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Effectiveness of platelet-rich plasma in the treatment of Achilles tendon disease

World Journal of Orthopedics 2023年第6期14卷 485-501页

作者： Dan Huang Djandan Tadum Arthur Vithran Hao-Li Gong Ming Zeng Zhong-Wen Tang Zhou-Zhou Rao Jie Wen Sheng Xiao department of Pediatric Orthopedics Hunan Provincial People’s HospitalThe First Affiliated Hospital of Hunan Normal UniversityChangsha 410013Hunan ProvinceChina department of orthopaedics Xiangya Hospital of Central South UniversityChangsha 410013Hunan ProvinceChina department of Physiology Hunan Normal University School of MedicineChangsha 410005Hunan ProvinceChina department of Anatomy Hunan Normal University School of MedicineChangsha 410005Hunan ProvinceChina

BACKGROUND The effectiveness of Platelet-Rich Plasma(PRP)in the treatment of patients with Achilles tendon rupture(ATR)and Achilles tendinopathy(AT)has been *** To assess PRP injections’effectiveness in treating ATR and *** A comprehensive review of relevant literature was conducted utilizing multiple databases such as Cochrane Library,PubMed,Web of Science,Chinese Science and Technology Journal,EMBASE,and China Biomedical *** present investigation integrated randomized controlled trials that assessed the effectiveness of platelet-rich plasma injections in managing individuals with Achilles tendon rupture and *** eligibility criteria for the trials encompassed publications that were published within the timeframe of January 1,1966 to December *** statistical analysis was performed utilizing the Review Manager 5.4.1,the visual analogue scale(VAS),Victorian institute Ankle Function Scale(VISA-A),and Achilles Tendon Thickness were used to assess *** This meta-analysis included 13 randomized controlled trials,8 of which were randomized controlled trials of PRP for AT and 5 of which were randomized controlled trials of PRP for *** for AT at 6 wk[weighted mean difference(WMD)=1.92,95%CI:-0.54 to 4.38,I2=34%],at 3 mo[WMD=0.20,95%CI:-2.65 to 3.05,I2=60%],and 6 mo[WMD=2.75,95%CI:-2.76 to 8.26,I2=87%)after which there was no significant difference in VISA-A scores between the PRP and control *** was no significant difference in VAS scores between the PRP group and the control group after 6 wk[WMD=6.75,95%CI:-6.12 to 19.62,I2=69%]and 6 mo[WMD=10.46,95%CI:-2.44 to 23.37,I2=69%]of treatment,and at mid-treatment at 3 mo[WMD=11.30,95%CI:7.33 to 15.27,I2=0%]after mid-treatment,the PRP group demonstrated better outcomes than the control ***-treatment patient satisfaction[WMD=1.07,95%CI:0.84 to 1.35,I2=0%],Achilles tendon thickness[WMD=0.34,95%CI:-0.04 to 0.71,I2=61%]and return to sport[WMD=1.11,95%CI:0.87

关键词： Platelet-Rich plasma Achilles tendon rupture Achilles tendinopathy Systematic evaluation Randomized controlled trial

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Correction to:Temporal and spatial cellular and molecular pathological alterations with single-cell resolution in the adult spinal cord after injury

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Signal Transduction and Targeted Therapy 2022年第6期7卷 2117-2118页

作者： Chen Li Zhourui Wu Liqiang Zhou Jingliang Shao Xiao Hu Wei Xu Yilong Ren Xingfei Zhu Weihong Ge Kunshan Zhang Jiping Liu Runzhi Huang Jing Yu Dandan Luo Xuejiao Yang Wenmin Zhu Rongrong Zhu Changhong Zheng Yi Eve Sun Liming Cheng Division of Spine Department of Orthopaedics Tongji Hospital Tongji University School of Medicine Shanghai 200065 China Key Laboratory of Spine and Spinal cord Injury Repair and Regeneration (Tongji University) Ministry of Education Shanghai 200072 China institute of Spinal and Spinal Cord Injury Tongji University School of Medicine Shanghai 200065 China Stem Cell Translational research Center Tongji Hospital Tongji University School of Medicine Shanghai 200065 China department of Psychiatry and Biobehavioral Sciences David Geffen School of Medicine University of California Los Angeles Los Angeles CA 90095 USA

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退变性半月板撕裂伤的治疗和外科手术的作用

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英国医学杂志中文版 2016年第4期19卷 233-236页

作者： Buchbinder Rachelle Harris Ian A Sprowson Andrew 公磊(译者) Monash department of Clinical Epidemiology Cabrini Institute Malvern VIC 3144 Australia department of Epidemiology and Preventive Medicine School of Public Health and Preventive Medicine Monash University The Alfred Centre Melbourne Vic Australia Whitlam orthopaedic researchCentre Ingham Institute for Applied Medical Research South Western Sydney Clinical School University of New South Wales Liverpool NSW Australia Warwick Clinical Trials Unit Warwick University Coventry UK 北京清华长庚医院外科

应用关节镜治疗退变性半月板撕裂伤在世界范嗣内得到了公认。然而，许多高质量随机对照研究发现了关节镜治疗的一些副损伤，这引起了对关节镜使用价值的质疑，但是观察研究发现这些副损伤一般没有症状，同时也鉴于使用关节镜是一个“很... 详细信息

应用关节镜治疗退变性半月板撕裂伤在世界范嗣内得到了公认。然而，许多高质量随机对照研究发现了关节镜治疗的一些副损伤，这引起了对关节镜使用价值的质疑，但是观察研究发现这些副损伤一般没有症状，同时也鉴于使用关节镜是一个“很难打破的习惯”1,因此现在亟需要对这类半月板撕裂伤的治疗方式进行综述。

关键词：手术管理撕裂板

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GelNB molecular coating as a biophysical barrier to isolate intestinal irritating metabolites and regulate intestinal microbial homeostasis in the treatment of inflammatory bowel disease

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Bioactive Materials 2023年第1期19卷 251-267页

作者： Qijiang Mao Haoqi Pan Yiyin Zhang Yi Zhang Qiuwen Zhu Yi Hong Zhengze Huang Yang Li Xu Feng Yifeng Fang WenChao Chen Pengfei Chen Bo Shen Hongwei Ouyang Yuelong Liang department of General Surgery Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou310016China Key Laboratory of Laparoscopic Technology of Zhejiang province Hangzhou310016China Zhejiang Province Medical research Center of Minimally Invasive Diagnosis and Treatment of Abdominal Diseases Hangzhou310028China Dr.Li Dak Sum&Yip Yio Chin Center for Stem Cells and Regenerative Medicine Department of Orthopedic Surgery of the Second Affiliated HospitalZhejiang University School of MedicineHangzhouChina Zhejiang University-University of Edinburgh institute Zhejiang University School of MedicineKey Laboratory of Tissue Engineering and Regenerative Medicine of Zhejiang ProvinceZhejiang University School of MedicineHangzhouChina The State Key Laboratory of Fluid Power and Mechatronic Systems School of Mechanical EngineeringZhejiang UniversityHangzhou310028China department of orthopaedic Surgery Sir Run Run Shaw HospitalMedical College of Zhejiang UniversityHangzhouZhejiang310016China

Inflammatory bowel disease(IBD)is a chronic,immune-mediated inflammatory disease characterized by the destruction of the structure and function of the intestinal epithelial *** to the poor remission effect and severe adverse events associated with current clinical medications,IBD remains an incurable ***,we demonstrated a novel treatment strategy with high safety and effective inflammation remission via tissue-adhesive molecular *** molecular coating is composed of o-nitrobenzaldehyde(NB)-modified Gelatin(GelNB),which can strongly bond with-NH_(2)on the intestinal surface of tissue to form a thin biophysical *** found that this molecular coating was able to stay on the surface of the intestine for long periods of time,effectively protecting the damaged intestinal epithelium from irritations of external intestinal metabolites and harmful *** addition,our results showed that this coating not only provided a beneficial environment for cell migration and proliferation to promote intestinal repair and regeneration,but also achieved a better outcome of IBD by reducing intestinal ***,the in vivo experiments showed that the GelNB was better than the classic clinical ***,our molecular coating showed potential as a promising strategy for the prevention and treatment of IBD.

关键词： Inflammatory bowel GelNB Molecular coating Biophysical barrier

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Global trends and hot topics in clinical applications of perovskite materials:a bibliometric analysis

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Biomaterials Translational 2023年第3期4卷 131-141页

作者： Tai-Long Shi Yi-Fan Zhang Meng-Xuan Yao Chao Li Hai-Cheng Wang Chuan Ren Jun-Sheng Bai Xu Cui Wei Chen department of orthopaedic Surgery Third Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina Key Laboratory of Biomechanics of Hebei Province ShijiazhuangHebei ProvinceChina NHC Key Laboratory of Intelligent orthopaedic Equipment ShijiazhuangHebei ProvinceChina Center for Human Tissues and Organs Degeneration Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong ProvinceChina

In recent years,perovskite has received increasing attention in the medical ***,there has been a lack of related bibliometric analysis in this research *** study aims to analyse the research status and hot topics of perovskite in the medical field from a bibliometric perspective and explore the research direction of *** study collected 1852 records of perovskite research in the medical field from 1983 to 2022 in the Web of Science(WOS)*** country,institution,journal,cited references,and keywords were analysed using CiteSpace,VOS viewer,and Bibliometrix *** number of articles related to perovskite research in the medical field has been increasing every *** and USA have published the most papers and are the main forces in this research *** University of London Imperial College of Science,Technology,and Medicine is the most active institution and has contributed the most *** Applied Materials&Interfaces is the most prolific journal in this field.“Medical electronic devices”,“X-rays”,and“piezoelectric materials”are the most researched directions of perovskite in the medical field.“Performance”,“perovskite”,and“solar cells”are the most frequently used keywords in this *** Materials is the most relevant and academically influential journal for perovskite *** perovskites have been a hot topic in this field in recent years and will be a future research trend.X-ray,electronic medical equipment,and medical stents are the main research directions.

关键词： bibliometrics bibliometrix CiteSpace perovskite R package

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Comprehensive Metabolic Profiling and Genome-wide Analysis Reveal Therapeutic Modalities for Hepatocellular Carcinoma

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research 2023年第3期6卷 433-449页

作者： Feng Qi Jia Li Zhuoran Qi Jian Zhang Bin Zhou Biwei Yang Wenxing Qin Wenguo Cui Jinglin Xia department of Oncology Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200000China National Medical Center and National Clinical research Center for Interventional Medicine Liver Cancer InstituteZhongshan HospitalFudan University180 Fenglin RoadShanghai 200032China department of Hepatic Surgery VI Eastern Hepatobiliary Surgery HospitalSecond Military Medical UniversityShanghai 200433China Phase I Clinical Trial Center Fudan University Shanghai Cancer CenterDepartment of OncologyShanghai Medical CollegeFudan UniversityNo.270Dong’an RoadShanghai 200032China department of orthopaedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint DiseasesShanghai Institute of Traumatology and OrthopaedicsRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200000China Key Laboratory of Diagnosis and Treatment of Severe Hepato-Pancreatic Diseases of Zhejiang Province The First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000China

Understanding the details of metabolic reprogramming in hepatocellular carcinoma(HCC)is critical to improve stratification for *** multiomics analysis and cross-cohort validation were performed to investigate the metabolic dysregulation of 562 HCC patients from 4 *** the basis of the identified dynamic network biomarkers,227 substantial metabolic genes were identified and a total of 343 HCC patients were classified into 4 heterogeneous metabolic clusters with distinct metabolic characteristics:cluster 1,the pyruvate subtype,associated with upregulated pyruvate metabolism;cluster 2,the amino acid subtype,with dysregulated amino acid metabolism as the reference;cluster 3,the mixed subtype,in which lipid metabolism,amino acid metabolism,and glycan metabolism are dysregulated;and cluster 4,the glycolytic subtype,associated with the dysregulated carbohydrate *** 4 clusters showed distinct prognoses,clinical characteristics and immune cell infiltrations,which was further validated by genomic alterations,transcriptomics,metabolomics,and immune cell profiles in the other 3 independent ***,the sensitivity of different clusters to metabolic inhibitors varied depending on their metabolic ***,cluster 2 is rich in immune cells in tumor tissues,especially programmed cell death protein 1(PD-1)-expressing cells,which may be due to the tryptophan metabolism disorders,and potentially benefiting more from PD-1 *** conclusion,our results suggest the metabolic heterogeneity of HCC and make it possible to treat HCC patients precisely and effectively on specific metabolic characteristics.

关键词： metabolism Carcinoma alterations

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基于中国族群的个性化增材制造全膝关节置换假体设计

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Engineering 2021年第3期7卷 248-265页

作者：徐振星梁国穗秦江辉石杜芳 P.Augat 黄文扬周冠豪黄雪莹陈致远赖毓霄容树恒秦岭张颖恺 department of orthopaedics and Traumatology Faculty of Medicine The Chinese University of Hong Kong department of orthopaedics and Traumatology Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School institute for Biomechanics Berufsgenossenschaftliche Unfallklinik Murnau institute for Biomechanic Paracelsus Medical University Salzburg Center for Translational Medicine research and Development Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences

目前市场上大多数全膝关节置换(TKR)假体是根据高加索人的体型设计的。大量研究表明,不同种族之间的人体解剖结构不同,中国的TKR患者与现有进口假体并不匹配。本研究测量了52名中国男性和女性的膝关节计算机断层扫描(CT)图像。通过定义... 详细信息

目前市场上大多数全膝关节置换(TKR)假体是根据高加索人的体型设计的。大量研究表明,不同种族之间的人体解剖结构不同,中国的TKR患者与现有进口假体并不匹配。本研究测量了52名中国男性和女性的膝关节计算机断层扫描(CT)图像。通过定义参数和几何尺寸,进行相关性分析。从测量结果中识别出关键参数。测量膝关节详细几何形状的坐标数据。基于与所标识的关键参数相关的解剖坐标系统,生成了可变形的三维(3D)膝关节模型。然后根据分析结果设计假体,进行表面匹配分析、切骨分析和尸体试验,并将其与商业假体产品进行比较以验证我们的设计。本研究设计的股骨组件与两种商业器械相比,具有更高的准确性[均方根比(RMS PS)为(1.08±0.20) mm],而切除的骨量最低(27 412 mm~3)。这项研究为基于族群的患者特定的股骨假体设计提出了一种新方法。使用一个易于获取的尺寸[即上髁宽度(ECW)]作为输入,可以根据分析的测量数据设计特定患者的股骨假体,并通过增材制造(AM)方法进行制造。同时,在原始CT扫描数据中将重建的股骨表面与原股骨表面进行比较。在所有数据中,重建的股骨表面的平均RMS PS距离为(1.10±0.18)mm,这与使用多个X射线照片作为输入数据的其他统计形状建模方法相当。目前市场上对基于中国族群人体测量的膝关节假体有很大需求。本研究基于中国族群人体测量学,设计出更适合中国患者的膝关节假体,并保留了更多的骨量,这是迈向个性化膝关节假体增材制造的重要一步。

关键词：增材制造基于族群的设计全膝关节置换膝关节假体人体测量

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Controlled release of hydrogen by implantation of magnesium induces P53-mediated tumor cells apoptosis

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Bioactive Materials 2022年第3期7卷 385-396页

作者： Rui Zan Hao Wang Weijie Cai Jiahua Ni Berengere J.C.Luthringer-Feyerabend Wenhui Wang Hongzhou Peng Weiping Ji Jun Yan Jiazeng Xia Yang Song Xiaonong Zhang State Key Laboratory of Metal Matrix Composites School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai200240China institute of Metallic Biomaterials Department of Biological CharacterisationHelmholtz-Zentrum Geesthacht(HZG)Geesthacht21502Germany department of General Surgery and Translational Medicine Center Wuxi No.2 People’s HospitalAffiliated Wuxi Clinical College of Nantong UniversityJiangsu214002China orthopaedic department Shanghai Jiao Tong University Affiliated Sixth People’s HospitalShanghai200233China department of General Surgery Shanghai Jiao Tong University Affiliated Sixth People’s HospitalShanghai200233China Suzhou Origin Medical Technology Co.Ltd. Suzhou215513China

Hydrogen has been used to suppress tumor growth with considerable *** of hydrogen gas and oral ingestion of hydrogen-rich saline are two common systemic routes of hydrogen *** have developed a topical delivery method of hydrogen at targeted sites through the degradation of magnesium-based ***,the underlying mechanism of hydrogen’s role in cancer treatment remains ***,we investigate the mechanism of tumor cell apoptosis triggered by the hydrogen released from magnesium-based *** find that the localized release of hydrogen increases the expression level of P53 tumor suppressor proteins,as demonstrated by the in vitro RNA sequencing and protein expression ***,the P53 proteins disrupt the membrane potential of mitochondria,activate autophagy,suppress the reactive oxygen species in cancer cells,and finally result in tumor *** anti-tumor efficacy of magnesium-based biomaterials is further validated in vivo by inserting magnesium wire into the subcutaneous tumor in a *** also discovered that the minimal hydrogen concentration from magnesium wires to trigger substantial tumor apoptosis is 91.2μL/mm^(3)per day,which is much lower than that required for hydrogen *** together,these findings reveal the release of H2 from magnesium-based biomaterial exerts its anti-tumoral activity by activating the P53-mediated lysosome-mitochondria apoptosis signaling pathway,which strengthens the therapeutic potential of this biomaterial as localized anti-tumor treatment.

关键词： Biodegradable magnesium Hydrogen Tumor apoptosis Underlying mechanism P53

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Biological approaches to the repair and regeneration of the rotator cuff tendon-bone enthesis:a literature review

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Biomaterials Translational 2023年第2期4卷 85-103页

作者： Ahlam A.Abdalla Catherine J.Pendegrass institute of Sport Exercise and Health(ISEH)Division of Surgery&Interventional SciencesUniversity College LondonLondonUK department of orthopaedics&Musculoskeletal Science Division of Surgery&Interventional SciencesUniversity College LondonBrockley HillStanmoreUK

Entheses are highly specialised organs connecting ligaments and tendons to bones,facilitating force transmission,and providing mechanical strengths to absorb forces *** types of entheses,fibrocartilaginous and fibrous,exist in *** gradual fibrocartilaginous type is in rotator cuff tendons and is more frequently injured due to the poor healing capacity that leads to loss of the original structural and biomechanical properties and is attributed to the high prevalence of *** methodologies and outcomes of biological approaches are challenges to overcome for them to be routinely used in ***,stratifying the existing literature according to different categories(chronicity,extent of tear,and studied population)would effectively guide repair *** literature review supports tissue engineering approaches to promote rotator cuff enthesis healing employing cells,growth factors,and scaffolds *** suggest its promising role in animal studies as well as some clinical trials and that combination therapies are more beneficial than individualized *** then highlights the importance of tailoring interventions according to the tear extent,chronicity,and the population being *** factors such as loading,deficiencies,and lifestyle habits should also be taken into *** results can be achieved if biological,mechanical,and environmental factors are *** is challenging to determine whether variations are due to the interventions themselves,the animal models,loading regimen,materials,or tear *** research should focus on tailoring interventions for different categories to formulate protocols,which would best guide regenerative medicine decision making.

关键词： enthesis rotator cuff stem cells tissue engineering tendon-bone enthesis

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Rationalising animal research synthesis in orthopaedic literature

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World Journal of Methodology 2021年第3期11卷 75-80页

作者： Konstantinos Tsikopoulos Konstantinos Sidiropoulos Dimitrios Kitridis Lorenzo Drago Rakesh Ebnezar David Lavalette orthopaedic department Harrogate and District Foundation TrustHarrogate HG27SXNorth YorkshireUnited Kingdom orthopaedic department General Hospital of SerresSerres 62120Greece First Orthopedic department of Aristotle University G.Papanikolaou General HospitalThessaloniki 55210Greece Laboratory of Clinical Microbiology Department of Biochemical Sciences for HealthUniversity of MilanMilan 20164Italy

Systematic reviews in orthopaedic literature are frequently criticised for offering inconsistent *** top of that,high-quality randomized human evidence on crucial orthopaedic topics is more often than not *** this situation,pooling animal literature could offer an excellent insight into unanswered critical clinical questions,thus potentially improving *** this paper,we sought to present the rationale and basic principles governing meta-analysis of animal *** specifically,we elaborated on the available evidence-based methods to achieve a scientifically sound animal data *** addition,we discussed result interpretation,strength of recommendations and clinical implications based on the results of these meta-analytic modalities.

关键词： Meta-analysis Animal research Evidence synthesis in vivo orthopaedics

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