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Chinese Journal of Integrative Medicine 2024年第4期30卷 379-384页

作者： XIN Li TAN Guo-yao ZHANG Qiang ZHANG Qun Good Clinical Practice Development Guangdong Provincial Key Laboratory of Bone and Joint Degeneration DiseasesThe Third Affiliated Hospital of Southern Medical UniversityGuangzhou(510630)China Department of Pharmacy Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou(510120)China

Phellodendron(PN)species,traditionally used in Chinese medicine for centuries,hold promise as a potential treatment for osteoporosis(OP)and osteoarthritis(OA)due to their bioactive *** bioactive compounds,including berberine and palmatine,exhibit anti-inflammatory,antioxidant,and bone-protective properties,contributing to their potential therapeutic benefits in promoting bone health and preventing bone ***,challenges such as the need for standardized preparation and dosing,limited clinical studies,and potential interactions with other medications hinder their clinical ***,the rich history of PN species in Chinese medicine provides a promising foundation for future investigation into their potential as alternative treatments for OP and *** research is needed to fully understand the underlying mechanisms of action and explore the clinical implications of PN for bone health.

关键词： Phellodendron species bone health osteoporosis osteoarthritis review

Unveiling the role of hypoxia-inducible factor 2alpha in osteoporosis:Implications for bone health

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World Journal of Stem Cells 2024年第4期16卷 389-409页

作者： Ling-Ling Wang Zhan-Jin Lu Shun-Kui Luo Yun Li Zhe Yang Hong-Yun Lu Department of Gerontology The Fifth Affiliated Hospital of Sun Yat-sen UniversityZhuhai 519000Guangdong ProvinceChina Department of Endocrinology and metabolism The Fifth Affiliated Hospital of Sun Yat-sen UniversityZhuhai 519000Guangdong ProvinceChina Guangdong Provincial Key Laboratory of Biomedical Imaging The Fifth Affiliated Hospital of Sun Yat-sen UniversityZhuhai 519000Guangdong ProvinceChina Department of Endocrinology and metabolism Zhuhai People’s Hospital(Zhuhai Clinical Medical College of Jinan Universitythe First Hospital Affiliated with Medical College of Macao University of Science and Technology)Zhuhai 519000Guangdong ProvinceChina

BACKGROUND osteoporosis(OP)has become a major public health problem *** OP treatments are based on the inhibition of bone resorption,and it is necessary to identify additional treatments aimed at enhancing *** the bone marrow(BM)niche,bone mesenchymal stem cells(BMSCs)are exposed to a hypoxic ***,a few studies have demonstrated that hypoxiainducible factor 2alpha(HIF-2α)is involved in BMSC osteogenic differentiation,but the molecular mechanism involved has not been *** To investigate the effect of HIF-2αon the osteogenic and adipogenic differentiation of BMSCs and the hematopoietic function of hematopoietic stem cells(HSCs)in the BM niche on the progression of *** Mice with BMSC-specific HIF-2αknockout(Prx1-Cre;Hif-2αfl/fl mice)were used for in vivo *** quantification was performed on mice of two genotypes with three interventions:Bilateral ovariectomy,semilethal irradiation,and dexamethasone ***,the hematopoietic function of HSCs in the BM niche was compared between the two mouse *** vitro,the HIF-2αagonist roxadustat and the HIF-2αinhibitor PT2399 were used to investigate the function of HIF-2αin BMSC osteogenic and adipogenic ***,we investigated the effect of HIF-2αon BMSCs via treatment with the mechanistic target of rapamycin(mTOR)agonist MHY1485 and the mTOR inhibitor *** The quantitative index determined by microcomputed tomography indicated that the femoral bone density of Prx1-Cre;Hif-2αfl/fl mice was lower than that of Hif-2αfl/fl mice under the three intervention *** vitro,Hif-2αfl/fl mouse BMSCs were cultured and treated with the HIF-2αagonist roxadustat,and after 7 d of BMSC adipogenic differentiation,the oil red O staining intensity and mRNA expression levels of adipogenesis-related genes in BMSCs treated with roxadustat were decreased;in addition,after 14 d of osteogenic differentiation,BMSCs treated with roxadusta

关键词： Hypoxia-inducible factor-2α bone marrow niche bone mesenchymal stem cells osteoporosis Osteogenic/adipogenic differentiation Mechanistic target of rapamycin signaling pathway

bone remodeling:an operational process ensuring survival and bone mechanical competence

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bone Research 2022年第3期10卷 421-439页

作者： Simona Bolamperti Isabella Villa Alessandro Rubinacci osteoporosis and bone and mineral metabolism unit IRCCS San Raffaele HospitalVia Olgettina 6020132 MilanoItaly

bone remodeling replaces old and damaged bone with new bone through a sequence of cellular events occurring on the same surface without any change in bone shape. It was initially thought that the basic multicellular unit(BMU) responsible for bone remodeling consists of osteoclasts and osteoblasts functioning through a hierarchical sequence of events organized into distinct stages. However, recent discoveries have indicated that all bone cells participate in BMU formation by interacting both simultaneously and at different differentiation stages with their progenitors, other cells, and bone matrix constituents. Therefore,bone remodeling is currently considered a physiological outcome of continuous cellular operational processes optimized to confer a survival advantage. bone remodeling defines the primary activities that BMUs need to perform to renew successfully bone structural units. Hence, this review summarizes the current understanding of bone remodeling and future research directions with the aim of providing a clinically relevant biological background with which to identify targets for therapeutic strategies in osteoporosis.

关键词： remodeling replace initially

Effects of raloxifene hydrochloride on bone mineral density, bone metabolism and serum lipids in Chinese postmenopausal women with osteoporosis: a multi-center, randomized, placebo-controlled clinical trial

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Chinese Medical Journal 2004年第7期117卷 1029-1035页

作者：刘建立朱汉民黄琪仁张忠兰李慧林秦跃娟张颖魏道林陆敬辉刘慧陈小平刘玉娟 Abie Ekangaki 郑以漫 Adolfo Diez-Perez Kristine Harper Department of Obstetrics and Gynaecology Department of Gerontology Center for Preventing and Treating osteoporosis Eli Lilly and Company

Background Raloxifene has been approved for prevention and treatment of postmenopausal osteoporosis in Caucasian women. It also has some positive effects on serum lipids in Caucasians. The objective of this study was to determine the effect of raloxifene hydrochloride on lumbar spine and total hip bone mineral density (BMD), bone metabolism, and serum lipids in Chinese postmenopausal women with *** This was a multi-center, randomized, double-blind, placebo-controlled clinical trial in which 204 postmenopausal Chinese women with osteoporosis were assigned to receive raloxifene (60 mg) or placebo treatment daily for 12 months. BMD, serum bone metabolism markers, and serum lipids were measured before and after drug administration. BMD was measured by Dual-Energy X-Ray Absorptiometry (DEXA) and bone metabolism markers were analyzed by one-step enzyme-linked immunosorbent assay. Serum lipids were measured by enzymatic *** At the end of the 12-month study, lumbar spine BMD increased in both groups with a mean increase of (3.3±4.8) % in the raloxifene group and (1.0±4.9) % in the placebo group (P0.05). In the raloxifene group, the median decreases in the biochemical markers of bone metabolism serum osteocalcin and C-telopeptide were 41.7% and 61.5%, respectively. These changes were statistically significant compared with those in the placebo group (10.6% and 35.6%, P<0.001, respectively). Both total cholesterol and low-density lipoprotein cholesterol decreased significantly in the raloxifene group compared with those in the placebo group (P<0.001, respectively) and there was no significant effect of raloxifene on high-density lipoprotein cholesterol and triglycerides compared

关键词： raloxifene · bone density · bone metabolism markers · osteoporosis postmenopausal

Hepatocellular carcinoma and musculoskeletal system: A narrative literature review

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World Journal of Gastroenterology 2024年第15期30卷 2109-2117页

作者： Jelena Jadzic Danijela Djonic Center of bone Biology Faculty of MedicineUniversity of BelgradeBelgrade 11000Serbia

Musculoskeletal alterations in hepatocellular carcinoma(HCC)are less common than liver-related ***,they can significantly impact the quality of life and overall prognosis of patients with *** main obstacle in the clinical assessment of HCC-induced musculoskeletal alterations is related to effective and timely diagnosis because these complications are often asym-ptomatic and unapparent during routine clinical *** narrative literature review aimed to provide a comprehensive overview of the contem-porary literature related to the changes in the musculoskeletal system in patients with HCC,focusing on its clinical implications and underlying etiopathogenetic *** bone metastases are the most common skeletal alterations associated with HCC,which could be associated with an increased risk of low-trauma bone ***,previous studies reported that osteopenia,sarcopenia,and myosteatosis are associated with poor clinical outcomes in patients with *** though low bone mineral density and sarcopenia are consistently reported as reliable predictors of pretransplantation and post-transplantation mortality in HCC patients,these complications are frequently overlooked in the clinical management of patients with *** together,contemporary literature suggests that a multidisciplinary approach is essential for early recognition and clinical management of HCC-associated musculoskeletal alterations to improve patient *** research into the mechanisms and treatment options for musculoskeletal complications is warranted to enhance our understanding and clinical management of this aspect of HCC.

关键词： Hepatocellular carcinoma Osteopenia osteoporosis Sarcopenia bone metastases bone fragility

Rhizoma Drynariae-derived nanovesicles reverse osteoporosis by potentiating osteogenic differentiation of human bone marrow mesenchymal stem cells via targeting ERα signaling

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Acta Pharmaceutica Sinica B 2024年第5期14卷 2210-2227页

作者： Qing Zhao Junjie Feng Fubin Liu Qianxin Liang Manlin Xie Jiaming Dong Yanfang Zou Jiali Ye Guilong Liu Yue Cao Zhaodi Guo Hongzhi Qiao Lei Zheng Kewei Zhao Guangzhou Key Laboratory of Chinese Medicine Research on Prevention and Treatment of osteoporosis the Third Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510378China Guangdong Engineering Research Center of Chinese Herbal-derived Vesicles Guangzhou University of Chinese MedicineGuangzhou 510006China Department of Laboratory Medicine Nanfang HospitalSouthern Medical UniversityGuangzhou 510515China Guangdong Engineering and Technology Research Center for Rapid Diagnostic Biosensors Nanfang HospitalSouthern Medical UniversityGuangzhou 510515China The Fifth Affiliated Hospital Sun Yat-sen University Zhuhai 519000China Department of Blood Transfusion Guangdong Heyou International HospitalFoshan 528306China School of Pharmacy Nanjing University of Chinese MedicineNanjing 210023China

Although various anti-osteoporosis drugs are available,the limitations of these therapies,including drug resistance and collateral responses,require the development of novel anti-osteoporosis *** Drynariae displays a promising anti-osteoporosis effect,while the effective component and mechanism remain ***,we revealed the therapeutic potential of Rhizoma Drynariae-derived nanovesicles(RDNVs)for postmenopausal osteoporosis and demonstrated that RDNVs potentiated osteogenic differentiation of human bone marrow mesenchymal stem cells(hBMSCs)by targeting estrogen receptor-alpha(ERα).RDNVs,a natural product isolated from fresh Rhizoma Drynariae root juice by differential ultracentrifugation,exhibited potent bone tissue-targeting activity and anti-osteoporosis efficacy in an ovariectomized mouse ***,effectively internalized by hBMSCs,enhanced proliferation and ERαexpression levels of hBMSC,and promoted osteogenic differentiation and bone ***,via the ERαsignaling pathway,RDNVs facilitated mRNA and protein expression of bone morphogenetic protein 2 and runt-related transcription factor 2 in hBMSCs,which are involved in regulating osteogenic *** analysis revealed that naringin,existing in RDNVs,was the active component targeting ERαin the osteogenic *** together,our study identified that naringin in RDNVs displays exciting bone tissue-targeting activity to reverse osteoporosis by promoting hBMSCs proliferation and osteogenic differentiation through estrogen-like effects.

关键词： Rhizoma Drynariae-derived nanovesicles bone marrow mesenchymal stem cells bone targeting Osteogenic differentiation ERαsignaling Naringin bone morphogenetic protein 2 Runt-related transcription factor 2

Hemiarthroplasty for irreparable distal radius fractures in the elderly:A comprehensive review

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World Journal of Orthopedics 2024年第6期15卷 578-584页

作者： Adriano Cannella Ludovico Caruso Giulia Maria Sassara Giuseppe Taccardo Marco Passiatore Marina Marescalchi Rocco De Vitis Department of Orthopaedics Fondazione Policlinico Universitario A Gemelli IRCCSRome 00168Italy Department of bone and Joint Surgery ASST-Spedali CiviliBrescia 25123Italy

BACKGROUND Elderly patients maintaining functional independence can now be candidates for primary wrist hemiarthroplasty to manage acute irreparable distal radius fractures(DRFs).However,further investigation with long-term follow-up is required to validate these initial *** To review the literature on the outcomes of distal radius hemiarthroplasty with available implants to assess its viability as a treatment *** A comprehensive review of the literature was conducted using electronic databases,including PubMed,Medline,and *** search terms employed were"distal radius fracture","hemiarthroplasty","wrist arthroplasty",and related *** search was restricted to articles published in English from 1980 until June *** criteria encompassed cases or case series of DRF treated with hemiarthroplasty,providing clinical or radiographic outcomes,and published in peer-reviewed *** A total of 2508 articles from PubMed and 883 from Scopus were identified *** screening and removal of duplicates,13 articles met the inclusion *** articles,predominantly clinical retrospective studies,provided insights into hemiarthroplasty outcomes,including functional improvements and *** was a treatment option for complex DRF,particularly those cases with severe comminution,intraarticular involvement,or severe *** outcomes demonstrated improvements in pain relief,wrist mobility,and grip strength,with variability across *** included implant loosening,infection,nerve injury,and stiffness,with varying incidence rates influenced by surgical techniques and implant ***-term outcomes were inadequately documented,warranting further *** Hemiarthroplasty is a promising treatment for irreparable DRF in the ***-term outcomes and complications require further study.

关键词： Irreparable distal radius fracture Hemiarthroplasty osteoporosis Wrist prosthesis Elderly

Association of estrogen receptor-alpha and vitamin D receptor genotypes with therapeutic response to calcium in postmenopausal Chinese women

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Acta Pharmacologica Sinica 2004年第12期25卷 124-131页

作者： Zhen-lin ZHANG1, Yue-juan QIN, Qi-ren HUANG, Jin-wei HE, Miao LI, Qi ZHOU, Yun-qiu HU, Yu-juan LIU Center for Preventing and Treating osteoporosis, osteoporosis Research unit, TheSixth People’sHospital, ShanghaiJiaotong University, Shanghai 200233, China Center for Preventing and Treating osteoporosis Osteoporosis Research Unit The Sixth People's Hospital Shanghai Jiaotong University 上海 200233

AIM: To investigate the correlation between calcium treatment in postmenopausal women and estrogen receptor- alpha (ER-alpha) Xba I and Pvu II genotype and vitamin D receptor (VDR) Apa I genotype. METHODS: One hundred fifteen postmenopausal Chinese women of Han population were enrolled and treated with calcichew-D3 (1000 mg calcium and 400 U vitamin D3) daily for 1 year. At entry and after 1 year treatment, the bone mineral density (BMD), serum and urinary bone turnover biochemical markers were evaluated. ER-alpha and VDR geno- type were analyzed using PCR-restriction fragment length polymorphism. RESULTS: After 1 year of calcium supplementation, a significant increase of BMD and a marked reduction in serum ALP and PTH levels, and a significant increase of serum 25-(OH) vitamin D level were observed (Pbone turnover marker levels. However, the percentage of change (median, QR) in Neck BMD was significantly different in homozygous XX [-4.14 (from -6.54 to -1.34)] in comparison with Xx [1.72 (from -1.12 to 3.20)] (Pbone mass loss in femoral neck after menopause and that they may have a poor responsiveness to calcium supplementation. The changes in BMD are not associated with ER-alpha Pvu II genotype and VDR Apa I genotype after 1 year of calcium supplementation.

关键词： bone density estrogen receptors calcitriol receptors polymorphism (genetics)

Association of vitamin D receptor and estrogen receptor-αgene polymorphism with peak bone mass and bone size in Chinese women

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Acta Pharmacologica Sinica 2004年第4期25卷 64-70页

作者： Yue-juan QIN1, Zhen-lin ZHANG, Qi-ren HUANG, Jin-wei HE, Yun-qiu HU, Qi ZHOU, Jing-hui LU, Miao LI, Yu-juan LIU Center for Preventing and Treating osteoporosis, osteoporosis Research unit, Shanghai JiaoTong UniversityAffiliated Sixth People’s Hospital, Shanghai 200233, China Center for Preventing and Treating osteoporosis Osteoporosis Research Unit Shanghai JiaoTong University Affiliated Sixth People's Hospital 上海 200233

AIM: To investigate if vitamin D receptor (VDR) gene Apa I polymorphism and estrogen receptor-α (ER-α) gene Pvu II, Xba I polymorphisms are related to bone mineral density (BMD), bone mineral content (BMC) and bone size in premenopausal Chinese women. METHODS: The VDR Apa I genotype and ER-α Pvu II, Xba I genotype were determined by PCR-restriction fragment length polymorphism (RFLP) in 493 unrelated healthy women aged 20-40 years of Han nationality in Shanghai city. BMD (g/cm2), BMC (g), and bone areal size (BAS, cm2) at lumbar spine 1-4 (L1-4) and proximal femur (femoral neck, trochanter and Ward’s triangle) were measured by duel-energy X-ray absorptionmetry. RESULTS: All allele frequencies did not deviate from Hardy-Weinberg equilibrium. After pheno- types were adjusted for age, height, and weight, a significant association was found between VDR Apa I genotype and BMC variation at L1-4and Ward’s triangle (Pbone mass in premenopausal Chinese women.

关键词： bone density bone remodeling calcitriol receptors estrogen receptors restriction fragment length polymorphism gene frequency genotype female

bone mineral density of the spine and femur in healthy Chinese men

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Asian Journal of Andrology 2006年第4期8卷 419-427,514页

作者： Zhang, ZL Qin, YJ Huang, QR Hu, YQ Li, M He, JW Zhang, H Liu, YJ Hu, WW Shanghai Jiao Tong Univ Ctr Preventing & Treating Osteoporosis Osteoporosis Res Unit Peoples Hosp 6 Shanghai 200233 Peoples R China

Aim:To establish bone mineral density(BMD)reference database in healthy Chinese men of Han ethnicity,and to estimate the prevalence of osteoporosis in the ***:The BMD in the lumbar spine 1-4(L1-4)and proximal femur was measured using dual energy X-ray absorptiometry in a total of 1385 healthy Chinese men of Han ethnicity aged 20-89 years old in ***:The highly significant negative correlation between age and BMD at any sites of proximal femur was found in the studied population,wheras no correlation between age and BMD at lumbar spine was *** peak BMD of the lumbar spine and any sites of hip in Chinese men was defined as the mean BMD for the subjects aged 20-39 *** to World Health Organization(WHO)criteria,the BMD cut-off values for osteoporosis of the L1-4,total hip,femoral neck,trochanter and intertrochanter in Chinese men are 0.719,0.638,0.575,0.437 and 0.725 g/cm^2,*** the current Chinese reference data,the prevalence of osteoporosis at the L1-4,total hip,femoral neck,trochanter and intertrochanter is 5.4%,3.8%,6.3%, 1.8% and 2.8% in 1084 men aged 50 years or older,***,using a database for US non-Hispanic white men(NHANES Ⅲ),the prevalence of osteoporosis or osteopenia at any sites of the hip was significantly higher than that while using the current Chinese reference ***:The BMD reference database was established in healthy Chinese men of Han ethnicity,and will facilitate more accurate diagnosis of osteoporosis in Chinese men. (Asian J Androl 2006 Jul;8:419-427)

关键词： bone mineral density men Chinese osteoporosis