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Percutaneous transhepatic cholangial drainage-guided methylene blue for fistulotomy using dual-knife for bile duct intubation: A case report

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World Journal of Gastrointestinal Surgery 2023年第6期15卷 1211-1215页

作者： Bing-Xi Tang Xin-Li Li Ning Wei Tao Tao Department of Gastroenterology Zibo Central HospitalZibo 255000Shandong ProvinceChina Laboratory Section Zibo Central HospitalZibo 255000Shandong ProvinceChina

BACKGROUND Difficult bile duct intubation is a big challenge for endoscopists during endoscopic retrograde cholangiopancreatography(ERCP)*** report a case of percutaneous transhepatic cholangial drainage(PTCD)-guided methylene blue for fistulotomy using dual-knife for bile duct *** SUMMARY A 50-year-old male patient had developed obstructive jaundice,and ERCP procedure need to be performed to treat the obstructive *** intubation cannot be performed if the duodenal papilla cannot be identified because of previous surgery for a perforated descending duodenal *** used PTCD-guided methylene blue to identify the intramural common bile duct before dual-knife fistulotomy,and bile duct intubation was successfully *** The method that combing methylene blue and dual-knife fistulotomy to achieve bile duct intubation during difficult ERCP is safe and effective.

关键词： Percutaneous transhepatic cholangial drainage Bile duct intubation Endoscopic retrograde cholangiopancreatography Methylene blue Case report

Effect of nourishing Yin and purging fire Chinese herbal mixture on delaying light-induced premature puberty in rats

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Journal of Traditional Chinese Medicine 2024年第1期44卷 95-102页

作者： SUN Yanyan XUE Yuanyuan SUN Wen WANG Yonghong YU Jian Department of Traditional Chinese Medicine Children's Hospital of Fudan UniversityShanghai 201102China Department of Pediatrics Zibo Central HospitalZibo 255000China

OBJECTIVE:To elucidate the mechanism of the nourishing Yin and purging fire Chinese herbal mixture(NYPF)in delaying light-induced premature puberty in ***:Twenty-one days old female SpragueDawley rats were randomly assigned to normal group(N),long light exposure group(L),NYPF and normal saline group(NS).Rats in the L,NYPF and NS groups were exposed to 16 h:350 lux light/8 h:dark,while rats in the N group were exposed to 12 h:50 lux light/12 h:*** and normal saline was administered to the rats in the NYPF group or NS group,respectively,from day *** rats in every group were sacrificed at 9 *** day 28(P28),on the day when rat's vulva opened in the L group(L-VO),on the day when the first estrous interphase occurred in rats of L group(L-E1),and on the day when the second estrous interphase occurred in rats of L group(L-E2),***:On day 34,all rats in the L group,80%of rats in the NS group,40%of rats in the N group,and 20%of rats in the NYPF group showed complete opening of the *** P28,m RNA level of hypothalamic kisspeptin(Kiss-1)in the L group was significantly higher than that in the N group(P<0.05).The rats in the L and NS groups had significantly lower hypothalamic argininephenylalanine-amide(RFamide)-related peptide 3(RFRP-3)m RNA levels than those in the N group(P<0.05),whereas RFRP-3 m RNA level was significantly higher in the NYPF group than that in the L group(P<0.05).At L-VO,the ovarian index of the L and NS groups was significantly higher than that of the N group(P<0.05)and estradiol(E2)level of the NYPF group was significantly lower than that of the N and NS groups(P<0.05);hypothalamic Kiss-1 m RNA level in the L and NS groups was significantly higher than that in the N and NYPF groups(P<0.05),whereas hypothalamic RFRP-3 m RNA level in the L,NYPF,and NS groups was significantly lower than that in the N group(P<0.05).At L-E1,E2 level of the L and NS groups was significantly higher than that of the N group(P<0.01),wher

关键词： light puberty precocious kisspeptins RFRP-3 melatonin Nourishing Yin and Purging Fire

Effect of 5-LOX/COX-2 common inhibitor DHDMBF30 on pancreatic cancer cell Capan2

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World Journal of Gastroenterology 2008年第16期14卷 2494-2500页

作者： Bo Zhang Chang-Liang Wang Wen-Hua Zhao Ming Lv ChunoYing Wang Wei-Xia Zhong WuoYuan Zhou Wen-Sheng Yu Yan Zhang Sheng Li Shandong Tumor hospital Jinan 250117 ShandongProvince China zibo central hospital Zibo 255001 Shandong ProvinceChina Qilu hospital of Shandong University Jinan 250011Shandong Province China

AIM: To study the effect of 5-lipoxygenase/cyclooxy- genase-2 (5-LOX/COX-2) dual inhibitor 7-tert-butyl-2, 3-dihydro-3, 3-dimethyl substituted dihydrofuran 30 (DHDMBF30) on proliferation and apoptosis of the pancreatic cancer cell line Capan-2 and the effect of DHDMBF30 on human pancreatic cancer in a nude mouse model. METHODS: Investigate the effect of 5-LOX/COX-2 dual inhibitor DHDMBF30 on proliferation and apoptosis of the pancreatic cancer cell line Capan-2 by RT-PCR, MTT assay, FCM and electron microscope. Cell line Capan-2 was inoculated percutaneously on the outer thigh of 12 nude mice. The VEGF mRNA of transplantation tumor was detected by RT-PCR. RESULTS: DHDMBF30 inhibits the proliferation of cell line Capan2, reduces the expression of 5-LOX, COX-2 and VEGF. After Capan2 was treated with DHDMBF30, we found that the apoptosis peak of the experimental group was significantly higher than that of the contrast group (3.08 ± 1.89 vs 27.67 ± 0.52, P < 0.001). The tumor weight of the DHDMBF30 group was significantly lower than PBS control groups (1.35 ± 0.47 vs 2.92 ± 0.73, P < 0.01). Expression of VEGF in the DHDMBF30 group was significantly decreased. CONCLUSION: DHDMBF30 inhibits the proliferation ofthe pancreatic cell line Capan2, and induces apoptosis and inhibits the growth of pancreatic cancer in nude mice.

关键词： 5-lipoxygenase pancreatic tumor Cyclooxygenase2 DHDMBF30 Carcinoma in nude mice

Closed reduction of hip dislocation associated with ipsilateral lower extremity fractures:A case report and review of the literature

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World Journal of Clinical Cases 2022年第34期10卷 12654-12664页

作者： Yong Xu Ming Lv Shu-Qiang Yu Guang-Ping Liu Department of Orthopaedics Chengdu Second People’s HospitalChengdu 610000Sichuan ProvinceChina Department of Orthopaedics Zibo Central HospitalShandong UniversityZibo 255000Shandong ProvinceChina Department of Orthopaedics The Fourth People's Hospital of ZiboZibo 255000Shandong ProvinceChina

BACKGROUND Traumatic hip dislocation usually occurs following high-velocity *** is imperative that the dislocation be reduced in a timely manner,especially in a closed manner,as an orthopedic ***,closed reduction can hardly be achieved in patients who also have ipsilateral lower extremity ***,we focus on hip dislocation associated with ipsilateral lower extremity fractures,excluding intracapsular fractures(femoral head and neck fractures),present an early closed hip joint reduction method for this injury pattern,and review the literature to discuss the appropriate closed reduction technique for this rare injury *** SUMMARY We report a case of a 37-year-old male who sustained a left acetabular posterior wall fracture,an ipsilateral comminuted subtrochanteric fracture and dislocation of the *** hip dislocation was reduced urgently in a closed manner using the joy-stick technique with a T-shaped Schanz *** fractures were reduced and fixed as a 2nd-stage surgery *** the 17-month postoperative follow-up,the patient had full range of motion of the affected *** Closed reduction of a hip dislocation associated with ipsilateral lower extremity fractures is rarely achieved by regular *** at closed reduction,by means of indirectly controlling the proximal fracture fragment or reconstructing the femoral leverage rapidly with the aid of various external reduction apparatuses,were shown to be effective in some *** open reduction is indicated in cases of failed closed reduction,particularly in irreducible dislocations.

关键词： Trauma Hip dislocation Close reduction Open reduction Fracture Case report

Accelerated and enhanced osteointegration of MAO-treated implants:histological and histomorphometric evaluation in a rabbit model

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International Journal of Oral Science 2018年第2期10卷 81-91页

作者： Xin Li Haiyang Xu Baodong Zhao Shuai Jiang Department of Oral Implantology the Affiliated Hospital of Qingdao UniversityQingdaoChina School of Stomatology Qingdao UniversityQingdaoChina Department of Oral Implantology of zibo Central hospital ZiboChina

Microarc oxidation（MAO） has become a promising technique for the surface modification of implants. Therefore, the aims of this study were to further quantitatively and qualitatively evaluate the osteointegration abilities of MAO-treated and smooth surface（SF） implants in vivo and to investigate the areas in which the superiority of MAO-treated implants are displayed. In a rabbit model,a comprehensive histomorphological, osteogenic, mineralizational, and integrative assessment was performed using light microscopy, fluorescence microscopy, confocal laser scanning microscopy, and radiographic analyses. Compared with the SF groups, the MAO-treated groups exhibited more active contact osteogenesis, as well as distant osteogenesis, under fluorescence examination, the mineral apposition rate was found to be greater for all of the MAO-treated implants, and the osteointegration index（OI） value was greater in the MAO-treated groups at different times. In conclusion, the calcium-rich amorphous layer created by MAO provided a better environment for osteointegration, with more active contact osteogenesis, a more rapid mineral apposition rate and greater OI values.

关键词： MAO Accelerated and enhanced osteointegration MAO-treated implants histological histomorphometric evaluation rabbit model

Maisonneuve injury with no fibula fracture:A case report

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World Journal of Clinical Cases 2021年第15期9卷 3733-3740页

作者： Guang-Ping Liu Ji-Gang Li Xiao Gong Jian-Min Li Department of Orthopedics Qilu HospitalCheeloo College of MedicineShandong UniversityJinan 250012Shandong ProvinceChina Department of Orthopedics Zibo Central HospitalShandong UniversityZibo 255000Shandong ProvinceChina Department of Radiology Zibo Central HospitalShandong UniversityZibo 255000Shandong ProvinceChina

BACKGROUND Ankle syndesmosis injury is difficult to diagnose accurately at the initial *** diagnosis or improper treatment can lead to chronic *** syndesmosis injury with a concomitant rupture of the interosseous membrane(IOM)is more unstable and *** relationship between this type of injury and Maisonneuve injury,in which the syndesmosis is also injured,has not been discussed in the literature *** SUMMARY A 16-year-old patient sustained left medial malleolar fracture,and the associated inferior tibiofibular syndesmotic instability was *** open reduction and internal fixation of the medial malleolar fracture,inferior tibiofibular syndesmosis diastasis with IOM rupture was detected by auxiliary *** surgical intervention was performed to reduce anatomically and fix with two trans-syndesmosis *** weeks later,the screws were *** the 6-mo follow-up,the patient gained full range of motion of the *** Complete syndesmosis injury with IOM rupture should be considered Maisonneuve-type *** reduction and internal fixation could obtain good outcomes.

关键词： Maisonneuve Syndesmosis injury Interosseous membrane Stress test Classification Case report

Loading uniform Ag_(3)PO_(4)nanoparticles on three-dimensional peony-like WO_(3)for good stability and excellent selectivity towards NH_(3)at room temperature

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Chinese Physics B 2023年第8期32卷 251-259页

作者：邵星炎贾福超刘婷婷刘健诚王小梅尹广超吕娜周通 Ramachandran Rajan 刘波 Laboratory of Functional Molecules and Materials School of Physics and Optoelectronic EngineeringShandong University of TechnologyZibo 255000China School of Material Science and Engineering Shandong University of TechnologyZibo 255000China Provincial Key Laboratory of Network Based Intelligent Computing University of JinanJinan 250022China Translational Medical Center Zibo Central HospitalZibo 255036China

A heterojunction structure design is a very good method for improving the properties of semiconductors in many research *** method is employed in the present study to promote the gas-sensing performance of Ag_(3)PO_(4)nanocomposites at room temperature(25℃).A nanocomposite of Ag_(3)PO_(4)nanoparticles and three-dimensional peony-like WO_(3)(WO_(3)/Ag_(3)PO_(4))was successfully prepared by the precipitation *** crystalline phases were analyzed by xray diffraction and the microstructure was characterized by scanning electron microscopy and transmission electron *** chemical bonding states were analyzed by x-ray photoelectron *** gas-sensing performance of WO_(3)/Ag_(3)PO_(4)sensors was systematically explored at room *** composite sensors possessed a higher response and lower detection limit(1 ppm)to NH_(3)than those made of a single type of material;this is ascribed to the synergistic effect achieved by the heterojunction *** the different composite sensors tested,gas sensor A5W5(Ag_(3)PO_(4):WO3mass ratio of 5:5)displayed the highest response to NH_(3)at room ***,the A5W5 gas sensor exhibited relatively good stability and excellent selectivity to NH_(3).The A5W5 sensor also displayed a relatively good response under high *** gas-sensing mechanism of the WO_(3)/Ag_(3)PO_(4)sensors is explained in *** together,the as-prepared sensor is highly efficient at detecting NH_(3)and could be suitable for practical *** addition,this study also provides a new method for developing Ag_(3)PO_(4)-based sensors in the gas-sensing field.

关键词： Ag_(3)PO_(4) peony-like WO_(3) NH_(3) room temperature

Huanglian decoction suppresses the growth of hepatocellular carcinoma cells by reducing CCNB1 expression

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World Journal of Gastroenterology 2021年第10期27卷 939-958页

作者： Min Li Hua Shang Tao Wang Shui-Qing Yang Lei Li Department of Gastroenterology Zibo Central HospitalZibo 255036Shandong ProvinceChina Department of General Surgery Zibo Central HospitalZibo 255036Shandong ProvinceChina School of Biological Science and Medical Engineering Beihang UniversityBeijing 100191China Department of Pathology University of OtagoDunedin px806New Zealand

BACKGROUND Hepatocellular carcinoma(HCC)is one of the most prevalent cancers in human populations *** decoction is one of the most important Chinese medicine formulas,with the potential to treat *** To investigate the role and mechanism of Huanglian decoction on HCC *** To identify differentially expressed genes(DEGs),we downloaded gene expression profile data from The Cancer Genome Atlas Liver Hepatocellular Carcinoma and Gene Expression Omnibus(GSE45436)*** obtained phytochemicals of the four herbs of Huanglian decoction from the Traditional Chinese Medicine Systems Pharmacology Database and Analysis *** also established a regulatory network of DEGs and drug target genes and subsequently analyzed key genes using bioinformatics ***,we conducted in vitro experiments to explore the effect of Huanglian decoction and to verify the *** particular,the CCNB1 gene was knocked down to verify the primary target of this *** the identification of the expression levels of key proteins,we determined the primary mechanism of Huanglian decoction in *** Based on the results of the network pharmacological analysis,we revealed 5 bioactive compounds in Huanglian decoction that act on *** addition,a protein-protein interaction network analysis of the target genes of these five compounds as well as expression and prognosis analyses were performed in ***1 was confirmed to be the primary gene that may be highly expressed in tumors and was significantly associated with a worse *** also noted that CCNB1 may serve as an independent prognostic indicator in ***,in vitro experiments demonstrated that Huanglian decoction significantly inhibited the growth,migration,and invasiveness of HCC cells and induced cell apoptosis and G2/M phase *** analysis showed that the decoction may inhibit the growth of HCC cells by downregulating the CCNB1 expression ***

关键词： Huanglian decoction(Coptidis Rhizoma,Zingiberis Rhizoma,Folium Artemisiae Argyi,Mume Fructus) Hepatocellular carcinoma The Cancer Genome Atlas Gene Expression Omnibus P53 pathway Cell cycle Apoptosis

The benefits of PCSK9 inhibitors in patients with acute coronary syndrome:a systematic review and meta-analysis

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Emergency and Critical Care Medicine 2024年第1期4卷 28-34页

作者： Guanzhao Zhang Shuting Chang Faming Zhao Xiangfeng Guan Zifan Nie Wenhao Liu Bo Li Department of Cardiology Binzhou Medical UniversityZibo Central HospitalZiboShandongChina Weifang Medical University WeifangShandongChina Department of Infectious Disease Zibo Infectious Disease HospitalZiboShandongChina.

Background:Proprotein convertase subtilisin/kexin 9(PSCK9)inhibitors have been beneficial for many patients with *** objective of this study was to investigate the benefit of PSCK9 inhibitors in patients with acute coronary syndrome(ACS).Methods:We systematically searched PubMed,EMBASE,and Cochrane Clinical Trials(published before January 2023;no language restriction)to compare the treatment of patients with ACS using PCSK9 inhibitors and *** primary end points were major adverse cardiovascular events,nonfatal myocardial infarction,cardiogenic death,stroke,hospitalization for recurrent ACS,and coronary ***-or random-effects models were used to assess the aggregated ***:Of the 1686 identified studies,5 were eligible and included in our analysis(of a total of 38,005 participants,18,609 cases were placed in the PCSK9 inhibitor treatment group and 19,396 cases in the placebo group).Compared with the placebo group,PCSK9 inhibitors significantly reduced the major adverse cardiovascular events(odds ratio[OR]:0.83;95%confidence interval[CI]:0.77–0.88;Phospitalization for recurrent ACS(OR:0.57;95%CI:0.40–0.83;P=0.003),or coronary revascularization(OR:0.82;95%CI:0.76–0.88;P<0.00001)all demonstrated a significant decrease in the comparison between the 2 ***:This meta-analysis demonstrated that treatment with PCSK9 inhibitors in patients with ACS reduced the probability of multiple cardiovascular events and improved patient prognosis.

关键词： Acute coronary syndrome Cardiovascular disease PCSK9 inhibitors