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Machine learning facilitated the modeling of plastics hydrothermal pretreatment toward constructing an on-ship marine litter-to-methanol plant

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Frontiers of Chemical Science and Engineering 2024年第10期18卷 105-117页

作者： Yi Cheng Qiong pan Jie Li Nan Zhang Yang Yang Jiawei Wang Ningbo Gao Department of Chemical Engineering and Applied Chemistry Aston UniversityBirmingham B47ETUK Energy and Bioproducts Research Institute Aston UniversityBirmingham B47ETUK centre for Process Integration Department of Chemical EngineeringSchool of EngineeringThe University of ManchesterManchester M139PLUK State Key Laboratory of Coal Combustion Huazhong University of Science and TechnologyWuhan 430074China School of Energy and Power Engineering Xi’an Jiaotong UniversityXi’an 710049China

An onboard facility shows promise in efficiently converting floating plastics into valuable products,such as methanol,negating the need for regional transport and land-based *** presents an effective means of processing plastics,requiring their transformation into gasification-compatible feedstock,such as *** study explores hydrochar composition modeling,utilizing advanced algorithms and rigorous analyses to unravel the intricacies of elemental composition ratios,identify influential factors,and optimize hydrochar production *** investigation begins with decision tree modeling,which successfully captures relationships but encounters overfitting ***,the decision tree vote analysis,particularly for the H/C ratio,yielding an impressive R2 of ***,the research delves into the economic feasibility of the marine plastics-to-methanol *** payback periods,driven by fluctuating methanol prices observed over a decade(ranging from 3.3 to 7 yr for hydrochar production plants),are *** factories emerge as resilient solutions,capitalizing on marine natural gas resources while striving for near-net-zero *** comprehensive study advances our understanding of hydrochar composition and offers insights into the economic potential of environmentally sustainable marine plastics-to-methanol processes.

关键词： marine plastics hydrothermal methanol machine learning technoeconomic assessment

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Genetic factors for differentiated thyroid cancer in French Polynesia:new candidate loci

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Precision Clinical Medicine 2023年第2期6卷 57-66页

作者： Monia Zidane Marc Haber Thérèse Truong Frédérique Rachédi Catherine Ory Sylvie Chevillard Hélène Blanché Robert Olaso Anne Boland Éric Conte Mojgan Karimi Yan Ren Constance Xhaard Vincent Souchard Jacques Gardon Marc Taquet André Bouville Jean-François Deleuze Vladimir Drozdovitch Florent de Vathaire Jean-Baptiste Cazier University Paris-Saclay UVSQInsermGustave RoussyCESPTeam"Radiations Epidemiology"Villejuif 94805France centre for Computational Biology University of BirminghamBirmingham B152TTUK Institute of cancer and Genomic Sciences University of BirminghamBirmingham B152TTUK University Paris-Saclay UVSQInsermGustave RoussyCESPTeam"Exposome and Heredity"Villejuif 94805France Endocrinology Unit Territorial Hospital TaaoneF-98713PapeeteTahiti 98713French Polynesia CEA Laboratoire de Cancérologie FondamentaleInstitut de Biologie François JacobiRCMSREITLaboratoire de Cancérologie Expérimentale(LCE)UniversitéParis-SaclayFontenay aux Roses 92265France Fondation Jean Dausset-centre d’Etude du Polymorphisme Humain Paris 75010France UniversitéParis-Saclay CEACentre National de Recherche en Génomique HumaineEvry 91057France U.S.R.2003(CNRS/UPF) Faa’aTahiti 98702France University of Lorraine INSERM CIC 1433Nancy CHRUINSERM U1116Nancy 54500France Hydrosciences Montpellier Research Institute for DevelopmentCNRSUniversity of MontpellierMontpellier 62307France Research Institute for Development Center IRD on TahitiArueTahiti 98713French Polynesia National cancer Institute(retired) BethesdaMD 20892USA Division of cancer Epidemiology and Genetics National Cancer InstituteNIHDHHSBethesdaMD 20892USA

Background:Populations of French Polynesia(FP),where France performed atmospheric tests between 1966 and 1974,experience a high incidence of differentiated thyroid cancer(DTC).However,up to now,no sufficiently large study of DTC genetic factors in this population has been performed to reach definitive *** research aimed to analyze the genetic factors of DTC risk among the native FP ***:We analyzed more than 300000 single nucleotide polymorphisms(SNPs)genotyped in 283 DTC cases and 418 matched controls born in FP,most being younger than 15 years old at the time of the first nuclear *** analyzed the genetic profile of our cohort to identify population *** then completed a genome-wide analysis study on the whole ***:We identified a specific genetic structure in the FP population reflecting admixture from Asian and European *** identified three regions associated with increased DTC risk at 6q24.3,10p12.2,and *** lead SNPs at these loci showed respective p-values of 1.66×10^(−7),2.39×10^(−7),and 7.19×10^(−7) and corresponding odds ratios of 2.02,1.89,and ***:Our study results suggest a role of the loci 6q24.3,10p12.2 and 17q21.32 in DTC ***,a whole genome sequencing approach would be better suited to characterize these factors than genotyping with microarray chip designed for the Caucasian ***,the functional impact of these three new loci needs to be further explored and validated.

关键词： differentiated thyroid cancer population genetics genetic susceptibility

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Research progress on protective coatings against molten nitrate salts for thermal energy storage in concentrating solar power plants

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Baosteel Technical Research 2023年第4期17卷 1-16页

作者： HOU Wenjie Maria Elena Navarro Rivero pan Jin ZOU Boyang Benjamin Grégoire Anabel Palacios DING Yulong Baowu Carbon Technology Co. Ltd.Shanghai 201999China birmingham centre for Energy Storage&School of Chemical Engineering University of BirminghamBirmingham B152TTUnited Kingdom

Concentrating solar power(CSP) has garnered considerable global attention as a reliable means of generating bulk electricity, effectively addressing the intermittent nature of solar *** integration of molten salt technology for thermal energy storage(TES) has further contributed to the growth of CSP plants;however, the corrosive nature of molten salts poses challenges to the durability of container materials, necessitating innovative corrosion mitigation *** review summarizes scientific advancements in high-temperature anticorrosion coatings for molten nitrate salts, highlighting the key challenges and future *** also explores various coating types, including metallic, ceramic, and carbon-based coatings, and compares different coating deposition *** review emphasizes the need for durable coatings that meet long-term performance requirements and regulatory limitations, with an emphasis on carbon-based coatings and emerging nanomaterials.A combination of multiple coatings is required to achieve desirable anticorrosion properties while addressing material compatibility and cost *** overall goal is to advance the manufacturing, assembly, and performance of CSP systems for increased efficiency, reliability, and durability in various applications.

关键词： anticorrosive coating high temperature molten salt concentrated solar power thermal energy storage

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Fabrication of niobium doped Pb(Zr,Ti)O_3 fibers by viscous polymer processing

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中国有色金属学会会刊：英文版 2006年第B1期16卷 29-32页

作者：徐玲芳陈文周静李君 T.W.Button 张斗赵春霞 Institute of Materials Science and Engineering Wuhan University of TechnologyWuhan 430070China State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070China Interdisciplinary Research centre in Materials Processing University of birmingham B15 2TTUnited Kingdom

A technique based on viscous polymer processing (VPP) was described, which can produce high ceramic content green fibers. PZT-5 ceramic powders were ball milled to get high dispersibility. The slurry prepared for VPP was a composition of PZT-5 powder, PVA binder and glycerin. High ceramic content PZT-5 fibers were extruded with the slurry. The results show that the ceramic powders have fine mean particle size of 0.54 μm, high specific surface area of 3.55 m2/g and zeta potential of 8.81 mV after 16 h milling. The fibers sintered at 1 280 ℃ for 4 h have pure perovskite structure and grains of 2-5 μm in size, with little pores or cracks. The ultimate tensile strength of sintered fibers is up to 13.84 MPa compared with 2.88 MPa of green fibers. The remnant polarization (Pr) and coercive field (Ec) of the fibers are 50.65 μC/cm2 and 2.45 kV/mm, respectively. This fiber can withstand an electric field of 9 kV/mm higher than the ceramic (5 kV/mm), which shows high directional and compact qualities.

关键词：铌掺杂 PZT-5纤维陶瓷纤维粘性聚合物过程钙钛矿型结构

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ACSL5,a prognostic factor in acute myeloid leukemia,modulates the activity of Wnt/β-catenin signaling by palmitoylation modification

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Frontiers of Medicine 2023年第4期17卷 685-698页

作者： Wenle Ye Jinghan Wang Jiansong Huang Xiao He Zhixin Ma Xia Li Xin Huang Fenglin Li Shujuan Huang Jiajia pan Jingrui Jin Qing Ling Yungui Wang Yongping Yu Jie Sun Jie Jin Department of Hematology The First Affiliated HospitalZhejiang University College of MedicineHangzhou 310003China Key Laboratory of Hematopoietic Malignancies Diagnosis and TreatmentHangzhou 310009China Research centre Centre hospitalier de l’Universitéde Montréal(CRCHUM)MontrealQuebec H2L 4M1Canada Women’s Hospital School of MedicineZhejiang UniversityHangzhou 310006China Zhejiang Province Key Laboratory of Anti-cancer Drug Research College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China cancer Center Zhejiang UniversityHangzhou 310058China

Acyl-CoA synthetase long chain family member 5(ACSL5),is a member of the acyl-CoA synthetases(ACSs)family that activates long chain fatty acids by catalyzing the synthesis of fatty *** dysregulation of ACSL5 has been reported in some cancers,such as glioma and colon ***,little is known about the role of ACSL5 in acute myeloid leukemia(AML).We found that the expression of ACSL5 was higher in bone marrow cells from AML patients compared with that from healthy ***5 level could serve as an independent prognostic predictor of the overall survival of AML *** AML cells,the ACSL5 knockdown inhibited cell growth both in vitro and in ***,the knockdown of ACSL5 suppressed the activation of the Wnt/β-catenin pathway by suppressing the palmitoylation modification of ***,triacsin c,a pan-ACS family inhibitor,inhibited cell growth and robustly induced cell apoptosis when combined with ABT-199,the FDA approved BCL-2 inhibitor for AML *** results indicate that ACSL5 is a potential prognosis marker for AML and a promising pharmacological target for the treatment of molecularly stratified AML.

关键词： acute myeloid leukemia acyl-CoA synthetase long chain family member 5 Wnt3a palmitoylation ABT-199

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New therapeutic opportunities for Hepatitis C based on small RNA

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World Journal of Gastroenterology 2007年第33期13卷 4431-4436页

作者： Qiu-wei pan Scot D Henry Bob J Scholte Hugo W Tilanus Harry LA Janssen Luc JW van der Laan Departments of Gastroenterology & Hepatology and Surgery Erasmus MC-University Medical Centre Rotterdam The Netherlands Department of Surgery Erasmus MC-University Medical Centre Rotterdam The Netherlands Department of Cell Biology Erasmus MC- University Medical Centre Rotterdam The Netherlands Department of Gastroenterology & Hepatology Erasmus MC-University Medical Centre Rotterdam The Netherlands

Hepatitis C virus （HCV） infection is one of the major causes of chronic liver disease, including cirrhosis and liver cancer and is therefore, the most common indication for liver transplantation. Conventional antiviral drugs such as pegylated interferon-alpha, taken in combination with ribavirin, represent a milestone in the therapy of this disease. However, due to different viral and host factors, clinical success can be achieved only in approximately half of patients, making urgent the requirement of exploiting alternative approaches for HCV therapy. Fortunately, recent advances in the understanding of HCV viral replication and host cell interactions have opened new possibilities for therapeutic intervention. The most recent technologies, such as small interference RNA mediated gene-silencing, antisense oligonucleotides （ASO）, or viral vector based gene delivery systems, have paved the way to develop novel therapeutic modalities for HCV. In this review, we outline the application of these technologies in the context of HCV therapy. In particular, we will focus on the newly defined role of cellular microRNA （miR-222） in viral replication and discuss its potential for HCV molecular therapy.

关键词： Hepatitis C virus therapy miR-122 RNAi Antisense oligonucleotides Viral vectors

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BMC Family Practice论文摘要汇编--全科医生对基层医疗机构中应用患者状况自评工具的看法:一项横断面调查与定性访谈分析

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中国全科医学 2020年第11期23卷 1415-1415页

作者： TURNER G M LITCHFIELD I FINNIKIN S 本刊编辑部(编译) Institute of Applied Health Research University of Birmingham Birmingham UK centre for Patient Reported Outcomes Research University of Birmingham Birmingham UK NIHR birmingham Biomedical Research centre University Hospitals Birmingham NHS Foundation Trust and University of Birmingham Birmingham UK

背景患者状况自评工具被日益广泛地用于评估疾病和治疗对患者生活质量和症状的影响。然而,其在基层医疗机构中的应用却尚未形成体系。本文旨在调查患者状况自评工具目前在基层医疗机构中的使用情况和影响其应用的有利和不利因素,以及如... 详细信息

背景患者状况自评工具被日益广泛地用于评估疾病和治疗对患者生活质量和症状的影响。然而,其在基层医疗机构中的应用却尚未形成体系。本文旨在调查患者状况自评工具目前在基层医疗机构中的使用情况和影响其应用的有利和不利因素,以及如何优化其应用。方法本研究基于对英国全科医生进行的横断面调查和半结构化访谈。通过在线医生社区平台,向100例全科医生发放自填式电子调查问卷,问卷内容涉及患者状况自评工具在基层医疗机构中的应用情况、不利于其应用的因素以及能促进其有效利用的方法。另外对25例全科医生进行半结构化访谈并对结果进行定性分析。结果 77%(77/100)接受问卷调查的全科医生称其在诊疗过程中使用了至少一种患者状况自评工具,主要是用于辅助临床管理(n=66)或筛查/诊断(n=62)。全科医生在访谈中强调了其在鉴别和选择患者状况自评工具时遇到的挑战。不过部分全科医生认为,这些工具在医患共同决策以及指引患者谈论病情时有重要意义。访谈发现,全科医生认为应用这些工具的不利因素为:(1)诊疗过程中使用这些工具进行评估的时间有限。(2)相关应用知识不足。(3)工具未能和临床系统集成为一体。(4)政策层面鼓励应用这些工具,但是却未咨询医生或对医生做出解释,具有强制性质。如果要促进这些工具在基层医疗机构中的接受和应用程度,需要给出有益处的证据。结论在基层医疗机构中应用患者状况自评工具需要与临床系统集成为一体。在集成二者时,需要对患者和全科医生进行有意义的咨询以进行工具的选择和系统设计;在使用时,还要对其做好应用相关的培训/支持。

关键词：基层医疗机构全科医生患者状况横断面调查系统集成定性访谈社区平台半结构化访谈

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Improved diagnosis of thyroid cancer aided with deep learning applied to sonographic text reports: a retrospective, multi-cohort, diagnostic study

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cancer Biology & Medicine 2022年第5期19卷 733-741页

作者： Qiang Zhang Sheng Zhang Jianxin Li Yi pan Jing Zhao Yixing Feng Yanhui Zhao Xiaoqing Wang Zhiming Zheng Xiangming Yang Lixia Liu Chunxin Qin Ke Zhao Xiaonan Liu Caixia Li Liuyang Zhang Chunrui Yang Na Zhuo Hong Zhang Jie Liu Jinglei Gao Xiaoling Di Fanbo Meng Wei Ji Meng Yang Xiaojie Xin Xi Wei Rui Jin Lun Zhang Xudong Wang Fengju Song Xiangqian Zheng Ming Gao Kexin Chen Xiangchun Li Department of Maxillofacial and Otorhinolaryngology Oncology National Clinical Research Center for Cancer Key Laboratory of Molecular Cancer Epidemiology of Tianjin Key Laboratory of Cancer Prevention and Therapy of Tianjin Tianjin Medical University Cancer Institute and Hospital Tianjin Medical University Department of Diagnostic and Therapeutic Ultrasonography National Clinical Research Center for Cancer Key Laboratory of Molecular Cancer Epidemiology of Tianjin Key Laboratory of Cancer Prevention and Therapy of Tianjin Tianjin Medical University Cancer Institute and Hospital Tianjin Medical University Department of Ultrasonography Weihai Municipal Hospital Cheeloo College of Medicine Shandong University Department of Pathology National Clinical Research Center for Cancer Key Laboratory of Molecular Cancer Epidemiology of Tianjin Key Laboratory of Cancer Prevention and Therapy of Tianjin Tianjin Medical University Cancer Institute and Hospital Tianjin Medical University Department of Ultrasonography Affiliated Hospital of Chifeng University Department of Ultrasonography Integrated Traditional Chinese and Western Medicine Hospital of Jilin city Jilin Province Department of Ultrasonography Dezhou Municipal Hospital Department of Ultrasound Room of Functions Branch Affiliated Hospital of Hebei University Department of Thyroid and Breast Surgery Weihai Municipal Hospital Cheeloo College of Medicine Shandong University Department of General Surgery Tianjin Medical University General Hospital Department of Thyroid and Breast Surgery Tianjin 4th Centre Hospital Department of Thyroid Surgery Affiliated Hospital of Chengde Medical University Department of Pathology The Second Hospital of Tianjin Medical University Department of Ultrasonography The Second Hospital of Tianjin Medical University Department of Thyroid the Second Hospital of Jilin University Department of Head and Neck Thyroid Surgery Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine of Hebei Province De

Objective: Large volume radiological text data have been accumulated since the incorporation of electronic health record(EHR) systems in clinical practice. We aimed to determine whether deep natural language processing algorithms could aid radiologists in improving thyroid cancer ***: Sonographic EHR data were obtained from the EHR database. Pathological reports were used as the gold standard for diagnosing thyroid cancer. We developed thyroid cancer diagnosis based on natural language processing(THCa Dx NLP) to interpret unstructured sonographic text reports for thyroid cancer diagnosis. We used the area under the receiver operating characteristic curve(AUROC) as the primary metric to measure the performance of the THCa Dx NLP. We compared the performance of thyroid ultrasound radiologists aided with THCa Dx NLP vs. those without THCa Dx NLP using 5 independent test ***: We obtained a total number of 788,129 sonographic radiological reports. The number of thyroid sonographic data points was 132,277, 18,400 of which were thyroid cancer patients. Among the 5 test sets, the numbers of patients per set were 439, 186, 82, 343, and 171. THCa Dx NLP achieved high performance in identifying thyroid cancer patients(the AUROC ranged from 0.857–0.932). Thyroid ultrasound radiologists aided with THCa Dx NLP achieved significantly higher performances than those without THCa Dx NLP in terms of accuracy(93.8% vs. 87.2%; one-sided t-test, adjusted P = 0.003), precision(92.5% vs. 86.0%; P = 0.018), and F1 metric(94.2% vs. 86.4%; P = 0.007).Conclusions: THCa Dx NLP achieved a high AUROC for the identification of thyroid cancer, and improved the accuracy, sensitivity, and precision of thyroid ultrasound radiologists. This warrants further investigation of THCa Dx NLP in prospective clinical trials.

关键词： Thyroid cancer sonographic text report deep learning natural language process

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MicroRNA-125b Accelerates and Promotes PML-RARa-driven Murine Acute Promyelocytic Leukemia

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Biomedical and Environmental Sciences 2022年第6期35卷 485-493页

作者： GUO Bo QIN Ran CHEN Ji Jun pan Wen LU Xue Chun Department of Hematology The Second Medical Centre&National Clinical Research Center for Geriatric DiseasesChinese PLA General HospitalBeijing 100853China Department of Genetics Yale University School of MedicineNew HavenConnecticut 06510USA Yale Stem Cell Center Yale Cancer CenterNew HavenCT06520USA

Objective Most acute promyelocytic leukemia cases are characterized by the PML-RARa fusion oncogene and low white cell counts in peripheral *** Based on the frequent overexpression of miR-125-family miRNAs in acute promyelocytic leukemia,we examined the consequence of this phenomenon by using an inducible mouse model overexpressing human *** MiR-125b expression significantly accelerates PML-RARa-induced leukemogenesis,with the resultant induced leukemia being partially dependent on continued miR-125b ***,miR-125b expression led to low peripheral white cell counts to bone marrow blast percentage ratio,confirming the clinical observation in acute promyelocytic leukemia *** This study suggests that dysregulated miR-125b expression is actively involved in disease progression and pathophysiology of acute promyelocytic leukemia,indicating that targeting miR-125b may represent a new therapeutic option for acute promyelocytic leukemia.

关键词： miR-125b PML-RARA White blood cell Bone marrow blast

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Covalently grafting first-generation PAMAM dendrimers onto MXenes with self-adsorbed AuNPs for use as a functional nanoplatform for highly sensitive electrochemical biosensing of cTnT

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Microsystems & Nanoengineering 2022年第2期8卷 119-133页

作者： Xin Liu Yong Qiu Deming Jiang Fengheng Li Ying Gan Yuxuan Zhu Yuxiang pan Hao Wan Ping Wang Zhejiang University 310027 HangzhouChina cancer centre Zhejiang University310058 HangzhouZhejiangChina State Key Laboratory of Transducer Technology Chinese Academy of Sciences200050 ShanghaiChina Binjiang Institute of Zhejiang University 310053 HangzhouChina. School of Biomedical Engineering Tianjin Medical University300070 TianjinChina Research Center of Smart Sensing ZhejiangLab310027 HangzhouChina

2D MXene-Ti3C2Tx has demonstrated promising application prospects in various fields;however,it fails to function properly in biosensor setups due to restacking and anodic oxidation *** expand beyond these existing limitations,an effective strategy to for modifying the MXene by covalently grafting first-generation poly(amidoamine)dendrimers onto an MXene in situ(MXene@PAMAM)was reported *** used as a conjugated template,the MXene not only preserved the high conductivity but also conferred a specific 2D architecture and large specific surface areas for anchoring *** PAMAM,an efficient spacer and stabilizer,simultaneously suppressed the substantial restacking and oxidation of the MXene,which endowed this hybrid with improved electrochemical performance compared to that of the bare MXene in terms of favorable conductivity and stability under anodic ***,the massive amino terminals of PAMAM offer abundant active sites for adsorbing Au nanoparticles(AuNPs).The resulting 3D hierarchical nanoarchitecture,AuNPs/MXene@PAMAM,had advanced structural merits that led to its superior electrochemical performance in *** a proof of concept,this MXene@PAMAM-based nanobiosensing platform was applied to develop an immunosensor for detecting human cardiac troponin T(cTnT).A fast,sensitive,and highly selective response toward the target in the presence of a[Fe(CN)6]^(3-/4-)redox marker was realized,ensuring a wide detection of 0.1-1000 ng/mL with an LOD of 0.069 ng/*** sensor's signal only decreased by 4.38%after 3 weeks,demonstrating that it exhibited satisfactory stability and better results than previously reported MXene-based *** work has potential applicability in the bioanalysis of cTnT and other biomarkers and paves a new path for fabricating high-performance MXenes for biomedical applications and electrochemical engineering.

关键词： electrochemical anodic properly

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