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Large animal models of cardiac ischemia-reperfusion injury:Where are we now?

Zoological Research 2023年第3期44卷 591-603页

作者： Attaur Rahman Yuhao Li To-Kiu Chan Hui Zhao Yaozu Xiang Xing Chang Hao Zhou Dachun Xu Sang-Bing Ong Department of Medicine and Therapeutics Faculty of MedicineThe Chinese University of Hong Kong(CUHK)Hong Kong SARChina Centre for Cardiovascular Genomics and Medicine(CCGM) Lui Che Woo Institute Innovative MedicineThe Chinese University of Hong Kong(CUHK)Hong Kong SARChina College of Veterinary Sciences and Animal Husbandry Abdul Wali Khan University MardanMardanKhyber Pakhtunkhwa 23200Pakistan School of Biomedical Sciences CUHK-GIBH CAS Joint Laboratory on Stem Cell and Regenerative MedicineThe Chinese University of Hong Kong(CUHK)Hong Kong SARChina Institute for Tissue Engineering and Regenerative Medicine(iTERM) The Chinese University of Hong Kong(CUHK)Hong Kong SARChina SBS Core Laboratory CUHK Shenzhen Research InstituteShenzhenGuangdong 518172China Kunming Institute of Zoology–The Chinese University of Hong Kong(KIZ-CUHK)Joint Laboratory of Bioresources and Molecular Research of Common Diseases Hong Kong SARChina Shanghai East Hospital Key Laboratory of Arrhythmias of the Ministry of Education of ChinaSchool of Life Sciences and TechnologyTongji UniversityShanghai 200092China Guang’anmen Hospital China Academy of Chinese Medical SciencesBeijing 100053China Department of Cardiology Chinese People’s Liberation Army General HospitalBeijing 100853China Center for Cardiovascular Research and Alternative Medicine University of Wyoming College of Health SciencesLaramieWY 82071USA Department of Cardiology Shanghai Tenth People’s HospitalTongji University School of MedicineShanghai 200072China Hong Kong Hub of paediatric Excellence(HK HOPE) Hong Kong Children’s Hospital(HKCH)Kowloon BayHong Kong SARChina CUHK Shenzhen Research Institute(SZRI) ShenzhenGuangdong 518172China Neural Vascularand Metabolic Biology Thematic Research ProgramSchool of Biomedical SciencesThe Chinese University of Hong Kong(CUHK)Hong Kong SARChina

Large animal models of cardiac ischemia-reperfusion are critical for evaluation of the efficacy of cardioprotective interventions prior to clinical ***,current cardioprotective strategies/interventions formulated in preclinical cardiovascular research are often limited to small animal models,which are not transferable or reproducible in large animal models due to different factors such as:(i)complex and varied features of human ischemic cardiac disease(ICD),which are challenging to mimic in animal models,(ii)significant differences in surgical techniques applied,and(iii)differences in cardiovascular anatomy and physiology between small versus large *** article highlights the advantages and disadvantages of different large animal models of preclinical cardiac ischemic reperfusion injury(IRI),as well as the different methods used to induce and assess IRI,and the obstacles faced in using large animals for translational research in the settings of cardiac IR.

关键词： Cardiovascular disorder Ischemic cardiac disease Ischemic-reperfusion injury Large animal model Myocardial infarction Translational gap

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儿童心脏CT成像技术和放射剂量综述

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国际医学放射学杂志 2011年第3期 294-294页

作者： C.Young A.M.Taylor C.M.Owens 郭丽君 Cardiorespiratory unit Great Ormond StreetHospital for Children

多层螺旋CT技术的出现提高了时间和空间分辨力,进而有针对性地部分解决了儿童(100次/min)的儿童在不使用β-受体阻滞剂时也可以进行心电后门控或前门控成像。新近研

关键词：儿童心脏CT 心电后门控心电前门控放射剂量

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右位心的患病阈值和多因素遗传模式

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科学通报:英文版 2023年第18期68卷 1993-1998,M0003页

作者：陈仲中高云倩卢磊李楠刘佩彭瑞刘玲玲黄荷凤傅启华洪海筏张建国王红艳 Obstetrics and Gynecology Hospital State Key Laboratory of Genetic EngineeringInstitute of Reproduction and DevelopmentFudan UniversityShanghai 200011China Pediatric Translational Medicine Institute Shanghai Children’s Medical CenterSchool of MedicineShanghai Jiao Tong UniversityShanghai 200127China Shanghai Key Laboratory of Metabolic Remodelling and Health Institute of Metabolism and Integrative BiologyFudan UniversityShanghai 200438China BGI Genomics Shenzhen 518083China Obstetrics and Gynecology Hospital of Fudan University Shanghai 200090China Department of Cardiothoracic surgery Shanghai Children’s Medical CenterSchool of MedicineShanghai Jiao Tong UniversityShanghai 200127China Children’s Hospital of Fudan University Shanghai 201102China

右位心指正常生长于左侧的心脏位置或方向发生异常,常伴发复杂的先天性心脏病(先心),发病率约为十万分之八大规模小鼠表型的正向遗传学筛查表明,纤毛基因在先心的发病机制中起着关键作用。然而,右位心这类复杂先天性畸形的遗传模式,其... 详细信息

右位心指正常生长于左侧的心脏位置或方向发生异常,常伴发复杂的先天性心脏病(先心),发病率约为十万分之八大规模小鼠表型的正向遗传学筛查表明,纤毛基因在先心的发病机制中起着关键作用。然而,右位心这类复杂先天性畸形的遗传模式,其中的遗传病因是否受纤毛基因驱动,以及适用于复杂性状的“全基因”模型能否解释尚不清楚。基于194名右位心患者及对照样本全基因组外显子测序的遗传学分析发现,“单例功能丧失性变异”(Singletonlossof functionvariant,SLoFV)的总数目与右位心显著相关(P=6.4x10-49).当个体携带的SLoFV个数大于8时,携带者发生右位心的风险呈指数增加。进一步通过斑马鱼模型,发现敲降心脏特异性高表达的核心基因,导致心脏结构的致畸率显著高于其他类型的相关基因.结果表明右位心存在基于SLoFV的全基因组遗传风险阈值,并证实了不同权重基因对心脏致畸的不同效应,丰富了全基因组模型下对核心基因遗传效应的理解,为理解复杂疾病右位心的遗传发病机制提供新的理论基础。

关键词：右位心 congenital 遗传模式

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XI因子先天性缺乏伴获得性XI因子抑制物患者经皮冠状动脉介入术

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世界核心医学期刊文摘(心脏病学分册) 2007年第6期 23-23页

作者： Mungee S Lapin R Cavusoglu E J.D.Marmur 杜媛 cardiac Catheterization and Interventional Cardiology SUNY Health Science Center at BrooklynBox 1257450 Clarkson AvenueBrooklynNY 11203-2098United States Dr

背景:XI因子缺乏症被认为与大多数继发于创伤的和手术后的出血素质有关,且取决于缺乏的严重程度。过去曾有报道XI因子缺乏患者经过恰当的替代治

关键词：获得性抑制物 XI 患者

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张力性胃胸

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世界核心医学期刊文摘（儿科学分册） 2006年第2期2卷 51-51页

作者： Horst M. Sacher P. Molz G. 平智广 Department of surgery University Children' s Hospital CH-8032 Zurich Switzerland

Background: Tension gastrothorax develops when the stomach herniated through a congenital diaphragmatic defect into the thorax is massively distended by trapped air. The authors present 5 cases and discuss the diagnostic and therapeutic management. Case Reports: Four children, aged 3, 4, 6, and 13 months, presented with progressive respiratory distress. In only 1 child was the diagnosis of tension gastrothorax established initially, and immediate insertion of a nasogastric tube led to complete resolution of respiratory distress symptoms. In the remaining 3 children, the initial chest radiograph was misread as tension pneumothorax. One of them developed cardiac arrest and was successfully resuscitated. In 2 patients, thoracostomy resulted in immediate respiratory improvement. Only on follow-up radiographic evaluation was diaphragmatic hernia with herniation of the stomach into the left hemithorax diagnosed. One child underwent diagnostic thoracoscopy revealing the correct diagnosis. All 4 children underwent uneventful repair of a classic Bochdalek hernia. The fifth child, aged 5 months, had sudden infant death. At autopsy tension gastrothorax was found. Conclusion: Tension gastrothorax is a life-threatening condition leading to acute and severe respiratory distress. The condition exhibits distinct radiographic features. Emergency decompression of the distended stomach should first be attempted via nasogastric tube. If this maneuver fails, decompression must be achieved either by needle puncture or by chest tube insertion into the stomach.

关键词：张力性气胸鼻胃管胸腔镜放射学诊断呼吸窘迫放射学特征治疗措施病例报道成功抢救心跳停止

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紧急医疗救护组可使儿科住院患者的心脏停搏和死亡率降低:初步研究

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世界核心医学期刊文摘（儿科学分册） 2006年第4期2卷 6-6页

作者： Tibballs J. Kinney S. Duke T. 张振 Intensive Care unit Royal Children's Hospital Flemington Road Melbourne Vic. 3052 Australia.Prof

Aims: To determine the impact of a paediatric medical emergency team (MET) on cardiac arrest, mortality, and unplanned admission to intensive care in a paediatric tertiary care hospital. Methods: Comparison of the retrospective incidnce of cardiac arrest and death during 41 months before introduction of a MET service with the prospective incidence of these events during 12 months after its introduction. Comparison of transgression of MET call criteria in patients who arrested and died before and after introduction of MET. Results: cardiac arrest decreased from 20 among 104 780 admissions (0.19/1000) to 4 among 35 892 admissions (0.11/1000) (risk ratio 1.71, 95% CI 0.59 to 5.01), while death decreased from 13 (0.12/ 1000) to 2 (0.06/1000) during these periods (risk ratio 2.22, 95% CI 0.50 to 9.87). Unplanned admissions to intensive care increased from 20 (SD 6) to 24 (SD 9) per month. The incidence of transgression of MET call criteria in patients who arrested decreased from 17 to 0 (risk difference 0.16/ 1000, 95% CI 0.09 to 0.24), and in those who died, decreased from 12 to 0 (risk difference 0.11/1000, 95% CI 0.05 to 0.18) after introduction of MET. Conclusions: Introduction of a medical emergency team service was coincident with a reduction of cardiac arrest and mortality and a slight increase in admissions to intensive care.

关键词：心脏停搏医疗救护重症监护救治率死亡发生率危险比非预期性死亡人数风险率

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临床表现明显的血管环伴先天性气管狭窄患儿的长期预后

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世界核心医学期刊文摘（儿科学分册） 2006年第9期2卷 20-20页

作者： Chiu P.P.L. Rusan M. Williams W.G. P.C.W. Kim 刘凯 Division of General surgery Hospital for Sick ChildrenUniversity of TorontoTorontoOnt. M5G 1X8Canada

Aim: congenital tracheal stenosis (CTS) associated with vascular rings (VRs) is considered a secondary condition,but relative indications for selective VRs or combined VR and CTS repairs are unclear. Here,we report long-term outcomes after VR repair associated with tracheal narrowing (TN). Method: Retrospective analysis of patients admitted to a single institution with VR from 1982 to 2004. Of 131 patients with VR (cardiac Registry Database),29 (19 males,10 females; age range,0 days-4 years) associated with symptomatic TN. Patients were followed until age 18 years. Results: One hundred thirty-one patients with VR were categorized into 3 treatment groups. There were 102 patients with VR with no symptomatic TN treated by VR repair (4 deaths,4% mortality). Of the 29 patients with VR + TN symptoms,16 were treated by selective VR repair (mean age,5.3 months; range,17-288 days) with 3 deaths (19% mortality) and 13 underwent combined VR and CTS repairs (mean age,11 months; range,1 day-4 years) with 6 deaths (46% mortality),for an overall mortality of 31% (P cardiac anomalies with 3 deaths (18% mortality). In contrast,7 of 29 patients with VR with TN and intracardiac anomalies died 4(57% mortality); 3 patients in combined cardiac and CTS repairs (2 deaths,67% mortality) and 4 in selective VR repairs (2 deaths,50% mortality). Conclusions: Not all cases of TN associated with VR require combined repairs. The presence of TN and/or intracardiac anomalies in patients with VR,however,increases mortality risk to the repair of VR. Surgical decision requires individualized clinical pathway.

关键词：气管狭窄血管环心脏畸形修复术总体死亡率联合修复继发性疾病个体特点修复手术

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来曲唑或克罗米芬治疗不孕后怀孕的911例新生儿中的先天性畸形分析

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世界核心医学期刊文摘（妇产科学分册） 2006年第10期2卷 33-33页

作者： Tulandi T. Martin J. Al-Fadhli R. R.F. Casper 李跃萍 The Toronto Centre for Advanced Reproductive Technology Division of Reproductive Sciences Reproductive Biology Unit Mount Sinai Hospital TorontoOnt. Canada Dr.

Objective: To evaluate the incidence of congenital malformations among offspring of mothers who conceived with clomiphene citrate(CC) or with letrozole treatment for infertility. Design: Retrospective study. Setting: 5 fertility centers in Canada. Patients: 911 newborns from women who conceived following CC or letrozole treatment. Interventions: Examination of medical files of both mother and newborn, and cross-checked with the parents by telephone calls. Main Outcome Measures: Identified major and minor congenital malformations, birth weight, age of the mother, and type of treatment that led to the conception. Results: Overall, congenital malformations and chromosomal abnormalities were found in 14 of 514 newborns in the letrozole group(2.4%) and in 19 of 397 newborns in the CC group(4.8%). The major malformation rate in the letrozole group was 1.2%(6/514) and in the CC group was 3.0%(12/397). One newborn in the letrozole group was found to have a ventricular septal defect(0.2%)-compared to 4 newborns in the CC group(1.0%). In addition, the rate of all congenital cardiac anomalies was significantly higher(P: 0.02) in the CC group(1.8%) compared to the letrozole group(0.2%). Conclusion: There was no difference in the overall rates of major and minor congenital malformations among newborns from mothers who conceived after letrozole or CC treatments. However, it appears that congenital cardiac anomaly is less frequent in the letrozole group. The concern that letrozole use for ovulation induction could be teratogenic is unfounded based on our data.

关键词：克罗米芬来曲唑先天性畸形诱导排卵染色体异常畸形发生率先天畸形医疗档案先天性心脏畸形

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Integrative single-cell analysis of cardiogenesis identifies developmental trajectories and non-coding mutations in congenital heart disease

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四川生理科学杂志 2022年第12期44卷 2229-2229页

作者： Mohamed Ameen Department of Cancer Biology Stanford University Stanford CA USA Department of Computer Science Stanford University Stanford CA USA Illumina Artificial Intelligence Laboratory Illumina Inc Foster City CA USA Cardiovascular Institute Stanford University Stanford CA USA Department of Physics Stanford University Stanford CA USA Department of Biomedical Informatics Stanford University Stanford CA USA Center for Stem Cell and Organoid Medicine CuSTOM Division of Developmental Biology Cincinnati Children’s Hospital Medical Center Cincinnati OH USA Department of Computer Science California Institute of Technology Pasadena CA USA Department of Cardiothoracic surgery Stanford University Stanford CA USA Department of Genetics Stanford University Stanford CA USA Department of Dermatology Stanford University School of Medicine Stanford CA USA Veterans Affairs Palo Alto Healthcare System Palo Alto CA USA Division of Cardiovascular Medicine Stanford University School of Medicine Stanford CA USA Department of Applied Physics Stanford University Stanford CA USA

To define the multi-cellular epigenomic and transcriptional landscape of cardiac cellular development,we generated single-cell chromatin accessibility maps of human fetal heart *** identified eight major differentiation trajectories involving primary cardiac cell types,each associated with dynamic transcription factor(TF)activity signatures.

关键词： cardiac congenital fetal

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