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Impacts of inter-satellite links on the ECOM model performance for BDS-3 MEO satellites

Satellite Navigation 2024年第1期5卷 140-154页

作者： Chao Yang Jing Guo Xiaolong Xu Longyu Wang Qile Zhao GNSS Research center Wuhan UniversityNo.129 Luoyu RoadWuhan430079China

Inter-satellite link(ISL)plays an essential role in current and future Global Navigation Satellite System(GNSS).In this study,we investigate the impact of ISL observations on precise orbit determination for BeiDou-3 Navigation Satellite System(BDS-3)Medium Earth Orbit(MEO)satellites based on different Extended CODE Orbit Models(ECOM).Thanks to the better observation geometry of the Ka-band ISL data compared to the L-band data for BDS-3 MEO satellites,the ISL solution substantially reduces Orbit Boundary Discontinuity(OBD)errors,except for C30,which suffers from unstable Ka-band hardware *** the external quality analysis,ISL significantly enhances the reliability of the orbit of MEO satellites manufactured by the China Academy of Space Technology(CAST).The standard deviation(STD)of the satellite laser ranging(SLR)residuals is approximately 2.5 cm,and the root mean square(RMS)is reduced by 10–23%compared to L-band ***,the Sun-elongation angle dependent systematic error in SLR residuals nearly vanishes based on the reduced 5-parameter ECOM(ECOM1)or extended 7-parameter ECOM(ECOM2)with ISL *** is because the ISL reduces the correlation between state parameters and solar radiation pressure(SRP)parameters as well as those among SRP parameters,leading to a more accurate estimation of both orbit and SRP perturbations,particularly those along B *** confirms that the deficiency of the SRP models for BDS-3 CAST satellites can be compensated by using better observation geometry from ISL *** the other hand,for the satellite manufactured by Shanghai Engineering center for Microsatellites(SECM),the ISL allows for a more accurate estimation of the Bc_(1)parameter in the ECOM1 *** only reduces linear systematic error,possibly because the impact generated by the satellite bus cannot be entirely absorbed by the B-direction parameters.

关键词： BDS-3 MEO Inter-satellite link Solar radiation pressure ECOM

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动态全场光学相干断层扫描结合深度学习在肿瘤患者术中诊断的应用:一项乳腺癌患者的前瞻性队列研究

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Science Bulletin 2024年第11期69卷 1748-1756页

作者：张舒玮杨滨杨后圃赵进张原媛高元绪 Olivia Monteiro 张康刘博王殊 Breast center Peking University People’s HospitalBeijing 100044China China ESG Institute Capital University of Economics and BusinessBeijing 100070China Faculty of Information Technology Beijing University of TechnologyBeijing 100124China Department of Pathology Peking University People’s HospitalBeijing 100044China center for Biomedicine and Innovations Faculty of MedicineMacao University of Science and TechnologyMacao 999078China College of future Technology Peking UniversityBeijing 100091China School of Mathematical and Computational Sciences Massey UniversityAuckland 0745New Zealand

An intraoperative diagnosis is critical for precise cancer surgery. However, traditional intraoperative assessments based on hematoxylin and eosin(H&E) histology, such as frozen section, are time-,resource-, and labor-intensive, and involve specimen-consuming concerns. Here, we report a near-real-time automated cancer diagnosis workflow for breast cancer that combines dynamic full-field optical coherence tomography(D-FFOCT), a label-free optical imaging method, and deep learning for bedside tumor diagnosis during surgery. To classify the benign and malignant breast tissues, we conducted a prospective cohort trial. In the modeling group(n = 182), D-FFOCT images were captured from April 26 to June 20, 2018, encompassing 48 benign lesions, 114 invasive ductal carcinoma(IDC), 10 invasive lobular carcinoma, 4 ductal carcinoma in situ(DCIS), and 6 rare tumors. Deep learning model was built up and fine-tuned in 10,357 D-FFOCT patches. Subsequently, from June 22 to August 17, 2018, independent tests(n = 42) were conducted on 10 benign lesions, 29 IDC, 1 DCIS, and 2 rare tumors. The model yielded excellent performance, with an accuracy of 97.62%, sensitivity of 96.88% and specificity of 100%;only one IDC was misclassified. Meanwhile, the acquisition of the D-FFOCT images was non-destructive and did not require any tissue preparation or staining procedures. In the simulated intraoperative margin evaluation procedure, the time required for our novel workflow(approximately 3 min)was significantly shorter than that required for traditional procedures(approximately 30 min). These findings indicate that the combination of D-FFOCT and deep learning algorithms can streamline intraoperative cancer diagnosis independently of traditional pathology laboratory procedures.

关键词： Cancer diagnosis Breast neoplasms Dynamic full-field optical coherence tomography Deep learning Image classification

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Structure-based design of pan-coronavirus inhibitors targeting host cathepsin L and calpain-1

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Signal Transduction and Targeted Therapy 2024年第4期9卷 1651-1664页

作者： Xiong Xie Qiaoshuai Lan Jinyi Zhao Sulin Zhang Lu Liu Yumin Zhang Wei Xu Maolin Shao Jingjing Peng Shuai Xia Yan Zhu Keke Zhang Xianglei Zhang Ruxue Zhang jian Li Wenhao Dai Zhen Ge Shulei Hu Changyue Yu Jiang Wang Dakota Ma Mingyue Zheng Haitao Yang Gengfu Xiao Zihe Rao Lu Lu Leike Zhang Fang Bai Yao Zhao Shibo Jiang Hong Liu Drug Discovery and Design center State Key Laboratory of Drug ResearchCAS Key Laboratory of Receptor ResearchShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Medical Molecular Virology(MOE/NHC/CAMS) School of Basic Medical SciencesShanghai Institute of Infectious Disease and BiosecurityFudan UniversityShanghai 200032China Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology ShanghaiTech UniversityShanghai 201210China State Key Laboratory of Virology Wuhan Institute of VirologyCenter for Biosafety Mega-ScienceChinese Academy of SciencesWuhan 430071China School of Chinese Materia Medica Nanjing University of Chinese Medicine138 Xian Lin RoadJiangsu 210023 NanjingChina School of Pharmaceutical Science and Technology Hangzhou Institute for Advanced StudyUCASHangzhou 310024China National Clinical Research center for Infectious Disease Shenzhen Third People's HospitalShenzhen 518112China

Respiratory disease caused by coronavirus infection remains a global health *** several SARS-CoV-2-specific vaccines and direct-acting antivirals are available,their effcacy on emerging coronaviruses in the future,including SARS-CoV-2 variants,might be ***-targeting antivirals provide preventive and therapeutic strategies to overcome resistance and manage future outbreak of emerging *** L(CTSL)and calpain-1(CAPN1)are host cysteine proteases which play crucial roles in coronaviral entrance into cells and infection-related immune ***,two peptidomimetic a-ketoamide compounds,14a and 14b,were identified as potent dual target inhibitors against CTSL and *** X-ray crystal structures of human CTSL and CAPN1 in complex with 14a and 14b revealed the covalent binding of a-ketoamide groups of 14a and 14b to C25 of CTSL and C115 of *** showed potent and broad-spectrum anticoronaviral activities in vitro,and it is worth noting that they exhibited low nanomolar potency against SARS-CoV-2 and its variants of concern(VOCs)with ECso values ranging from 0.80 to 161.7 nM in various *** mechanistic exploration indicated that they exhibited anticoronaviral activity through blocking viral ***,14a and 14b exhibited good oral pharmacokinetic properties in mice,rats and dogs,and favorable safety in *** addition,both 14a and 14b treatments demonstrated potent antiviral potency against SARS-CoV-2 XBB 1.16 variant infection in a K18-hACE2 transgenic mouse *** 14b also showed effective antiviral activity against HCoV-OC43 infection in a mouse model with a final survival rate of 60%.Further evaluation showed that 14a and 14b exhibited excellent antiinflammatory effects in Raw 264.7 mouse macrophages and in mice with acute *** together,these results suggested that 14a and 14b are promising drug candidates,providing novel insight into developing pan-coronavirus inhibitors with anti

关键词： calpain overcome entrance

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Metal-organic framework-based single-atom electro-/ photocatalysts: Synthesis, energy applications, and opportunities

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Carbon Energy 2024年第1期6卷 1-43页

作者： Munir Ahmad Jiahui Chen Jianwen Liu Yan Zhang Zhongxin Song Shahzad Afzal Waseem Raza Liaqat Zeb Andleeb Mehmood Arshad Hussain Jiujun Zhang Xian-Zhu Fu Jing-Li Luo Shenzhen Key Laboratory of Energy Electrocatalytic Materials Guangdong Research Center for Interfacial Engineering of Functional MaterialsCollege of Materials Science and EngineeringShenzhen UniversityShenzhenGuangdongChina College of Physics and Optoelectronic Engineering Shenzhen UniversityShenzhenGuangdongChina College of Chemistry and Environmental Engineering Shenzhen UniversityShenzhenGuangdongChina Department of Environmental Engineering China Jiliang UniversityHangzhouZhejiangChina Institute for Advanced study Shenzhen UniversityShenzhenGuangdongChina School of Bioengineering Dalian University of TechnologyDalianLiaoningChina College of Materials Science and Engineering Fuzhou UniversityFuzhouFujianChina Institute for Sustainable Energy Shanghai UniversityShanghaiChina

Single-atom catalysts(SACs)have gained substantial attention because of their exceptional catalytic ***,the high surface energy limits their synthesis,thus creating significant challenges for further *** the last few years,metal–organic frameworks(MOFs)have received significant consideration as ideal candidates for synthesizing SACs due to their tailorable chemistry,tunable morphologies,high porosity,and chemical/thermal *** this perspective,this review thoroughly summarizes the previously reported methods and possible future approaches for constructing MOF-based(MOF-derived-supported and MOF-supported)***,MOF-based SAC's identification techniques are briefly assessed to understand their coordination environments,local electronic structures,spatial distributions,and catalytic/electrochemical reaction *** review systematically highlights several photocatalytic and electrocatalytic applications of MOF-based SACs for energy conversion and storage,including hydrogen evolution reactions,oxygen evolution reactions,O_(2)/CO_(2)/N_(2) reduction reactions,fuel cells,and rechargeable *** light is also shed on the future development of this highly exciting field by highlighting the advantages and limitations of MOF-based SACs.

关键词： carbon energy generation MOF-derived-supported MOF-supported single atoms

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Ultrathin curved PdNiRu nanosheets as bifunctional catalysts for oxygen reduction and ethylene glycol oxidation

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Nano Research 2024年第5期17卷 3777-3784页

作者： Xianzeng Li Tingyu Lu Huan Pang Mingyi Zhang Dongdong Xu Lin Xu Min Han Jun Yang Jiangsu Key Laboratory of New Power Batteries Jiangsu Collaborative Innovation Center of Biomedical Functional MaterialsSchool of Chemistry and Materials ScienceNanjing Normal UniversityNanjing 210023China Fujian Cross Strait Institute of Flexible Electronics(future Technology) Fujian Normal UniversityFuzhou 350117China State Key Laboratory of Multiphase Complex Systems Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China State Key Laboratory of Coordination Chemistry Nanjing UniversityNanjing 210023China School of Chemistry and Chemical Engineering Yangzhou UniversityYangzhou 225009China Key Laboratory for Photonic and Electronic Bandgap Materials Ministry of EducationSchool of Physics and Electronic EngineeringHarbin Normal UniversityHarbin 150025China

Pd-based metallic nanosheets with advanced physicochemical properties have been widely prepared and employed in various electrocatalytic ***,few concerns were focused on their multiple performances in different ***,highly curved and ultrathin PdNiRu nanosheets(NSs)are developed by facile wet-chemistry strategy and exhibit excellent electrocatalytic performance toward both oxygen reduction reaction(ORR)and ethylene glycol oxidation reaction(EGOR).Owing to the synergistically structural(e.g.,ultrathin,curved,defects/steps-rich)and compositional(ternary alloy)advantages,PdNiRu NSs exhibited enhanced ORR and EGOR specific/mass activities and better stability/durability than control *** specific activity(5.52 mA·cm^(−2))and mass activity(1.13 A·mg_(Pd)^(−1))of the PdNiRu NSs in ORR are 4.8 and 3.4 times as the ones of commercial Pt/C,*** mass activity of PdNiRu NSs(3.86 A·mg_(Pd)^(−1))in EGOR is 2.6 times as commercial Pd/C(1.51 A·mg_(Pd)^(−1)).This study is helpful for the development of desired electrocatalysts with multi-functional application in practical fuel cells.

关键词： ultrathin nanosheets noble metal electrocatalysts bifunctional

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Diagnosis,Treatment,and Associated Factors Among Patients with HCV Infection—Jiangsu Province,China,2004–2020

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China CDC weekly 2024年第1期6卷 1-5,I0001-I0003页

作者： Dandan Yang Jing Lu Zhi Zhang Chuanwu Sun Zhuping Xu Yao Qi XiaoXia Liu Huan Ding Feifei Chai Zhengdong Zhang Baoli Zhu Department of Genetic Toxicology The Key Laboratory of Modern Toxicology of Ministry of EducationCenter for Global HealthSchool of Public HealthNanjing Medical UniversityNanjing CityJiangsu ProvinceChina Department of Sexually Transmitted Diseases and AIDS Center for Disease Control and Prevention of Jiangsu ProvinceNanjing CityJiangsu ProvinceChina Department of Sexually Transmitted Diseases and AIDS Center for Disease Control and Prevention of XuzhouXuzhou CityJiangsu ProvinceChina Department of Sexually Transmitted Diseases and AIDS Center for Disease Control and Prevention of WuxiWuxi CityJiangsu ProvinceChina Department of Sexually Transmitted Diseases and AIDS Center for Disease Control and Prevention of YanchengYancheng CityJiangsu ProvinceChina Department of Sexually Transmitted Diseases and AIDS Center for Disease Control and Prevention of ZhenjiangZhenjiang CityJiangsu ProvinceChina.

What is already known on this topic?The global efforts to address the hepatitis C virus(HCV)are progressing,but there are still significant gaps in the diagnosis and treatment of HCV,leading to an increasing number of deaths related to *** is added by this report?An extensive investigation was conducted to assess HCV RNA diagnosis,treatment uptake,and associated factors among individuals infected with HCV within Jiangsu *** study encompassed a large geographical area and utilized a substantial sample *** are the implications for public health practice?Implementing focused interventions to improve the timely diagnosis of HCV RNA and increase the uptake of HCV treatment could effectively reduce the future burden of HCV-related health problems,deaths,and healthcare *** is essential for achieving the global target of eliminating hepatitis C.

关键词： diagnosis utilized Jiangsu

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Traditional Chinese medicine for the treatment of immune-related nephropathy:A review

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Acta Pharmaceutica Sinica B 2024年第1期14卷 38-66页

作者： Pu Jiang Changliang Yao De-an Guo School of Pharmacy Nanjing University of Chinese MedicineNanjing 210023China Shanghai Research center for Modernization of Traditional Chinese Medicine National Engineering Research Center of TCM Standardization TechnologyShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China

Immune-related nephropathy(IRN)refers to immune-response-mediated glomerulonephritis and is the main cause of end-stage renal *** pathogenesis of IRN is not fully understood;therefore,treatment is *** Chinese medicines(TCMs)have potent clinical effects in the treatment of the IRN conditions immunoglobulin A nephropathy,lupus nephropathy,and diabetic *** underlying mechanisms mainly include its inhibition of inflammation;improvements to renal interstitial fibrosis,oxidative stress,autophagy,apoptosis;and regulation of *** this review,we summarize the clinical symptoms of the three IRN subtypes and the use of TCM prescriptions,herbs,and bioactive compounds in treating IRN,as well as the potential mechanisms,intending to provide a reference for the future study of TCM as IRN treatments.

关键词： IgA nephropathy Diabetic nephropathy Lupus nephritis Traditional Chinese medicine Immunity Pathogenesis Mechanism Pathophysiology

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Diphylleia Grayi-Inspired Intelligent Temperature-Responsive Transparent Nanofiber Membranes

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Nano-Micro Letters 2024年第4期16卷 67-78页

作者： Cengceng Zhao Gaohui Liu Yanyan Lin Xueqin Li Na Meng Xianfeng Wang Shaoju Fu Jianyong Yu Bin Ding Shanghai Frontier Science Research center of Advanced Textiles College of TextilesDonghua UniversityShanghai 201620People’s Republic of China

Nanofiber membranes(NFMs) have become attractive candidates for next-generation flexible transparent materials due to their exceptional flexibility and breathability. However, improving the transmittance of NFMs is a great challenge due to the enormous reflection and incredibly poor transmission generated by the nanofiber-air interface. In this research, we report a general strategy for the preparation of flexible temperature-responsive transparent(TRT) membranes,which achieves a rapid transformation of NFMs from opaque to highly transparent under a narrow temperature window. In this process, the phase change material eicosane is coated on the surface of the polyurethane nanofibers by electrospray technology. When the temperature rises to 37 ℃, eicosane rapidly completes the phase transition and establishes the light transmission path between the nanofibers, preventing light loss from reflection at the nanofiber-air interface. The resulting TRT membrane exhibits high transmittance(> 90%), and fast response(5 s). This study achieves the first TRT transition of NFMs, offering a general strategy for building highly transparent nanofiber materials, shaping the future of next-generation intelligent temperature monitoring, anti-counterfeiting measures, and other high-performance devices.

关键词： Biomimetic Transparent Nanofibrous membrane Temperature response Phase change materials

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Ophthalmic exam and ophthalmology residents’ subspecialty preference

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International Journal of Ophthalmology(English edition) 2024年第2期17卷 359-364页

作者： Ari Leshno Daf Shalev Daphna Landau Prat Goldschleger Eye Institute Sheba Medical CenterTel Hashomer 5262000Israel Sackler Faculty of Medicine Tel Aviv UniversityTel Aviv 6997801Israel Department of Ophthalmology Edith Wolfson Medical CenterHolon 5822012Israel

AIM:To evaluate residents’perceptions and attitudes toward the various aspects of a comprehensive ophthalmic examination,and to determine if these factors correlate with their choices for fellowship and future career ***:This is a cross-sectional study.A questionnaire on the perception of the ophthalmic exam was sent via SurveyMonkey to ophthalmology residents throughout *** of them(one-half of all ophthalmology residents in 2019)completed *** first part related to how they perceived each component of the ophthalmic *** second part related to their future fellowship *** Chi-squared test was used to compare categorical variables and Student’s t-test and One-way ANOVA were used to compare continuous *** logistic regression analysis was applied as needed to detect interactions between variables and to exclude confounder ***:Slit-lamp examination of the anterior and posterior segments ranked as the most likeable aspects,whereas gonioscopy,ocular motility examination and visual acuity assessment were least *** segment and retina subspecialties were the ones most sought ***-nine respondents(61.3%)noted a direct correlation between their preferred parts of comprehensive ophthalmic evaluations and their choice of *** of selected components of those evaluations were significantly associated with responders’intentions to pursue anterior segment,retina,or oculoplastic fellowships(P<0.05).CONCLUSION:Perspectives of residents toward the ophthalmic examination,and most specifically its individual components,play an important role in their choice of subspecialty training.

关键词： residency subspecialty ophthalmic examination career choice ophthalmology

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Using a Game to Engage Stakeholders in Extreme Event Attribution Science

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International Journal of Disaster Risk Science 2016年第4期7卷 353-365页

作者： Hannah R.Parker Rosalind J.Cornforth Pablo Suarez Myles R.Allen Emily Boyd Rachel James Richard G.Jones Friederike E.L.Otto Peter Walton Department of Meteorology University of Reading Walker Institute University of Reading Red Cross Red Crescent Climate Centre pardee center for the study of the longer-range future Boston University Environmental Change Institute University of Oxford Atmospheric Oceanic and Planetary PhysicsUniversity of Oxford Department of Geography and Environmental Science University of Reading Present Address:Lund University Centre for Sustainability Studies Met Office Hadley Centre School of Geography and the Environment University of Oxford

The impacts of weather and climate-related disasters are increasing,and climate change can exacerbate many *** communicating climate risk and integrating science into policy requires scientists and stakeholders to work *** dialogue between scientists and policymakers can be challenging given the inherently multidimensional nature of the issues at stake when managing climate *** on the growing use of serious games to create dialogue between stakeholders,we present a new game for policymakers called Climate Attribution Under Loss and Damage:Risking,Observing,Negotiating(CAULDRON).CAULDRON aims to communicate understanding of the science attributing extreme events to climate change in a memorable and compelling way,and create space for dialogue around policy decisions addressing changing risks and loss and damage from climate *** describe the process of developing CAULDRON,and draw on observations of players and their feedback to demonstrate its potential to facilitate the interpretation of probabilistic climate information and the understanding of its relevance to informing *** looking to engage with stakeholders can learn valuable lessons in adopting similar innovative *** suitability of games depends on the policy context but,if used appropriately,experiential learning can drive coproduced understanding and meaningful dialogue.

关键词： Climate change Extreme event attribution Loss and damage policy Participatory games Probabilistic event attribution(PEA) Risk management

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