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Copper homeostasis and neurodegenerative diseases

Neural Regeneration Research 2025年第11期20卷 3124-3143页

作者： Yuanyuan Wang Daidi Li Kaifei Xu Guoqing Wang Feng Zhang International Research laboratory of Ethnomedicine of Ministry of Education Key Laboratory of Basic Pharmacology of Ministry of EducationLaboratory Animal Center and Key Laboratory of Basic Pharmacology of Guizhou ProvinceZunyi Medical UniversityZunyiGuizhou ProvinceChina

Copper,one of the most prolific transition metals in the body,is required for normal brain physiological activity and allows various functions to work normally through its range of *** homeostasis is meticulously maintained through a complex network of copper-dependent proteins,including copper transporters(CTR1 and CTR2),the two copper ion transporters the Cu-transporting ATPase 1(ATP7A)and Cu-transporting beta(ATP7B),and the three copper chaperones ATOX1,CCS,and *** in copper homeostasis can lead to either the deficiency or accumulation of copper in brain *** evidence suggests that abnormal copper metabolism or copper binding to various proteins,including ceruloplasmin and metallothionein,is involved in the pathogenesis of neurodegenerative ***,the exact mechanisms underlying these processes are not *** is a potent oxidant that increases reactive oxygen species production and promotes oxidative *** reactive oxygen species levels may further compromise mitochondrial integrity and cause mitochondrial *** oxygen species serve as key signaling molecules in copper-induced neuroinflammation,with elevated levels activating several critical inflammatory ***,copper can bind aberrantly to several neuronal proteins,including alphasynuclein,tau,superoxide dismutase 1,and huntingtin,thereby inducing neurotoxicity and ultimately cell *** study focuses on the latest literature evaluating the role of copper in neurodegenerative diseases,with a particular focus on copper-containing metalloenzymes and copper-binding proteins in the regulation of copper homeostasis and their involvement in neurodegenerative disease *** synthesizing the current findings on the functions of copper in oxidative stress,neuroinflammation,mitochondrial dysfunction,and protein misfolding,we aim to elucidate the mechanisms by which copper contributes to a wide range of heredit

关键词： Alzheimer's disease amyotrophic lateral sclerosis disease copper homeostasis copper toxicity Huntington's disease Menkes'disease multiple sclerosis neurodegenerative disease Parkinson's disease Wilson's disease

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Does cryptic dichromatism exist in the Saffron Finch(Sicalis flaveola)?Colorimetric variables and the avian visual model

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Avian Research 2023年第3期14卷 405-415页

作者： Lorena Cruz-Bernate Camilo Espinosa-Bravo Hector Fabio Rivera-Gutierrez ornithology and animal behavior laboratory-oyca GEAHNA GroupBiology Department of the Natural and Exact Sciences FacultyUniversidad del ValleCaliColombia Ecology and Evolution Vertebrates Group Biology InstituteNatural and Exact Sciences FacultyUniversidad de AntioquiaMedellínColombia

Sexual dichromatism,a particular type of sexual dimorphism,occurs in several species and has been associated with sexual *** some cases,the differences are so small that they are imperceptible to humans,but possibly detected by *** objective measurement of color with spectrophotometers and detailed analyses according to the perception ability of the avian eye have revealed that some species that were once considered to be monochromatic,are in fact dichromatic and able to perceive these *** the tropics,the Saffron Finch(Sicalis flaveola) does not present marked sexual dimorphism in coloration,which makes studies in behavioral ecology,natural history and population dynamics *** assess whether there is dichromatism in the species,the reflectance(between 300 and 700 nm) of ten body regions was measured in 196 wild adults in *** was determined using the CHD1 gene on the sex *** spectra were analyzed using:colorimetric variables and the avian visual *** found that reflectance shows a bimodal curve in all body regions,except the *** presented higher reflectance at long wavelengths,while for females this occurred in ultraviolet *** the visual model,we found that there are significant intrasexual differences;however only in crown coloration is there a possible perceived difference between *** conclude that in the Saffron Finch there are color differences between the sexes in all regions considering the physical phenomenon(reflectance),but in general,when evaluating color perception(avian visual model),there are no differences between the sexes in most of the body *** intrasexual differences are significant,indicating the possibility of these being signals that influence social interactions in the species.

关键词： Carotenoids Color discrimination Colombia Intrasexual signals Social selection Tanagers Tropical region

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Ecotoxicological effects of waterborne PFOS exposure on swimming performance and energy expenditure in juvenile goldfish (Carassius auratus)

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Journal of Environmental Sciences 2013年第8期25卷 1672-1679页

作者： Jigang Xia Shijian Fu Zhendong Cao Jianglan Peng Jing Peng Tingting Dai Lili Cheng laboratory of Evolutionary Physiology and behavior Chongqing Key Laboratory of Animal Biology Chongqing Normal University

The potential risks of perfluorooctane sulfonate （PFOS） are of increasing ecological concern. Swimming performance is linked to the fitness and health of fish. However, the impacts of PFOS on swimming performance remain largely unknown. We investigated the ecotoxicological effects of acute exposure to PFOS on the swimming performance and energy expenditure of juvenile goldfish （Carassius auratus）. The fish were exposed to a range of PFOS concentrations （0, 0.5, 2, 8 and 32 mg/L） for 48 hr. The spontaneous swimming activity, fast-start swimming performance, critical swimming speed （Ucrit） and active metabolic rate （AMR） of the goldfish were examined after exposure to PFOS. PFOS exposure resulted in remarkable effects on spontaneous activity. Motion distance was reduced, and the proportion of motionless time increased with increasing concentrations of PFOS. However, no significant alterations in the fast-start performance-related kinematic parameters, such as latency time, maximum linear velocity, maximum linear acceleration or escape distance during the first 120 msec after stimulus, were observed after PFOS exposure. Unexpectedly, although PFOS exposure had marked influences on the swimming oxygen consumption rates and AMR of goldfish, the U crit of the goldfish was not significantly affected by PFOS. This may result in a noteworthy increase in the energetic cost of transport. The overall results indicate that, in contrast to spontaneous activity, underlying swimming capabilities are maintained in goldfish after short-term exposure to PFOS, but energy expenditure during the process of swimming is dramatically aggravated.

关键词： perfluorooctane sulfonate (PFOS) spontaneous activity fast-start performance critical swimming speed energy expenditure goldfish

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The dual antimicrobial and immunomodulatory roles of host defense peptides and their applications in animal production

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Journal of animal Science and Biotechnology 2023年第2期14卷 501-514页

作者： Di Wu Linglong Fu Weizhang Wen Na Dong State Key laboratory of animal Nutrition College of Animal Science and TechnologyChina Agricultural UniversityBeijing 100193China

Host defense peptides(HDPs)are small molecules with broad-spectrum antimicrobial activities against infectious bacteria,viruses,and *** evidence suggests that HDPs can also indirectly protect hosts by modulating their immune *** to these dual roles,HDPs have been considered one of the most promising antibiotic substitutes to improve growth performance,intestinal health,and immunity in farm *** review describes the antimicrobial and immunomodulatory roles of host defense peptides and their recent applications in animal production.

关键词： Antimicrobials Host defense peptides Immunomodulation Poultry Ruminants Swine

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Gut health benefit and application of postbiotics in animal production

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Journal of animal Science and Biotechnology 2022年第4期13卷 999-1010页

作者： Yifan Zhong Shanshan Wang Hanqiu Di Zhaoxi Deng Jianxin Liu Haifeng Wang College of animal Science Zhejiang UniversityThe Key Laboratory of Molecular Animal NutritionMinistry of EducationHangzhou 310058China

Gut homeostasis is of importance to host health and imbalance of the gut usually leads to disorders or diseases for both human and *** have been applied in manipulating of gut health,and utilization of postbiotics threads new lights into the host *** with the application of probiotics,the characteristics such as stability and safety of postbiotics make it a potential alternative to *** have reported the beneficial effects of components derived from postbiotics,mainly through the mechanisms including inhibition of pathogens,strengthen gut barrier,and/or regulation of immunity of the *** this review,we summarized the characteristics of postbiotics,main compounds of postbiotics,potential mechanisms in gut health,and their application in animal production.

关键词： animal production Gut health Postbiotics

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New horizons for selenium in animal nutrition and functional foods

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animal Nutrition 2022年第4期11卷 80-86页

作者： Xin Gu Chun-qi Gao Guangdong Provincial Key laboratory of animal Nutrition Control/Key laboratory of Chicken Genetics Breeding and ReproductionMinistry of AgricultureCollege of Animal ScienceSouth China Agricultural University GuangdongChina College of Animal SciencesZhejiang UniversityHangzhouChina

Selenium(Se),one of the indispensable nutrients for both human health and animal growth,participates in various physiological functions,such as antioxidant and immune responses and *** role of dietary Se,in its organic and inorganic forms,has been well documented in domestic ***,many feeding strategies for different animals have been developed to increase the Se concentration in animal products to address Se deficiency and even as a potential nutritional strategy to treat free radical-associated ***,studies on investigating the optimum addition of Se in feed,the long-term consequences of Se usage in food for animal nutrition,the mechanism of metallic Se nanoparticle(SeNP)transformation in vivo,and the nutritional effects of SeNPs on feed workers and the environment are urgently *** from the absorption and metabolism mechanism of Se,this review discusses the antioxidant role of Se in *** on this characteristic,we further investigated the application of Se in animal health and described some unresolved issues and unanswered questions warranting further *** review is expected to provide a theoretical reference for improving the quality of food animal meat as well as for the development of Se-based biological nutrition enhancement technology.

关键词： Selenium Antioxidant Meat quality Functional foods

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Review on the development of genotyping methods for assessing farm animal diversity

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Journal of animal Science and Biotechnology 2013年第4期4卷 235-240页

作者： Wanjie Yang Xiaolong Kang Qingfeng Yang Yao Lin Meiying Fang Department of animal Genetics and Breeding National Engineering Laboratory for Animal Breeding MOA Laboratory of Animal Genetics and Breeding College of Animal Science and Technology China Agricultural University College of Agriculture Ningxia University National animal Husbandry and Veterinary Service

Advances in molecular biotechnology have introduced new generations of molecular markers for use in the genetic improvement of farm animals. Consequently, more accurate genetic information can be obtained to better understand existing animal genetic resources. This review gives a brief summary on the development of genetic markers including both the classical genetic markers and more advanced DNA-based molecular markers. This review will help us better understand the characteristics of different genetic markers and the genetic diversity of animal genetic resources.

关键词： Farm animal genetic resources Genetic evaluation Genetic markers Molecular markers

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Effects of relative humidity on animal health and welfare

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Journal of Integrative Agriculture 2017年第8期16卷 1653-1658页

作者： XIONG Yan MENG Qing-shi GAO Jie TANG Xiang-fang ZHANG Hong-fu State Key laboratory of animal Nutrition Institute of Animal SciencesChinese Academy of Agricultural SciencesBeijing 100193P.R.China

Farm animals are sources of meat, milk and eggs for the humans, and animal health ensures the quality and security of these agricultural and sideline products. The animal raising conditions in livestock stations and poultry houses play vital roles in both animal health and production. One of the major factors affecting raising conditions, relative humidity, has not received much attention even though it is important for animal husbandry. In this review, we summarize the impacts of relative humidity on animal health and welfare to draw attention for its importance in the improvement of animal raising conditions in the future.

关键词： relative humidity animal health welfare

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Oligodendroglial heterogeneity in health,disease,and recovery:deeper insights into myelin dynamics

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Neural Regeneration Research 2025年第11期20卷 3179-3192页

作者： Pieter-Jan Serneels Julie D.De Schutter Lies De Groef Lieve Moons Steven Bergmans KU Leuven Leuven Brain InstituteDepartment of BiologyAnimal Physiology and Neurobiology DivisionNeural Circuit Development&Regeneration Research GroupLeuvenBelgium KU Leuven Leuven Brain InstituteDepartment of BiologyAnimal Physiology and Neurobiology DivisionCellular Communication&Neurodegeneration Research GroupLeuvenBelgium

Decades of research asserted that the oligodendroglial lineage comprises two cell types:oligodendrocyte precursor cells and ***,recent studies employing single-cell RNA sequencing techniques have uncovered novel cell states,prompting a revision of the existing *** forward,the oligodendroglial lineage should be delineated into five distinct cell states:oligodendrocyte precursor cells,committed oligodendrocyte precursor cells,newly formed oligodendrocytes,myelin-forming oligodendrocytes,and mature *** new classification system enables a deeper understanding of the oligodendroglia in both physiological and pathological *** this uniform terminology will facilitate comparison and integration of data across ***,including the consolidation of findings from various demyelinating models,is essential to better understand the pathogenesis of demyelinating ***,comparing injury models across species with varying regenerative capacities can provide insights that may lead to new therapeutic strategies to overcome remyelination ***,by standardizing terminology and synthesizing data from diverse studies across different animal models,we can enhance our understanding of myelin pathology in central nervous system disorders such as multiple sclerosis,Alzheimer's disease,and amyotrophic lateral sclerosis,all of which involve oligodendroglial and myelin dysfunction.

关键词： animal models demyelination fish mammals multiple sclerosis myelin neurodegeneration oligodendrocytes oligodendroglial lineage remyelination

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Cloning and expression of swine myostatin gene and its application in animal immunization trial

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Science China(Life Sciences) 2005年第4期48卷 368-374页

作者： MA Xianyong CAO Yongchang SHU Dingming BI Yingzuo Genetic Engineering laboratory College of Animal Science South China Agricultural University Guangzhou 510642 China Genetic Engineering Laboratory College of Animal Science South China Agricultural University Guangzhou 510642 China Genetic Engineering Laboratory College of Animal Science South China Agricultural University Guangzhou 510642 China Genetic Engineering Laboratory College of Animal Science South China Agricultural University Guangzhou 510642 China

We have amplified swine myostatin (MSTN) gene by reverse transcription poly-merase chain reaction (RT-PCR) and cloned it into pGEM-T Easy vector. The cloned swine MSTN gene consists of 1128 nucleotides, which has been submitted to GenBank (acquired reg-istered code- AY448008). The cloned swine MSTN gene was successfully expressed in E. coli without the first 25 amino acids. Crude extraction of the expressed recombinant MSTN protein was used to immunize mice to investigate the effects on their bodyweights. We show here that the body weights of the immunized mice were higher than that of the controls, even though the difference was not significant. Surprisingly, the progenies of the immunized mice also were heavier than the controls. Especially at day 3, the average body weight of the immunized mice was 10.5% higher than that of the controls , which is significant (p < 0.05).

关键词： myostatin, gene cloning, sequencing, protein expression, detection, immunization.

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