检索结果-南通市图书馆

MMP-9 deficiency accelerates the progress of periodontitis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Genes & Diseases 2024年第5期11卷 117-121页

作者： Chun-Yan Wan Yixin Yin Xiaoyan Li Meng Meng Liu Graham Goldman Li-An Wu Feng Wang Dao-Shu Luo Zhuo Chen Wen-An Xu Stephen Chen Mary MacDougall Merry L.Lindsey Zhi Chen Shuo Chen Department of Endodontics The Affiliated Hospital of Qingdao UniversitySchool of StomatologyQingdao UniversityQingdaoShandong 266003China Department of Developmental Dentistry School of DentistryThe University of Texas Health Science Center at San AntonioSan AntonioTX 78229USA oral Implantology Center Jinan Stomatological HospitalJinanShandong 250001China Department of Endodontics School and Hospital of StomatologyCheeloo College of MedicineShandong Key Laboratory of Oral Tissue RegenerationShandong Engineering Laboratory for Dental Materials and Oral Tissue RegenerationShandong UniversityJinanShandong 250012China Department of Pediatric Dentistry School of StomatologyThe Fourth Military Medical UniversityXi’anShaanxi 710032China Laboratory of Clinical Applied Anatomy Department of Human AnatomySchool of Basic Medical SciencesFujian Medical UniversityFuzhouFujian 350108China Key Laboratory for oral Biomedical Research of Zhejiang Province Affiliated Hospital of StomatologyMedical CollegeZhejiang UniversityHangzhouZhejiang 310027China Department of Stomatology Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdong 510515China UBC Faculty of Dentistry University of British ColumbiaVancouverBC V6T 1Z3Canada School of Graduate Studies and Research Meharry Medical College and Research BiologistResearch Service Nashville VA Medical CenterNashvilleTN 37208USA State Key Laboratory Breeding Base of Basic Science of Stomatology(Hubei-MOST) Key Laboratory for Oral Biomedicine of Ministry of Education(KLOBM)School and Hospital of StomatologyWuhan UniversityWuhanHubei 430079China

Periodontitis is a chronic inflammatory disease caused by periodontopathic bacteria that affects periodontal support tissues.1 If left untreated,it results in loss of periodontal attachment and alveolar bone *** one-half of adults in the United States older than 30 years have periodontal disease.2 Though the disease is initiated by bacterial infection,it activates host defense systems that eventually lead to the degradation of the *** periodontitis,the disease progress involves further production of pro-inflammatory mediators such as cytokines,proteolytic enzymes like matrix metalloproteinases(MMPs),and their inhibitors.

关键词： period eventually untreated

The protective effect of Limosilactobacillus reuteri against gestational diabetes mellitus through restoring intestinal microbiota homeostasis and attenuating inflammation in mice

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Food Science and Human Wellness 2024年

作者： Ce Qi Haowen Zhang Zhenli Liu Xiaolin Liu Lintao Zhang Liangliang You Jin Sun Institute of Nutrition and Health Qingdao University QingDao Newhope QinPai Dairy Co.Ltd. Tai'an Maternal and Child Health Hospital Jiaozhou Maternity and Child Health and Family Planning service Center

Limosilactobacillus reuteri QS01 is potential probiotic isolated from the intestinal microbiota of healthy women in early pregnancy. In the current study， we examined whether QS01 can prevent gestational diabetes mellitus (GDM) in an enhanced mouse model of the condition. Female C57BL/6J mouse offspring (F1 generation) born to dams fed a control (CON) or low-protein diet (GDM group) during gestation and lactation were used. Pregnant F1 mice fed a standard diet were randomly assigned to 5 groups: CON， GDM， and GDM mice treated with metformin， QS01 or Lacticaseibacillus rhamnosus HN001. An oral glucose tolerance test was performed before sacrifice at gestational day 17. Glucose tolerance was significantly ameliorated by all three treatments. QS01 supplementation fortified the intestinal mucosal barrier and inhibited the escalation of plasma inflammatory cytokines. QS01 treatment altered the cecal microbiota composition and function. Plasma and cecal metabolite profiles were modulated by QS01， prominently demonstrating significant upregulation of indole lactate and L-tryptophan in plasma and 5-hydroxy-tryptophan in the cecum， positively correlated with gut Lactobacillus abundance. In summary， QS01 plays a role in preventing GDM by remodeling the intestinal microbiota， reinforcing the intestinal mucosal barrier and alleviating chronic inflammation.

关键词：

In vitro antimicrobial effects of grape seed extract on peri-implantitis microflora in craniofacial implants

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Asian Pacific Journal of Tropical Biomedicine 2012年第10期2卷 822-825页

作者： Binit Shrestha M.L.Srithavaj Theerathavaj Sroisiri Thaweboon Boonyanit Thaweboon maxillofacial Prosthetic service Faculty of DentistryMahidol University Department of oral Microbiology Faculty of DentistryMahidol University

Objective:To determine the antimicrobial effects of grape seed on peri-implantitis ***:The grape seed extract was tested against peri-implantitis microflora most commonly found in craniofacial implants including reference strains of Staphylococcus aureus(***),Escherichia coli(***),Candida albicans(***)and clinical strains of ***,Klebsiella pneumonia(***)and Candida parapsilosis(***)by disk diffusion *** inhibitory concentrations(MIC)and minimum cidal concentrations(MCC)were determined using modified agar dilution millpore *** extract was further combined with polyethylene glycol and propylene glycol,and was tested for antimicrobial ***:Grape seed extract showed positive inhibitory effects with *** at MIC of 0.625 mg/mL and MCC of1.25 mg/mL *** the extracts showed minimal or no reactivity against strains of ***,***,*** and *** use of grape seed extract in combination with polyethylene glycol and propylene glycol also showed dose dependent inhibitory effect on ***:The results of the study showed that grape seed has potential antimicrobial effects which can be further studied and developed to be used in the treatment of infected skinabutment interface of craniofacial implants.

关键词： Peri-implantitis Grape seed extract Craniofacial implants Staphylococcus aureus

Vertical direction impaction of kissing molars:A case report

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2022年第12期10卷 3959-3965页

作者： Cai Wen Rong Jiang Zhi-Qiang Zhang Bo Lei Yuan-Zheng Yan Ying-Quan Zhong Long Tang Department of oral Implantology The Affiliated Stomatological Hospital of Southwest Medical UniversityLuzhou 646000Sichuan ProvinceChina Department of VIP Dental service The Affiliated Stomatological Hospital of Southwest Medical UniversityLuzhou 646000Sichuan ProvinceChina Luzhou Key Laboratory of oral&maxillofacial Reconstruction and Regeneration The Affiliated Stomatological Hospital of Southwest Medical UniversityLuzhou 646000Sichuan ProvinceChina Department of Dentistry People's Hospital of Aba Tibetan and Qiang Autonomous PrefectureMa'erkang 624000Sichuan ProvinceChina Department of Radiology People's Hospital of Aba Tibetan and Qiang Autonomous PrefectureMa'erkang 624000Sichuan ProvinceChina

BACKGROUND Kissing molars(KMs)are a scarcely reported form of molar impaction in which the occlusal surfaces contact each other within a single dental follicle and the roots point in opposite *** direction of KMs impaction is generally *** with vertical direction impaction have not been reported in the *** SUMMARY A 25-year-old female visited a dentist for right maxillary wisdom teeth extraction and was diagnosed with two vertically impacted KMs in the left mandible on panoramic *** cone-beam computed tomography examination confirmed no secondary complication,the patient chose to undergo observation and regular follow-up.A literature review of KMs revealed that vertical impacted KMs are rare;high-quality evidence regarding their prevalence is still *** present,the causality of KMs is *** this study,we have tried to provide a detailed definition of KMs to allow an accurate evaluation of their prevalence and classification based on their impaction direction which may be related to their *** treatment plan of KMs depends on the condition and location of the affected teeth and associated complications;they may be either directly extracted or treated using a multidisciplinary approach including maxillofacial surgeons and *** KMs are a rare clinical condition of impacted teeth with unclear *** impacted KMs were seldom *** definition and classification of KMs can help in the understanding of their causes and prevalence.

关键词： Kissing molars Impacted tooth Pathogenesis Prevalence Classification Case report

Correlation between the Bizygomatic Distance and the Width of the Upper Central Incisor in the Cameroonian Melanoderma Adult

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Stomatology 2022年第10期12卷 294-304页

作者： Achoundong Makeumo Ericka Flavie Kumpanya Ntumba Pierrot Njajou Omer Agbor Michael Sekele Isouradi Bourley Jean Paul Nyimi Bushabu Fidele Faculty of Dental Surgery University of the Mountains Bangangte Cameroon Department of Prosthodontics and Orthodontics Faculty of Dental Medicine University of Kinshasa Kinshasa Democratic Republic of the Congo Department of oral and Maxilla-Facial Surgery Service of Oral Maxillofacial-Head and Neck Oncology Surgery Faculty of Dental Medicine University of Kinshasa Kinshasa Democratic Republic of the Congo

Bizygomatic distance is a relevant reference used to assist and to guide the choice of antero superior prosthetic teeth, especially when no information about the natural teeth was available. The aim of the present paper was to determine the distance between the canine tips from a bizygomatic distance and to estimate the width of the upper central incisor in normal-dental-facial indices of Cameroonians. Materials and methods: A cross-sectional study of 900 normal Cameroonians of both sexes was conducted. Measurements of bizygomatic distance, distance between the two upper pointers and the mesio-distal width of the upper central incisor were made with a manual and a digital caliper respectively. The equation for calculating the distance of higher canine pointers from the bizygomatic distance was DCT = 0.081 (BZD) + 26.201. The width prediction of the central incisor was obtained by the following formula: WUCI = 6.252 + 0.019 (BZD) + 0.035(DCT) + 0.062 (Reg cul) + (?0.479) sex. *** represents the cultural region of origin. Results: Female sex was represented by 56.6% against 43.30% males. The average age was 37± (32 SD) years. The average value of the bizygomatic distance was 130.23 mm, the width of the upper central incisor was 9.39 mm while the distance between the two upper canine pointers was 36.70 mm. Significant correlations between bizygomatic distance, the distance between the two canine pointers, and the width of the upper central incisor were found (P = 0.000). Conclusion: The width of the central incisor and the distance between the two upper canine pointers may be determined by the non-invasively method of the bizygomatic distance in the perspective of choosing the teeth for dental prosthesis.

关键词： Bizygomatic Distance Dental Prosthesis Cameroonian Melanoderma Facial Indices

Single-cell sequencing analysis reveals the molecular mechanism of promotion of SCAP proliferation upon AZD2858 treatment

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

BIOCELL 2023年第4期47卷 825-836页

作者： YIFAN XU DONGMEI CHENG LEI HU XIN DONG LIYING LV CHEN ZHANG JIAN ZHOU Beijing Laboratory of oral Health School of StomatologyCapital Medical UniversityBeijing100050China Department of Neurobiology School of Basic Medical SciencesCapital Medical UniversityBeijing100069China Department of VIP Dental service School of StomatologyCapital Medical UniversityBeijing100050China Laboratory for oral and General Health Integration and Translation Beijing Tian Tan HospitalCapital Medical UniversityBeijing100070China

The Wnt/β-catenin signaling pathway is the main target of tooth regeneration *** of cells with AZD2858 stimulates the Wnt/β-catenin signaling pathway,yet the function of this pathway in tooth regeneration remains ***,we found that AZD2858 promotes the accumulation ofβ-catenin in the nuclei of stem cells from the apical papilla(SCAPs)and enhances cell ***-cell sequencing was performed on SCAPs treated with *** clusters were identified,namely SCAPs-CNTNAP2,SCAPs-DTL,SCAPs-MYH11,SCAPs-MKI67,SCAPs-CXCL8,SCAPs-TPM2,SCAPs-IFIT2 and *** pseudo-time trajectory analysis showed that AZD2858 enhanced the evolution of SCAPs from SCAPs-TMP2 clusters to SCAPs-MYH11,SCAPs-CNTNAPs and SCAPs-NEK10 clusters via up-regulation of PRKCA,SMURF2,MAGI2,RBMS3,EXT1,CAMK2D,PLCB4,and *** results demonstrate that AZD2858 enhances the proliferation of SCAPs-TPM2 cluster by activating the non-canonical Wnt/β-catenin signaling pathway.

关键词： AZD2858 Cell proliferation Stem cells Single-cell sequencing Wnt/β-catenin signaling pathway

Average Odontometric Value of the Width of the Upper Central Incisor in the Congolese Bantu of Kinshasa, Democratic Republic of Congo

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Stomatology 2022年第3期12卷 77-86页

作者： Kumpanya Ntumba Pierrot Sekele Isourady Bourley Jean Paul Sekele Marob Ndjock Patrick Nyimi Bushabu Fidele Kayembe Bukama Jean Marie Mudogo Nzanzu Celestin Kashiya Muamba Hyves Mantshumba Milolo Agustin Ntumba Mulumba Hybert oral and maxillofacial Prosthodontics service Department of Dental Medicine Faculty of Medicine University of Kinshasa Kinshasa Democratic Republic of Congo Periodontology Unit Department of Dental Medicine Faculty of Medicine University of Kinshasa Kinshasa Democratic Republic of Congo oral and maxillofacial service Department of Dental Medicine Faculty of Medicine University of Kinshasa Kinshasa Democratic Republic of Congo Operative Dentistry service Department of Dental Medicine Faculty of Medicine University of Kinshasa Kinshasa Democratic Republic of Congo Department of Basic Sciences Faculty of Medicine University of Kinshasa Kinshasa Democratic Republic of Congo Department of Epidemiology and Biostatistics School of Public Health of Kinshasa University of Kinshasa Kinshasa Democratic Republic of Congo

Objective: The aim of this study was to determine the average values of width of the upper central incisor (WUCI) in Congolese Bantu and compare them to those of Caucasians and Asiatic. Material and Methods: It was a prospective cross-sectional study carried out at the Université de Kinshasa on the Congolese Bantu, Department of Dental Medicine, from March 2020 to March 2021. A maxillary imprint was taken by Jeltrate-type alginate. The measurement of two healthy upper central incisors (UCI) was carried out by the hard plaster casting type 4, with a brand caliper, carbon fiver composite mark. The study was approved by the Ethics Committee of the School of Public Health in the Université de Kinshasa and verbal consent was obtained from each participant. Results: The Average Width of the UCI was 8.74 mm ± 0.56. The average width of the right Upper Central incisor (RUCI) and the left UCI (LUCI) was 8.71 mm ± 0.57 and 8.77 mm ± 0.56, respectively. The average width of the RUCI and LUCI was not the same for men and women (p 0.001). A significant difference was observed between the average of the RUCI and the 18 - 28 and 40 - 50 age group (p = 0.056) as well as for the average LUCI (p = 0.085). The width average of UCI between the Congolese Bantu with those of Caucasians and Asians was significantly different (p = 0.000 and p = 0.009). Conclusion: The average width of the RUCI and LUCI was different among sex and age group. The average width of UCI of the Congolese Bantu is different from that of Caucasians and Asians.

关键词： Odontometry Average Width Upper Central Incisor Congolese Bantu

Schwannoma of Hypoglossal Nerve Origin in the Upper Neck: Case Report and Review of the Literature

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Stomatology 2014年第8期4卷 418-423页

作者： Yoshihiro Morita Chisato Kawakita Misako Taya Keiko Yuzaki Takahisa Kotani Takaki Iwagami Kazuyo Kobayashi Nobuo Morita Department of oral and maxillofacial Surgery Seichokai Hannan City Hospital Hannan Japan Department of oral-maxillofacial Surgery NS Medical & Healthcare Service General Incorporation Foundation Wakayama Japan

Schwannomas originating from the hypoglossal nerve are extremely rare neoplasms. Hypoglossal schwannomas usually occur between the third and fifth decades of life, with no sex predilection, commonly presenting as a painless, slow-growing, and lateral neck mass. The best treatment is complete surgical excision with preservation of the neural pathway, if possible. In fact, since these tumors are almost always benign, a conservative surgical approach is emphasized by most authors. We report a case of a large schwannoma of hypoglossal nerve origin in the upper neck in a 31-year-old male. Magnetic resonance imaging of the area demonstrated a 43 × 39 × 36 mm well-circumscribed mass with high and nonhomogeneous signal intensity on the right side of the upper neck. The lesion was successfully treated by extirpation, with no recurrence. The extracranial hypoglossal nerve sheath was as the origin of this tumor because the patient experienced remarkable disturbance of tongue motility after surgery.

关键词： Hypoglossal Nerve Benign Tumors Schwannoma Magnetic Resonance Imaging

Secretory carcinoma——impact of translocation and gene fusions on salivary gland tumor

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Cancer Research 2017年第5期29卷 379-384页

作者： Ryoko Inaki Masanobu Abe Liang Zong Takahiro Abe Aya Shinozaki-Ushiku Tetsuo Ushiku Kazuto Hoshi Department of oral & maxillofacial Surgery University of Tokyo Hospital Division for Health service Promotion University of Tokyo Graduate School of Medicine University of Tokyo Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing) Department of Gastrointestinal Surgery Peking University Cancer Hospital & Institute Department of Pathology Graduate School of Medicine University of Tokyo

Secretory carcinoma（SC）, previously described as mammary analogue secretory carcinoma（MASC）, is a recently described salivary gland tumor which morphologically resembles mammary secretory carcinoma. The first description of SC/MASC, reported by Skálová et al. in 2010, was as a rare salivary carcinoma imitating secretory carcinoma of the breast. SC/MASC is a unique salivary gland tumor with morphological overlap with acinic cell carcinoma（Aci CC）, mucoepidermoid carcinoma（MEC）, and adenocarcinoma not otherwise specified（ADCNOS）. SC/MASC shares similar clinicopathological features with Aci CC. As a critical difference between SC/MASC and Aci CC, SC/MASC characteristically has the chromosomal translocation t（12;15）（p13;q25） which leads to a fusion gene between the ETV6 gene on chromosome 12 and the NTRK3 gene on chromosome 15. This genetic background is an important differential diagnostic finding for excluding other salivary gland tumors and may be a critical factor determining the prognosis for patients with SC/MASC. Research in recent years has provided a large body of new data on SC/MASC and suggests the possibility that the ETV6-NTRK3 translocation could be a therapeutic target. Here, we review the morphological and clinicopathological features of SC/MASC and discuss new directions for therapy.

关键词： Secretory carcinoma mammary analogue secretory carcinoma MASC ETV6-NTRK3 fusion gene salivary gland tumor