-DHC)following risk stratification with a triage *** To observe the effect of risk stratification using a triage tool on patient outcomes,primarily sedation reversal *** We observed all outpatient endoscopy procedures performed at AEC-DHC and APC from April 2013 to September *** were stratified to their respective sites using a triage *** evaluated each procedure for which sedation reversal with flumazenil and naloxone was *** and characteristics recorded include patient age,gender,body mass index(BMI),American Society of Anesthesiologists(ASA)classification,procedure type,and reason for sedation *** There were 97366 endoscopic procedures performed at AEC-DHC and 22494 at the APC during the study *** these,17 patients at AEC-DHC and 9 at the APC underwent sedation reversals(0.017%vs 0.04%;P=0.06).Demographics recorded for those requiring reversal at AEC-DHC vs APC included mean age(53.5±21 vs 60.4±17.42 years;P=0.23),ASA class(1.66±0.48 vs 2.22±0.83;P=0.20),BMI(27.7±6.7 kg/m^(2) vs 23.7±4.03 kg/m^(2);P=0.06),and female gender(64.7%vs 22%;P=0.04).The mean doses of sedative agents and reversal drugs used at AEC-DHC vs APC were midazolam(5.9±1.7 mg vs 8.9±3.5 mg;P=0.01),fentanyl(147.1±49.9μg vs 188.9±74.1μg;P=0.10),flumazenil(0.3±0.18μg vs 0.17±0.17μg;P=0.13)and naloxo

关键词： Ambulatory care Conscious sedation Endoscopy Colonoscopy Risk assessment Risk factors

Postpartum depression and partner support during the period of lactation:Correlation research and its influencing factors

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World Journal of Psychiatry 2024年第1期14卷 119-127页

作者： Ji-Ming Ruan Ling-Juan Wu Department of Obstetrics and Gynecology Huzhou Maternity and Child Health Care HospitalHuzhou 313000Zhejiang ProvinceChina

BACKGROUND Postpartum depression(PPD)not only affects the psychological and physiological aspects of maternal health but can also affect neonatal growth and *** who are in close contact with parturient women play a key role in communication and emotional *** study explores the PPD support relationship with partners and its influencing factors,which is believed to establish psychological well-being and improve maternal partner *** To explore the correlation between PPD and partner support during breastfeeding and its influencing *** Convenience sampling was used to select lactating women(200 women)who underwent postpartum examinations at the Huzhou Maternity and Child health Care Hospital from July 2022 to December 2022.A cross-sectional survey was conducted on the basic information(general information questionnaire),depression level[edinburgh postnatal depression scale(EPDS)],and partner support score[dyadic coping inventory(DCI)]of the selected ***’s correlation analysis was used to analyze the correlation between PPD and DCI in lactating *** affecting PPD levels during lactation were analyzed using multiple linear *** The total average score of EPDS in 200 lactating women was(9.52±1.53),and the total average score of DCI was(115.78±14.90).Dividing the EPDS,the dimension scores were:emotional loss(1.91±0.52),anxiety(3.84±1.05),and depression(3.76±0.96).Each dimension of the DCI was subdivided into:Pressure communication(26.79±6.71),mutual support(39.76±9.63),negative support(24.97±6.68),agent support(6.87±1.92),and joint support(17.39±4.19).Pearson’s correlation analysis demonstrated that the total mean score and individual dimension scores of EPDS during breastfeeding were inversely correlated with the total score of partner support,stress communication,mutual support,and cosupport(P<0.05).The total mean score of the EPDS and its dimensions were positively correlated with negative

关键词： Lactation period Puerpera Postpartum depression Partner support Correlation

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南京归来兮溪庄园酒店

现代装饰 2024年第3期 122-135页

作者：无黄早慧(摄影) YuQiang&partners于强室内建筑师事务所设计团队不详

自古以来,隐士生活与田园、山林相伴,归隐的真谛便在于物我关系的重塑,摒弃对纷繁物质的无限渴求,转而向内求索,觅得内心的平静与安然。诚如陶渊明在《归去来兮辞》中写:“云无心以出,鸟倦飞而知还”,在《归园田居》中写下“结庐在人境... 详细信息

自古以来,隐士生活与田园、山林相伴,归隐的真谛便在于物我关系的重塑,摒弃对纷繁物质的无限渴求,转而向内求索,觅得内心的平静与安然。诚如陶渊明在《归去来兮辞》中写:“云无心以出,鸟倦飞而知还”,在《归园田居》中写下“结庐在人境,而无车马喧”的静谧情景。当人从俗世的烦扰与羁中短暂抽离出来,函需一隅静地,这是一个自在呼吸的出口,也是让身心慢下来的归处。

关键词：《归去来兮辞》物我关系《归园田居》陶渊明隐士归隐慢下来田园