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Time trends in antithrombotic therapy prescription patterns: Realworld monocentric study in hospitalized patients with atrial fibrillation

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World Journal of cardiology 2022年第11期14卷 576-598页

作者： Maurizio Giuseppe Abrignani Alberto Lombardo Annabella Braschi NicolòRenda Vincenzo Abrignani Renzo M Lombardo operative unit of cardiology Department of MedicineS.Antonio Abate Hospital of TrapaniASP TrapaniTrapani 91100TrapaniItaly Department of Psychology Educational Science and Human MovementUniversity of PalermoPalermo 90100PalermoItaly Department of Medicine and Surgery University of ParmaParma 43100ParmaItaly operative unit of Internal Medicine with Stroke Care Department of Health PromotionMother and Child CareInternal Medicine and Medical Specialties(ProMISE)"G.D'Alessandro"University of PalermoPalermo 90100PalermoItaly Department of cardiology Operative Unit of CardiologyDepartment of MedicineS.Antonio Abate Hospital of TrapaniTrapani 91100TrapaniItaly

BACKGROUND Since 2010,the European Society of cardiology has extended prescription criteria for oral antithrombotic therapy(OAT)in atrial fibrillation(AF).Direct oral anticoagulants(DOACs)were upgraded from an IIAa recommendation in 2012 to an IA in *** real-world scenarios,however,OAC prescription is still suboptimal,mainly for *** To evaluate OAT temporal prescription patterns in a cohort of patients hospitalized with AF in a cardiology *** A retrospective observational study was conducted on a cohort of hospitalized patients in a secondary setting(Trapani,Italy)from 2010 to 2021 with AF as the main or secondary *** 4089 consecutive patients,the variables extracted from the cardiology department database were:Sex,age,time of hospitalization,antithrombotic therapy(warfarin,acenocoumarol,apixaban,dabigatran,edoxaban,rivaroxaban,aspirin,clopidogrel,other antiplatelet agents,low molecular weight heparin,and fondaparinux),diagnosis at discharge and used *** features are presented as percentage values for categorized variables and as mean+/-SD for categorized *** From January 1st,2010 to October 6th,2021,25132 patients were hospitalized in our department;4089(16.27%,mean age 75.59+/-10.82)were discharged with AF diagnosis;of them,2245 were males(54.81%,mean age 73.56+/-11.45)and 1851 females(45.19%,mean age 78.06+/-9.47).Average length of stay was 5.76+/-4.88 days;154 patients died and 88 were moved to other Departments/*** was the main diagnosis in 899 patients(21.94%).The most frequent main diagnosis in patients with AF was acute myocardial infarction(1973 discharges,48.19%).The most frequent secondary cardiac diagnosis was chronic coronary syndrome(1864 discharges,45.51%),and the most frequent secondary associated condition was arterial hypertension(1010 discharges,24.66%).For the analysis of antithrombotic treatments,the final sample included 3067 patients,after excluding in-hospital deaths,transferre

关键词： Atrial fibrillation Antithrombotic agents Time series Warfarin Direct-acting oral anticoagulants Aspirin

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Proton pump inhibitors and gastroprotection in patients treated with antithrombotic drugs: A cardiologic point of view

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世界心脏病学杂志:英文版(电子版) 2023年第8期15卷 375-394页

作者： Maurizio Giuseppe Abrignani Alberto Lombardo Annabella Braschi Nicolo Renda Vincenzo Abrignani operative unit of cardiology P.Borsellino HospitalASP TrapaniMarsala 91025TrapaniItaly operative unit of cardiology S.Antonio Abate HospitalASP TrapaniErice 91100TrapaniItaly Department of Psychology Educational Science and Human MovementUniversity of PalermoPalermo 90100Italy Department of Direction CTA SalusGibellina 91024TrapaniItaly operative unit of Internal Medicine with Stroke Care Department of Health PromotionMother and Child CareInternal Medicine and Medical Specialties(ProMISE)“G.D’Alessandro”University of PalermoPalermo 90100Italy

Aspirin,other antiplatelet agents,and anticoagulant drugs are used across a wide spectrum of cardiovascular and cerebrovascular diseases.A concomitant proton pump inhibitor(PPI)treatment is often prescribed in these patients,as gastrointestinal complications are relatively *** the other hand,a potential increased risk of cardiovascular events has been suggested in patients treated with PPIs;in particular,it has been discussed whether these drugs may reduce the cardiovascular protection of clopidogrel,due to pharmacodynamic and pharmacokinetic interactions through hepatic ***,the concomitant use of clopidogrel and omeprazole or esomeprazole has been *** contrast,it remains less known whether PPI use may affect the clinical efficacy of ticagrelor and prasugrel,new P2Y12 receptor *** guidelines recommend PPI use in combination with antiplatelet treatment in patients with risk factors for gastrointestinal bleeding,including advanced age,concurrent use of anticoagulants,steroids,or non-steroidal anti-inflammatory drugs,and Helicobacter pylori(***)*** patients taking oral anticoagulant with risk factors for gastrointestinal bleeding,PPIs could be recommended,even if their usefulness deserves further *** infection should always be investigated and treated in patients with a history of peptic ulcer disease(with or without complication)treated with antithrombotic *** present review summarizes the current knowledge regarding the widespread combined use of platelet inhibitors,anticoagulants,and PPIs,discussing consequent clinical implications.

关键词： Antithrombotic drugs Anticoagulants Aspirin Clopidogrel Gastrointestinal bleeding Proton pump inhibitors

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A CLINICAL CLASSIFICATION OF HYPERTENSION

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Chinese Medical Journal 2006年第1期119卷 80-83页

作者： GEORGE THOMAS DEPARTMENT OF cardiology INDIRA GANDHI CO-OPERATIVE HOSPITAL GANDHI NAGAR KOCHI 682 020 INDIA

Hypertension is a common cardiovascular problem worldwide. As with any other disease it is important to assess the severity of the disease. However the present classification of hypertension by the Joint National Committee in its seventh report （JNC 7） with numerical values staging the severity of hypertension is theoretically correct but difficult to apply in practice （Table 1）. Admittedly this is a step in the right direction with lesser number of stages compared to the sixth report.

关键词： hypertension classification, cfinical treatment outcomes qualitative aspects

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Climatic influences on cardiovascular diseases

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World Journal of cardiology 2022年第3期14卷 152-169页

作者： Maurizio Giuseppe Abrignani Alberto Lombardo Annabella Braschi NicolòRenda Vincenzo Abrignani operative unit of cardiology Department of MedicineS.Antonio Abate Hospital of TrapaniASP TrapaniTrapani 91100Italy Department of Internal Medicine Department of PsychologyEducational Science and Human MovementUniversity of PalermoPalermo 90100Italy Department of Mental Health ASP TrapaniTrapani 91100Italy School of Medicine University of BolognaBologna 40126Italy

Classical risk factors only partially account for variations in cardiovascular disease incidence;therefore,also other so far unknown features,among which meteorological factors,may influence heart diseases(mainly coronary heart diseases,but also heart failure,arrhythmias,aortic dissection and stroke)*** most studied phenomenon is ambient *** relation between mortality,as well as cardiovascular diseases incidence,and temperature appears graphically as a"U"*** to cold,heat and heat waves is associated with an increased risk of acute coronary *** climatic variables,such as humidity,atmospheric pressure,sunlight hours,wind strength and direction and rain/snow precipitations have been hypothesized as related to fatal and nonfatal cardiovascular diseases *** limitation of these studies is the unavailability of data on individual exposure to weather *** of weather may vary depending on other factors,such as population disease profile and age *** stress may increase direct and indirect risks to human health via different,complex pathophysiological pathways and exogenous and endogenous *** data have attracted growing interest because of the recent earth’s climate change,with consequent increasing ambient temperatures and climatic *** review evaluates the evidence base for cardiac health consequences of climate conditions,and it also explores potential further implications.

关键词： Weather Climate Meteorology Cardiovascular diseases Myocardial infarction Angina pectoris

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Coronary Artery Anomalies in D-Transposition of the Great Artery Following Arterial Switch Operation

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Congenital Heart Disease 2022年第3期17卷 297-311页

作者： Thita Pacharapakornpong Jarupim Soongswang Chodchanok Vijarnsorn Paweena Chungsomprasong Kritvikrom Durongpisitkul Prakul Chanthong Supaluck Kanjanauthai Division of cardiology Department of PediatricsFaculty of Medicine Siriraj HospitalMahidol UniversityBangkokThailand

Background:The survival rate of patients following arterial switch operation(ASO)exceeds 95%,but coronary artery anomalies(CAA)contribute to a 2%incidence of sudden cardiac arrest later in ***,we aimed to assess abnormal findings of coronary arteries in post-ASO ***:Coronary computed tomography angiography(CCTA)is performed on post-ASO patients who meet institutional *** findings of coronary artery patterns were retrospectively reviewed and categorized using the Leiden classification *** artery anomalies were detected by CCTA and associations with coronary artery compromise were ***:Forty-three patients who had CCTA with a median age of 15.6 years(12–21.3 years)were included in the *** coronary patterns were identified in 20(46%)patients before *** identified 25 CAA in 22 patients(eleven with prepulmonic course,nine with interarterial course,three with acute take-off angle,and two with significant stenosis).Postoperative CAA was more common in patients with unusual coronary patterns(90%vs.17.4%;poperative coronary artery patterns should undergo coronary artery imaging when ***-up imaging studies are indicated in patients with post-operative coronary artery abnormalities.

关键词： Coronary artery anomalies arterial switch operation d-transposition of great arteries

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Cardiac myxomas:A narrative review

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World Journal of cardiology 2022年第4期14卷 206-219页

作者： A K M Monwarul Islam Department of cardiology National Institute of Cardiovascular DiseasesDhaka 1207Bangladesh

Cardiac myxomas are common primary neoplasms of the *** are biologically benign but“functionally malignant”because of the potential for *** arise most commonly from the left atrium,but no chambers of the heart are *** may be sporadic in the majority but also familial as a part of the Carney *** morphological forms exist:polypoid and *** myxomas often present with obstructive features,while the papillary forms are more prone to *** is still controversial;the current view centres around origin from the primitive pluripotent mesenchymal *** may be of giant proportion,be calcified or get *** presentation typically involves the triad of intracardiac obstruction,embolic events and constitutional *** examination findings may simulate those of mitral or tricuspid *** presence of tumour plop and change of the physical findings with changing position may help differentiation between the *** is the investigation of *** polypoid or papillary mobile mass within the atrial cavity remaining attached to the interatrial septum through a stalk are the tell-tale echocardiographic *** magnetic resonance and computed tomographic scanning may have incremental diagnostic *** examination reveals abundant loose myxoid stroma with scattered round,polygonal or stellate cells with dense irregular *** testing may detect mutations in the PRKAR1A gene in the familial form of cardiac myxoma,*** Carney *** excision is the mainstay of treatment with low operative mortality,excellent postoperative survival and low recurrence *** current trend favours minimal-access surgery with or without robotic *** should have appropriate preparedness to make a timely diagnosis and enthusiastic treatment to avoid potentially fatal complications.

关键词： Myxoma Cardiac Neoplasm Carney Complex Echocardiography Embolism

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Electrical Storms after Levonorgestrel (Synthetic Progestin)-Releasing Intra-Vaginal Device Insertion. A Case Report and a Short Review of Literature

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Open Journal of Obstetrics and Gynecology 2018年第4期8卷 338-343页

作者： Sergio Fasullo Giorgio Maringhini Piero Fasullo Filippo Ganci Arcangelo Giamporcaro Sebastiano Scalzo Fernanda Pipitone Vito Pinto Graziella Vetrano Gabriella Terrazzino Stefania Davì Nicolò Renda Antonio Maiorana Division of cardiology “Paolo Borsellino” G.F. Ingrassia Hospital Palermo Italy operative unit of Gynecology S. Antonio Abate Hospital Trapani Italy Chemistry and Pharmaceutical Technologies University of Palermo Palermo Italy Psychiatry CTA La Rinascita Palermo Italy operative unit of Gynecology ARNAS Civico Palermo Italy

We report a case of arrhythmic storm in a patient with recent vaginal insertion of a device with release of levonorgestrel (synthetic progestin). A woman of 60 years was hospitalized for runs of monomorphic sustained ventricular tachycardia. She received a vaginal device levonorgestrel-releasing 2 days before admission. No history of associated cardiovascular or thyroid disease or risk factors was reported. Laboratory parameters as well as ECG and echocardiogram were normal. After 48 hours from removal of the vaginal device, the patient was asymptomatic and showed only single ectopic beats, sometimes in pairs. The subsequent coronary angiography, electrophysiological study and cardiac magnetic resonance resulted negative.

关键词： Levonorgestrel Progesterone Ventricular Arrhythmias

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Long-term effect of a large dose of iodinated contrast in patients with mild thyroid dysfunction:a prospective cohort study

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Chinese Medical Journal 2023年第17期136卷 2044-2049页

作者： Hailong Si Kangyin Chen Qin Qin Yuanyuan Liu Bingrang Zhao Department of cardiology Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular DiseaseTianjin Institute of CardiologyThe Second Hospital of Tianjin Medical UniversityTianjin 300211China Department of Cardiovascular Disease Tianjin Chest HospitalTianjin 300051China Tianjin Institute of Cardiovascular Diseases Tianjin Chest HospitalTianjin 300051China Comprehensive Disease Center Tianjin Chest HospitalTianjin 300051China

Background:More than 75 million procedures with intravascular iodine-based contrast media(ICM)are performed worldwide every year,and some patients undergoing these procedures do not have normal thyroid *** long-term effects of ICM in patients with mild thyroid dysfunction(TD)are ***:This prospective cohort study was conducted in *** with stable angina pectoris with total triiodothyronine(TT3)reduction,normal thyroid-stimulating hormone,and reverse triiodothyronine(rT3)were enrolled and divided into high-dose(≥100 mL ICM)and low-dose groups(operative TD occurred in the high-dose *** patient developed severe hypothyroidism with myxedema,requiring drug intervention 1 year after ICM *** level of rT3 showed no statistically significant changes during post-operative follow-up(P=0.848).The TGAB level decreased at 6th month(P<0.001),but increased at 1 year after ICM exposure(P=0.002).Conclusions:Patients with T3 reduction are at a risk of transient subclinical TD and hypothyroidism after a single large dose of ***-up of this population at 9-12 months after ICM exposure is warranted.

关键词： Coronary heart disease Stable angina pectoris Iodinated contrast agents Low T3 Subclinical thyroid dysfunction Non-thyroidal illness

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Multi-phase post-mortem CT-angiography： a pathologic correlation study on cardiovascular sudden death

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Journal of Geriatric cardiology 2016年第10期13卷 855-865页

作者： Emanuela Turillazzi Paola Frati Natascha Pascale Cristoforo Pomara Giampaolo Grilli Rocco Valerio Viola Vittorio Fineschi Section of Forensic Pathology Department of Clinical and Experimental Medicine University of Foggia Foggia Italy Department of Anatomy Histology Forensic Medicine and Orthopaedics Sapienza University of Rome Rome Italy Depariment of Anatomy University of Malta Malta operative unit of Radiodiagnostics Ospedali Riuniti Foggia Italy

多相验尸， CT-angiography (MPMCTA ) 有大潜力增加质量验尸调查，特别在突然的死亡的区域；然而，它到病理工具箱的平淡的补充仍然作为它被询问的角色需要进一步被标准化。这研究的目的是在成年人并且特别地在突然的心血管的死亡在突... 详细信息

多相验尸， CT-angiography (MPMCTA ) 有大潜力增加质量验尸调查，特别在突然的死亡的区域；然而，它到病理工具箱的平淡的补充仍然作为它被询问的角色需要进一步被标准化。这研究的目的是在成年人并且特别地在突然的心血管的死亡在突然的 unexplained 死亡的情况下调查 MPMCTA 的贡献。成年人的 68 突然的意外死亡在我们在 2012 和 2013 之间的机构被调查。十个案例经历了 MPMCTA 和尸体并且在学习被包括。在由脉管的系统的完全的充满的 angiographic 步前，在身体的任何操作以前，非对比 CT 扫描被执行。图象重建在一个 CT 工作站(Vitrea ) 上被执行，与帖子 mortem 成像经验丰富的二个放射线学者解释了 MPMCTA 调查结果。在所有 10 个案例中，我们能说在联合之间的好关联验尸 CT 和 MPMCTA 和尸体过程，证实高诊断的敏感。当面对突然的死亡时，与这个案例系列，我们想要说明执行 MPMCTA 提供的优点，不管为急性冠的症候群或脉管的其它或 ischemic 疾病的特定的怀疑。

关键词： CT扫描心血管病理猝死多相急性冠脉综合征突然死亡像对

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Correction of hypovitaminosis D improved global longitudinal strain earlier than left ventricular ejection fraction in cardiovascular older adults after orthopaedic surgery

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Journal of Geriatric cardiology 2018年第8期15卷 519-522页

作者： Matteo Briguglio Luigi Gianturco Daniele Stellat Chiara Colombo Marika Bonadies Oscar Salat Mauro Anselmi Giuseppe Banff Maurizio Turiel cardiology unit IRCCS Orthopaedic Institute Galeazzi Milan Italy Scientific Direction IRCCS Orthopaedic Institute Galeazzi Milan Italy University Vitae Salute San Raffaele Milan Italy

BackgroundCardiovascular 疾病和维生素 D 的不够的层次是为不利外科的结果的风险因素，并且他们是在经历整形外科的外科的更老的成年人之中通常在场的两个。给维生素 D 的心血管的效果， hypovitaminosis D 的外科手术前的诊断将是为... 详细信息

BackgroundCardiovascular 疾病和维生素 D 的不够的层次是为不利外科的结果的风险因素，并且他们是在经历整形外科的外科的更老的成年人之中通常在场的两个。给维生素 D 的心血管的效果， hypovitaminosis D 的外科手术前的诊断将是为补充协议的实现的珍贵的步。如果，我们调查了浆液 25 的正规化[哦] D 能改善受不了心血管的 *** 的更老的成年人的心脏的性能注册了为主要整形外科的外科安排的 47 个更老的成年人并且受不了 hypovitaminosis D。病人们与开始的剂量经历了 6 月的 calcifediol 补充 50 湩琠敨攠敶瑮的起初手术后的白天吗？

关键词：整形外科成年人心血管喷射外科手术血液动力学风险因素临床症状

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