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Internet and social media usage of orthopaedic patients:A questionnaire-based survey

World Journal of Orthopedics 2017年第2期8卷 178-186页

作者： Tahir Mutlu Duymus Hilmi Karadeniz Mehmet Akif Cacan Baran Komür Abdullah Demirtas Sinan Zehir Ibrahim Azboy department of orthopaedics Haydarpasa Numune Training and Research Hospital department of orthopaedics and Traumatology Bah?elievler Medikal Park Hospital department of orthopaedics Bitlis State Hospital department of orthopaedics Kanuni Sultan Süleyman Training and Research Hospital department of Orthopedics and Traumatology G?ztepe Training and Research HospitalIstanbul Medeniyet University department of orthopaedics and Traumatology Hitit University Faculty of Medicine department of orthopaedics and Traumatology Dicle University Faculty of Medicine

AIM To evaluate social media usage of orthopaedic patients to search for solutions to their health problems. METHODS The study data were collected using face-to-face questionnaire with randomly selected 1890 patients aged over 18 years who had been admitted to the orthopaedic clinics in different cities and provinces across Turkey. The questionnaire consists of a total of 16 questions pertaining to internet and social media usage and demographics of patients, patients' choice of institution for treatment, patient complaints on admission, online hospital and physician ratings, communication between the patient and the physician and its *** It was found that 34.2%(n = 647) of the participants consulted with an orthopaedist using the internet and 48.7%(n = 315) of them preferred websites that allow users to ask questions to a physician. Of all questionaskers, 48.5%(n = 314) reported having found the answers helpful. Based on the educational level of the participants, there was a highly significant difference between the rates of asking questions to an orthopaedist using the internet(P = 0.001). The rate of questionasking was significantly lower in patients with an elementary education than that in those with secondary, high school and undergraduate education(P = 0.001) The rate of reporting that the answers given was helpful was significantly higher in participants with an undergraduate degree compared to those who were illiterate, those with primary, elementary or high school education(P = 0.001). It was also found that the usage of the internet for health problems was higher among managers-qualified participants than unemployed-housewives, officers, workers-intermediate staff(P < 0.05).CONCLUSION We concluded that patients have been increasingly using the internet and social media to select a specific physician or to seek solution to their health problems in an effective way. Even though the internet and social media offer beneficial effects for physician

关键词： Patient Internet Orthopedist Social media Communication

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Fabrication and Characterizations of Metallic Mg Containing PMMA-Based Partially Degradable Composite Bone Cements

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Acta Metallurgica Sinica(English Letters) 2019年第7期32卷 808-816页

作者： Xiao Lin Adrian Chan Xiao-Xiao Tan Hui-Lin Yang Lei Yang orthopaedic institute Soochow University Suzhou 215006 China department of orthopaedics The First Affiliated Hospital of Soochow University Suzhou 215006 China Waterloo institute for Nanotechnology (WIN) University of Waterloo 200 University Ave West Waterloo ON Canada School of Materials Engineering Shanghai University of Science and Engineering Shanghai 201620 China

Inadequate strength at the bone/cement interface is one of the main drawbacks of poly(methylmethacrylate)(PMMA) bone cement in the current orthopedic surgeries. In the present work, a partially degradable PMMA/Mg composite bone cement (PMC) was developed for enhancing the bone/cement interfacial strength, which is proposed to be accomplished by increasing the osteo-conductivity of PMMA and enhancing the mechanical interlocking between bone tissue and the porous PMMA surface formed by the degradation of Mg on the surface of the cement. PMCs were prepared with various concentrations of Mg particles with different sizes and alloy compositions. The effects of Mg particle size, composition and content on the injectability, mechanical and degradation properties, and biocompatibility of PMCs were evaluated. The results show that these parameters affected the properties of the PMCs simultaneously. The good injectability and compressive strengths of PMMA were preserved, while the compatibility to osteoblasts was enhanced when adding Mg particles in a proper manner. The PMCs degraded at the surface with time and formed porous surface structures in the physiological environment, while maintaining the original compressive strengths. This preliminary study shows that the PMC is promising for minimally invasive orthopedic surgery;however, it still requires to be optimized and evaluated in the future.

关键词： Biomaterials Composite Magnesium Poly(methylmethacrylate) Bone cement Kyphoplasty

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Multiple stress fractures of unilateral femur:A case report

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World Journal of Clinical Cases 2022年第13期10卷 4280-4287页

作者： Mao-Ting Tang Chun-Feng Liu Jin-Lian Liu Saijilafu Zhen Wang department of orthopaedics Suzhou Kowloon Hospital Shanghai Jiao Tong University School of MedicineSuzhou 215028Jiangsu ProvinceChina orthopaedic institute Medical CollegeSoochow UniversitySuzhou 215007Jiangsu ProvinceChina

BACKGROUND Stress fractures of the femoral neck are not common in clinical practice,and simultaneous stress fractures of the femoral neck and proximal femur of the unilateral femur are even more *** introduce a case of this type of fracture that was treated in our department,analyze the causes,and review similar stress fractures reported in the literature to provide references for the diagnosis and treatment of such *** SUMMARY A 62-year-old female,with a free medical history,was admitted to the hospital mainly due to pain in the right hip and worsening pain in the right *** patient had no obvious history of trauma.X-ray and computed tomography showed fracture of the femoral neck and proximal *** patient had undergone surgery 1 year prior to address a fracture of the left proximal femur that had occurred in a traffic *** first consideration was stress fracture of the femoral neck;however,simultaneous stress fractures of the femoral neck and proximal femur of the unilateral femur were *** femoral neck stress fracture was a tension fracture,with obvious displacement and varus deformity of the *** that the patient was an elderly female,we performed total hip ***-up X-rays showed that the stress fracture of the proximal femur had mostly healed after 3 *** Muscle fatigue and hip varus deformity provide an anatomical basis for the occurrence of femoral neck stress fractures.

关键词： Femoral neck fracture Femoral fracture Stress fracture Fatigue fracture Hip pain Case report

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Oxidized phospholipids are ligands for LRP6

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Bone research 2018年第3期6卷 266-279页

作者： Lei Wang Yu Chai Changjun Li Haiyun Liu Weiping Su Xiaonan Liu Bing Yu Weiqi Lei Bin Yu Janet L.Crane Xu Cao Mei Wan department of orthopaedics and Traumatology Nanfang Hospital Southern Medical University department of orthopaedic Surgery Johns Hopkins University School of Medicine department of Endocrinology Endocrinology Research Center The Xiangya Hospital of Central South University department of Dermatology Johns Hopkins University School of Medicine department of Pediatric Endocrinology Johns Hopkins University School of Medicine

Low-density lipoprotein receptor–related protein 6(LRP6) is a co-receptor for Wnt signaling and can be recruited by multiple growth factors/hormones to their receptors facilitating intracellular signaling activation. The ligands that bind directly to LRP6 have not been identified. Here, we report that bioactive oxidized phospholipids(oxPLs) are native ligands of LRP6, but not the closely related LRP5. oxPLs are products of lipid oxidation involving in pathological conditions such as hyperlipidemia, atherosclerosis, and inflammation. We found that cell surface LRP6 in bone marrow mesenchymal stromal cells(MSCs) decreased rapidly in response to increased oxPLs in marrow microenvironment. LRP6 directly bound and mediated the uptake of oxPLs by MSCs. oxPL-LRP6 binding induced LRP6 endocytosis through a clathrin-mediated pathway, decreasing responses of MSCs to osteogenic factors and diminishing osteoblast differentiation ability. Thus, LRP6 functions as a receptor and molecular target of oxPLs for their adverse effect on MSCs, revealing a potential mechanism underlying atherosclerosis-associated bone loss.

关键词： Low-density lipoprotein receptor–related protein 6

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Transdermal delivery of 4-aminopyridine accelerates motor functional recovery and improves nerve morphology following sciatic nerve crush injury in mice

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Neural Regeneration research 2020年第1期15卷 136-144页

作者： Andrew RClark Chia George Hsu M A Hassan Talukder Mark Noble John CElfar Center for orthopaedic research and Translational Science Penn State Hershey College of MedicineMilton S.Hershey Medical CenterHersheyPAUSA department of orthopaedics The University of Rochester Medical CenterRochesterNYUSA department of Medicine Aab Cardiovascular Research InstituteUniversity of Rochester School of Medicine and DentistryRochesterNYUSA department of Biomedical Genetics The University of Rochester Medical CenterRochesterNYUSA

Oral 4-aminopyridine(4-AP)is clinically used for symptomatic relief in multiple sclerosis and we recently demonstrated that systemic 4-AP had previously unknown clinically-relevant effects after traumatic peripheral nerve injury including the promotion of re-myelination,improvement of nerve conductivity,and acceleration of functional *** hypothesized that,instead of oral or injection administration,transdermal 4-AP(TD-4-AP)could also improve functional recovery after traumatic peripheral nerve *** with surgical traumatic peripheral nerve injury received TD-4AP or vehicle alone and were examined for skin permeability,pharmacokinetics,functional,electrophysiological,and nerve morphological properties.4-AP showed linear pharmacokinetics and the maximum plasma 4-AP concentrations were proportional to TD-4-AP *** a single dose of TD-4-AP administration demonstrated rapid transient improvement in motor function,chronic TD-4-AP treatment significantly improved motor function and nerve conduction and these effects were associated with fewer degenerating axons and thicker myelin sheaths than those from vehicle *** findings provide direct evidence for the potential transdermal applicability of 4-AP and demonstrate that 4-AP delivered through the skin can enhance in-vivo functional recovery and nerve conduction while decreasing axonal *** animal experiments were approved by the University Committee on Animal research(UCAR)at the University of Rochester(UCAR-2009-019)on March 31,2017.

关键词： 4-aminopyridine electron microscopy functional recovery nerve conduction velocity peripheral nerve injury pharmacokinetics transdermal administration

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Silver nanoparticle technology in orthopaedic infections

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世界骨科杂志:英文版 2023年第9期14卷 662-668页

作者： Madhan Jeyaraman Naveen Jeyaraman Arulkumar Nallakumarasamy Karthikeyan P Iyengar Vijay Kumar Jain Anish G Potty Ashim Gupta department of orthopaedics ACS Medical College and HospitalDr MGR Educational and Research InstituteChennai 600077Tamil NaduIndia department of orthopaedics South Texas Orthopaedic Research InstituteLaredoTX 78045United States department of Trauma and orthopaedics Southport&Ormskirk Hosp NHS Trust SouthportRichmond PR86PNSouthportUnited Kingdom department of orthopaedics Atal Bihari Vajpayee Institute of Medical SciencesDr Ram Manohar Lohia HospitalDelhi 110001New DelhiIndia department of Regenerative Medicine Future BiologicsLawrencevilleGA 30043United States department of Regenerative Medicine BioIntegarteLawrencevilleGA 30043United States

The irrational and prolonged use of antibiotics in orthopaedic infections poses a major threat to the development of antimicrobial *** combat antimi-crobial resistance,researchers have implemented various novel and innovative modalities to curb *** involves doping ions/metals onto the scaffolds to reach the target site to eradicate the infective *** this conno-tation,we reviewed silver nanoparticle technology in terms of mechanism of action,clinical applications,toxicity,and regulatory guidelines to treat ortho-paedic infections.

关键词： Antimicrobial resistance Biofilms Silver Nanoparticles orthopaedics

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Multi-View Point-Based Registration for Native Knee Kinematics Measurement with Feature Transfer Learning

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Engineering 2021年第6期7卷 881-888页

作者： Cong Wang Shuaining Xie Kang Li Chongyang Wang Xudong Liu Liang Zhao Tsung-Yuan Tsai Shanghai Key Laboratory of orthopaedic Implants&Clinical Translational R&D Center of 3D Printing Technology Department of Orthopaedic SurgeryShanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineSchool of Biomedical Engineering&Med-X Research InstituteShanghai Jiao Tong UniversityShanghai 200030China SenseTime research Shanghai 200233China Engineering research Center of Digital Medicine and Clinical Translation Ministry of EducationShanghai 200030China department of orthopaedics New Jersey Medical SchoolRutgers UniversityNewarkNJ 07103USA department of orthopaedics Shanghai Jiao Tong University Affiliated Sixth People’s HospitalShanghai 200233China

Deep-learning methods provide a promising approach for measuring in-vivo knee joint motion from fast registration of two-dimensional(2D)to three-dimensional(3D)data with a broad range of ***,if there are insufficient data for training,the data-driven approach will *** propose a feature-based transfer-learning method to extract features from fluoroscopic *** three subjects and fewer than 100 pairs of real fluoroscopic images,we achieved a mean registration success rate of up to 40%.The proposed method provides a promising solution,using a learning-based registration method when only a limited number of real fluoroscopic images is available.

关键词： 2D–3D registration Machine learning Domain adaption Point correspondence

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Function-oriented design:A novel strategy for advanced biomedical materials

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Journal of Materials Science & Technology 2023年第14期145卷 197-209页

作者： Zhiyu Zhou Wentao Wang Jianmin Wang Hongshui Wang Yi Xia Wei Zhang Yuxiao Lai Xiao Lin Yongcan Huang Xuenong Zou Martin J.Stoddart Zhen Li Wei Tian Shaoyu Liu Xinbao Wu Manman Gao Junhong Li Lei Yang Dafu Chen department of orthopaedic Surgery the Seventh Affiliated Hospital of Sun Yat-sen UniversityShenzhen 518107China Guangdong Provincial Key Laboratory of orthopaedics and Traumatology the First Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510080China Center for Health Science and Engineering School of Health Sciences and Biomedical EngineeringHebei University of TechnologyTianjin 300130China Centre for Translational Medicine research&Development Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518063China Orthopedic institute and department of Orthopedics the First Affiliated HospitalSoochow UniversitySuzhou 215000China Shenzhen Engineering Laboratory of orthopaedic Regenerative Technologies Department of Spine SurgeryPeking University Shenzhen HospitalShenzhen 518034China AO research institute Davos Davos7270Switzerland h Laboratory of Bone Tissue EngineeringBeijing Laboratory of Biomedical MaterialsBeijing Research Institute of Orthopaedics and TraumatologyBeijing Jishuitan HospitalBeijing 100035China department of Sport Medicine Institute of Translational Medicinethe First Affiliated Hospital of Shenzhen UniversityShenzhen Second People’s HospitalShenzhen 518025China Shenzhen Key Laboratory of Anti-aging and Regenerative Medicine Department of Medical Cell Biology and GeneticsHealth Sciences CenterShenzhen UniversityShenzhen 518060China The department of orthopaedics and Trauma the Affiliated Hospital of Yunnan UniversityYunnan UniversityKunming 650091China

It has always been a dream to construct tissues and even organs for transplantation to replace those with defects caused by diseases or *** engineering is another milestone in the developmental history of life science after cellular and molecular ***,despite decades of rapid de-velopment,tissue-engineered biomaterials have not been widely used *** constructed by physical and chemical methods have lots of difficulty in precisely mimicking the macroscopic and mi-croscopic structures of human *** ultimate way to build organoid tissue for regeneration is to enable the cells to take the initiative and build suitable *** on the thoughts of tissue engi-neering,organoid technology holds great potential as a research tool for a wide range of fields,including developmental biology,disease pathology,cell biology,precision medicine,and drug toxicity and efficacy *** technology also holds tremendous potential for regenerative medicine,as organoids present the possibility for autologous and allogeneic cell therapy through the replacement of damaged or dis-eased tissues with organoid-propagated tissue or stem cell *** this review work,we briefly outlook the development history of organoid technology,summarize the current bottlenecks and the un-derlying reasons,and propose the unified term“function-oriented design in tissue engineering”,a new topic that may provide a solution to overcome these bottlenecks.

关键词： Biomaterial Organoid Tissue engineering Function-oriented design

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Bioadaptive Nanorod Topography of Titanium Surface to Control Cell Behaviors and Osteogenic Differentiation of Preosteoblast Cells

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Journal of Materials Science & Technology 2016年第9期32卷 944-949页

作者： Shao Xu Zhiyu Zhou Manman Gao Changye Zou Yinglin Che Bünger Cody Xuenong Zou Lei Zhou department of Stomatology The Third Affiliated Hospital of Southern Medical University Guangdong Provincial Key Laboratory of Orthopedics and Traumatology/Orthopedic research institute The First Affiliated Hospital of Sun Yat-sen University department of Musculoskeletal Oncology The First Affiliated Hospital of Sun Yat-sen University orthopaedic research Laboratory Department of Orthopaedic Surgery Aarhus University Hospital Guangdong Provincial Stomatological Hospital Southern Medical University

Titanium （Ti） nanorods fabricated using selective corrosion of Ti substrate by anodic technology show better biocompatibility with pre-osteoblast cells. The current study investigated the response of the murine pre-osteoblast cell MCST3-E1 on Ti nanorod topography and untreated Ti surfaces by means of examination of the morphology and osteogenic differentiation responsible for the pre-osteoblast reaction. The morphology of MCST3-E1 cells was observed using scanning electron microscopy, and alkaline phosphatase （ALP） activity was measured using a colorimetric assay after incubation for 7, 14, and 21 days. The expression of three osteogenic differentiation markers including ALP, osteocalcin （OCN）, and collagen type 1A1 （COL1A1） and two transcription factors including runt related transcription factor 2 （Runx2） and osterix （Osx） at different time points was detected using real-time polymerase chain reaction analysis in both groups. Osx was used to confirm the protein level. The results showed that Ti nanorod surfaces provided prolonged higher levels of ALP activity compared with unmodified Ti surface on the 14th and 21st days. Gene expression analysis of ALP, OCN, and COL1A1 showed significant upregulation with modified nanorod topography after incubation for 14 and 21 days. Osteogenic transcription factors of Runx2 and Osx exhibited changes consistent with the osteogenic differentiation markers, and this may contribute to the persistently active differentiation of MC3T3-E1 cells in the Ti nanorod group. These results demonstrated that the current nanostructured surface may be considered bioadaptive topography to control cellular behaviors and osteoblast differentiation. The in vivo performance and applicability are further required to investigate osseointegration between implant and host bone in the early stages for prevention of aseptic implant loosening.

关键词： Titanium Nanorods Osteointegration Osteoblast differentiation

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Natural diatomite particles： Size-, dose- and shape- dependent cytotoxicity and reinforcing effect on injectable bone cement

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Journal of Materials Science & Technology 2018年第6期34卷 1044-1053页

作者： Xiang Zhang Huilin Yang Song Li Gaowu Qin Lei Yang College of Chemistry Chemical Engineering and Materials Science Orthopaedic Institute Soochow University Suzhou 215006 China Key LaboratoryforAnisotropy and Texture of Materials (Ministry of Education) School of Materials Science and Engineering Northeastern University Shenyang 110819 China International research Center for Translational orthopaedics (IRCTO) Soochow University Suzhou 215006 China

Natural diatomite （DT） is the ancient deposit of diatom skeleton with many regular pores of 50-200 nm and also an abundant source of biogenic silica. Although silica is considered biologically safe and there is an increasing interest of using natural diatomite for biomedical applications, the toxicity information about natural diatomite is still missing. Here, cytotoxicity of natural diatomite on osteoblasts and fibroblasts were compared to hydroxyapatite and the relationships between cytotoxicity and diatomite sizes, dose, geometry or impurity were systematically investigated. Cell adhesion and interaction with diatomite particles were also fluorescently observed, The results clearly suggested a size-, dose- and shape-dependent cytotoxicity of natural diatomite. Disk-shaped diatomite particles with average size of 30μm in diameter revealed the least toxicity, while the diatomite particles with irregular shapes and sizes less than 10 μm were remarkably toxic. Diatomite particles with proper sizes were then selected to investigate the reinforcing effect on injectable calcium phosphate bone cement. Results showed that diatomite significantly improved the compressive strength of bone cement but did not alter the injectability of the cement, This work provided important biocompatibility information of natural diatomite and demonstrated the feasibility of using selected diatomite as bone implant material.

关键词： Biocompatibility Size and shape effect Bone cement Particle Silica Kyphoplasty

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