检索结果-南通市图书馆

中国毒理学会第七次全国毒理学大会暨第八届湖北科技论坛

作者： Zhang Yunhai J.Eric McDuffie Manisha sonee Ma Jing Ying Meng Ryan pd&s Asia PacificJanssen Research & Development pd&s Janssen Research &Development pd&s Janssen Research & Development

【Aims】serum creatinine(sCr),blood urea nitrogen(BUN),and serum cystatin C(sCys C) are non-specific traditional biomarkers for monitoring progressive drug- induced kidney injury(DIKI).Most investigations of novel DIKI biomarkers have been carried out in *** this study,we evaluated temporal changes in selected novel DIKI biomarkers in male cynomolgus monkeys following intravenous infusion of the nephrotoxicant,Amphotericin B(AmpB).【 Materials & Methods 】 Monkeys(5/group) were intravenously dosed at 0 and 0.4 mg/kg/day for 10 *** animals were necropsied on Day 11.【 Results 】 AmpB related kidney histopathology findings were characterized primarily as increased mtra-tubular crystal deposition 【interstitial】,increased intra-tubular casts and moderate to mild increased cortical tubular dilatation and ***- induced significant increase in sCr was apparent on Day 9,while no remarkable changes in BUN were observed(when compared to predose values).AmpB-induced acute proteinuria[specifically significant increases in urinary N-acetyl- β-glucosaminidase(uNAG),alpha 1 microglobulin(uAlM),osteopontin(uOPN),albumin(uALB),kidney injury molecule 1(uKIM-1) and total protein(uTP) and moderate but significantly insignificant neutrophil gelatinase-associated lipoprotein(NGAL),clusterin(uCLU) onay 2 only(when compared to pre-dose values)]was evident on Day 2 and uNAG persisted throughout the duration of the ***- induced significant increase in sCys C was evident at termination *** NGAL,OPN,KIM-1 and AIM positive immunolabeling was localized in the damaged cortex-medullary proximal tubular epithelial cells concurrent to acute increases in AIM,OPN,NGAL CLU,and Glutathione s-transferase alpha(GsTa) mRNA expression changes in flash frozen ***-induced acute changes increases in uNAG,uAlM,uOPN,uAlb,uTP,uKIM-1 and uCLU(Day 2) were indicative of cortico-medullary tubular alterations and appeared prior to increases in sCr(Day 9) and sCys C(Day 11).C

关键词： Amphotericin B monkey kidney tubule-specific injury biomarker

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

High-performance piezoresistive sensors based on transfer-free large-area pdse_(2) films for human motion and health care monitoring

引用

InfoMat 2024年第1期6卷 139-149页

作者： Rui Zhang Jie Lin Tao He Jiafang Wu Zhuojun Yang Liwen Liu shaofeng Wen Yimin Gong Haifeng Lv Jing Zhang Yi Yin Fangjia Li Changyong Lan Chun Li state Key Laboratory of Electronic Thin Films and Integrated Devices School of Optoelectronic Science and EngineeringUniversity of Electronic Science and Technology of ChinaChengduthe People's Republic of China school of Physics University of Electronic Science and Technology of ChinaChengduthe People's Republic of China sichuan Academy of Medical sciences and sichuan People's Hospital Chengduthe People's Republic of China school of Medicine University of Electronic Science and Technology of ChinaChengduthe People's Republic of China

Two-dimensional transition metal dichalcogenides(TMDs)are needed in highperformance piezoresistive sensors due to their strong strain-induced bandgap modification and thereby large gauge ***,integrating a conventional high-temperature chemical vapor deposition(CVD)-grown TMD with a flexible substrate necessitates a transfer process that inevitably degrades the sensing properties of the TMDs and increases the overall fabrication *** present a high-performance piezoresistive strain sensor that employs largearea pdse_(2) films grown directly on polyimide(PI)substrates via plasma-assisted selenization of a sputtered pd *** reliable strain transfer from the substrate to the pdse_(2) film ensures an outstanding strain-sensing capability of the ***,the sensors have a gauge factor of up to315±2.1,a response time under 25 ms,a detection limit of 8×10^(-6),and an exceptional stability of over 104 loadingunloading *** attaching the sensors to the skin surface,we demonstrate their application for measuring physiological parameters in health care monitoring,including motion,voice,and arterial pulse ***,using the pdse_(2) film sensor combined with deep learning technology,we achieved intelligent recognition of artery temperature from arterial pulse signals with only a 2%difference between predicted and actual *** excellent sensing performance,together with the advantages of low-temperature fabrication and simple device structure,make the pdse_(2) film sensor promising for wearable electronics and health care sensing systems.

关键词： layered crystal pdse_(2) piezoresistive effect strain sensor

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Time-resolved characteristics of a nanosecond pulsed multi-hollow needle plate packed bed dielectric barrier discharge

引用

Plasma science and Technology 2024年第7期26卷 48-57页

作者：秦亮李瑶郭浩姜楠宋颖贾锐周雄峰袁皓杨德正 Key Laboratory of Materials Modification by Laser Ionand Electron Beams(Dalian University of Technology)Ministry of EducationDalian 116024People’s Republic of China school of Electrical Engineering Dalian University of TechnologyDalian 116024People’s Republic of China state Key Laboratory of Complex Electromagnetic Environment Effects on Electronics and Information system Luoyang 471003People’s Republic of China school of Physics and Materials Engineering Dalian Minzu UniversityDalian 116600People’s Republic of China

In this paper,self-designed multi-hollow needle electrodes are used as a high-voltage electrode in a packed bed dielectric barrier discharge reactor to facilitate fast gas flow through the active discharge area and achieve large-volume stable *** dynamic characteristics of the plasma,the generated active species,and the energy transfer mechanisms in both positive discharge(pd)and negative discharge(ND)are investigated by using fast-exposure intensified charge coupled device(ICCD)images and time-resolved optical emission *** experimental results show that the discharge intensity,number of discharge channels,and discharge volume are obviously enhanced when the multi-needle electrode is replaced by a multihollow needle *** a single voltage pulse period,pd mainly develops in a streamer mode,which results in a stronger discharge current,luminous intensity,and E/N compared with the diffuse mode observed in *** pd,as the gap between dielectric beads changes from 0 to250μm,the discharge between the dielectric bead gap changes from a partial discharge to a standing filamentary micro-discharge,which allows the plasma to leave the local area and is conducive to the propagation of surface *** ND,the discharge only appears as a diffusionlike mode between the gap of dielectric beads,regardless of whether there is a discharge ***,the generation of excited states N_(2)^(+)(B^(2)∑_(u)^(+))and N2(C^(3)Π_(u))is mainly observed in pd,which is attributed to the higher E/N in pd than that in ***,the generation of the OH(A^(2)∑^(+))radical in ND is higher than in *** is not directly dominated by E/N,but mainly by the resonant energy transfer process between metastable N_(2)(A^(3)∑_(u)^(+))and OH(X^(2)Π).Furthermore,both pd and ND demonstrate obvious energy relaxation processes of electron-to-vibration and vibration-to-vibration,and no vibration-to-rotation energy relaxation process is observed.

关键词： packed bed reactor multi-hollow needle electrodes positive and negative discharges optical emission spectra time-resolved images

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Assessment of programmed death-ligand 1 expression in primary tumors and paired lymph node metastases of gastric adenocarcinoma

引用

World Journal of Gastrointestinal Oncology 2024年第3期16卷 883-893页

作者： Brendha Cação Coimbra Marina Alessandra Pereira Leonardo Cardili Venancio Avancini Ferreira Alves Evandro sobroza de Mello Ulysses Ribeiro Jr Marcus Fernando Kodama Pertille Ramos Department of Gastroenterology Instituto do CancerHospital das Clínicas da Faculdade de Medicina da Universidade de São PauloFaculdade de MedicinaUniversidade de São PauloSão Paulo 01246000Brazil Department of Pathology Instituto do CancerHospital das Clínicas da Faculdade de Medicina da Universidade de São PauloSão Paulo 01246000Brazil

BACKGROUND Anti-programmed death-1/programmed death-ligand 1(pd-1/pd-L1)immuno-therapy has demonstrated promising results on gastric cancer(GC).However,pd-L1 can express differently between metastatic sites and primary tumors(PT).AIM To compare pd-L1 status in PT and matched lymph node metastases(LNM)of GC patients and to determine the correlation between the pd-L1 status and clinicopathological *** We retrospectively reviewed 284 GC patients who underwent ***-L1 was evaluated by immunohistochemistry(clone sP142)using the com-bined positive *** pd-L1+PT staged as pN+were also tested for pd-L1 expression in their ***-L1(-)GC with pN+served as the comparison *** Among 284 GC patients included,45 had pd-L1+PT and 24 of them had pN+.For comparison,44 pd-L1(-)cases with pN+were included(sample loss of 4 cases).Of the pd-L1+PT,54.2%(13/24 cases)were also pd-L1+in the *** pd-L1(-)PT,9.1%(4/44)had pd-L1+in the *** agreement between PT and LNM had a kappa value of *** tumor size and moderate/severe peritumoral inflammatory response were associated with pd-L1 positivity in both *** was no statistical difference in overall survival for PT and LNM according to the pd-L1 status(P=0.166 and P=0.837,respectively).CONCLUsION Intra-patient heterogeneity in pd-L1 expression was observed between the PT and matched *** disagreement in pd-L1 status may emphasize the importance of considering different tumor sites for analyses to select patients for immunotherapy.

关键词： Gastric cancer Lymph node Programmed death ligand 1 stomach neoplasms Immunohistochemistry Metastasis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A stable Open-shell Conjugated Diradical Polymer with Ultra-High Photothermal Conversion Efficiency for NIR-Ⅱ Photo-Immunotherapy of Metastatic Tumor

引用

Nano-Micro Letters 2024年第2期16卷 1-14页

作者： Yijian Gao Ying Liu Xiliang Li Hui Wang Yuliang Yang Yu Luo Yingpeng Wan Chun‑sing Lee shengliang Li Xiao‑Hong Zhang College of Pharmaceutical sciences Soochow UniversitySuzhou 215123People’s Republic of China Institute of Functional Nano&soft Materials(FUNsOM) Soochow UniversitySuzhou 215123People’s Republic of China Center of super‑Diamond and Advanced Films(COsDAF)&Department of Chemistry City University of Hong Kong83 Tat Chee AvenueKowloonHong Kong SARPeople’s Republic of China

Massive efforts have been concentrated on the advance of eminent near-infrared(NIR) photothermal materials(PTMs) in the NIR-Ⅱ window(1000–1700 nm), especially organic PTMs because of their intrinsic biological safety compared with inorganic PTMs. However, so far, only a few NIR-Ⅱresponsive organic PTMs was explored, and their photothermal conversion efficiencies(PCEs) still remain relatively low. Herein, donor–acceptor conjugated diradical polymers with open-shell characteristics are explored for synergistically photothermal immunotherapy of metastatic tumors in the NIR-Ⅱ window. By employing side-chain regulation, the conjugated diradical polymer TTB-2 with obvious NIR-Ⅱ absorption was developed, and its nanoparticles realize a record-breaking PCE of 87.7% upon NIR-Ⅱ light illustration. In vitro and in vivo experiments demonstrate that TTB-2 nanoparticles show good tumor photoablation with navigation of photoacoustic imaging in the NIR-Ⅱ window, without any side-effect. Moreover, by combining with pd-1 antibody,the pulmonary metastasis of breast cancer is high-effectively prevented by the efficient photo-immunity effect. Thus, this study explores superior PTMs for cancer metastasis theranostics in the NIR-Ⅱ window, offering a new horizon in developing radical-characteristic NIR-Ⅱ photothermal materials.

关键词： NIR-Ⅱconjugated polymer Photothermal Radical Nanoparticles Cancer therapy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Enhancing the Electrocatalytic Oxidation of 5-Hydroxymethylfurfural Through Cascade structure Tuning for Highly stable Biomass Upgrading

引用

Nano-Micro Letters 2024年第12期16卷 449-467页

作者： Xiaoli Jiang Xianhui Ma Yuanteng Yang Yang Liu Yanxia Liu Lin Zhao Penglei Wang Yagang Zhang Yue Lin Yen Wei school of Materials and Energy University of Electronic Science and Technology of ChinaChengdu 611731People’s Republic of China Hefei National Research Center for Physical sciences at the Microscale University of Science and Technology of ChinaHefei 230026People’s Republic of China The Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology(Ministry of Education) Department of ChemistryTsinghua UniversityBeijing 100084People’s Republic of China school of Materials science and Engineering North Minzu UniversityYinchuan 750021People’s Republic of China

Electrocatalytic 5-hydroxymethylfurfural oxidation reaction(HMFOR)provides a promising strategy to convert biomass derivative to highvalue-added ***,a cascade strategy is proposed to construct pd-NiCo_(2)O_(4)electrocatalyst by pd loading on Ni-doped Co3O4 and for highly active and stable synergistic HMF *** elevated current density of 800 mA cm^(-2)can be achieved at 1.5 V,and both Faradaic efficiency and yield of 2,5-furandicarboxylic acid remained close to 100%over 10 consecutive *** and theoretical results unveil that the introduction of pd atoms can modulate the local electronic structure of Ni/Co,which not only balances the competitive adsorption of HMF and OH-species,but also promote the active Ni^(3+)species formation,inducing high indirect oxidation *** have also discovered that Ni incorporation facilitates the Co2+pre-oxidation and electrophilic OH*generation to contribute direct oxidation *** work provides a new approach to design advanced electrocatalyst for biomass upgrading.

关键词： 5-Hydroxymethylfurfural oxidation reaction Competitive adsorption Cascade strategy Elevated current density

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Preparation of palladium-based catalyst by plasma-assisted atomic layer deposition and its applications in CO_(2) hydrogenation reduction

引用

Plasma science and Technology 2024年第6期26卷 31-39页

作者：唐守贤田地李筝王正铎刘博文程久珊刘忠伟 Laboratory of Plasma Physics and Materials Beijing Institute of Graphic CommunicationBeijing 102600People’s Republic of China

supported pd catalyst is an important noble metal material in recent years due to its high catalytic performance in CO_(2)hydrogenation.A fluidized-bed plasma assisted atomic layer deposition(FP-ALD) process is reported to fabricate pd nanoparticle catalyst over γ-Al_(2)O_(3)or Fe_(2)O_(3)/γ-Al_(2)O_(3)support,using palladium hexafluoroacetylacetonate as the pd precursor and H_(2)plasma as *** transmission electron microscopy exhibits that highdensity pd nanoparticles are uniformly dispersed over Fe_(2)O_(3)/γ-Al_(2)O_(3)support with an average diameter of 4.4 *** deposited pd-Fe_(2)O_(3)/γ-Al_(2)O_(3)shows excellent catalytic performance for CO_(2)hydrogenation in a dielectric barrier discharge *** a typical condition of H_(2)to CO_(2)ratio of 4 in the feed gas,the discharge power of 19.6 W,and gas hourly space velocity of10000 h^(-1),the conversion of CO_(2)is as high as 16.3% with CH_(3)OH and CH4selectivities of 26.5%and 3.9%,respectively.

关键词： atomic layer deposition CO_(2)hydrogenation palladium based catalyst

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Boosting Electrochemical Urea synthesis via Constructing Ordered pd–Zn Active Pair

引用

Nano-Micro Letters 2024年第11期16卷 529-540页

作者： Weiliang Zhou Chao Feng Xuan Li Xingxing Jiang Lingyan Jing shuai Qi Qihua Huo Miaoyuan Lv Xinbao Chen Tianchi Huang Jingwen Zhao Na Meng Hengpan Yang Qi Hu Chuanxin He College of Chemistry and Environmental Engineering Shenzhen UniversityShenzhen 518060GuangdongPeople’s Republic of China school of Chemistry and Chemical Engineering/state Key Laboratory Incubation Base for Green Processing of Chemical Engineering Shihezi UniversityShihezi 832003XinjiangPeople’s Republic of China

Electrochemical co-reduction of nitrate(NO_(3)^(-))and carbon dioxide(CO_(2))has been widely regarded as a promising route to produce urea under ambient conditions,however the yield rate of urea has remained ***,we report an atomically ordered intermetallic pallium-zinc(pdZn)electrocatalyst comprising a high density of pdZn pairs for boosting urea *** is found that pd and Zn are responsible for the adsorption and activation of NO_(3)^(-)and CO_(2),respectively,and thus the co-adsorption and co-activation NO_(3)^(-)and CO_(2) are achieved in ordered pdZn *** importantly,the ordered and well-defined pdZn pairs provide a dual-site geometric structure conducive to the key C-N coupling with a low kinetical barrier,as demonstrated on both operando measurements and theoretical ***,the pdZn electrocatalyst displays excellent performance for the co-reduction to generate urea with a maximum urea Faradaic efficiency of 62.78%and a urea yield rate of 1274.42μg mg^(-1) h^(-1),and the latter is 1.5-fold larger than disordered pairs in pdZn *** work paves new pathways to boost urea electrosynthesis via constructing ordered dual-metal pairs.

关键词： Electrochemical C-N coupling Urea electrosynthesis Intermetallic compounds Geometric structures Active pairs

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Efficacy and predictive factors of transarterial chemoembolization combined with lenvatinib plus programmed cell death protein-1 inhibition for unresectable hepatocellular carcinoma

引用

World Journal of Gastrointestinal Oncology 2024年第4期16卷 1236-1247页

作者： Kun-Peng Ma Jin-Xin Fu Feng Duan Mao-Qiang Wang Department of Interventional Radiology The Fifth Medical Center of Chinese People's Liberation Army General HospitalBeijing 100853China Chinese People's Liberation Army Medical school Beijing 100853China

BACKGROUND The efficacy and safety of transarterial chemoembolization(TACE)combined with lenvatinib plus programmed cell death protein-1(pd-1)for unresectable hepato-cellular carcinoma(HCC)have rarely been evaluated and it is unknown which factors are related to *** To evaluate the efficacy and independent predictive factors of TACE combined with lenvatinib plus pd-1 inhibitors for unresectable *** This study retrospectively enrolled patients with unresectable HCC who received TACE/lenvatinib/pd-1 treatment between March 2019 and April *** survival(Os)and progression-free survival(PFs)were *** objective response rate(ORR)and disease control rate(DCR)were evaluated in accordance with the modified Response Evaluation Criteria in solid ***,the prognostic factors affecting the clinical outcome were *** One hundred and two patients were enrolled with a median follow-up duration of 12.63 *** median Os was 26.43 months(95%CI:17.00-35.87),and the median PFs was 10.07 months(95%CI:8.50-11.65).The ORR and DCR were 61.76%and 81.37%,*** patients with Barcelona Clinic Liver Cancer Classification(BCLC)B stage,early neutrophil-to-lymphocyte ratio(NLR)response(decrease),or early alpha-fetoprotein(AFP)response(decrease>20%)had superior Os and PFs than their *** This study showed that TACE/lenvatinib/pd-1 treatment was well tolerated with encouraging efficacy in patients with unresectable *** patients with BCLC B-stage disease with early NLR response(decrease)and early AFP response(decrease>20%)may achieve better clinical outcomes with this triple therapy.

关键词： Transarterial chemoembolization Efficacy Lenvatinib Programmed cell death protein-1 inhibitors Unresectable hepatocellular carcinoma

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

safflower Yellow Inhibits Progression of Hepatocellular Carcinoma by Modulating Immunological Tolerance via FAK Pathway

引用

Chinese Journal of Integrative Medicine 2024年第4期30卷 339-347页

作者： JI Hua-feng YANG Zi-qiang HAN Jun-jun LI He-fang JIN Zhao-qing CHEN Wei-qing CHEN Fei-hua GONG Mou-chun Department of General surgery First People's Hospital of Hangzhou Lin'an DistrictHangzhou(311300)China

Objective To explore the anti-tumor effect of safflower yellow(sY)against hepatocellular carcinoma(HCC)and the underlying potential *** An in vitro model was established by mixing Luc-Hepa1-6 cells and CD3^(+)CD8^(+)T cells,followed by adding programmed cell death protein 1(pd-1)antibody(Anti-mpd-1)with or without *** apoptosis was detected by flow cytometry and the level of inflammatory cytokines was determined by enzyme-linked immunosorbent *** protein levels of programmed cell death 1 ligand 1(pd-L1),chemokine ligand(CCL5),C-X-C motif chemokine ligand 10(CXCL10)were measured by Western *** in situ animal model was established in mice followed by treatment with anti-mpd-1 with or without *** imaging was monitored with an AniView 100 imaging *** establish the FAK-overexpressed Luc-Hepa1-6 cells,cells were transfected with adenovirus containing pcDNA3.1-FAK for 48 *** The fluorescence intensity,apoptotic rate,release of inflammatory cytokines,and CCL5/CXCL10 secretion were dramatically facilitated by anti-mpd-1(Ppd-1/pd-L1 axis,which were extremely further enhanced by sY(Psed fluorescence intensity,elevated percentage of CD3+CD8+T cells,facilitated release of inflammatory cytokines,inactivated pd-1/pd-L1 axis,and increased CCL5/CXCL10 secretion were observed in Anti-mpd-1 treated mice(PsY(Ps of sY on inhibiting tumor cell growth,facilitating apoptosis and inflammatory cytokine releasing,suppressing the pd-1/pd-L1 axis,and inducing the CCL5/CXCL10 secretion in Anti-mpd-1 treated mixture of Luc-Hepa1-6 cells and CD3+CD8+T cells were abolished by FAK overexpression(Psion sY inhibited the progression of HCC by mediating immunological tolerance through inhibiting FAK.

关键词： hepatocellular carcinoma safflower yellow Chinese medicine tumor microenvironment programmed cell death protein 1 focal adhesion kinase

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：