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Caving performance through the integration of microseismic activity and numerical modeling at DOZ-pt Freeport,Indonesia

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International Journal of Minerals,Metallurgy and Materials 2009年第1期16卷 1-6页

作者： Rubio Enrique Napitupulu Daulat Mining Engineering Department Universidad de Chile Geotechnical Engineering Department PT Freeport IndonesiaTembagapuraIndonesia

This article describes an undergoing research at pt Freeport, Indonesia, in which the main goal is to use the microseismic information recorded as a result of mining to analyze cave propagation and stress performance on the actual production and fixed infrastructure. At the moment, several numerical experiments have been conducted to correlate the mining activity with the microseismic events using the data collected during year 2005 and 2006. As a result of the preliminary analysis a micro- and a macrocracking envelop were proposed on the basis of computation of stress behavior at the location of the events. Stresses have been computed using standard elastic continuous boundary element models. The correlation between the average source radius and the stress performance has provided a method to propose a macrocracking criterion. Several techniques have been tested to nucleate the microseismic activity around different geological features. This last attempt was aimed to look at potential overstresses induced over the undercut and extraction level drifts. A method was devised to integrate the microseismicity into a 3-dimensional ride distribution model. This model has shown to be very effective to quantify the overstress induced as a result of computing volumetric microseismicity density. The volumetric microseismic model showed to induce overstress up to 10 MPa over a period of two months. The future work will concentrate on the calibration of the integrated model with actual damage observations made at the current mining infrastructure.

关键词： microseism underground mining block caving stress distribution microcrack criterion

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Beyond wrecking a wall:revisiting the concept of blood–brain barrier breakdown in ischemic stroke

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Neural Regeneration Research 2025年第7期20卷 1944-1956页

作者： Julia Castillo-González Elena González-Rey Institute of Parasitology and Biomedicine Lopez-Neyra(IPBLN) CSICPT SaludGranadaSpain

The blood–brain barrier constitutes a dynamic and interactive boundary separating the central nervous system and the peripheral *** tightly modulates the ion transport and nutrient influx,while restricting the entry of harmful factors,and selectively limiting the migration of immune cells,thereby maintaining brain *** the well-established association between blood–brain barrier disruption and most neurodegenerative/neuroinflammatory diseases,much remains unknown about the factors influencing its physiology and the mechanisms underlying its ***,the role of blood–brain barrier breakdown in the translational failure underlying therapies for brain disorders is just starting to be *** review aims to revisit this concept of“blood–brain barrier breakdown,”delving into the most controversial aspects,prevalent challenges,and knowledge gaps concerning the lack of blood–brain barrier *** moving beyond the oversimplistic dichotomy of an“open”/“bad”or a“closed”/“good”barrier,our objective is to provide a more comprehensive insight into blood–brain barrier dynamics,to identify novel targets and/or therapeutic approaches aimed at mitigating blood–brain barrier ***,in this review,we advocate for considering the diverse time-and location-dependent alterations in the blood–brain barrier,which go beyond tight-junction disruption or brain endothelial cell breakdown,illustrated through the dynamics of ischemic stroke as a case *** this exploration,we seek to underscore the complexity of blood–brain barrier dysfunction and its implications for the pathogenesis and therapy of brain diseases.

关键词： blood–brain barrier disruption drug delivery ischemic stroke neuroinflammation tight-junctions

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紧跟行业需求分享东盟商机——访印度尼西亚pt Pamerindo展览公司总经理Ben Wong

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出展世界（中英文版） 2015年第2期 40-42页

作者：苏希玲 Ben Wong 不详印度尼西亚pt Pamerindo展览公司

记者:ptP展览公司是印度尼西亚知名的展会主办方。请介绍一下公司展览会涵盖的领域以及见证了印尼展览市场的哪些变化?Ben:ptP展览公司在印尼举办国际展览会已有超过30年的历史。多年来,我们的展览会项目不断壮大,以适应印尼商业领域日... 详细信息

记者:ptP展览公司是印度尼西亚知名的展会主办方。请介绍一下公司展览会涵盖的领域以及见证了印尼展览市场的哪些变化?Ben:ptP展览公司在印尼举办国际展览会已有超过30年的历史。多年来,我们的展览会项目不断壮大,以适应印尼商业领域日益增长的需要。我们有四个主要的展览会集群:能源和矿产资源;制造业;食品与酒店业;IT和基础设施建设。

关键词：展会主办方酒店业矿产资源国际展览会基础设施建设行业需求制造业印度尼西亚

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日本辐照血液和血液成分预防pt—GVHD指南

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国外医学（输血及血液学分册） 2002年第4期25卷 375-377页

作者： T.Asai S.Inaba H.othto 祝君日本输血协会预防pt-GVHD分委会成都市血液中心

日本输血协会(JSBT)已先后制订了3个辐照血液和血液成分预防输血后移植物抗宿主病(pt—GVHD)指南。第一个指南发表于1992年1月1日,是在认识到免疫活性受者手术后发生pt—GVHD,指南推荐心血管手术、先天性免疫缺陷、新生儿和其他免疫低... 详细信息

日本输血协会(JSBT)已先后制订了3个辐照血液和血液成分预防输血后移植物抗宿主病(pt—GVHD)指南。第一个指南发表于1992年1月1日,是在认识到免疫活性受者手术后发生pt—GVHD,指南推荐心血管手术、先天性免疫缺陷、新生儿和其他免疫低下患者,以及换血的新生儿输用辐照血液。日本厚生省随后认定辐照血液为公共卫生保险法定的预防措施。1993年,日本红十字会分析了医院pt—GVHD问卷调查结果,发现多数pt—GVHD为心血管或癌症手术输血患者。因此于1995年5月12日发布了第二个指南,推荐癌症手术的输血和采血后72小时内的血液应辐照。

关键词：日本辐照血液血液成分预防 pt-GVHD 指南

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Combinatorial therapies for spinal cord injury repair

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Neural Regeneration Research 2025年第5期20卷 1293-1308页

作者： Carla S.Sousa Andreia Monteiro António J.Salgado Nuno A.Silva Life and Health Sciences Research Institute(ICVS) School of MedicineUniversity of MinhoCampus de Gualtar-gualtarBragaPortugal ICVS/3B’s Associate Lab PT Government Associated LabCampus de Gualtar-gualtarBragaPortugal

Spinal cord injuries have profound detrimental effects on individuals, regardless of whether they are caused by trauma or non-traumatic events. The compromised regeneration of the spinal cord is primarily attributed to damaged neurons, inhibitory molecules, dysfunctional immune response, and glial scarring. Unfortunately, currently, there are no effective treatments available that can fully repair the spinal cord and improve functional outcomes. Nevertheless, numerous pre-clinical approaches have been studied for spinal cord injury recovery, including using biomaterials, cells, drugs, or technological-based strategies. Combinatorial treatments, which target various aspects of spinal cord injury pathophysiology, have been extensively tested in the last decade. These approaches aim to synergistically enhance repair processes by addressing various obstacles faced during spinal cord regeneration. Thus, this review intends to provide scientists and clinicians with an overview of pre-clinical combinatorial approaches that have been developed toward the solution of spinal cord regeneration as well as update the current knowledge about spinal cord injury pathophysiology with an emphasis on the current clinical management.

关键词： electric stimulation neural tissue regeneration neuroprotection polytherapy spinal cord injury

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FIXED POINTS OF A PAIR OF ASYMptOTICALLY REGULAR MAPPINGS

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Applied Mathematics and Mechanics(English Edition) 1997年第8期18卷 771-778页

作者： B. K. Sharma B. S. Thakur(School of Studies in Mathematics.pt. Ravishankar Shukla University. Raipur-492010 India)(Received Nov. 20. 1996. Communicated by Ding Xieping) School of Studies in Mathematics Pt. Ravishankar Shukla University Raipur India

In this paper some theorems on fixed points of pair of asymptotically regularmappings in p-uniformly convex Banach space are proved For these mappings somefixed point theorems in a Hilbert *** Lp spaces in Hardy space... 详细信息

关键词： asymptotically regular mappings p-uniformly convex Banach space asymptotic center fixed points

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Optimization of variables and assessment of in-vitro and in-vivo antihyperlipidemic activity of Eudragit RS nanoparticles containing simvastatin

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Particuology 2024年第7期90卷 189-198页

作者： Bina Gidwani Vishal Jain Veenu Joshi Ravindra Kumar Pandey Shiv Shankar Shukla Amber Vyas Columbia Institute of Pharmacy Raipur(C.G.)India University Institute of Pharmacy Pt Ravishankar Shukla UniversityRaipur(C.G.)India Center for Basic Science and Research Pt Ravishankar Shukla UniversityRaipur(C.G.)India

Simvastatin, a BCS class II drug, is associated with poor aqueous solubility, first-pass metabolism and short half-life. In the present work, nanoparticles were prepared and evaluated. Optimization of formulation and process parameters was done through the use of independent and dependent variables. Preliminary studies were done to determine suitable range of the concentration of Eudragit polymer (10%–30%) and the ratio of drug to polymer (1:1 to 1:5) for the formation of nanoparticles by emulsification and a solvent evaporation technique. Results revealed that the mean size of nanoparticles was affected by stirring speed from 5000 RPM, 8000 RPM, and 12000 RPM. The results of increase in association efficiency and percent yield with increase in amount of drug from 100 mg, 150 mg, and 200 mg in selected range were observed. In-vitro release studies showed that two formulations possess highest initial burst and slow sustained drug release. There was 2.93-fold decrease in total cholesterol and 3.27-fold increases in triglyceride level during in-vivo study.

关键词： Simvastatin Eudragit RS 100 Nanoparticles Hyperlipidemia

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Secretome of polarized macrophages:potential for targeting inflammatory dynamics in spinal cord injury

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Neural Regeneration Research 2025年第11期20卷 3231-3232页

作者： Andreia Monteiro Susana Monteiro Nuno A.Silva Life and Health Sciences Research Institute(ICVS) School of MedicineUniversity of MinhoBragaPortugal ICVS/3B’s Associate Lab PT Government Associated LabBraga/GuimaraesPortugal

Spinal cord injury(SCI)involves an initial traumatic phase,followed by secondary events such as ischemia,increased blood-spinal cord barrier permeability,ionic disruption,glutamate excitotoxicity,and metabolic alterations.A pe rsistent and exagge rated inflammato ry response within the spinal cord accompanies these events(Lima et al.,2022).The complexity and interplay of these mechanisms exacerbate the initial injury,leading to a degenerative process at the injury *** the initial trauma is unavoidable,the secondary injury begins within minutes and can last for months,creating an optimal window for therapeutic intervention.

关键词： alterations injury companies

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Beyond neurodegeneration:engineering amyloids for biocatalysis

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Neural Regeneration Research 2025年第10期20卷 2915-2916页

作者： Andrea Bartolomé-Nafría Javier García-Pardo Salvador Ventura Institut de Biotecnologia i de Biomedicina(IBB)and Departament de Bioquímica i Biologia Molecular Universitat Autònoma de BarcelonaBellaterraBarcelonaSpain Hospital Universitari Parc Taulí Institut d’Investigaciói InnovacióParc Taulí(I3PT-CERCA)Universitat Autònoma de BarcelonaSabadellSpain

Amyloid fibrils are highly organized protein or peptide aggregates,often characterized by a distinctive supramolecular cross-β-sheet *** formation and accumulation of these structures have been traditionally associated with neural or systemic human diseases,such as Alzheimer’s disease,Parkinson’s disease,type-2 diabetes,or amyotrophic lateral sclerosis(Wei et al.,2017;Wittung-Stafshede,2023).

关键词： structure amyloid

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To Prevent and Handle Positional Deformational Skull Asymmetry in Infants<br/>—A Survey on Child Health Care Nurses and Parents’ Perception of the Given Information

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Open Journal of Therapy and Rehabilitation 2020年第2期8卷 13-27页

作者： Anna Ohman Emilie Holmberg Bjarlestam pt PhD Friskispraktiken Vastra Hamngatan 7 Gothenburg Sweden pt M.Sc. Aleris Rehab Liljeholmen Stockholm Sweden

Background: Infants with developmental skull asymmetry referred to the physiotherapist have increased since 1990. At the physiotherapy clinic the parents often claim that they did not get enough or unclear information from the Health Care Centre. Aim: To investigate where a possible gap between parents and nurses comprehension is, and also to give proposals how to achieve more effective information. Method: A survey with quantitative approach, questionnaires were distributed to nurses and parents. Results: 84% of the nurses totally agreed that they inform all parents about preventative intervention. 98% of the nurses totally agreed that they inform about tummy time and 85% stated that they inform about the variation of head position. There were significant differences between nurses and parents’ perception regarding optimal time of receiving information, parents estimated that it was provided late. Only 19% of the nurses totally agreed that the routines were good enough. Conclusion: This study indicates that nurses inform but the parents do not always comprehend the information or understand the importance. Only a fifth of the nurses totally agreed that the routines are good enough, this indicates that better routines are needed. The nurses found it easier to give preventative information than giving information when a skull asymmetry had developed.

关键词： Plagiocephaly Prevention Nurses Parents Routines Guidelines

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