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Electroacupuncture alleviates zymosan-induced colorectal hypersensitivity

Journal of Traditional Chinese Medicine 2025年第1期45卷 32-38页

作者： LI Siting WANG Shaojun YIN Yehui DE Gejing LI Caicai WANG Ziyan CAO Wenjie institute of Acupuncture and Moxibustion China Academy of Chinese Medical Sciences institute of Chinese Materia Medica China Academy of Chinese Medical Sciences

OBJECTIVE: this study to investigate the mechanism underlying the electroacupuncture(EA) alleviates colorectal hypersensitivity, a feature of irritable bowel syndrome(IBS). METHODS: The colorectal hypersensitivity model was established by treating mice with zymosan. Electrophysiological techniques, Western blotting and immunofluorescence staining were used to detect the changes of the sensitive state of the colorectum and the response in spinal ganglion and spinal cord after acupuncture intervention. RESULTS: colorectal distension studies revealed that repetitive applied electroacupuncture treatment on mice could significant alleviates colorectal intensity. Western blotting studies with nerve growth factor(NGF) in the colorectum, substance P(SP) in the spinal ganglion, protein kinase C gamma(PKCγ) in the spinal cord, and transient receptor potential vanilloid 1(TRPV1) showed that electroacupuncture suppressed zymosan-induced expression of TRPV1, NGF and SP in multiple tissues. Immunofluorescence labeling results showed that EA attenuated the expression of NGF in the colorectum, SP in the spinal ganglion, PKCγ in the spinal cord, and TRPV1 in all three tissues in zymosan-treated mice. Moreover, the number of neurons double-positive for TRPV1/Isolectin B4(IB4) and TRPV1/Neurofilament(NF) 200 was increased in the spinal ganglion. CONCLUSION: these results provide molecular-level evidence that EA alleviates zymosan-induced colorectal hypersensitivity by altering the expression of pain-associated proteins in the colorectum and spinal cord. EA has a potential to be therapeutic intervention option for IBS treatment.

关键词： colorectal hypersensitivity electroacupuncture nerve growth factor protein kinase C gamma substance P transient receptor potential channels

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Promising effects of Persian shallot extract on the serum markers and blood pressure of patients with metabolic syndrome:a double-blinded randomized controlled trial

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Journal of Traditional Chinese Medicine 2025年第1期45卷 100-106页

作者： Neda Naimipoor Zahra Bagheri-Hosseinabadi Mohammad Reza Hajizadeh Mitra Abbasifard Mohammad Reza Mirzaei Akram Ghadiri Anari Maryam Mohammad-Sadeghipour Mehdi Mahmoodi Department of Clinical Biochemistry School of MedicineRafsanjan University of Medical Sciences Department of Internal Medicine School of MedicineAli-Ibn Abi-Talib HospitalRafsanjan University of Medical Sciences Molecular Medicine Research Center Research Institute of Basic Medical SciencesRafsanjan University of Medical Sciences Diabetes Research Center Shahid Sadoughi University of Medical Sciences Department of Clinical Biochemistry Afzalipour School of MedicineKerman University of Medical Sciences Physiology Research Center Institute of NeuropharmacologyKerman University of Medical Sciences

OBJECTIVE: To evaluate the effect of Persian shallot extract on the serum markers and blood pressure of patients with metabolic syndrome(MetS). METHODS: Fifty patients with Met S diagnosis were randomly assigned to the intervention(Persian shallot extract) and the control(placebo) group. Both groups received treatment for three months. Before the study and at the end of the study, 5 mL peripheral blood was taken from each patient. The measured factors included total antioxidant capacity(TAC), superoxide dismutase enzyme(SOD), malondialdehyde, oxidized low-density lipoprotein(Ox-LDL), apolipoprotein H(Apo-H), fasting blood glucose(FBS), total cholesterol, triglycerides, high-density lipoprotein(HDL), LDL, and systolic and diastolic blood pressure. RESULTS: At baseline, the evaluated parameters were not significantly different between the intervention and control groups. At the end of the study, the mean serum levels of malondialdehyde and ox-LDL were significantly lower in the intervention group. The mean FBS, cholesterol, triglycerides, and LDL were significantly lower in the intervention group. The mean TAC and HDL were significantly higher in the intervention group(P < 0.05). Moreover, the intervention group significantly reduced systolic and diastolic blood pressure. No other significant association was observed. CONCLUSION: Persian shallot extract has several beneficial effects in Met S patients, including optimizing oxidative balance, reducing blood pressure, fasting blood sugar, and blood lipid profile.

关键词： antioxidants medicine, Persian metabolic syndrome shallots

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Integrating machine learning and human use experience to identify personalized pharmacotherapy in Traditional Chinese Medicine:a case study on resistant hypertension

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Journal of Traditional Chinese Medicine 2025年第1期45卷 192-200页

作者： CHE Qianzi LIU Dasheng XIANG Xinghua TIAN Yaxin XIE Feibiao XU Wenyuan LIU Jian WANG Xuejie WANG Liying BAI Weiguo HAN Xuejie YANG Wei Department of medical Statistics Institute of Basic Research in Clinical MedicineChina Academy of Chinese Medical Sciences Department of Science and Education Medical Statistics Teaching and Research OfficeInstitute of Basic Research in Clinical MedicineChina Academy of Chinese Medical Sciences Computer Department Xiyuan Hospital of the China Academy of Chinese Medical Sciences Traditional Chinese Medicine Standards Research Center Medical Statistics Teaching and Research OfficeInstitute of Basic Research in Clinical MedicineChina Academy of Chinese Medical Sciences

OBJECTIVE: To enhance the understanding of identifying personalized pharmacotherapy options in Traditional Chinese Medicine(TCM), and further support the registration of new TCM drugs. METHODS: Generalized Boosted Models and XGBoost were employed to construct a classification model to identify the bad prognosis factors in resistant hypertension(RH) patients. Furthermore, we used association analysis to explore the rules of "symptomsyndrome" and "symptom-herb" for the major influencing factors, in order to summarize prescription pattern and applicable patients of TCM. RESULTS: Patients with major adverse cardiac events mostly have complex symptoms of phlegm, stasis, deficiency and fire intermingled with each other, and finally summarized the human experience of using Chinese herbal medicine to precisely intervene in some symptoms of RH patients on the basis of conventional Western medical treatment. CONCLUSIONS: Machine learning algorithms can make full use of human use experience and evidence to save clinical trial resources and accelerate the development of TCM varieties.

关键词： human clinical experience machine learning new drugs registration personalized pharmacotherapy

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Injury/ischemia-induced stem cells: up-to-date knowledge and future perspectives for neural regeneration

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Neural Regeneration Research 2025年第3期20卷 797-798页

作者： Takayuki Nakagomi institute for Advanced medical sciences Hyogo Medical UniversityNishinomiyaJapan Department of Therapeutic Progress in Brain Diseases Hyogo Medical UniversityNishinomiyaJapan

Brain injuries like ischemic stroke induce endogenous stem cell production. Although the precise traits of stem cells in pathological brains remain unclear, we previously demonstrated that injury/ischemia-induced stem... 详细信息

关键词： ischemia injuries

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Improving the Position Accuracy and Computational Efficiency of UAV Terrain Aided Navigation Using a Two-Stage Hybrid Fuzzy Particle Filtering Method

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Computers, Materials & Continua 2025年第1期82卷 1193-1210页

作者： Sofia Yousuf Muhammad Bilal Kadri College of Engineering Karachi Institute of Economics&TechnologyKarachi75190Pakistan College of Computer and Information sciences Prince Sultan UniversityRiyadh11586Saudi Arabia

Terrain Aided Navigation(TAN)technology has become increasingly important due to its effectiveness in environments where Global Positioning System(GPS)is *** recent years,TAN systems have been extensively researched for both aerial and underwater navigation ***,many TAN systems that rely on recursive Unmanned Aerial Vehicle(UAV)position estimation methods,such as Extended Kalman Filters(EKF),often face challenges with divergence and instability,particularly in highly non-linear *** address these issues,this paper proposes and investigates a hybrid two-stage TAN positioning system for UAVs that utilizes Particle *** enhance the system’s robustness against uncertainties caused by noise and to estimate additional system states,a Fuzzy Particle Filter(FPF)is employed in the first *** approach introduces a novel terrain composite feature that enables a fuzzy expert system to analyze terrain non-linearities and dynamically adjust the number of particles in *** design allows the UAV to be efficiently localized in GPS-denied environments while also reducing the computational complexity of the particle filter in real-time *** the second stage,an Error State Kalman Filter(ESKF)is implemented to estimate the UAV’s *** ESKF is chosen over the conventional EKF method because it is more suitable for non-linear *** results demonstrate that the proposed fuzzy-based terrain composite method achieves high positional accuracy while reducing computational time and memory usage.

关键词： Sensor fusion fuzzy logic particle filter composite feature terrain aided navigation

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The transcriptome of MHV-infected RAW264.7 cells offers an alternative model for macrophage innate immunity research

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Animal Models and Experimental Medicine 2025年第1期8卷 57-66页

作者： Yun Liu Ting-Ting Feng Wei Tong Zhi Guo Xia Li Qi Kong Zhi-Guang Xiang institute of Laboratory Animal sciences Chinese Academy of Medical Sciences(CAMS)and Comparative Medicine CenterPeking Union Medical College(PUMC)BeijingP.R.China

Background:Macrophages are the primary innate immune cells encountered by the invading coronaviruses,and their abilities to initiate inflammatory reactions,to main-tain the immunity homeostasis by differential polarization,to train the innate immune system by epigenic modification have been reported in laboratory animal ***:In the current in vitro research,murine macrophage RAW 264.7 cell were infected by mouse hepatitis virus,a coronavirus existed in *** 3-,6-,12-,24-,and 48-h post infection(hpi.),the attached cells were washed with PBS and harvested in Trizol *** The harvest is subjected to transcriptome ***:The transcriptome analysis showed the immediate(3 hpi.)up regulation of DEGs related to inflammation,like Il1b and *** related to M2 differential po-larization,like Irf4 showed up regulation at 24 hpi.,the late term after viral *** addition,DEGs related to metabolism and histone modification,like Ezh2 were de-tected,which might correlate with the trained immunity of ***:The current in vitro viral infection study showed the key innated im-munity character of macrophages,which suggested the replacement value of viral infection cells model,to reduce the animal usage in preclinical research.

关键词： coronavirus innate immunity macrophage transcriptome

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In vivo direct neuronal conversion as a therapeutic strategy for ischemic stroke

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Neural Regeneration Research 2025年第8期20卷 2309-2310页

作者： Takashi Irie Taito Matsuda Department of Stem Cell Biology and Medicine Graduate School of Medical SciencesKyushu UniversityFukuokaJapan Department of Neurology Neurological InstituteGraduate School of Medical SciencesKyushu UniversityFukuokaJapan

Stroke causes neuronal loss,which ultimately results in persistent neurological ***,stroke was the third-leading cause of death and disability combined in all ages in 2019,after neonatal disorders and ischemic heart *** that year,there were 12.2 million incident strokes,101 million prevalent strokes,and 143 million disability-adjusted life-years due to stroke.

关键词： neonatal death therapeutic

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DNA walker induced “signal on” fluorescence aptasensor strategy for rapid and sensitive detection of extracellular vesicles in gastric cancer

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Chinese Chemical Letters 2025年第2期36卷 328-331页

作者： Gaojian Yang Zhiyang Li Rabia Usman Zhu Chen Yuan Liu Song Li Hui Chen Yan Deng Yile Fang Nongyue He State Key Laboratory of Digital medical Engineering School of Biological Science and Medical Engineering Southeast University Department of Clinical Laboratory the Affiliated Drum Tower Hospital of Nanjing University Medical School Hunan Key Laboratory of Biomedical Nanomaterials and Devices Hunan University of Technology institute of Cytology and Genetics School of Basic Medical Sciences Hengyang Medical School University of South China institute for Future sciences University of South China

The extracellular vesicles show great potential as a noninvasive biomarker for the early detection of cancer. Hence, there is an urgent requirement to create biosensors that are time-saving, simple, and easily scalable in order to accomplish rapid, sensitive, and quantitative detection of extracellular vesicles. In this study, we present a self-propelled DNA walker powered by endonuclease *** CI, which enables the development of a “signal on” sensing platform for the rapid and highly sensitive detection of extracellular vesicles. The DNA motor employed tracks made of streptavidin magnetic beads, which consisted of substrate strands labeled with fluorescein and motor strands locked by aptamers. The aptamer recognition of the target protein on extracellular vesicles unlocked the motor strand, initiating the DNA motor process. After replacing the optimal buffer solution containing the endonuclease *** I, the motor strands autonomously moved along the streptavidin magnetic beads track, continuously releasing fluorescent molecules and producing detectable fluorescence signals. Under optimal conditions, the detection range was from 2×10～4particles/mL to 2×10～9particles/mL, with a detection limit of 2.9×10～3particles/mL,demonstrating excellent selectivity. This method has demonstrated good selectivity in different tumorderived extracellular vesicles and performs well in complex biological samples. The ability to effectively analyze surface proteins of extracellular vesicles in a short period of time gives our DNA walker a tremendous potential for developing simple and cost-effective clinical diagnostic devices.

关键词： Aptamer Detection Extracellular vesicles Nt.BbvCI Streptavidin magnetic beads

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Therapeutic use of music listening in patients undergoing invasive coronary procedures:A meta-analysis

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World Journal of Cardiology 2025年第1期17卷 78-91页

作者： Ahmed Kamal Siddiqi Aimen Shafiq Mushood Ahmed Anusha Anwer Muhammad Talha Maniya Aymen Ahmed Muhammad Azhar Chachar Md Al Hasibuzzaman Division of Cardiothoracic Imaging Department of Radiology and Imaging SciencesEmory UniversityAtlantaGA 30322United States Department of Medicine Dow University of Health SciencesKarachi 74200Pakistan Department of Internal Medicine Rawalpindi Medical UniversityRawalpindi 74200Pakistan Department of Internal Medicine Dow Medical CollegeDow University of Health SciencesKarachi 74200Pakistan Department of Medicine Ziauddin Medical UniversityKarachi 74200Pakistan Department of Medicine Niramoy HospitalPanchagarh 5010Bangladesh Department of Medicine The First Affiliated Hospital of Ningbo UniversityNingbo 315211Zhejiang ProvinceChina

BACKGROUND Listening to music has been shown to reduce pain and anxiety before,during,and after invasive coronary *** To perform a systematic review and meta-analysis to explore the effect of therapeutic use of music on both,perioperative and postoperative outcomes of invasive coronary *** An exhaustive literature search of 3 electronic databases(MEDLINE,Scopus,Cochrane CENTRAL)was conducted from inception until 10th December *** results of our analyses are presented as standard mean difference(SMD)or weighted mean difference,with 95%CI and pooled using a random effects model.A P value<0.05 was considered significant in all *** From 21 studies,2141 participants were included in our *** pooled analysis demonstrated that music listening significantly improves post-procedural pain(SMD=-0.78,95%CI:-1.34 to-0.23;P=0.006),anxiety(SMD=-0.86,95%CI:-1.43 to-0.29;P=0.003),heart rate[mean difference(MD)=-3.38,95%CI:-5.51 to-1.25;P=0.002],and systolic blood pressure(MD=-5.89,95%CI:-9.75 to-2.02;P=0.003).There was no significant improvement in diastolic blood pressure(MD=-3.22,95%CI:-6.58 to 0.14;P=0.06)or respiratory rate(MD=-0.97,95%CI:-1.98 to 0.03;P=0.06).CONCLUSION Music listening can be used in healthcare settings for patients undergoing invasive coronary procedures to reduce anxiety levels and improve their physiological parameters.

关键词： Music Music therapy Percutaneous coronary intervention Coronary artery bypass grafting Angiography Anxiety Pain management

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DTD1 modulates synaptic efficacy by maintaining D-serine and D-aspartate homeostasis

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Science China(Life sciences) 2025年第2期68卷 467-483页

作者： Xiao Liu Chaojuan Yang Zhuoran Lin Jianing Li Bin Yin Xuepei Lei Wei Han Boqin Qiang Pengcheng Shu Chen Zhang Xiaozhong Peng State KeyLaboratoryofCommon Mechanism Research for Major Diseases Departmentof Biochemistry&Molecular BiologyMedicalPrimate Research CenterNeuroscienceCenterInstituteof Basic Medical Sciences Chinese Academy of Medical SciencesSchool of Basic Medicine Peking Union Medical CollegeBeijing 100005China State Key Laboratory of Respiratory Health and Multimorbidity Beijing 100005China institute of Laboratory Animal sciences Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100021China School of Basic medical sciences Beijing Key Laboratory of Neural Regeneration and RepairCapital Medical UniversityBeijing 100069China Key Laboratoryof Biomechanics and Mechanobiology(Beihang University) Ministryof EducationBeijing AdvancedInnovation Center for Biomedical EngineeringSchoolof Engineering MedicineBeihang UniversityBeijing 100191China Chinese institute for Brain Research Beijing 102206China

D-serine and D-aspartate are involved in N-methyl-D-aspartate receptor(NMDAR)-related physiological and pathological ***-t RNA deacylase 1(DTD1)may biochemically contribute to D-serine or D-aspartate ***,it is unclear thus far whether DTD1 regulates D-serine or D-aspartate content in neurobiological *** the present research,we found that DTD1 was essential to maintain the D-serine or D-aspartate homeostasis,which was consistent with the phenomenon that DTD1-deficiency resulted in changes in the quantity changes of functional NMDAR subunits in postsynaptic ***,DTD1 played a considerable role in regulating dendritic morphology and synaptic *** a consequence,DTD1 affected neurobiological events,including the synaptic strength of the CA3-to-CA1 circuit,dendritic spine density of hippocampal pyramidal neurons,and behavioral performance of mice in the Morris water *** findings highlight the important role of DTD1 in synaptic transmission,neuronal morphology,and spatial learning and memory and suggest an undisclosed mechanism of DTD1 that participates the regulation of D-serine or D-aspartate homeostasis in hippocampal neurons.

关键词： D-aminoacyl-tRNA deacylase 1 D-serine D-aspartate synaptic transmission neuronal morphology spatial learning and memory

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