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RUFY4 deletion prevents pathological bone loss by blocking endo-lysosomal trafficking of osteoclasts

Bone Research 2024年第2期12卷 407-420页

作者： Minhee Kim Jin Hee Park Miyeon Go Nawon Lee Jeongin Seo Hana Lee Doyong Kim Hyunil Ha Taesoo Kim Myeong Seon Jeong Suree Kim Taesoo Kim Han Sung Kim Dongmin Kang Hyunbo Shim Soo Young Lee Department of Life Science Ewha Womans UniversitySeoul 03760South Korea The Research center for Cellular Homeostasis Ewha Womans UniversitySeoul 03760South Korea Department of Biomedical Engineering Yonsei UniversityWonju 26493South Korea KM Convergence Research Division Korea Institute of Oriental MedicineDaejeon 34054South Korea Chuncheon center Korea Basic Science InstituteChuncheon 24341South Korea Fluorescence Core Imaging center and Bioimaging Data Curation center Ewha Womans UniversitySeoul 03760South Korea Multitasking Macrophage Research center Ewha Womans UniversitySeoul 03760South Korea

Mature osteoclasts degrade bone matrix by exocytosis of active proteases from secretory lysosomes through a ruffled ***,the molecular mechanisms underlying lysosomal trafficking and secretion in osteoclasts remain largely ***,we show with GeneChip analysis that RUN and FYVE domain-containing protein 4(RUFY4)is strongly upregulated during *** lacking Rufy4 exhibited a high trabecular bone mass phenotype with abnormalities in osteoclast function in ***,deleting Rufy4 did not affect osteoclast differentiation,but inhibited bone-resorbing activity due to disruption in the acidic maturation of secondary lysosomes,their trafficking to the membrane,and their secretion of cathepsin K into the extracellular ***,RUFY4 promotes late endosome-lysosome fusion by acting as an adaptor protein between Rab7 on late endosomes and LAMP2 on primary ***,Rufy4-deficient mice were highly protected from lipopolysaccharide-and ovariectomy-induced bone ***,RUFY4 plays as a new regulator in osteoclast activity by mediating endo-lysosomal trafficking and have a potential to be specific target for therapies against bone-loss diseases such as osteoporosis.

关键词： osteoclast inhibited traffic

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Amelioration of habitat since the early Holocene contributed to the origin of agriculture in the farming-pastoral zone of northern China

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Science China Earth Sciences 2024年第8期67卷 2535-2546页

作者： Xin JIA Zhiping ZHANG Yonggang SUN Runqi JIANG Shuangwen YI Wei CHEN Jue SUN Guoqiang LI Shuzhi WANG Enrui LI Xiaonong HU Qingchun BAO Harry F.LEE Huayu LU Jiangsu center for Collaborative Innovation in Geographical Information Resource Development and Application Nanjing 210023China Schlool of History and Culture Chifeng UniversityChifeng 024000China School of Geography and Ocean Science Nanjing UniversityNanjing 210023China State Key Laboratory of Palaeobiology and Stratigraphy Nanjing Institute of Geology and PalaeontologyChinese Academy of SciencesNanjing 210008China Key Laboratory of Western China’s Environmental Systems(Ministry of Education) College of Earth and Environmental SciencesLanzhou UniversityLanzhou 730000China Institute of archaeology Chinese Academy of Social SciencesBeijing 100710China Ulanqab Museum Ulanqab 012000China The Institute of Cultural Relics and archaeology Hohhot 010011China Department of Geography and Resource Management The Chinese University of Hong KongHong Kong 999077China Key Laboratory of Virtual Geographic Environment(Ministry of Education of PRC) Nanjing Normal UniversityNanjing 210023China School of Geography Nanjing Normal UniversityNanjing 210023China Institute of Environmental archaeology Nanjing Normal UniversityNanjing 210023China

The origin of agriculture in the farming-pastoral zone of northern China remains in *** central region of the Inner Mongolia Plateau is located in the core area of the farming-pastoral zone;thus,it is a critical region for exploring the origin of the dryland farming system in northern *** study selected the Yumin Site and Banan Site,which belong to the Yumin Culture-the beginning of Neolithic culture in Inner Mongolia-as the research *** on the quartz optically stimulated luminescence(OSL)dating on the sedimentary sections from the Yumin site(YM)and Banan site(BN1 and BN2),the Holocene chronology framework of each section was *** that,by identifying carbonized grains in the Yumin site and the multi-proxy analysis of each section,we investigated the relationship between the origin of agriculture and climate change in this *** results revealed that the timing of the origin of agriculture recorded in the Yumin site lagged behind the timing of a significant increase of precipitation during the early Holocene but coincided with the timing of a significant increase of vegetation around 8.4 *** phenomenon was further confirmed by the published high-resolution paleoenvironmental records from the surrounding area of the Yumin *** propose that with the gradual amelioration of hydrothermal conditions since the beginning of the Holocene,the regional ecosystem had been improved,resulting in the gradual conversion of the land surface from infertile sand to organic-rich soil,providing an appropriate environmental foundation for the origin of dryland farming in northern China around 8.4 *** study highlighted that the“accumulative environmental effects”during the early Holocene played a vital role in the origin of agriculture in northern China and provided a reference for agricultural management in the context of future climate change.

关键词： Origin of agriculture Accumulative environmental effects Yumin Culture Northern China Holocene

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A VGGNet-based correction for satellite altimetry-derived gravity anomalies to improve the accuracy of bathymetry to depths of 6500 m

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Acta Oceanologica Sinica 2024年第1期43卷 112-122页

作者： Xiaolun Chen Xiaowen Luo Ziyin Wu Xiaoming Qin Jihong Shang Huajun Xu Bin Li Mingwei Wang Hongyang Wan Key Laboratory of Submarine Geosciences Second Institute of OceanographyMinistry of Natural ResourcesHangzhou 310012China Ocean College Zhejiang UniversityZhoushan 316021China Key Laboratory of Ocean Space Resources Management Technology Marine Academy of ZhejiangHangzhou 310012China School of Oceanography Shanghai Jiao Tong UniversityShanghai 200240China School of Civil Engineering and Architectures Zhejiang University of Science and TechnologyHangzhou 310023China National center for archaeology Beijing 100013China

Understanding the topographic patterns of the seafloor is a very important part of understanding our *** the science involved in bathymetric surveying has advanced much over the decades,less than 20%of the seafloor has been precisely modeled to date,and there is an urgent need to improve the accuracy and reduce the uncertainty of underwater survey *** this study,we introduce a pretrained visual geometry group network(VGGNet)method based on deep *** apply this method,we input gravity anomaly data derived from ship measurements and satellite altimetry into the model and correct the latter,which has a larger spatial coverage,based on the former,which is considered the true value and is more *** obtaining the corrected high-precision gravity model,it is inverted to the corresponding bathymetric model by applying the gravity-depth *** choose four data pairs collected from different environments,i.e.,the Southern Ocean,Pacific Ocean,Atlantic Ocean and Caribbean Sea,to evaluate the topographic correction results of the *** experiments show that the coefficient of determination(R~2)reaches 0.834 among the results of the four experimental groups,signifying a high *** standard deviation and normalized root mean square error are also evaluated,and the accuracy of their performance improved by up to 24.2%compared with similar research done in recent *** evaluation of the R^(2) values at different water depths shows that our model can achieve performance results above 0.90 at certain water depths and can also significantly improve results from mid-water depths when compared to previous ***,the bathymetry corrected by our model is able to show an accuracy improvement level of more than 21%within 1%of the total water depths,which is sufficient to prove that the VGGNet-based method has the ability to perform a gravity-bathymetry correction and achieve outstanding results.

关键词： gravity anomaly bathymetry inversion VGGNet multibeam sonar satellite altimetry

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Reconstructing the food structure of ancient coastal inhabitants from Beiqian village:Stable isotopic analysis of fossil human bone

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Chinese Science Bulletin 2012年第12期57卷 2148-2154页

作者： WANG Fen FAN Rong KANG HaiTao JIN GuiYun LUAN FengShi FANG Hui LIN YuHai YUAN ShiLing oriental archaeology researeh center Shandong UniversityJinan 250100China School of Chemistry and Chemical Engineering Shandong UniversityJinan 250100China Institute of Conservation and archaeology of Qingdao Qingdao 266003China

The Beiqian site located in Jimo city,Qingdao,a few kilometers from the modern coastline was excavated in 2007,2009 and 2011.A large number of human bones from the early Dawenkou period were *** C and N stable isotopic analysis,the food structure of the "Beiqian" ancestors was reconstructed and the influence of terrestrial and marine resources on their lifestyle was *** on the δ13C and δ15N stable isotopic values of human bone collagen,the analytical results obtained through a ternary mixed model reveal that the food sources of the Beiqian ancestors included about 44.1% marine species(probably shellfish and fish),34.1% C4 plants(possibly millet),and 21.8% land *** results indicate that they lived mainly from fishing and farming,supplemented by hunting or poultry *** with other sites in the same period,the stable isotope results show that 5000-6000 years ago,the lifestyles of ancestors in the Yangtze River basin,Yellow River basin,Northern coastal area and inland area were very *** ancestors from the Yangtze River basin focused on rice farming and fishing,whereas the ancestors in the Yellow River basin farmed millet and raised *** in coastal areas relied mostly on farming and marine fishing.

关键词：稳定同位素分析沿海地区食物结构古代居民海洋生物资源人骨化石内陆地区

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Delphi study for developing a checklist of adverse events associated with acupotomy

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Journal of Integrative Medicine 2024年第5期22卷 579-587页

作者： Hyungsun Jun Haebeom Lee Sang-Hoon Yoon Chan-Young Kwon Damin Jeon Jun-Hwan Lee Jungtae Leem Department of Diagnostics College of Korean MedicineWonkwang UniversityIksan 54538Republic of Korea 7Days Inc. Seoul 06247Republic of Korea Chung-Yeon Korean Medicine Clinic Seoul 06224Republic of Korea Department of oriental Neuropsychiatry Dong-Eui University College of Korean MedicineBusan 47227Republic of Korea Chonnam National University Hwasun Hospital Hwasun 58128Republic of Korea KM Science Research Division Korea Institute of Oriental MedicineDaejeon 34054Republic of Korea Department of Korean Convergence Medical Science KIOM SchoolUniversity of Science&Technology(UST)Daejeon 34054Republic of Korea Department of Physical Medicine and Rehabilitation Spaulding Rehabilitation HospitalHarvard Medical SchoolBostonMA 02115USA Research center of Traditional Korean Medicine College of Korean MedicineWonkwang UniversityIksan 54538Republic of Korea

Background Acupotomy,a more invasive procedure than acupuncture,involves the use of a thicker needle with an integrated knife at the tip,necessitating safety *** aimed to define relevant adverse events(AEs)and create a standardized form of the ACUPOtomy-related AEs CHECKlist(ACUPOCHECK).Methods Before conducting the Delphi process,a systematic review and pilot prospective study were conducted to gather information on previously reported *** these data,pilot versions of the ACUPOCHECK and Delphi questionnaires were *** Delphi questionnaire involved selecting types of AE for inclusion,establishing separate criteria for acupotomy-related AEs,and achieving a consensus on AE *** Korean doctors with experience in acupotomy or AE research were recruited to participate in each Delphi *** was considered to have been reached if the critical value for the content validity ratio met or exceeded *** The final ACUPOCHECK was developed using four rounds of the Delphi method and one face-to-face consensus *** included 12 local AEs(pain,hemorrhage,bruise,hematoma,edema,pruritus,rash,infection,nerve damage,dysesthesia,movement impairment,and pneumothorax)and 14 systemic AEs(disease aggravation,needle fatigue,sleepiness,procedural nausea,procedural vomiting,procedural headache,procedural dizziness,sweating,procedural shock,syncope,dyspnea,procedural pain,sleep disorder,and postprocedural infection).Separate criteria were established for pain,hemorrhage and bruising:pain was defined as pain that occurrs during daily activities and persists for longer than 72 h,hemorrhage as bleeding that continues for≥3 min despite pressure application,and bruising as having a bruise with a diameter of≥3 ***-ended descriptions were allowed for AEs not covered by the checklist,and severity and causality were assessed using the Common Terminology Criteria for Adverse Events and modified World Health Organization-Uppsala Monitoring C

关键词： Acupotomy Delphi technique Patient safety Safety management Adverse event

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Single-atom Pd anchored in the porphyrin-center of ultrathin 2D-MOFs as the active center to enhance photocatalytic hydrogen-evolution and NO-removal

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Chinese Chemical Letters 2024年第9期35卷 364-368页

作者： Xingyan Liu Chaogang Jia Guangmei Jiang Chenghua Zhang Mingzuo Chen Xiaofei Zhao Xiaocheng Zhang Min Fu Siqi Li Jie Wu Yiming Jia Youzhou He Chongqing Key Laboratory of Catalysis and New Environmental Materials College of Environment and ResourcesChongqing Technology and Business UniversityChongqing 400067China School of Pharmacy North Sichuan Medical CollegeNanchong 637100China Carbon Neutrality Technology Application Research center College of River and Ocean EngineeringChongqing Jiaotong UniversityChongqing 400074China State Key Joint Laboratory of Environment Simulation and Pollution Control School of EnvironmentTsinghua UniversityBeijing 100084China National Local Joint Engineering Research center for Road Engineering and Disaster Prevention and Reduction Technology in Mountainous Areas China Merchants Chongqing Communications Technology Research and Design Institute Co.Ltd.Chongqing 400067China Chongqing Culture Relics and archaeology Research Institute Chongqing 400013China

Single-atom catalysts were widely used to treat atmospheric pollution and alleviate energy crises through ***,how to prevent the aggregation of single atoms during the preparation and catalytic processes remained a great ***,a novel ultrathin two-dimensional porphyrin-based single-atom photocatalyst Ti-MOF(abbreviated as TMPd)obtained through a simple hydrothermal synthesis strategy was used for photocatalytic hydrogen evolution and NO removal,in which the singleatom Pd tightly anchored in the center of porphyrin to ensure single-atom Pd stable *** with most reported MOFs-based photocatalysts,the TMPd showed an excellent hydrogen evolution rate(1.32 mmol g^(-1)h^(-1))and the NO removal efficiency(62%)under visible light *** high-angle annular dark-field scanning transmission electron microscope(HAADF-STEM)and synchrotron-radiation-based X-ray absorption fine-structure spectroscopy(XAFS)proved that pd in TMPd existed in an isolated state,and the atomic force microscope(AFM)proved the ultrathin morphology of *** calculations had demonstrated that single-atom Pd could serve as the active center and more effectively achieve electron transfer,indicating that single-atom Pd played a vital role in photocatalytic hydrogen *** addition,a possible photocatalytic pathway of NO removal was proposed based on ESR and in-situ infrared spectra,in which the catalysts anchored with single-atom Pd could produce more active substances and more effectively oxidize NO to NO_(2)^(-)or NO_(3)^(-).The results suggested that coordinating single-atom metal species as the active site in the center of porphyrin could be a feasible strategy to obtain various ultrathin porphyrin-based single-atom photocatalysts to acquire excellent photocatalytic performance further.

关键词： Porphyrin-based MOFs Single-atom Pd Ultrathin 2D nanosheets Hydrogen evolution NO removal

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Viral-host molecular interactions and metabolic modulation:Strategies to inhibit flaviviruses pathogenesis

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World Journal of Virology 2024年第4期13卷 41-50页

作者： Zeeshan Ahmad Khan Mukesh Kumar Yadav Dong-Woo Lim Hojun Kim Jing-Hua Wang AbuZar Ansari Biohealth Products Research center(BPRC) Research Center for Agedlife Redesign(RCAR)Department of Physical TherapyINJE UniversityGimhae 5084South Korea Department of Microbiology Central University of PunjabBathinda 151401India Department of Diagnostics College of Korean MedicineDongguk UniversityGoyang 10326South Korea Division of Rehabilitation Medicine of Korean Medicine Department of Oriental Rehabilitation MedicineDongguk UniversityIlsan HospitalGoyang 10326South Korea Institute of oriental Medicine Dongguk UniversityGoyang 10326South Korea Department of Obstetrics and Gynecology Ewha Womans UniversitySeoul 07985South Korea

Flaviviruses,which include globally impactful pathogens,such as West Nile virus,yellow fever virus,Zika virus,Japanese encephalitis virus,and dengue virus,contribute significantly to human *** the ongoing emergence and resurgence of flavivirus-mediated pathogenesis,the absence of specific therapeutic options remains a challenge in the prevention and treatment of flaviviral *** the intricate processes of fusion,transcription,replication,and maturation,the complex interplay of viral and host metabolic interactions affects *** interactions involve metabolic molecules,such as amino acids,glucose,fatty acids,and nucleotides,each playing a pivotal role in the replication and maturation of *** viral-host metabolic molecular interactions hijack and modulate the molecular mechanisms of host metabolism.A comprehensive understanding of these intricate metabolic pathways offers valuable insights,potentially unveiling novel targets for therapeutic interventions against flaviviral *** review emphasizes promising avenues for the development of therapeutic agents that target specific metabolic molecules,such as amino acids,glucose,fatty acids,and nucleotides,which interact with flavivirus replication and are closely linked to the modulation of host *** clinical limitations of current drugs have prompted the development of new inhibitory strategies for flaviviruses based on an understanding of the molecular interactions between the virus and the host.

关键词： Flavivirus Nonstructural proteins Virus-host interaction Metabolism Inhibitors Vaccines

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Ancient DNA unravels species identification from Laosicheng site,Hunan Province,China,and provides insights into maternal genetic history of East Asian leopards

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Zoological Research 2024年第1期45卷 226-229页

作者： Ming Zhang Cai-Hui Wang Yu-Xin Zheng Qi-Gao Jiangzuo Ye-Mao Hou Peng Cao Qing-Yan Dai Ruo-Wei Yang Feng Liu Xiao-Tian Feng Lin-Heng Mo Qiao-Mei Fu China-Central Asia"the Belt and Road"Joint Laboratory on Human and Environment Research Key Laboratory of Cultural Heritage Research and ConservationSchool of Culture HeritageNorthwest UniversityXi’anShaanxi 710127China Shanghai Qi Zhi Institute Shanghai 200232China College of Life Sciences Northwest UniversityXi’anShaanxi 710127China Key Laboratory of Vertebrate Evolution and Human Origins Institute of Vertebrate Paleontology and PaleoanthropologyCenter for Excellence in Life and PaleoenvironmentChinese Academy of SciencesBeijing 100044China Cultural Relics and archaeology Institute of Hunan ChangshaHunan 410083China University of the Chinese Academy of Sciences Beijing 100049China

DEAR EDITOR,The Laosicheng site in Yongshun County,Hunan Province,China,plays an important role in elucidating the animal population composition of the region prior to the middle Qing Dynasty(approximately 300 years ago).This site has yielded a substantial number of animal bones,11960 of which have been identified to the species level,serving as direct evidence of ancient animal populations(Hunan Provincial Institute of Cultural Relics and archaeology,2018).

关键词： Hunan Ancient insight

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A preliminary study of early agriculture practices at the Haojiatai site in Luohe city,Henan Province

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Science China Earth Sciences 2021年第2期64卷 307-317页

作者： Zhenhua DENG Hai ZHANG Wei LI Fawei LIANG Yanpeng CAO center for the Study of Chinese archaeology Peking UniversityBeijing 100871China School of archaeology and Museology Peking UniversityBeijing 100871China Henan Provincial Institute of Cultural Relics and archaeology Zhengzhou 450099China

As the most fundamental economic sector of human societies,farming has played a significant role in interactions between humans and the *** study of crop patterns in various regions could not only clarify the economic foundations of early societies,but also greatly improve our understanding of interactions among human beings,the environment,and other *** this regard,this study focuses on early agriculture practices at the Haojiatai site,situated in the cultural and natural transitional region between North and South *** plant remains from this site reveal that foxtail millet was the most important staple crop here during the Longshan and Xinzhai periods(4300–3800 *** BP),along with common millet and a small amount of rice and *** crop pattern is in contrast to the ancient environmental conditions of this region,and cultural factors such as agriculture traditions and food preferences may have been more important in the formation process of this crop pattern.

关键词： Huang-Huai Plain Longshan period Agriculture pattern Cultural influence

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Use-wear analysis confirms the use of Palaeolithic bone tools by the Lingjing Xuchang early human

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Chinese Science Bulletin 2010年第21期55卷 2282-2289页

作者： LI ZhanYang 1,4 & SHEN Chen 2,3,4 1 Henan Provincial Institute of Cultural Relics and archaeology,Zhengzhou 450000,China 2 The Joint Laboratory of Human Evolution and Archaeometry,Chinese Academy of Sciences,Beijing 100044,China 3 The Royal Ontario Museum,Toronto ON M5S2C6,Canada 4 oriental archaeology Research center of Shandong University,Jinan 250100,China Henan Provincial Institute of Cultural Relics and archaeology Zhengzhou China oriental archaeology Research center of Shandong University Jinan China The Joint Laboratory of Human Evolution and Archaeometry Chinese Academy of Sciences Beijing China The Royal Ontario Museum Toronto Canada

During 2007-2008 excavations at the Lingjing site near Xuchang,Henan Province,dated back to around 100-80 ka ago,a large quantity of mammalian fossil remains were recovered along with a remarkable cluster of Early Modern Human(EMH) skull fragments in *** some of those animal bones were probably modified into tools.A use-wear analysis was carried out to examine the functions of modified bone *** results suggest that Lingjing bone tools were used for drilling,penetrating,and scraping animal substances,and that some might have been hafted during the *** study confirms that early existence ofintentionally-modified bone tools at human occupations of the early Late Pleistocene in northern *** discovery suggests making and use of bone tools were inevitably a part of early human behaviors and cultural development,as such of stone tools.

关键词：早期人类磨损分析旧石器时代工具许昌哺乳动物化石现代人类动物骨头

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