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Direct in vivo injection of ^(131)I-GMS and its distribution and excretion in rabbit

World Journal of Gastroenterology 2010年第17期16卷 2120-2128页

作者： Yu Ma,Yi Wan,Li-Geng Duan,Xiao-Li Chen,The Research Unit of Hepato-Bilio-pancreatology and department of Hepatic Surgery,West China Hospital of Sichuan University,Chengdu 610041,Sichuan Province,China Dong-Hui Luo,Chuan-Qin Xia,College of Chemistry,Sichuan University,Chengdu 610041,Sichuan Province,China Lin Li,department of Nuclear Medicine and The National Key Discipline of Medical Imaging and Nuclear Medicine,West China Hospital of Sichuan University,Chengdu 610041,Sichuan Province,China The Research Unit of Hepato-Bilio-pancreatology and department of Hepatic Surgery West China Hospital of Sichuan University Chengdu 610041 Sichuan Province China.

AIM: To explore the distribution and metabolism of 131 I-gelatin microspheres ( 131 I-GMSs) in rabbits after direct injection into rabbits’ ***: Twenty-eight healthy New Zealand rabbits were divided into seven groups,with four rabbits per *** rabbit’s hepatic lobes were directly injected with 41.336 ± 5.106 MBq 131 *** day after 131 I-GMSs administration,4 rabbits were randomly selected,and 250 μL of serum was collected for γ *** and thyroid functions were tested on days 1,4,8,16,24,32,48 and 64 after 131 I-GMSs ***-photon emission computed tomography (SPECT) was taken for each group on days 0,1,4,8,16,24,32,48,64 after 131 I-GMSs administration.A group of rabbits were sacrificed respectively on days 1,4,16,24,32,48,64 after 131 I-GMSs *** livers were taken out for histological ***: After 131 I-GMSs administration,the nuclide was collected in the hepatic area with *** radiation could be detected on day 48 after 131 IGMSs administration,and radiography could be seen in thyroid areas in SPECT on days 4,8,16 and *** day after 131 I-GMSs administration,the liver function was damaged but recovered 4 d *** days after 131 I-GMSs administration,the levels of free triiodothyronine and free thyroxin were reduced,which restored to normal levels on day *** examination showed that the microspheres were degraded to different degrees at 24,32 and 48 d after 131 I-GMSs *** surrounding parts of injection points were in fibrous *** microspheres were detected in histological examination on day 64 after 131 I-GMSs ***: Direct in vivo injection of 131 I-GMSs is safe in *** may be a promising method for treatment of malignant tumors.

关键词： 131 I Label Gelatin microspheres Animal Rabbit Hepatic Direct injection

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Carbon dioxide for gut distension during digestive endoscopy:Technique and practice survey

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World Journal of Gastroenterology 2009年第12期15卷 1475-1479页

作者： Filip Janssens Jacques Deviere Pierre Eisendrath Jean-Marc Dumonceau Division of Gastroenterology and Hepatology Geneva University HospitalsMicheli-du-Crest street241205 GenevaSwitzerland Medical-Surgical department of Gastroenterology and Hepato-pancreatology Erasme HospitalUniversité Libre de BruxellesBrusselsBelgium

AIM:To assess the adoption of Carbon dioxide(CO2)insufflation by endoscopists from various European countries,and its ***:A survey was distributed to 580 endoscopists attending a live course on digestive ***:The response rate was 24.5%.Fewer than half the respondents(66/142,46.5%)were aware of the fact that room air can be replaced by CO2 for gut distension during endoscopy,and 4.2%of respondents were actually using CO2 as the insufflation *** aware of the possibility of CO2 insufflation mentioned technical difficulties in implementing the system and the absence of significant advantages of CO2 in comparison with room air as barriers to adoption in daily practice(84%and 49%of answers,respectively;two answers were permitted for this item).CONCLUSION:Based on this survey,adoption of CO2 insufflation during endoscopy seems to remain relatively exceptional.A majority of endoscopists were not aware of this possibility,while others were not aware of recent technical developments that facilitate CO2 implementation in an endoscopy suite.

关键词：二氧化碳消化内镜实践调查肠道 CO2气腹室内空气内视镜喷射剂

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Automated quantification of fibrosis-related parameters using dual-photon microscopy replace diagnosis of pathologists in NAFLD

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Hepatobiliary Surgery and Nutrition 2020年第6期9卷 815-816页

作者： Yoshio Sumida Takeshi Okanoue Atsushi Nakajima Japan Study Group of NAFLD(JSG-NAFLD) Division of Hepatology and pancreatology Department of Internal MedicineAichi Medical UniversityAichiKarimataJapan Hepatology Center Saiseikai Suita HospitalSuitaOsakaJapan department of Gastroenterology and Hepatology Yokohama City UniversityKanagawaJapan 不详

We read with great interest the article by Wong and colleagues(1).Hepatic fibrosis is the most important determinant of mortality in patients with NAFLD(2).Although noninvasive tests or imaging modalities such as FibroScan and MR elastography have been developed for evaluation of hepatic fibrosis(3),liver biopsy is now the gold *** biopsy has several drawbacks including intra-observers’and inter-observers’variability(4-7),because the histology-based fibrosis is depend on the subjective evaluation by the *** this article,automated quantification of fibrosis-related parameters(q-FPs)using dual-photon microscopy can accurately diagnose fibrosis stage and predict cumulative incidence of liver-related events(1).It is expected that this novel method will replace diagnosis by pathologists.

关键词： diagnosis NAFLD replace

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Glucagon-like peptide-1 analogue prevents nonalcoholic steatohepatitis in non-obese mice

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World Journal of Gastroenterology 2016年第8期22卷 2512-2523页

作者： Takaya Yamamoto Yukiomi Nakade Taeko Yamauchi Yuji Kobayashi Norimitsu Ishii Tomohiko Ohashi Kiyoaki Ito Ken Sato Yoshitaka Fukuzawa Masashi Yoneda Division of Hepatology and pancreatology Department of Internal Medicine Aichi Medical University

AIM: To investigate whether a glucagon-like peptide-1(GLP-1) analogue inhibits nonalcoholic steatohepatitis(NASH), which is being increasingly recognized in Asia, in non-obese mice. METHODS: A methionine-choline-deficient diet(MCD) along with exendin-4(20 μg/kg per day, ip), a GLP-1 analogue, or saline was administered to male db/db mice(non-obese NASH model). Four or eight weeks after commencement of the diet, the mice were sacrificed and their livers were excised. The excised livers were examined by histochemistry for evidence of hepatic steatosis and inflammation. Hepatic triglyceride(TG) and free fatty acid(FFA) content was measured, and the expression of hepatic fat metabolism- and inflammation-related genes was evaluated. Oxidative stress-related parameters and macrophage recruitment were also examined using ***: Four weeks of MCD feeding induced hepatic steatosis and inflammation and increased the hepatic TG and FFA content. The expression of fattyacid transport protein 4(FATP4), a hepatic FFA influxrelated gene; macrophage recruitment; and the level of malondialdehyde(MDA), an oxidative stress marker, were significantly augmented by a 4-wk MCD. The levels of hepatic sterol regulatory element-binding protein-1c(SREBP-1c) m RNA(lipogenesis-related gene) and acyl-coenzyme A oxidase 1(ACOX1) m RNA(β-oxidation-related gene) had decreased at 4 wk and further decreased at 8 wk. However, the level of microsomal triglyceride transfer protein m RNA(a lipid excretion-related gene) remained unchanged. The administration of exendin-4 significantly attenuated the MCD-induced increase in hepatic steatosis, hepatic TG and FFA content, and FATP4 expression as well as the MCD-induced augmentation of hepatic inflammation, macrophage recruitment, and MDA levels. Additionally, it further decreased the hepatic SREBP-1c level and alleviated the MCD-mediated inhibition of the ACOX1 m RNA level. CONCLUSION: These results suggest that GLP-1 inhibits hepatic s

关键词： Glucagon like peptide-1 Nonalcoholic steatohepatitis Kupffer cells Free fatty acid Oxidative stress

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Risk factors for de novo hepatitis B during solid cancer treatment

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World Journal of Clinical Cases 2020年第24期8卷 6264-6273页

作者： Rie Sugimoto Masayuki Furukawa Takeshi Senju Yoshihusa Aratake Yuki Tanaka Hiroki Inada Tatsuya Noguchi Lingaku Lee Masami Miki Yuji Maruyama Risa Hashimoto Terumasa Hisano Mototsugu Shimokawa department of Hepato-Biliary-pancreatology National Hospital Organization Kyushu Cancer CenterFukuoka City 811-1395Fukuoka PrefectureJapan National Hospital Organization Kyushu Cancer Center Clinical Research InstituteFukuoka City 811-1395Fukuoka PrefectureJapan department of Biostatistics Yamaguchi University Graduate School of MedicineUbe City 755-8505Yamaguchi PrefectureJapan

BACKGROUND Reactivation of hepatitis B virus(HBV)during anticancer treatment is a critical *** treating patients with solid tumors,it is unclear whether specific cancer types or treatments affect HBV reactivation in hepatitis B surface antigen(HBsAg)-negative and hepatitis B core antibody(HBcAb)-positive patients,socalled de novo hepatitis B *** risk of de novo hepatitis B may vary based on different background *** To determine the frequency and risk factors for de novo hepatitis B during solid tumor *** This retrospective cohort study comprised 1040 patients without HBsAgs and with HBcAbs and/or hepatitis B surface antibodies(HBsAbs).The patients were treated for solid cancer from 2008 to 2018 at the National Kyushu Cancer Center and underwent HBV DNA *** characteristics and disease and treatment information were *** DNA measurements were performed using TaqMan polymerase chain reaction(PCR).To identify the risk factors associated with HBV DNA expression,the age,sex,original disease,pathology,treatment method,presence or absence of hepatitis C virus(HCV),and HBsAb and/or HBcAb titers of all subjects were *** patients with HBV DNA,the time of appearance,presence of HBsAgs and HBsAbs at the time of appearance,and course of the subsequent fluctuations in virus levels were also *** Among the 1040 patients,938 were HBcAb positive,and 102 were HBcAb negative and HBsAb *** DNA expression was observed before the onset of treatment in nine patients(0.9%)and after treatment in 35 patients(3.7%),all of whom were HBcAb *** HBV reactivation group showed significantly higher median HBcAb values[9.00(8.12-9.89)vs 7.22(7.02-7.43),P=0.0001]and significantly lower HBsAb values(14 vs 46,P=0.0342)than the group without ***,the reactivated group showed a significantly higher proportion of cancers in organs related to digestion and absorption(79.0%vs 58.7%,

关键词： Hepatitis B Reactivation Solid cancer treatment Digestion and absorption organ Hepatitis B surface antibody Hepatitis B core antibody titer

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A new treatment strategy for acute liver failure

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World Journal of Hepatology 2010年第11期2卷 395-400页

作者： Kazuhiro Kotoh Masaki Kato Motoyuki Kohjima Makoto Nakamuta Munechika Enjoji department of Hepatology and pancreatology Kyushu University Hospital department of Gastroenterology and Clinical Research Center Kyushu Medical Center National Hospital Organization Health Care Center Fukuoka University

Acute liver failure (ALF) is a syndrome def ined by coa g ulopathy and encephalopathy and no effective treat ments have been established, except for liver transplantation. However, considering the limited supply of donors, we should endeavor to prevent the progre ssion of this syndrome in its early stage to improve the prognosis of patients with ALF. Recently, several authors have reported that over-activation of intrahepatic macrophages plays an important role in the progression of ALF and we have developed a new treatment method, transcatheter arterial steroid injection therapy (TASIT), to suppress macrophage activation. We have now used TASIT for 5 years and have found that TASIT is effective for patients with over-activation of macrophages in the liver but not for those with les ser activation of macrophages. Therefore, to identify the most appropriate patients for TASIT, we tried to categorize patients with ALF or acute liver injury according to markers for the degree of intrahepatic macrophage activation. This approach was helpful to select the appro-priate treatment including liver transplantation. We believe that it is essential to analyze disease progression in each patient before selecting the most appropriate treatment.

关键词： Acute liver failure Steroids Macrophages Hepatitis Ferritin

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Role of endoscopic ultrasound in the screening and follow-up of high-risk individuals for familial pancreatic cancer

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World Journal of Gastroenterology 2019年第34期25卷 5082-5096页

作者： Diane Lorenzo Vinciane Rebours Frédérique Maire Maxime Palazzo Jean-Michel Gonzalez Marie-Pierre Vullierme Alain Aubert Pascal Hammel Philippe Lévy Louis de Mestier pancreatology department Beaujon HospitalAssistance Publique-Hopitaux de ParisClichyand Paris Diderot UniversityParis 75013France INSERM UMR1149Paris 92110France Departement of Gastroenterology Aix Marseille university-APHM-Hopital NordMarseille 13000France Radiology department Beaujon HospitalAssistance Publique-Hopitaux de ParisClichyand Paris Diderot UniversityParis 92110France Oncology department Beaujon HospitalAssistance Publique-Hopitaux de ParisClichyand Paris Diderot UniversityParis 92110France

Managing familial pancreatic cancer(FPC)is challenging for gastroenterologists,surgeons and ***-risk individuals(HRI)for pancreatic cancer(PC)(FPC or with germline mutations)are a heterogeneous group of subjects with a theoretical lifetime cumulative risk of PC over 5%.Screening is mainly based on annual magnetic resonance imaging(MRI)and endoscopic ultrasound(EUS).The goal of screening is to identify early-stage operable cancers or high-risk precancerous lesions(pancreatic intraepithelial neoplasia or intraductal papillary mucinous neoplasms with high-grade dysplasia).In the literature,target lesions are identified in 2%-5%of HRI who undergo *** appears to provide better identification of small solid lesions(0%-46%of HRI)and chronicpancreatitis-like parenchymal changes(14%-77%of HRI),while MRI is probably the best modality to identify small cystic lesions(13%-49%of HRI).There are no specific studies in HRI on the use of contrast-enhanced harmonic *** can also be used to obtain tissue ***,there is still limited evidence on the accuracy of imaging procedures used for screening or agreement on which patients to *** cost-effectiveness of screening is also *** new EUS-related techniques,such as searching for DNA abnormalities or protein markers in pancreatic fluid,appear to be promising.

关键词： Endoscopic ultrasound Familial pancreatic cancer Fine-needle aspiration Intraductal papillary mucinous neoplasm Pancreatic cancer Pancreatic intraepithelial neoplasia Pancreatic cancer screening guidelines

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Advanced small-bowel well-differentiated neuroendocrine tumours:An international survey of practice on 3rd-line treatment

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World Journal of Gastroenterology 2021年第10期27卷 976-989页

作者： Angela Lamarca Mauro Cives Louis de Mestier Joakim Crona Francesca Spada KjellÖberg Marianne Pavel Teresa Alonso-Gordoa department of Medical Oncology European Neuroendocrine Tumor Society Centre of ExcellenceThe Christie NHS Foundation TrustUniversity of ManchesterManchester M204BXUnited Kingdom department of Biomedical Sciences and Human Oncology University of Bari Aldo MoroBari 70121Italy department of Gastroenterology and pancreatology European Neuroendocrine Tumor Society Center of ExcellenceParis-Diderot UniversityClichy 75006France department of Medical Sciences Uppsala UniversityUppsala SE-75185Sweden Gastrointestinal Medical Oncology and Neuroendocrine Tumors Unit European Institute of OncologyMilan 20141Italy department of Endocrine Oncology Uppsala University HospitalUppsala SE-75185Sweden department of Endocrinology Universitatsklinikum ErlangenErlangen 91054Germany Medical Oncology department The Ramón y Cajal Health Research InstituteAlcaláUniversityUniversity Hospital Ramon y CajalMadrid 28034Spain

BACKGROUND Somatostatin analogues are an established first-line therapy for well differentiated small bowel neuroendocrine tumours(Wd-SBNETs),while and peptide receptor radionuclide therapy(PRRT)is frequently used as a second-line *** treatment selection of third-line treatment remains challenging due to the limited prospective data currently available on the best therapeutic *** To understand current practice and rationale for decision-making by physicians in the 3rd-line setting by building an online *** Weighted average(WA)of likelihood of usage between responders(1 very unlikely;4 very likely)was used to reflect the relevance of factors *** Replies from representatives of 28 centers were received(5/8/2020-21/9/2020);medical oncologist(53.6%),gastroenterologist(17.9%);United Kingdom(21.4%),Spain(17.9%),Italy(14.3%).Majority from European Neuroendocrine Tumor Society(ENETS)Centres of Excellence(57.1%),who followed ENETS guidelines(82.1%).Generally speaking,3rd-line treatment for Wd-SBNETs was:everolimus(EVE)(66.7%),PRRT(18.5%),liver embolization(LE)(7.4%)and interferon-alpha(IFN)(3.7%);chemotherapy(0%);decision was based on clinical trial data(59.3%),or personal experience(22.2%).EVE was most likely used if Ki-67<10%(WA 3.27/4)or age<70 years(WA 3.23/4),in the 3rd-line setting(WA 3.23/4);regardless of presence/absence of carcinoid syndrome(CS),rate of progression or extent of *** was mainly utilised only if rapid progression(within 6 mo)(WA 3.35/4),Ki-6710%-20%(WA 2.77/4),negative somatostatin receptor imaging(WA 2.65/4)or high tumour burden(WA 2.77/4);temozolomide or streptozocin was used with capecitabine or 5-fluorouracil(5-FU)(57.7%),FOLFOX(5-FU combined with oxaliplatin)(23.1%).LE was selected if presence of CS(WA 3.24/4)or Ki-67<10%(WA 2.8/4),after progression to other treatments(WA 2.8/4).IFN was rarely used(WA 1.3/4).CONCLUSION Everolimus was the most frequently used therapeutic option in the t

关键词： Neuroendocrine tumour Small bowel Survey Third-line Advanced Practice

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N-acetylcysteine and glycyrrhizin combination:Benefit outcome in a murine model of acetaminophen-induced liver failure

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World Journal of Hepatology 2020年第9期12卷 596-618页

作者： Charlotte Minsart Sandrine Rorive Arnaud Lemmers Eric Quertinmont Thierry Gustot Laboratory of Experimental Gastroenterology Erasme HospitalUniversitéLibre de BruxellesBrussels 1070Belgium department of Pathology Erasme HospitalUniversitéLibre de BruxellesBrussels 1070Belgium DIAPATH-Center for Microscopy and Molecular Imaging UniversitéLibre de BruxellesGosselies 6041Belgium department of Gastroenterology Hepato Pancreatology and Digestive OncologyErasme HospitalUniversitéLibre de BruxellesBrussels 1070Belgium Inserm Unité1149 Centre de Recherche sur l’inflammationParis 75006France UMR S_1149 UniversitéParis DiderotParis 75006France

BACKGROUND Acetaminophen overdose is the most frequent cause of drug-induced liver failure in developed *** progress has been made in understanding the mechanism of hepatocellular injury,but N-acetylcysteine remains the only effective treatment despite its short therapeutic ***,other hepatoprotective drugs are needed for the delayed treatment of acetaminopheninduced *** interest focused on glycyrrhizin for its role as an inhibitor of high mobility group box 1(HMGB1)protein,a member of the family of damage-associated molecular pattern,known to play an important pathological role in various *** To investigate the efficacy of the N-acetylcysteine/glycyrrhizin combination compared to N-acetylcysteine alone in the prevention of liver *** Eight-week-old C57BL/6J wild-type female mice were used for all our *** fasted for 15 h were treated with acetaminophen(500 mg/kg)or vehicle(phosphate-buffered saline)by intraperitoneal injection and separated into the following groups:Glycyrrhizin(200 mg/kg);N-acetylcysteine(150 mg/kg);and N-acetylcysteine/*** all groups,mice were sacrificed 12 h following acetaminophen *** assessment of hepatotoxicity was performed by measuring plasma levels of alanine aminotransferase,aspartate aminotransferase and lactate *** was also evaluated by histological examination of hematoxylin and eosin-stained tissues *** rates were compared between various groups using Kaplan-Meier *** Consistent with data published in the literature,we confirmed that intraperitoneal administration of acetaminophen(500 mg/kg)in mice induced severe liver injury as evidenced by increases in alanine aminotransferase,aspartate aminotransferase and lactate dehydrogenase but also by liver necrosis *** administration was shown to reduce the release of HMGB1 and significantly decreased the severity of liver injury.

关键词： Acetaminophen Acute liver injury Glycyrrhizin N-acetylcysteine Nacetylcysteine/glycyrrhizin combination Murine model High mobility group box 1

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Impact of liver enzymes on SARS-CoV-2 infection and the severity of clinical course of COVID-19

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Liver Research 2021年第1期5卷 21-27页

作者： Fátima Higuera-de la Tijera Alfredo Servín-Caamaño Daniel Reyes-Herrera Argelia Flores-López Enrique J.A.Robiou-Vivero Felipe Martínez-Rivera Victor Galindo-Hernández Oscar Chapa-Azuela Alfonso Chávez-Morales Victor H.Rosales-Salyano Multidisciplinary Team for the Attention and Care of Patients with COVID-19 Hospital General de México Dr.Eduardo LiceagaMexico CityMexico Gastroenterology and Hepatology department Hospital General de México Dr.Eduardo LiceagaMexico CityMexico Internal Medicine department Hospital General de México Dr.Eduardo LiceagaMexico CityMexico Hepatobiliary and pancreatology Clinic Surgery DepartmentHospital General de México Dr.Eduardo LiceagaMexico CityMexico Intensive Care Unit Hospital General de México Dr.Eduardo LiceagaMexico CityMexico

Background and aim Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),the virus responsible for the current pandemic,can have multi-organ *** studies show that liver injury could be a manifestation of the disease,and that liver disease could also be related to a worse *** aim was to compare the characteristics of patients with severe coronavirus disease 2019(COVID-19)due to SARS-CoV-2 who required intubation versus stable hospitalized patients to identify the early biochemical predictive factors of a severe course of COVID-19 and subsequent requirement for intubation,specifically in *** This was an observational case-control study nested in a cohort *** medical records of patients admitted for confirmed COVID-19 at a tertiary level center in Mexico City were *** and biochemical data were collected,and the characteristics of patients who required invasive mechanical ventilation(IMV)(cases)were compared with stable hospitalized patients without ventilation(controls).Results We evaluated 166 patients with COVID-19 due to SARS-CoV-2 infection;114(68.7%)were men,the mean age was 50.6±13.3 years,and 27(16.3%)required *** comparative analysis between cases and controls showed(respectively)significantly lower blood oxygen saturation(SpO_(2))(73.5±12.0%vs.83.0±6.8%,P<0.0001)and elevated alanine aminotransferase(ALT)(128(14–1123)IU/L vs.33(8–453)IU/L,P=0.003),aspartate aminotransferase(AST)(214(17–1247)vs.44(12–498)IU/L,P=0.001),lactic dehydrogenase(LDH)(764.6±401.9 IU/L vs.461.0±185.6 IU/L,P=0.001),and D-dimer(3463(524–34,227)ng/mL vs.829(152–41,923)ng/mL,P=0.003)*** in the cases group were older(58.6±12.7 years vs.49.1±12.8 years,P=0.001).Multivariate analysis showed that important factors at admission predicting the requirement for IMV during hospitalization for COVID-19 were AST≥250 IU/L(odds ratio(OR)=64.8,95%confidence interval(CI)7.5–560.3,P<0.0001)and D-dimer≥3500 ng/mL(OR=4.1,95

关键词： Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) Coronavirus disease 2019(COVID-19) Liver enzymes D-dimer Disease severity Invasive mechanical ventilation(IMV) Multi-organ failure

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