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Bibliometric analysis of research on the effects of human immunodeficiency virus in orthopaedic and trauma surgery

World Journal of Orthopedics 2021年第3期12卷 169-177页

作者： Ciaran Brennan Maritz Laubscher Sithombo Maqungo Simon Matthew Graham orthopaedic Research Unit University of Cape TownCape Town 7925South Africa Division of orthopaedic surgery Groote Schuur HospitalCape Town 7925South Africa Institute of Population Health Sciences University of LiverpoolLiverpool L97ALUnited Kingdom Department of orthopaedic and trauma surgery Liverpool University Teaching Hospitals TrustLiverpool L97ALUnited Kingdom Department of Clinical Sciences Liverpool School of Tropical MedicineLiverpool L97ALUnited Kingdom

BACKGROUND There is little research investigating how human immunodeficiency virus(HIV)affects outcomes in orthopaedic *** advances in treatment,HIV has become a chronic health problem and the chance of orthopaedic surgeons encountering it in clinical practice is *** To ascertain the quantity and quality of peer-reviewed publications in orthopaedic journals about *** A search of the Web of Science database was carried out,identifying any articles relating to HIV published in orthopaedic *** were assessed for geographic origin and level of *** Of 48.7%of orthopaedic journals listed on the Web of Science database had published articles relating to *** were 168 articles about HIV in orthopaedic journals with only 40.5%(n=68)published in the time frame we analysed(January 2007 to September 2017).Very few articles came from lowincome countries and any articles published from that setting were *** of the articles were low level of *** There is a need for more high level orthopaedic and trauma research investigating the effects of HIV,particularly research from low-income countries,where higher level research will help to guide improvements in their treatment of its musculoskeletal manifestations and complications.

关键词： Human immunodeficiency virus Research Bibliometric analysis Analysis orthopaedic

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Use of three-dimensional printing in preoperative planning in orthopaedic trauma surgery: A systematic review and meta-analysis

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World Journal of Orthopedics 2020年第1期11卷 57-67页

作者： Catrin Morgan Chetan Khatri Sammy A Hanna Hutan Ashrafian Khaled M Sarraf trauma and orthopaedics Imperial College NHS TrustLondon W21NYUnited Kingdom The Royal London Hospital Barts Health NHS TrustLondon E11BBUnited Kingdom Department of surgery and Cancer Imperial College LondonLondon W21NYUnited Kingdom

BACKGROUND With the increasing complexity of surgical interventions performed in orthopaedic trauma surgery and the improving technologies used in threedimensional(3D)printing,there has been an increased interest in the *** has been shown that 3D models allow surgeons to better visualise anatomy,aid in planning and performing complex *** is however not clear how best to utilise the technique and whether this results in better *** To evaluate the effect of 3D printing used in pre-operative planning in orthopaedic trauma surgery on clinical *** We performed a comprehensive systematic review of the literature and a ***,Ovid and Embase were searched from inception to February 8,*** controlled trials,case-control studies,cohort studies and case series of five patients or more were included across any area of orthopaedic *** primary outcomes were operation time,intra-operative blood loss and fluoroscopy *** Seventeen studies(922 patients)met our inclusion criteria and were *** use of 3D printing across all specialties in orthopaedic trauma surgery demonstrated an overall reduction in operation time of 19.85%[95%confidence intervals(CI):(-22.99,-16.71)],intra-operative blood loss of 25.73%[95%CI:(-31.07,-20.40)],and number of times fluoroscopy was used by 23.80%[95%CI:(-38.49,-9.10)].CONCLUSION Our results suggest that the use of 3D printing in pre-operative planning in orthopaedic trauma reduces operative time,intraoperative blood loss and the number of times fluoroscopy is used.

关键词： orthopaedic surgery trauma Three-dimensional printing

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Adipose-derived regenerative therapies for the treatment of knee osteoarthritis

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World Journal of Stem Cells 2024年第4期16卷 324-333页

作者： Ilias E Epanomeritakis Wasim S Khan Division of trauma and orthopaedic surgery Addenbrooke’s HospitalCambridge University Hospitals NHS Foundation TrustCambridge CB20QQUnited Kingdom Division of trauma and orthopaedic surgery Department of SurgeryUniversity of CambridgeCambridge CB20QQUnited Kingdom

Knee osteoarthritis is a degenerative condition with a significant disease burden and no disease-modifying *** treatment ultimately requires joint *** capable of regenerating cartilage could significantly reduce financial and clinical *** regenerative potential of mesenchymal stromal cells(MSCs)has been extensively studied in the context of knee *** has yielded promising results in human studies,and is likely a product of immunomodulatory and chondroprotective biomolecules produced by MSCs in response to ***-derived MSCs(ASCs)are becoming increasingly popular owing to their relative ease of isolation and high proliferative *** vascular fraction(SVF)and micro-fragmented adipose tissue(MFAT)are produced by the enzymatic and mechanical disruption of adipose tissue,*** avoids expansion of isolated ASCs ex vivo and their composition of heterogeneous cell populations,including immune cells,may potentiate the reparative function of *** this editorial,we comment on a multicenter randomized trial regarding the efficacy of MFAT in treating knee *** discuss the study’s findings in the context of emerging evidence regarding adipose-derived regenerative *** underlying mechanism of action of ASCs is proposed while drawing important distinctions between the properties of isolated ASCs,SVF,and MFAT.

关键词： Knee osteoarthritis Mesenchymal stromal cells Adipose tissue Stromal vascular fraction Micro-fragmented adipose tissue Regeneration

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High dose of tranexamic acid infusion in primary total knee arthroplasty:A randomized multicenter clinical trail

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Chinese Medical Journal 2024年第3期137卷 359-361页

作者： Jinwei Xie Qiang Huang Zeyu Huang Fei Wang Jun Liu Hua Tian Wei Huang Fuxing Pei Department of orthopaedic surgery West China HospitalSichuan UniversityChengduSichuan 610041China Department of orthopaedic surgery The Third Hospital of Hebei Medical UniversityShijiazhuangHebei 050051China Department of orthopaedic surgery Tianjin HospitalTianjin 300211China Department of orthopaedic surgery Peking University Third HospitalHaidian DistrictBeijing 100191China Department of orthopaedic surgery The First Affiliated Hospital of Chongqing Medical UniversityYuzhong DistrictChongqing 400016China

To the Editor:Significant hyperfibrinolysis is always accompanied by surgical trauma and tourniquet use in total knee arthroplasty(TKA),leading to considerable hidden blood loss,inflammation,and pain,thereby impeding the recovery *** recovery after surgery(ERAS)has promoted the development of patient blood management in recent *** numerous methods of blood conservation,including tranexamic acid(TXA),a lysine analog competitive inhibitor of plasmin and plasminogen,have been studied.^([1–3])However,some issues remain controversial,such as the optimal TXA regimen in *** the other hand,the use of TXA in arthroplasty is considered off-label,although the current guideline or consensus suggests its routine use in arthroplasty.

关键词： arthroplasty infusion routine

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PFNA2 versus 95 Degree Condylar Blade Plate in the Management of Unstable Trochanteric Fractures

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Open Journal of Orthopedics 2024年第2期14卷 93-104页

作者： Piyush Gadegone Wasudeo Gadegone Vijayanand Lokhande Virender Kadian Department of orthopaedic Trauma and Orthopaedic Hospital Chandrapur India

Purpose: The proximal femoral nail anti-rotation (PFNA) is known to have advantages in enhancing the anchorage ability of internal fixation in elderly unstable osteoporotic intertrochanteric fracture patients. However whether it is superior to condylar blade fixation is not clear. This study aimed to determine which treatment has better clinical outcomes in older patients. Materials and Methods: A total of 86 patients over the age of 60 with unstable trochanteric fractures within the past 3 weeks, were included in this prospective study conducted from June 1, 2018, to May 31, 2021. All the intertrochanteric fractures were classified according to AO/OTA classification. Among them, 44 cases were treated with the Proximal Femoral Nail (PFNA2) with or without an augmentation screw, and 42 cases were treated with the Condylar Blade Plate. In addition, the operative time, intraoperative blood loss, intraoperative and postoperative blood transfusion, postoperative weight-bearing time, hospitalization time, Harris score of hip function, Kyle’s criteria and postoperative complications were compared between the two groups. Results: The mean duration of surgery for the PFN group was 66.8 minutes (on average), whereas for the condylar blade plate group, it was 99.30 minutes (on average). The PFNA2 group experienced less blood loss (average of 80 mL) compared to the condylar blade plate group (average of 120 mL). Union and partial weight-bearing occurred earlier in the PFNA2 group (14.1 weeks and 10.6 weeks, respectively) compared to the Condylar blade plate group (18.7 weeks and 15.8 weeks). In two patients from the PFNA2 group, screw backing out and varus collapse complications were encountered;however, these patients remained asymptomatic and did not require revision surgery. In two other patients, screw cut out and breakage of the nail at the helical screw hole leading to non-union of the proximal femur were observed during the nine-month follow-up, necessitating revision su

关键词： Proximal Femoral Nail Anti-Rotation Condylar Blade Plate Internal Fixation Unstable Intertrochanteric Fracture Osteoporotic

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Surgical management of the diabetic foot:The current evidence

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World Journal of Orthopedics 2024年第5期15卷 404-417页

作者： Richard Henry Randall Roberts Gareth Rhys Davies-Jones James Brock Vaishnav Satheesh Greg AJ Robertson Department of trauma and orthopaedics Wrexham Maelor HospitalWrexham LL137TDUnited Kingdom Department of trauma and orthopaedics The Robert Jones and Agnes Hunt Orthopaedic HospitalOswestry SY107AGUnited Kingdom

The prevalence of diabetes mellitus and its associated complications,particularly diabetic foot pathologies,poses significant healthcare challenges and economic burdens *** review synthesises current evidence on the surgical management of the diabetic foot,focusing on the interplay between neuropathy,ischemia,and infection that commonly culminates in ulcers,infections,and,in severe cases,*** escalating incidence of diabetes mellitus underscores the urgency for effective management strategies,as diabetic foot complications are a leading cause of hospital admissions among diabetic patients,significantly impacting morbidity and mortality *** review explores the pathophysiological mechanisms underlying diabetic foot complications and further examines diabetic foot ulcers,infections,and skeletal pathologies such as Charcot arthropathy,emphasising the critical role of early diagnosis,comprehensive management strategies,and interdisciplinary care in mitigating adverse *** addressing surgical interventions,this review evaluates conservative surgeries,amputations,and reconstructive procedures,highlighting the importance of tailored approaches based on individual patient profiles and the specific characteristics of foot *** integration of advanced diagnostic tools,novel surgical techniques,and postoperative care,including offloading and infection control,are discussed in the context of optimising healing and preserving limb function.

关键词： Diabetes Diabetic foot Charcot Osteomyelitis Amputation Diabetic foot attack Conservative surgery

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Unicompartmental knee arthroplasty vs high tibial osteotomy for knee osteoarthritis:A comparison of clinical and radiological outcomes

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World Journal of Orthopedics 2024年第5期15卷 444-456页

作者： Frederick William Wyatt Oday Al-Dadah Translational and Clinical Research Institute Faculty of Medical SciencesNewcastle UniversityNewcastle Upon Tyne NE24HHUnited Kingdom Department of trauma and orthopaedic surgery South Tyneside District HospitalSouth Shields NE340PLUnited Kingdom

BACKGROUND Unicompartmental knee arthroplasty(UKA)and high tibial osteotomy(HTO)are well-established operative interventions in the treatment of knee ***,which intervention is more beneficial to patients with knee osteoarthritis remains unknown and a topic of much ***,there is a paucity of research assessing the relationship between radiographic parameters of knee joint alignment and patient-reported clinical outcomes,preoperatively and following HTO or *** To compare UKAs and HTOs as interventions for medial-compartment knee osteoarthritis:Examining differences in clinical outcome and investigating the relationship of joint alignment with respect to *** This longitudinal observational study assessed a total of 42 patients that had undergone UKA(n=23)and HTO(n=19)to treat medial compartment knee ***-reported outcome measures(PROMs)were collected to evaluate clinical *** included two disease-specific(Knee Injury and Osteoarthritis Outcome Score,Oxford Knee Score)and two generic(EQ-5D-5L,Short Form-12)*** radiographic parameters of knee alignment assessed were the:Hip-knee-ankle angle,mechanical axis deviation and angle of Mikulicz *** Statistical analyses demonstrated significant(P<0.001),preoperative to postoperative,improvements in the PROM scores of both *** were,however,no significant inter-group differences in the postoperative PROM scores of the UKA and HTO *** significant correlations associated a more distolaterally angled Mikulicz line with worse knee function and overall health preoperatively(P<0.05).Postoperatively,two clusters of significant correlations were observed between the disease-specific PROM scores and knee joint alignment parameters(hip-knee-ankle angle,mechanical axis deviation)within the HTO group;yet no such associations were observed within the UKA *** UKAs and HTOs are both efficacious operations that provide a comp

关键词： Arthroplasty Osteotomy Medial compartment Osteoarthritis Knee alignment Patient reported outcome measures

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Long noncoding RNA protein-disulfide isomerase-associated 3 regulated high glucose-induced podocyte apoptosis in diabetic nephropathy through targeting miR-139-3p

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World Journal of Diabetes 2024年第2期15卷 260-274页

作者： Yin-Xi He Ting Wang Wen-Xian Li Yan-Xia Chen Department of orthopaedic trauma The Third Hospital of ShijiazhuangShijiazhuang 050000Hebei ProvinceChina Department of Endocrinology The Second Hospital of Hebei Medical UniversityShijiazhuang 050000Hebei ProvinceChina Department of Endocrinology The First Hospital of ZhangjiakouZhangjiakou 075000Hebei ProvinceChina

BACKGROUND Podocyte apoptosis plays a vital role in proteinuria pathogenesis in diabetic nephropathy(DN).The regulatory relationship between long noncoding RNAs(lncRNAs)and podocyte apoptosis has recently become another research hot spot in the DN *** To investigate whether lncRNA protein-disulfide isomerase-associated 3(Pdia3)could regulate podocyte apoptosis through miR-139-3p and revealed the underlying *** Using normal glucose or high glucose(HG)-cultured podocytes,the cellular functions and exact mechanisms underlying the regulatory effects of lncRNA Pdia3 on podocyte apoptosis and endoplasmic reticulum stress(ERS)were *** Pdia3 and miR-139-3p expression were measured through quantitative real-time polymerase chain *** cell viability was detected through the cell counting kit-8 colorimetric *** podocyte apoptosis rate in each group was measured through flow *** interaction between lncRNA Pdia3 and miR-139-3p was examined through the dual luciferase reporter ***,western blotting was performed to detect the effect of lncRNA Pdia3 on podocyte apoptosis and ERS via *** The expression of lncRNA Pdia3 was significantly downregulated in HG-cultured ***,lncRNA Pdia3 was involved in HG-induced podocyte ***,the dual luciferase reporter assay confirmed the direct interaction between lncRNA Pdia3 and *** Pdia3 overexpression attenuated podocyte apoptosis and ERS through miR-139-3p in HG-cultured *** Taken together,this study demonstrated that lncRNA Pdia3 overexpression could attenuate HG-induced podocyte apoptosis and ERS by acting as a competing endogenous RNA of miR-139-3p,which might provide a potential therapeutic target for DN.

关键词： Long noncoding RNAs Diabetic nephropathy Podocyte apoptosis Endoplasmic reticulum stress Competing endogenous RNA

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Early Treatment Outcome of Humeral Shaft Fracture Non-Union in Adults: Comparative Study of Plating versus Interlocking Nailing

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Health 2024年第4期16卷 371-381页

作者： Abdullallahi Bello Galadima Lukman Olalekan Ajiboye Muhammad Nuhu Salihu Isha Nurudeen Orthopedics and trauma Department Usmanu Danfodiyo University/Teaching Hospital Sokoto Nigeria Department of orthopaedics and trauma University of Abuja Abuja Nigeria Orthopedic Department National Orthopaedic Hospital Dala Nigeria

Background: Fractures of humeral shaft in adults are common injuries. Humeral shafts non-union either from late presentation after initial treatment by traditional bone setters or failed non-operative orthodox care is a major problem in this part of the world. This non-union is a major treatment challenge with increased cost of care and morbidity in this part of the world. Humeral shaft non-union can be treated with locked intra-medullary nailing (LIMN) or dynamic compression plating (DCP). Study on comparison of these methods of fixation in this part of the world is scarce in literature search, hence the reason for this study. Objective: The objectives of this study are: (1) to compare early clinical outcome following fixation of humeral shaft fracture nonunion with DCP versus LIMN;(2) to compare the time of radiologic fracture union of DCP with LIMN;(3) to compare complications following fixation of humeral shaft fracture nonunion with DCP versus LIMN. Patients and Methods: This was a randomized control study done for 2 years in which fifty adult patients with humeral shaft non-union were recruited. The patients were grouped into 2 (P = DCP & N = LIMN). Forty five of the patients completed the follow up periods of the study and then analyzed. The P group had ORIF with DCP while the N group had ORIF with LIMN. Both groups had grafting with cancellous bones. Each patient was followed up for a period of 6 months at the time which radiographic union is expected. Any patient without clinical and/or radiographic evidence of union after six months of surgery was diagnosed as having recurrent non-union. The data generated was analyzed using SPSS Version 23. The results were presented in charts and tables. The paired t-test was used while considering p value Result: Forty five patients completed follow up. There was a male preponderance (4:1), right humerus predominated (3:2). Motor vehicular accidents were the commonest cause of the fractures (62%). Most non-union fractur

关键词： Humeral Shaft Non-Union Dynamic Compression Plating Locked Intra-Medullary Nailing Early Treatment Outcome Early Outcome

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Anterior cruciate ligament reconstruction:Effect of graft tunnel position on early to mid-term clinical outcomes

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World Journal of Orthopedics 2024年第8期15卷 744-753页

作者： Oliver Mann Oday Al-Dadah The Medical School Newcastle UniversityNewcastle upon Tyne NE24HHUnited Kingdom Translational and Clinical Research Institute Faculty of Medical SciencesNewcastle UniversityNewcastle upon Tyne NE24HHUnited Kingdom Department of trauma and orthopaedic surgery South Tyneside District HospitalHarton LaneSouth Tyneside NE340PLUnited Kingdom

BACKGROUND Patient reported outcome measures(PROMs)can be used to assess knee function following anterior cruciate ligament(ACL)***-operatively,femoral and tibial tunnels are created to accommodate the new ACL *** is postulated that there is an optimum position and orientation of these tunnels and that outcomes from this procedure are affected by their *** To evaluate the influence of graft tunnel position on early to mid-term clinical outcomes following ACL *** Six PROMs were collected following ACL reconstruction which included the Knee Injury and Osteoarthritis Outcome Score(KOOS),International Knee Documentation Committee,Lysholm,Tegner,EuroQol-5 Dimension-5 level,and Short Form 12-item Health Survey.A total of 8 radiological parameters were measured from post-operative X-rays relating to graft tunnel *** data was analysed to assess for any correlations between graft tunnel position and postoperative *** A total of 87 patients were included in the study with a mean post-operative follow-up of 2.3 years(range 1 to 7 years).Posterior position of tibial tunnel was associated with improved KOOS quality of life(rho=0.43,P=0.002)and EQ-5D VAS(rho=0.36,P=0.010).Anterior position of EndoButton femoral tunnel was associated with an improved EQ-5D index(rho=-0.38,P=0.028).There were no other significant correlations between any of the other radiological parameters and PROM *** Overall,graft tunnel position had very little correlation with clinical outcomes following ACL reconstruction.A few(posterior)tibial tunnel and(anterior)EndoButton femoral tunnel measurements were associated with better PROMs.

关键词： Anterior cruciate ligament Reconstruction Patient reported outcome measures Graft tunnel X-ray Correlation

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