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Synergy effects of Asperosaponin Ⅵ and bioactive factor BMP-2 on osteogenesis and anti-osteoclastogenesis

Bioactive Materials 2022年第4期7卷 335-344页

作者： Fangping Chen Qing Liang Lijie Mao Yanrong Yin b Lixin Zhang Cuidi Li Changsheng Liu Key Laboratory for Ultrafine Materials of Ministry of Education School of Materials Science and EngineeringEast China University of Science and TechnologyShanghai200237PR China Engineering research Center for Biomedical Materials of Ministry of Education East China University of Science and TechnologyShanghai200237PR China department of orthopaedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint DiseasesShanghai Institute of Traumatology and OrthopaedicsRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai200025PR China Frontiers Science Center for Materiobiology and Dynamic Chemistry East China University of Science and TechnologyShanghai200237PR China

Osteoporosis is a reduction in skeletal mass due to the decrease of osteogenic ability and the activation of the osteoclastic *** bone resorption and accelerating the new bone formation is a promising strategy to repair the bone defect of *** this study,we first systematically investigated the roles of Chinese medicine Asperosaponin Ⅵ(ASP Ⅵ)on osteogenic mineralization of BMSCs and osteoclastogenesis of BMMs,and then explored the synergistic effect of ASP Ⅵ and BS(BMP-2 immobilized in 2-N,6-O-sulfated chitosan)on bone *** result showed that ASP Ⅵ with the concentration lower than 10^(-4) M contributed to the expression of osteogenic gene and inhibited osteoclastic genes RANKL of ***,ASP Ⅵ significantly reduced the differentiation of mononuclear osteoclasts in the process of osteoclast formation induced by M-CSF and ***,by stimulating the SMADs,TGF-β1,VEGFA,and OPG/RANKL signaling pathways,ASBS(ASP Ⅵ and BS)substantially enhanced osteogenesis,greatly promoted angiogenesis,and suppressed *** findings provide a new perspective on osteoporosis care and prevention.

关键词： AsperosaponinⅥ rhBMP-2 Osteoporosis Osteogenesis Osteoclastogenesis

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桡骨远端骨折掌侧钢板固定后尺骨茎突骨折是否需要固定？

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中华骨科杂志 2010年第6期30卷 I0050-I0054页

作者： Jae Kwang Kim Young-Do Koh Nam-Hoon Do 朱丹杰(译) 夏冰(译) Investigation performed at the department of Orthopedic Surgery Ewha Medical Research Institute School of Medicine Ewha Womans University Seoul South Korea 浙江省人民医院 310014

背景：尺骨茎突骨折常伴发于桡骨远端骨折。本研究的目的是确定桡骨远端骨折牢固内固定后伴发的尺骨茎突骨折对腕关节功能或远期下尺桡关节不稳定的发展是否有影响。方法：138例不稳定的桡骨远端骨折手术治疗病例纳入本研究。手术过程... 详细信息

背景：尺骨茎突骨折常伴发于桡骨远端骨折。本研究的目的是确定桡骨远端骨折牢固内固定后伴发的尺骨茎突骨折对腕关节功能或远期下尺桡关节不稳定的发展是否有影响。方法：138例不稳定的桡骨远端骨折手术治疗病例纳入本研究。手术过程中伴发的尺骨茎突骨折未进行内固定。患者尺骨茎突骨折被分为未骨折组、非基底部骨折组和基底部骨折组，根据受伤时尺骨茎突骨折移位程度分为未骨折组、轻度移位组（≤2mm）和明显移位组（〉2mm）。术后评估包括握力和腕关节活动范围的测量；改良Mayo腕关节评分和臂、肩、手不稳定（DASH）评分系统，以及在平均术后19个月的测试下尺桡关节的不稳定。结果：138例中76例（55％）存在尺骨茎突骨折。47例（62％）为尺骨茎突非基底部骨折，29例（38％）为尺骨茎突基底部骨折。34例（45％）轻度移位，42例（55％）明显移位（〉2mm）。我们没有发现尺骨茎突骨折位置或移位程度与腕关节功能有显著相关性。2例腕关节（1．4％）出现下尺桡关节慢性不稳。结论：桡骨远端骨折稳定内固定后伴发的尺骨茎突骨折对腕关节功能或下尺桡关节的稳定性没有明显的不利影响。

关键词：尺骨茎突骨折桡骨远端骨折钢板固定骨折移位程度腕关节功能下尺桡关节掌侧关节活动范围

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Effect of quantum therapy on pork quality

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2011年第11期12卷 892-899页

作者： Martin BODNáR Jozef NAGY Peter POPELKA Beáta KORéNEKOVá Ján MAANGA Alena NAGYOVá Private Veterinary Clinique Kremnická 9040 11 Kosicethe Slovak Republic department of Food Hygiene and Technology University of Veterinary Medicine and Pharmacy in KosiceKomenského 73041 81 Kosicethe Slovak Republic department of Environment Veterinary Legislation and EconomicsInstitute of Forensic and Public Veterinary MedicineUniversity of Veterinary Medicine and Pharmacy in KosiceKomenského 73041 81 Kosicethe Slovak Republic

In this study the impact of quantum therapy on meat quality of slaughtered pigs was *** this purpose the pigs were treated with different doses of magnet-infrared-laser(MIL) *** were divided into four groups according to radiation doses(4096,512,and 64 Hz,and control without application),which were applied in the lumbar area of musculus longissimus dorsi(loin) at various time intervals prior to the slaughter(14 d,24 h,and 1 h).Animals were slaughtered and the meat quality was evaluated by determining of pH value(1,3,and 24 h post slaughter),drip loss,colour,and lactic acid and phosphoric acid *** therapy can be used in various fields of veterinary medicine as are surgery and orthopaedics,internal medicine,dentistry,pulmonology,gastroenterology,gynaecology,urology,nephrology,and *** results achieved showed that MIL radiation used in a short period before slaughter(1 h) can cause a change in the meat quality,as reflected by the non-standard development of pH values,increases in drip loss,and changes of meat colour.

关键词： Quantum therapy Meat quality Colour Drip loss Lactic acid pH

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Wnt/b-catenin signaling plays an ever-expanding role in stem cell self-renewal,tumorigenesis and cancer chemoresistance

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Genes & Diseases 2016年第1期3卷 11-40页

作者： Maryam K.Mohammed Connie Shao Jing Wang Qiang Wei Xin Wang Zachary Collier Shengli Tang Hao Liu Fugui Zhang Jiayi Huang Dan Guo Minpeng Lu Feng Liu Jianxiang Liu Chao Ma Lewis L.Shi Aravind Athiviraham Tong-Chuan He Michael J.Lee The University of Chicago Pritzker School of Medicine ChicagoIL 60637USA Molecular Oncology Laboratory Department of Orthopaedic Surgery and Rehabilitation MedicineThe University of Chicago Medical CenterChicagoIL 60637USA Ministry of Education Key Laboratory of Diagnostic Medicine and the Affiliated Hospitals of Chongqing Medical UniversityChongqing 400016China department of Surgery West China Hospital of Sichuan UniversityChengdu 610041China departments of General Surgery and Neurosurgerythe Affiliated Zhongnan Hospital of Wuhan UniversityWuhan 430071China department of orthopaedic Surgery Union Hospital of Tongji Medical CollegeHuazhong University of Science&TechnologyWuhan 430022China

Wnt signaling transduces evolutionarily conserved pathways which play important roles in initiating and regulating a diverse range of cellular activities,including cell proliferation,calcium homeostasis,and cell *** role of Wnt signaling in controlling cell proliferation and stem cell self-renewal is primarily carried out through the canonical pathway,which is the best-characterized the multiple Wnt signaling *** past 10 years has seen a rapid expansion in our understanding of the complexity of this pathway,as many new components of Wnt signaling have been identified and linked to signaling regulation,stem cell functions,and adult tissue ***,a substantial body of evidence links Wnt signaling to tumorigenesis of cancer types and implicates it in the development of cancer drug ***,a better understanding of the mechanisms by which dysregulation of Wnt signaling precedes the development and progression of human cancer may hasten the development of pathway inhibitors to augment current *** review summarizes and synthesizes our current knowledge of the canonical Wnt pathway in development and *** begin with an overview of the components of the canonical Wnt signaling pathway and delve into the role this pathway has been shown to play in stemness,tumorigenesis,and cancer drug ***,we hope to present an organized collection of evidence implicating Wnt signaling in tumorigenesis and chemoresistance to facilitate the pursuit of Wnt pathway modulators that may improve outcomes of cancers in which Wnt signaling contributes to aggressive disease and/or treatment resistance.

关键词： Cancer drug resistance Cancer stem cells Canonical Wnt b-Catenin Wnt

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Erratum to:Double-edged effects caused by magnesium ions and alkaline environment regulate bioactivities of magnesiumincorporated silicocarnotite in vitro

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Regenerative Biomaterials 2021年第6期8卷 318-318页

作者： Qiang Wu Shunxiang Xu Fei Wang Bo He Xin Wang Ye Sun Congqin Ning Kerong Dai Shanghai Key Laboratory of Orthopedic Implant Department of Orthopaedic SurgeryShanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineNo.639Zhizaoju RoadShanghaiHuangpu District 200011China The Education Ministry Key Lab of Resource Chemistry and Shanghai Key Laboratory of Rare Earth Functional Materials Shanghai Normal UniversityNo.100Guilin RoadShanghaiXuhui District 200234China department of Orthopedics Trauma and Microsurgery Zhongnan Hospital of Wuhan UniversityNo.169East Lake RoadWuchang DistrictWuhan 430071China department of orthopaedics The First Affiliated Hospital of Nanjing Medical UniversityNo.300Guangzhou RoadDrum-tower DistrictNanjing210029China State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesNo.1295Dingxi RoadChangning DistrictShanghai 200050China

[This corrects the article DOI: 10.1093/rb/rbab016.].

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统计学笔记:相对差异百分比、对称性和自然对数

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英国医学杂志中文版 2022年第12期25卷 729-731页

作者： Tim J Cole Douglas G Altman 李戈(译) 刘欣月(译) 孙凤(校) Population Policy and Practice ProgrammeGreat Ormond Street Institute of Child HealthUniversity College LondonLondon WC1N 1EHUK Centre for Statistics in Medicine Nuffield Department of OrthopaedicsRheumatology and Musculoskeletal SciencesUniversity of OxfordOxford OX37LDUK 天津中医药大学健康科学与工程学院北京大学公共卫生学院流行病与卫生统计学系

对数变换具有非常实用的性质,因此在统计学中被广泛应用,但是即便是统计学家对其属性也知之甚少,而非统计学家则感觉其很不友好。对数变换两种常见形式为:以10为底的普通对数(lg)和以e作底的自然对数(ln)。以自然对数为例,解释如下:任... 详细信息

对数变换具有非常实用的性质,因此在统计学中被广泛应用,但是即便是统计学家对其属性也知之甚少,而非统计学家则感觉其很不友好。对数变换两种常见形式为:以10为底的普通对数(lg)和以e作底的自然对数(ln)。以自然对数为例,解释如下:任意两个数字a、b,其对数差ln(a)-ln(b),实际上反映的是二者比值大小。在此结果上乘以100,100xln(a)-100xln(b),即为α、b基于对数变换的相对差异百分比。

关键词：对数变换自然对数统计学家常见形式对称性百分比

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统计学注释:什么是相对差异百分比?

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英国医学杂志中文版 2022年第3期25卷 165-165页

作者： Tim J Cole Douglas G Altman 李戈(译) 刘欣月(译) 孙凤(校) Population Policy and Practice ProgrammeGreat Ormond Street Institute of Child HealthUniversity College LondonLondon WC1N 1EHUK Centre for Statistics in Medicine Nuffield Department of OrthopaedicsRheumatology and Musculoskeletal SciencesUniversity of OxfordOxford 0X37LDUK 天津中医药大学健康科学与工程学院北京大学公共甦学院流行病与卫生统计学系

我们用百分数表示差异对整体的占比。根据该定义可以列出直观算法1:相对差异百分比=100×(差异/对比数据)。例如:欲了解英国20岁成年人平均身高的相对差异百分比。已知男、女身高均数分别为177.3 cm,163.6 cm,两者绝对差异为13.7 cm,则... 详细信息

我们用百分数表示差异对整体的占比。根据该定义可以列出直观算法1:相对差异百分比=100×(差异/对比数据)。例如:欲了解英国20岁成年人平均身高的相对差异百分比。已知男、女身高均数分别为177.3 cm,163.6 cm,两者绝对差异为13.7 cm,则女性比男性低100×(13.7/177.3)=7.7%,而男性比女性高100×(13.7/163.6)=8.4%,由于分母不同,导致两个相对差异百分比不同,而绝对差异本身是对称的——女性比男性低13.7 cm,男性比女性高13.7 cm。

关键词：对比数据身高统计学

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Nanozymes for biomedical applications in orthopaedics

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Particuology 2023年第5期76卷 32-45页

作者： Anqi Lin Shujie Liu Hui Wei department of Biomedical Engineering College of Engineering and Applied SciencesNanjing National Laboratory of MicrostructuresJiangsu Key Laboratory of Artificial Functional MaterialsNanjing UniversityNanjing210023China State Key Laboratory of Analytical Chemistry for Life Science School of Chemistry and Chemical EngineeringChemistry and Biomedicine Innovation Center(ChemBIC)Nanjing UniversityNanjing210023China

As the next generation of artificial enzymes,nanozymes have attracted increasing attention in biomedical applications due to their multienzyme-like characteristics,multifunctionalities,low cost,and high *** taking advantage of their diverse activities,a growing number of nanozyme-mediated therapeutic strategies have been developed for various ***,we provide a brief review of the representative studies of nanozymes,especially in orthopaedic diseases over the past decade,which include arthritis,osteoporosis,bone regeneration,bacteria-associated infections,and ***,the future potential applications and some major challenges are also *** review would not only provide some instructive views of nanozymes but also promote the development of enzyme-mimetic strategies in orthopaedics.

关键词： Nanozymes Artificial enzymes orthopaedics Nanomedicine Nanomaterials

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肢体延长的起源、理论突破与技术进展

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中华骨科杂志 2020年第11期40卷 749-754页

作者：秦泗河臧建成 Dror·Paley 国家康复辅具研究中心附属康复医院矫形骨科民政部康复辅具技术与系统重点实验室北京市老年功能障碍康复辅助技术重点实验室100176 Paley Orthopedic and Spine institute West Palm BeachFloridaUSA

Ilizarov技术催生了骨再生和肢体延长,是20世纪骨科发展的重要里程碑之一。进入21世纪,随着进化论、系统控制论、再生医学、人工智能、3D打印等参入临床,突破了既往骨科的范畴,从头颅、脊柱、骨盆、手指、足趾以及神经性溃疡,缺血性坏... 详细信息

Ilizarov技术催生了骨再生和肢体延长,是20世纪骨科发展的重要里程碑之一。进入21世纪,随着进化论、系统控制论、再生医学、人工智能、3D打印等参入临床,突破了既往骨科的范畴,从头颅、脊柱、骨盆、手指、足趾以及神经性溃疡,缺血性坏疽等几乎都能实施再生、修复与重建,进一步证明了生物力可激发人体组织自我修复的潜能。本文追溯了肢体延长术100多年的历史,阐述了最初的截骨、延长理念和Ilizarov技术、牵拉成骨技术以及牵拉成组织技术等重要的生物学理论及其在前苏联,欧洲,北美等世界范围内的传播与发展;介绍了从Wagner、Bastiani、Orthofix、Ilizarov外固定器到全髓内骨骼延长钉等手术器械的优势、劣势和改良;展示了牵拉成组织技术跨越多学科、不同组织再生重建的临床应用。在肢体延长不断发展的历史过程中,国际肢体延长与重建学会以及各国学术组织发挥着重要的推动作用。中国的肢体延长起源与发展可分为四个阶段,即Ilizarov技术前期即骨外固定自主研发和肢体弹性延展延长期、Ilizarov牵拉成骨延长技术期、后Ilizarov技术时代以及应力调控主导下的肢体再生延长与重建期,目前已进入了快速发展的新时代。

关键词：骨延长术骨重建伊利扎罗夫技术骨生成,牵张

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