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Supramolecular Biomaterials for Cancer Immunotherapy

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Research 2024年第2期2023卷 491-509页

作者： Huan Liang Qingqing Lu Jie Yang guocan Yu College of Science Nanjing Forestry UniversityNanjing 210037P.R.China Key Laboratory of Bioorganic phosphorus chemistry&Chemical Biology Department of ChemistryTsinghua UniversityBeijing 100084P.R.China

Cancer immunotherapy has achieved tremendous successful clinical results and obtained historic victories in tumor ***,great limitations associated with feeble immune responses and serious adverse effects still cannot be neglected due to the complicated multifactorial etiology and pathologic microenvironment in *** rapid development of nanomedical science and material science has facilitated the advanced progress of engineering biomaterials to tackle critical *** supramolecular biomaterials with flexible and modular structures have exhibited unparalleled advantages of high cargo-loading efficiency,excellent biocompatibility,and diversiform immunomodulatory activity,thereby providing a powerful weapon for cancer *** past decades,supramolecular biomaterials were extensively explored as versatile delivery platforms for immunotherapeutic agents or designed to interact with the key moleculars in immune system in a precise and controllable *** this review,we focused on the crucial role of supramolecular biomaterials in the modulation of pivotal steps during tumor immunotherapy,including antigen delivery and presentation,T lymphocyte activation,tumor-associated macrophage elimination and repolarization,and myeloid-derived suppressor cell *** on extensive research,we explored the current limitations and development prospects of supramolecular biomaterials in cancer immunotherapy.

关键词： biomaterials limitations thereby

Nanozyme catalysis in a crowded environment:The impact of diffusion and surface shielding

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Nano Research 2024年第7期17卷 5795-5800页

作者： Vasily g.panferov Juewen Liu department of chemistry Waterloo Institute for NanotechnologyWaterlooOntario N2L 3G1Canada

Nanozymes are widely used in various applications as nanosized catalysts for replacing *** accurate estimation of the catalytic activity of nanozymes in real conditions is *** this article,for the first time,we systematically studied the effect of macromolecular molecules co-existing in the real system on the oxidoreductase(peroxidase,oxidase,and catalase)-mimicking nanozymes made of a gold nanoparticle core and a platinum shell,prussian Blue,Mn2O3 and CoO *** were made with horseradish *** distinguished two main mechanisms of the negative impact of macromolecules on nanozyme catalysis—slowed diffusion and surface shielding of *** the first mechanism is typical for enzymes,the second one is specific only for *** the mechanisms is essential for developing approaches to reduce the unavoidable impact of macromolecules for various analytical and biomedical applications.

关键词： molecular crowding biosensors nanoparticles

Recent Advances in 0D Ni/Co-based Hollow Electrocatalysts for Electrochemical Water Splitting

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Chemical Research in Chinese Universities 2024年第3期40卷 437-450页

作者： gE Wenjing CHEN Xiaocui MA Ruizhao ZHENg Siyuan SHANg Ningzhao ZHAO Xiaoxian department of chemistry College of ScienceHebei Agricultural UniversityBaoding 071001P.R.China

Electrochemical water splitting using renewable energy sources has been recognized as a sustainable way to produce hydrogen energy due to the characteristics of low-carbon and no ***,the slow hydrogen/oxygen evolution reactions(HER/OER)seriously hinder the practical application of large-scale water *** this paper,the 0D Ni/Co-based hollow material is discussed in detail because of adjustable morphology,low mass density and abundant active sites,which provides an effective solution for improving the HER/OER reaction *** synthesis methods of hollow materials,such as hard template,soft template and self-template are ***,catalysts with different structural designs of hollow structures are reviewed,including hollow single-shelled structure,hollow core-shelled structure,hollow double-shelled structure and hollow multi-shelled structure(HoMS)***,the research progress of the 0D Ni/Co-based HoMS electrocatalysts in recent years and their prominent performances in water splitting are ***,the challenges and development prospects of designing Ni/Co-based HoMS catalysts in water splitting in the future are discussed.

关键词： Electrochemical watersplitting Morphological regulation Hollow structure Hollow multi-shelled structure(HoMS)

Nanomaterial Assisted Exosome Analysis Using Mass Spectrometry

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Chemical Research in Chinese Universities 2024年第2期40卷 237-254页

作者： ZHANg Yi ZHOU Bokai LI Qiuning JIN Mingshi BAI Yu Beijing National Laboratory for Molecular Sciences Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of EducationCollege of Chemistry and Molecular EngineeringPeking UniversityBeijing100871P.R.China department of chemistry Yanbian UniversityYanji133002P.R.China

Exosomes,extracellular vesicles(EVs)that play crucial roles in biological processes,have emerged as attractive targets for noninvasive disease diagnosis and *** spectrometry(MS)offers high sensitivity,high throughput,and excellent qualification and quantification capacity,which is the ideal approach for exosome ***’unique physiochemical properties,controllable morphology,and large surface area make them promising in biological sample pretreatment and *** contributed diverse functions to the exosome MS analysis,encompassing substrates for exosome isolation and cargos enrichment,matrices for laser desorption/ionization(LDI),read-out signals and supporters for signal amplification strategies,*** this review,recent progress in the applications of nanomaterial in the exosome MS analysis was summarized and a comprehensive discussion on the challenges and perspectives was proposed for the development of an advancing analysis approach of exosomes for the accurate diagnosis and monitoring of diseases.

关键词： Exosome Nanomaterial Enrichment Matrix Mass spectrometry

Formadinium Cation Doping Stabilized Ultra-deep-blue Lead Halide perovskite Nanocrystal Light-emitting Diodes

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Chemical Research in Chinese Universities 2024年第3期40卷 556-560页

作者： pui Kei KO Jonathan E.HALpERT department of chemistry The Hong Kong University of Science and TechnologyKowloonHong Kong 999077P.R.China

The halide migration effect in mixed-halide lead-based perovskite is a serious problem hindering the development of its display *** this study,we have successfully addressed this issue by reporting formadinium(FA)doped mixed-halide perovskite nanocrystals(NCs)with ultra-deep-blue emission of 450 nm,narrow bandwidth of 16 nm,and a high photoluminescence quantum yield(pLQY)of 66%.The perovskite nanocrystal light-emitting diodes(NC-LEDs)using this nanocrystal as an active layer achieved a maximum external quantum efficiency(EQE)of 0.32%,30-fold improved compared to that of pristine and stable electroluminescence(EL)spectra at 450 nm under a 4.9–8.0 V *** findings demonstrate the potential of our approach in developing stable and efficient deep blue perovskite NC-LEDs.

关键词： Halide perovskite Light-emitting diode Deep-blue

Thermochemical co-conversion of biomass-plastic waste to biochar:a review

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green Chemical Engineering 2024年第1期5卷 31-49页

作者： Adewale george Adeniyi Kingsley O.Iwuozor Ebuka Chizitere Emenike Oluwaseun J.Ajala Samuel Ogunniyi Kabir B.Muritala department of Chemical Engineering Faculty of Engineering and TechnologyUniversity of IlorinIlorinP.M.B.1515Nigeria department of Chemical Engineering Landmark UniversityOmu-AranKwara StateP.M.B.1001Nigeria department of pure and Industrial chemistry Nnamdi Azikiwe UniversityAwkaP.M.B.5025Nigeria department of chemistry Federal University of TechnologyBosso CampusMinnaNiger StateP.M.B.65Nigeria

Biomass and plastics are two of the most common municipal solid wastes globally that have continuously placed a burden on the *** is therefore important that they are properly *** coconversion offers a valuable opportunity to recycle biomass and plastics simultaneously into biochar,which reduces the time and cost of recycling them individually while producing a material with a wide range of *** study is a review of published literature that discusses the thermochemical co-processing of biomass and plastic wastes into *** was observed that co-pyrolysis and co-hydrothermal carbonization are the most commonly utilized technologies for this *** characteristics of different biomass and plastics that have been thermochemically converted into biochar were *** properties of the resulting biochar are affected by the feedstock composition,pre-treatment and blending ratio,the reactor’s configuration,reaction temperature,and the presence of a *** studies found that treating the feedstocks separately resulted in a lower yield of biochar than processing them *** biochar created by this procedure has been used as a soil additive and as an adsorbent for water *** perspectives and suggestions,such as the necessity for some technical advancement,biochar’s economic benefits,improved government participation,and raised social awareness,were also *** factors have the potential to propel this field of study to great horizons.

关键词： Biomass Co-pyrolysis plastic Thermochemical process Valorization

Strategy for Detecting Systemic Treatment Sensitivity of primary Liver Cancer Based on a Novel Infrared-emissive Organic Nanoparticle

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Chemical Research in Chinese Universities 2024年第1期40卷 145-152页

作者： WU Jun LI Yongzhi QIN Hanjiao gAO Ying YANg Bing SHENg Jiyao ZHANg Xuewen department of Hepatobiliary and pancreatic Surgery the Second Hospital of Jilin UniversityChangchun130022P.R.China department of Radiation Oncology the Second Hospital of Jilin UniversityChangchun130022P.R.China State Key Laboratory of Supramolecular Structure and Materials Institute of Theoretical ChemistryCollege of ChemistryJilin UniversityChangchun130012P.R.China

In this study,we synthesized an organic material with near-infrared emission capabilities:4-(2-(4-(9-(4-(diphenylamino)phenyl)naphtho[2,3-c][1,2,5]thiadiazol-4-yl)phenyl)-1H-phenol-1-ylidene)malononitrile(TpA).Furthermore,TpA-pEg2000 fluorescent nanoparticles were prepared via coating the shells with ***-pEg2000 exhibited strong near-infrared emission near 700 nm,with a photoluminescence quantum yield of 15.09%,indicating a high emission *** biology experiments have confirmed its low toxicity and excellent *** cholesterol and phospholipid levels in liver cancer cell membranes with low sensitivity or high drug resistance lead to increased rigidity,reduced membrane fluidity,reduced endocytic efficiency,and reduced ***,the uptake of TpA-pEg2000 nanoparticles into cells and the near-infrared fluorescence intensity can be used to evaluate the sensitivity of systemic liver cancer treatment in a simple and efficient manner.

关键词： Nanoparticle Near-infrared Fluorescence Systemic treatment sensitivity Cell membrane fluidity

Self-powered Flexible Multicolor Electrochromic Devices for Information Displays

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Research 2024年第2期2023卷 529-540页

作者： Wenzhao Xue Yun Zhang Feng Liu Yao Dou Mei Yan Wenshou Wang School of chemistry and Chemical Engineering University of JinanJinan 250022P.R.China

The development of self-powered flexible multicolor electrochromic(EC)systems that could switch different color without an external power supply has remained extremely ***,a new trilayer film structure for achieving self-powered flexible multicolor EC displays based on self-charging/discharging mechanism is proposed,which is simply assembled by sandwiching an ionic gel film between 2 cathodic nickel hexacyanoferrate(NiHCF)and prussian blue(pB)nanoparticle films on indium tin oxide *** display exhibits independent self-powered color switching of NiHCF and pB films with fast responsive time and high reversibility by selectively connecting the Al wire as anodes with the 2 EC *** switching is thus achieved through a color overlay effect by superimposing the 2 EC films,including green,blue,yellow,and *** bleaching/coloration process of the displays is driven by the discharging/self-charging mechanism for NiHCF and pB films,respectively,ensuring the self-powered color switching of the displays reversibly without an external power *** is further demonstrated that patterns can be easily created in the self-powered EC displays by the spray-coating method,allowing multicolor changing to convey specific ***,a self-powered ionic writing board is demonstrated based on the self-powered EC displays that can be repeatedly written freehand without the need of an external power *** believe that the design concept may provide new insights into the development of self-powered flexible multicolor EC displays with self-recovered energy for widespread applications.

关键词： connecting repeatedly powered

Chemically Mediated Interactions between grapevine, Aphid, Ladybird, and Ant in the Context of Insect Chemical Ecology

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phyton-International Journal of Experimental Botany 2024年第7期93卷 1523-1542页

作者： Taghreed Alsufyani Noura J.Alotaibi Nour Houda M’sakni Mona A.Almalki Eman M.Alghamdi department of chemistry College of ScienceTaif UniversityP.O.Box 11099Taif21944Saudi Arabia department of Biology College of ScienceTaif UniversityP.O.Box 11099Taif21944Saudi Arabia chemistry department Faculty of ScienceKing AbdulAziz UniversityP.O.Box 80200Jeddah21589Saudi Arabia

This study simpliﬁes the complex relationship among grapevine plants,aphids,ladybirds,and ants,which is essential for effective pest management and ecological *** study investigated the impact of aphid attacks and the presence of ants and ladybirds on the volatile compounds proﬁle released into the chemosphere of the community consisting of the common vine Vitis vinifera,the aphid Aphis illinoisensis,the ladybird Cocci-nella undecimpunctata-and the ant Tapinoma *** study aims to analyze the volatile compounds emitted by the grapevine and surrounding insects in response to these intricate *** extraction of volatile organic compounds(VOCs)was carried out using closed-loop stripping(CLS)and then analyzed via gas chromatography-mass spectrometry(gC-MS)and principles coordinated analysis(pCA)was *** grapevine was exposed to different types and order of treatments,including non-infested,aphid-infested,aphid-infested with ant,aphid-infested with ladybird,and various combinations of ant and *** the aphid attack,the outcomes uncovered massive alterations in the volatile compound proﬁ*** grapevine displayed distinct emissions of germacrene D,an alcohol,and an alkene compared to non-infested *** characteristic VOC proﬁle was the share of infested grapes in the presence of ants,with benzene derivatives and sesquiterpenes dominating the *** coexistence of ladybirds with ants and aphids resulted in a dif-ferent volatile proﬁle characterized by elevated levels of aldehydes,ketones,α-farnesene,and its hydroxy *** was concluded that the emission of VOCs into the chemosphere of the grapevine communities varied qualitatively and quantitatively depending on the level of the relationship complexity within each community in response to the infestation of grapevines by aphids,the presence of ladybirds as natural predators,and the presence of ant as *** grapevine’s status-dependent compounds

关键词： Aphids Aphis illinoisensis volatile organic compounds chemosphere pest management gas chromatography-mass spectrometry closed-loop stripping