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Microfluidic Generation of Multicomponent Soft Biomaterials

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Engineering 2022年第6期8卷 128-143页

作者： Yuetong Wang Luoran Shang Yuanjin Zhao Lingyun Sun Department of Rheumatology and Immunology Nanjing Drum Tower Hospital&School of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210096China School of Food Science and Pharmaceutical Engineering Nanjing Normal UniversityNanjing 210046China Shanghai Xuhui Central Hospital&Zhongshan-Xuhui Hospital&Shanghai Key laboratory of Medical Epigenetics&International Co-laboratory of Medical Epigenetics and Metabolism of Ministry of Science and Technology Institutes of Biomedical SciencesFudan UniversityShanghai 200032China oujiang laboratory(Zhejiang Lab for Regenerative Medicine Vision and Brain Health)&Wenzhou InstituteUniversity of Chinese Academy of SciencesWenzhou 325001China

Soft biomaterials hold great potential for a plethora of biomedical applications because of their deforma-bility,biodegradability,biocompatibility,high bioactivity,and low *** soft bio-materials are particularly attractive as a way of accommodating components made of different materials and generating combinative *** technology has emerged as an outstanding tool in generating multicomponent materials with elaborate structures and constituents,in that it can manipu-late multiphasic flows precisely on the micron *** recent decades,much progress has been achieved in the microfluidic fabrication of multicomponent soft biomaterials with finely defined physicochemical properties capable of controllable therapeutics delivery,three-dimensional(3D)cell culture,flexible devices and wearable electronics,and biosensing for *** the paper,we summarize current pro-gress in multicomponent soft biomaterials derived from microfluidics and emphasize their applications in biomedical *** also provide an outlook of the remaining challenges and future trends in this field.

关键词： Soft biomaterial Microfluidics Multicomponent Microparticle Microfiber

Bio-inspired dual-adhesive particles from microfluidic electrospray for bone regeneration

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Nano Research 2023年第4期16卷 5292-5299页

作者： Lei Yang Xiaocheng Wang Yunru Yu Luoran Shang Wei Xu Yuanjin Zhao Department of Rheumatology and Immunology Nanjing Drum Tower HospitalSchool of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210096China oujiang laboratory(Zhejiang Lab for Regenerative Medicine Vision and Brain Health)Wenzhou InstituteUniversity of Chinese Academy of SciencesWenzhou 325001China Shanghai Xuhui Central Hospital Zhongshan-Xuhui Hospitaland the Shanghai Key Laboratory of Medical Epigeneticsthe International Colaboratory of Medical Epigenetics and Metabolism(Ministry of Science and Technology)Institutes of Biomedical SciencesFudan UniversityShanghai 200032China Department of Orthopedics Tongren HospitalShanghai Jiao Tong University School of MedicineShanghai 200336China

Bioadhesive hydrogels have demonstrated great potential in bone ***,the relatively simple adhesion mechanism and lack of intricate structural design restrict their further ***,inspired by multiple adhesion mechanisms of pollen particles and marine mussels,we present a novel type of dual-adhesive hydrogel particles fabricated from microfluidic electrospray for bone *** the particles are rapidly solidified via liquid nitrogen-assisted cryogelation,they exhibit pollen-mimicking hierarchical porous morphology and gain structure-related ***,the particles are further coated by polydopamine(PDA)to achieve molecular-level adhesion especially to physiological wet surfaces of bone *** from such dual-adhesion mechanisms,the particles can strongly adhere to bone tissue defects,and function as porous ***,the dual-adhesive particles can serve as effective vehicles to release key growth factors more than two *** vitro experiments showed that the growth factors-loaden particles have excellent biocompatibility and more significantly promote angiogenesis(~2-fold)and osteogenic differentiation(~3-fold)than *** vivo experiments indicated that the dual-adhesive particles could significantly enhance bone regeneration(~4-fold)than control by coupling osteogenesis and angiogenesis *** on these features,the bio-inspired dual-adhesive particles have great potentials for bone repair and wound healing applications.

关键词： microfluidics particles growth factors adhesion bone regeneration

Solid-to-molecular-orientational-hexatic melting induced by local environment determined defect proliferations

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Chinese Physics B 2022年第12期31卷 396-403页

作者： Zhanglin Hou Jieli Wang Ying Zeng Zhiyuan Zhao Xing Huang Kun Zhao Fangfu Ye Wenzhou Institute University of Chinese Academy of SciencesWenzhou 325001China Key laboratory of Systems Bioengineering(Ministry of Education) School of Chemical Engineering and TechnologyTianjin UniversityTianjin 300072China School of Physical Science University of Chinese Academy of SciencesBeijing 100049China Research Center of Computational Physics School of Mathematics and PhysicsMianyang Teachers’CollegeMianyang 621000China Sichuan Provincial People’s Hospital University of Electronic Science and Technology of ChinaChengdu 610054China Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of ChinaChengdu 610054China Beijing National laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China Songshan Lake Materials laboratory Dongguan 523808China oujiang laboratory(Zhejiang laboratory for Regenerative Medicine Vision and Brain Health)Wenzhou 325001China

Two-dimensional(2D)melting is a fundamental research topic in condensed matter physics,which can also provide guidance on fabricating new functional ***,our understanding of 2D melting is still far from being complete due to existence of possible complicate transition mechanisms and absence of effective analysis ***,using Monte Carlo simulations,we investigate 2D melting of 60°rhombs which melt from two different surface-fullycoverable crystals,a complex hexagonal crystal(cHX)whose primitive cell contains three rhombs,and a simple rhombic crystal(RB)whose primitive cell contains one *** melting of both crystals shows a sequence of solid,hexatic in molecular orientation(Hmo),and isotropic phases which obey the Berezinskii-Kosterlitz-Thouless-Halperin-Nelson-Young(BKTHNY)***,local polymorphic configuration(LPC)based analysis reveals different melting mechanisms:the cHX-Hmotransition is driven by the proliferation of point-like defects during which defect-associated LPCs are generated sequentially,whereas the RB-Hmotransition is driven by line defects where defect-associated LPCs are generated *** differences result in the observed different solid-Hmotransition points which areφA=0.812 for the cHX-HmoandφA=0.828 for the *** work will shed light on the initial-crystal-dependence of 2D melting behavior.

关键词： two-dimensional melting phase transition molecular-orientational forming liquid crystal local environment melting mechanism

Adaptive Cache Allocation with Prefetching Policy over End-to-End Data Processing

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Journal of Signal and Information Processing 2017年第3期8卷 152-160页

作者： Hang Qin Li Zhu Computer School Yangtze University Jingzhou China oujiang College Wenzhou University Chashan University Wenzhou China

With the speed gap between storage system access and processor computing, end-to-end data processing has become a bottleneck to improve the total performance of computer systems over the Internet. Based on the analysis of data processing behavior, an adaptive cache organization scheme is proposed with fast address calculation. This scheme can make full use of the characteristics of stack space data access, adopt fast address calculation strategy, and reduce the hit time of stack access. Adaptively, the stack cache can be turned off from beginning to end, when a stack overflow occurs to avoid the effect of stack switching on processor performance. Also, through the instruction cache and the failure behavior for the data cache, a prefetching policy is developed, which is combined with the data capture of the failover queue state. Finally, the proposed method can maintain the order of instruction and data access, which facilitates the extraction of prefetching in the end-to-end data processing.

关键词： End-to-End Data Processing Storage System Cache Prefetching

Bioinspired porous microspheres for sustained hypoxic exosomes release and vascularized bone regeneration

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Bioactive Materials 2022年第8期7卷 377-388页

作者： Yike Gao Zuoying Yuan Xiaojing Yuan Zhuo Wan Yingjie Yu Qi Zhan Yuming Zhao Jianmin Han Jianyong Huang Chunyang Xiong Qing Cai Department of Pediatric Dentistry Peking University School and Hospital of StomatologyNational Center of StomatologyNational Clinical Research Center for Oral DiseasesNational Engineering Laboratory for Digital and Material Technology of StomatologyBeijing100081China Department of Mechanics and Engineering Science College of EngineeringPeking UniversityBeijing100871China State Key laboratory of Organic-Inorganic Composites Beijing Laboratory of Biomedical MaterialsBeijing University of Chemical TechnologyBeijing100029China Tianjin Key laboratory of Composite and Functional Materials School of Materials Science and EngineeringTianjin UniversityTianjin300072China Dental Medical Devices Testing Center Dental Materials LaboratoryPeking University School and Hospital of StomatologyBeijing100081China Wenzhou Institute University of Chinese Academy of SciencesOujiang LaboratoryWenzhouZhejiang325000China

Exosomes derived from mesenchymal stem cells(MSCs)have demonstrated regenerative potential for cell-free bone tissue engineering,nevertheless,certain challenges,including the confined therapeutic potency of exosomes and ineffective delivery method,are still ***,we confirmed that hypoxic precondition could induce enhanced secretion of exosomes from stem cells from human exfoliated deciduous teeth(SHEDs)via comprehensive proteomics analysis,and the corresponding hypoxic exosomes(H-Exo)exhibited superior potential in promoting cellular angiogenesis and osteogenesis via the significant up-regulation in focal adhesion,VEGF signaling pathway,and thyroid hormone ***,we developed a platform technology enabling the effective delivery of hypoxic exosomes with sustained release kinetics to irregular-shaped bone defects via *** platform is based on a simple adsorbing technique,where exosomes are adsorbed onto the surface of injectable porous poly(lactide-co-glycolide)(PLGA)microspheres with bioinspired polydopamine(PDA)coating(PMS-PDA microspheres).The PMS-PDA microspheres could effectively adsorb exosomes,show sustained release of H-Exo for 21 days with high bioactivity,and induce vascularized bone regeneration in 5-mm rat calvarial *** findings indicate that the hypoxic precondition and PMS-PDA porous microsphere-based exosome delivery are efficient in inducing tissue regeneration,hence facilitating the clinical translation of exosome-based therapy.

关键词： Hypoxic exosomes Stem cells from human exfoliated deciduous teeth Porous microsphere Sustained release Vascularized bone regeneration

Mechanical stretching boosts expansion and regeneration of intestinal organoids through fueling stem cell self-renewal

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Cell Regeneration 2022年第1期11卷 399-412页

作者： Fanlu Meng Congcong Shen Li Yang Chao Ni Jianyong Huang Kaijun Lin Zanxia Cao Shicai Xu Wanling Cui Xiaoxin Wang Bailing Zhou Chunyang Xiong Jihua Wang Bing Zhao Shandong Key laboratory of Biophysics Institute of BiophysicsDezhou UniversityDezhou 253023China Department of Mechanics and Engineering Science College of EngineeringPeking UniversityBeijing 100871China State Key laboratory of Genetic Engineering School of Life SciencesZhongshan HospitalFudan UniversityShanghai 200438China Beijing Innovation Center for Engineering Science and Advanced Technology College of EngineeringPeking UniversityBeijing 100871China Wenzhou Institute University of Chinese Academy of SciencesOujiang LaboratoryWenzhou 325000ZhejiangChina

Intestinal organoids,derived from intestinal stem cell self-organization,recapitulate the tissue structures and behav-iors of the intestinal epithelium,which hold great potential for the study of developmental biology,disease modeling,and regenerative *** intestinal epithelium is exposed to dynamic mechanical forces which exert profound effects on gut ***,the conventional intestinal organoid culture system neglects the key role of mechanical microenvironments but relies solely on biological ***,we show that adding cyclic stretch to intestinal organoid cultures remarkably up-regulates the signature gene expression and proliferation of intestinal stem ***,mechanical stretching stimulates the expansion of SOX9+progenitors by activating the Wnt/β-Catenin *** data demonstrate that the incorporation of mechanical stretch boosts the stemness of intestinal stem cells,thus benefiting organoid *** findings have provided a way to optimize an organoid generation system through understanding cross-talk between biological and mechanical factors,paving the way for the application of mechanical forces in organoid-based models.

关键词： Mechanical stretching Intestinal organoid Lgr5+stem cell Regeneration Wnt/β-catenin signaling

Microtubes with gradient decellularized porcine sciatic nerve matrix from microfluidics for sciatic nerve regeneration

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Bioactive Materials 2023年第3期21卷 511-519页

作者： Binghui Jin Yunru Yu Xiangxiang Chen Yanhong Yang Yushan Xiong Young Jun Im Yuanjin Zhao Jian Xiao oujiang laboratory(Zhejiang Lab for Regenerative Medicine Vision and Brain Health)School of Pharmaceutical SciencesWenzhou Medical UniversityWenzhouZhejiang Province325035China Department of Rheumatology and Immunology Nanjing Drum Tower HospitalSchool of Biological Science and Medical EngineeringSoutheast UniversityNanjing210096China College of Pharmacy Chonnam National UniversityGwangju61186Republic of Korea Wenzhou Institute University of Chinese Academy of SciencesWenzhouZhejiang325001China

Long-range peripheral nerve defect is a severe and worldwide *** the increasing development of tissue engineering,the excellent ability of nerve extracellular matrix(ECM)in peripheral nerve injury(PNI)has been widely studied and ***,we present a novel microtube that contains gradient decellularized porcine sciatic nerve ECM hydrogel(pDScNM-gel)from microfluidics for sciatic nerve *** pDScNM is confirmed to enhance cell proliferation and migration,and improve the axon growth of primary dorsal root ganglions(DRGs)in a concentration-related *** behaviors were also achieved when cells were co-cultured in a gradient pDScNM *** in vivo sciatic nerve regeneration and functional recovery were also demonstrated by assembling the gradient pDScNM microtubes with a medical silicon *** results indicated that the microtubes with gradient pDScNM could act as a promising alternative for repairing peripheral nerve defects and showed great potential in clinical use.

关键词： Microfiber Peripheral nerve injury Extracellular matrix Microfluidics Nerve regeneration

Ellipsoidal porous patch with anisotropic cell inducing ability for inhibiting skin scar formation

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Engineered Regeneration 2022年第3期3卷 262-269页

作者： Wanqing Weng Junjie Chi Xiaocheng Wang Keqing Shi Fangfu Ye Yuanjin Zhao Joint Center of Translational Medicine The First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325035China Department of Clinical laboratory Nanjing Drum Tower HospitalSchool of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210096China oujiang laboratory(Zhejiang Lab for Regenerative Medicine Vision and Brain Health)Wenzhou InstituteUniversity of Chinese Academy of SciencesWenzhou 325001China Key laboratory of Intelligent Treatment and Life Support for Critical Diseases of Zhejiang Provincial Zhejiang Engineering Research Center for Hospital Emergency and Process DigitizationWenzhouZhejiang 325000China Beijing National laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China

Scar formation has always been a difficult point to overcome in the field of clinical wound ***,we present an ellipsoidal porous patch with cell inducing ability for inhibiting scar *** patch was prepared by stretching a poly(lactic-co-glycolic acid)(PLGA)inverse opal film at the glass transition temperature to form a neatly arranged three-dimensional ellipsoidal porous *** anisotropic structure showed dramatic capability in directing cell growth and arrangement by reconstructing cell ***,the prolifera-tion of cells growing on the stretched patch was significantly suppressed without cell *** addition,benefitting from the abundant and connected nanopores,the patch could be imparted with a potent ability to promote cell migration by encapsulating fibroblast growth factor 2(FGF2)via the second filling of functional gelatin methacryloyl(GelMA)hydrogel into its *** a typical scar model,we have demonstrated that the resultant patch performed well in inhibiting scar formation characterized by inhibiting the excessive proliferation of fibroblasts,decreasing the deposition of type I collagen,reducing the scar index and achieved complete tissue *** results indicate the anisotropic inverse opal patch has an excellent application prospect in inhibiting scar formation during wound repair.

关键词： Inverse opal Biomaterial Porous film Hypertrophic scar Anisotropy

A Rapid Trace Analysis of GBS using the Specific Spectral Absorption of Chromogenic Culture Media

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Biomedical and Environmental Sciences 2023年第7期36卷 649-652页

作者： CHEN Yang ZHANG Yan Yan SHU Yao Gen Engineering Research Center of Clinical Functional Materials and Diagnosis and Treatment Devices of Zhejiang Province Wenzhou InstituteUniversity of Chinese Academy of SciencesWenzhou 325000ZhejiangChina Biomedical Engineering Wenzhou Medical UniversityWenzhou 325035ZhejiangChina College of Chemical Engineering Fuzhou UniversityFuzhou 350108FujianChina Research Center of Quantitative Detection Technology NMPA Key Laboratory for Quality Monitoring and Evaluation of Vaccines and Biological ProductsWenzhou 325000ZhejiangChina oujiang laboratory(Zhejiang Lab for Regenerative Medicine Vision and Brain Health)Wenzhou 325024ZhejiangChina

Group B streptococcus(GBS)is a Gram-positive,encapsulated bacterium that belongs to the group of pyogenic streptococci,and it is an asymptomatic colonizer of the digestive and genitourinary tracts of healthy human ***,it can cause severe invasive infections in neonates and immunocompromised *** the 1960s,GBS was identified as a leading cause of life-threatening neonatal infections[1,2].

关键词： urinary GBS neonatal