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Amyloid-beta and tau protein beyond Alzheimer's disease

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Neural Regeneration Research 2024年第6期19卷 1262-1276页

作者： Morteza Abyadeh Vivek Gupta Joao A.Paulo Arezoo Gohari Mahmoudabad Sina Shadfar Shahab Mirshahvaladi Veer Gupta Christine T.O.Nguyen David I.Finkelstein Yuyi You Paul A.Haynes Ghasem H.Salekdeh Stuart L.Graham Mehdi Mirzaei ProGene technologies pty ltd. SydneyNSWAustralia Department of Clinical Medicine Faculty of MedicineHealth and Human SciencesMacquarie Medical SchoolMacquarie UniversityMacquarie ParkNorth RydeSydneyNSWAustralia Department of Cell Biology Harvard Medical SchoolBostonMAUSA School of Medicine Deakin UniversityGeelongVICAustralia Department of Optometry and Vision Sciences School of Health SciencesFaculty of Medicine Dentistry and Health SciencesUniversity of MelbourneParkvilleVICAustralia The Florey Institute of Neuroscience and Mental Health The University of MelbourneParkvilleVICAustralia School of Natural Sciences Macquarie UniversityMacquarie ParkNSWAustralia

The aggregation of amyloid-beta peptide and tau protein dysregulation are implicated to play key roles in Alzheimer's disease pathogenesis and are considered the main pathological hallmarks of this devastating ***,these two proteins are produced and expressed within the normal human ***,under pathological conditions,abnormal expression,posttranslational modifications,conformational changes,and truncation can make these proteins prone to aggregation,triggering specific disease-related *** studies have indicated associations between aberrant behavior of amyloid-beta and tau proteins and various neurological diseases,such as Alzheimer's disease,Parkinson's disease,and amyotrophic lateral sclerosis,as well as retinal neurodegenerative diseases like Glaucoma and age-related macular ***,these proteins have been linked to cardiovascular disease,cancer,traumatic brain injury,and diabetes,which are all leading causes of morbidity and *** this comprehensive review,we provide an overview of the connections between amyloid-beta and tau proteins and a spectrum of disorders.

关键词： amyloid-beta cancer cardiovascular diseases diabetes neurodegeneration Tau traumatic brain injury

A three-dimensional feature extraction-based method for coal cleat characterization using X-ray μCT and its application to a Bowen Basin coal specimen

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第1期16卷 153-166页

作者： Yulai Zhang Matthew Tsang Mark Knackstedt Michael Turner Shane Latham Euan Macaulay Rhys Pitchers ARC Training Centre for M3D Innovation Research School of PhysicsAustralian National UniversityCanberraACT2601Australia Department of Materials Physics Research School of PhysicsAustralian National UniversityCanberraACT2601Australia Anglo American Steelmaking Coal BrisbaneQLD4000Australia SCT Operations pty ltd. WollongongNSW2500Australia

Cleats are the dominant micro-fracture network controlling the macro-mechanical behavior of *** understanding of the spatial characteristics of cleat networks is therefore important to the coal mining *** fracture networks(DFNs)are increasingly used in engineering analyses to spatially model fractures at various *** reliability of coal DFNs largely depends on the confidence in the input cleat *** of these parameters can be made from image-based three-dimensional(3D)characterization of coal cleats using X-ray micro-computed tomography(m CT).One key step in this process,after cleat extraction,is the separation of individual cleats,without which the cleats are a connected network and statistics for different cleat sets cannot be *** this paper,a feature extraction-based image processing method is introduced to identify and separate distinct cleat groups from 3D X-ray m CT ***(filters)representing explicit cleat features of coal are built and cleat separation is successfully achieved by convolutional operations on 3D coal *** new method is applied to a coal specimen with 80 mm in diameter and 100 mm in length acquired from an Anglo American Steelmaking Coal mine in the Bowen Basin,Queensland,*** is demonstrated that the new method produces reliable cleat separation capable of defining individual cleats and preserving 3D topology after ***-parallel fractures are also identified and separated,which has his-torically been challenging to delineate and rarely reported.A variety of cleat/fracture statistics is measured which not only can quantitatively characterize the cleat/fracture system but also can be used for DFN ***,variability and heterogeneity with respect to the core axis are *** heterogeneity is observed and suggests that the representative elementary volume(REV)of the cleat groups for engineering purposes may be a complex problem requ

关键词： Cleat separation Cleat statistics Feature extraction Discrete fracture network(DFN)modeling

Spectral matching based remote sensing identification of two main crop rotation patterns in a large irrigation district

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中国水利水电科学研究院学报(中英文) 2024年

作者： DUAN Yuanyuan CHEN Xiuhua LIU Jun YE Mao LU Wenjing LIU Hongjie China Institute of Water Resources and Hydropower Research Application Center of Remote Sensing Technology Research Center on Flood & Drought Disaster Prevention and Reduction of the Ministry of Water Resources Qingdao Comcore technologies Co. Ltd Sucheng District Water Resources Bureau

Abstract:The rapid identification of planting patterns for major crops in a large irrigated district has vital importance for irrigation management,water fee collection,and crop yield *** this study,the OTSU algorithm and Mean-Shift algorithm were employed to automatically determine threshold values for mapping two main rotated crop patterns at the pixel scale.A time series analysis was conducted to extract the spatial distribution of rice-wheat and wheat-maize rotations in the Chuanhang irrigation district from 2016 to *** results demonstrate that both threshold segmentation algorithms are reliable in extracting the spatial distribution of the crops,with an overall accuracy exceeding 80%.Additionally,both Kappa coefficients surpass 0.7,indicating better performance by OTSU *** the period from 2016 to 2020,the area occupied by ricewheat rotation cropping ranged from 12 500 to 14 400 hm2;whereas wheat-maize rotation cropping exhibited smaller and more variable areas ranging from 19730 to 34070 *** findings highlight how remote sensing-based approaches can provide reliable support for rapidly and accurately identifying the spatial distribution of main crop rotation patterns within a large irrigation district.

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Travellers:Design Collaboration and Digital Media

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Tsinghua Science and Technology 2008年第S1期13卷 234-240页

作者： J. Bahoric P. Nicholas G. Ormston Arup pty ltd spatial Information Architecture Laboratory RMIT University Melbourne 3000 Australia City of Melbourne

This paper examines the use of 3D electronic medium as a tool for procuring detailed design information for the Sandridge Bridge Travellers project. The Sandridge Bridge Travellers project required the production of 10 7.5 m of tall × 5 ― 12 m of wide figures under very tight programme and budget constraints. This was achieved through a synthesis of art and engineering, whereby structure and sculpture become one and the same. Traditional procurement routes would have entailed the production and interpretation of drawings and design details at all discipline interfaces before fabrication; an approach that was unfeasible given the constraints. Instead, The Travellers project saw a single electronic file pass backwards and forwards from client to architect, engineer, and fabricator, with information from the initial artistic concept work phases through to analysis, design, member scheduling and fabrication all integrated and facilitated by a single electronic medium. Key to the delivery was the use of 3D modeling and scripting programs that enabled the efficient use and development of design information through all stages of the design process. This enabled total integration of all trades requiring a collaborative approach where each party maintained joint ownership of the 3D design information from inception to conception.

关键词： Sandridge Bridge Travellers sculpture 3-D modeling collaborative approach 3-D electronic medium AutoCAD R2004TM RhinoTM formats spline rationalization

Virtual Australia:its key elementsknow,think,communicate

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International Journal of Digital Earth 2008年第1期1卷 66-87,I0005页

作者： B.Thompson T.O.Cha R.Slee P.Kinne A.Jahshan P.Woodgate I.Bishop D.McKenzie spatial Information Infrastructure Department of Sustainability and EnvironmentLevel 13Marland House570 Bourke StreetMelbourne Victoria 3000Australia Oracle Fusion Middleware Sales Oracle Corporation Asia Pacific4 Julius AvenueNorth Ryde NSW 2113Australia open spatial technologies pty ltd 433 Logan RoadStones Corner QLD 4120Australia Australian Cooperative Research Centre for spatial Information 723 Swanston StreetUniversity of MelbourneVictoria 3010Australia Department of Geomatics The University of Melbourne VictoriaAustralia

Virtual Australia is not a well-defined or agreed *** discussion paper conceptualises Virtual Australia as a‘virtual[digital]model containing and representing all non-trivial objects and their contextual environmentfrom blue sky to bedrockin real world Australia’.It describes a scenario for Virtual Australia,one or two decades from now,in which the locations and conditions of non-trivial objects and their environment are updated automatically through a combination of remote sensing and wireless communication technologies in support of a‘Supranet’.It then examines the concept of the‘Supranet’a pervasive information network based largely on wireless technology linking the physical world to a virtual model in real timeand develops and discusses three principal characteristics of the Supranet:the ability to have or collect specific information(know);the ability to process information(think);and the ability to communicate that ***,in the near future,any or all non-trivial devices are to some extent able to know,think and communicate,the potential for object autonomy will be realised.

关键词： virtual spatial supranet digital information sensors motes innovation Australia

Distributed phase-matching measurement for dynamic strain and temperature sensing based on stimulated Brillouin scattering enhanced four-wave mixing

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Photonics Research 2024年第1期12卷 141-153页

作者： YUAN WANG PEDRO TOVAR JUNTONG YANG LIANG CHEN XIAOYI BAO Nexus for Quantum technologies University of OttawaOttawaOntario K1N 6N5Canada

A Brillouin dynamic grating(BDG) can be used for distributed birefringence measurement in optical fibers,offering high sensitivity and spatial resolution for sensing ***,it is quite a challenge to simultaneously achieve dynamic measurements with both high accuracy and high spatial *** this work,we propose a sensing mechanism to achieve distributed phase-matching measurement using a chirped pulse as a probe *** BDG reflection,the peak reflection corresponds to the highest four-wave mixing(FWM) conversion efficiency,and it requires the Brillouin frequency in the fast and slow axes to be equal,which is called the phase-matching *** condition changes at different fiber positions,which requires a range of frequency injection for the probe *** proposed method uses a chirped pulse as a probe wave to cover this frequency range associated with distributed birefringence *** allows us to detect distributed phase matching for birefringence changes that are introduced by temperature and strain *** to the single shot and direct time delay measurement capability,the acquisition rate in our system is only limited by the fiber ***,unlike conventional BDG spectrum recovery-based systems,the spatial resolution here is determined by both the frequency chirping rate of the probe pulse and the birefringence profile of the *** the experiments,an acquisition rate of 1 k Hz(up to fiber length limits) and a spatial resolution of 10 cm using a 20 ns probe pulse width are *** minimum detectable temperature and strain variation are 5.6 mK and 0.37 με along a 2 km long polarization-maintaining fiber(PMF).

关键词： fiber scattering polarization

地理大数据挖掘——“水-能源-粮食”纽带研究的新机遇

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Journal of Geographical Sciences 2024年第2期34卷 203-228页

作者：杨洁曹小曙姚俊康喆文畅建霞王义民 Northwest Land and Resources Research Center Global Regional and Urban Research InstituteInstitute ofTransport Geography and Spatial PlanningShaanxi Normal UniversityXi’an 710119China Hanjiang-to-Weihe River Valley Water Diversion Project Construction Co.ltd. Shaanxi ProvinceXi’an710010China State Key Laboratory of Eco-hydraulics in Northwest Arid Region Xi’an University of TechnologyXi’an710048China

Since the Bonn 2011 conference,the“water-energy-food”(WEF)nexus has aroused global concern to promote sustainable *** WEF nexus is a complex,dynamic,and open system containing interrelated and interdependent ***,the nexus studies have mainly focused on natural elements based on massive earth observation *** elements(e.g.,society,economy,politics,culture)are described insufficiently,because traditional earth observation technologies cannot effectively perceive socioeconomic characteristics,especially human feelings,emotions,and ***,it is difficult to simulate the complex WEF *** the development of earth observation sensor technologies and human activity perception methods,geographical big data covering both human activities and natural elements offers a new opportunity for in-depth WEF nexus *** study proposes a five-step framework by leveraging geographical big data mining to dig for the hidden value in the data of various natural and human *** framework can enable a thorough and comprehensive analysis of the WEF *** application examples of the framework,major challenges,and possible solutions are *** big data mining is a promising approach to enhance the analysis of the WEF nexus,strengthen the coordinated management of resources and sectors,and facilitate the progress toward sustainable development.

关键词： geographical big data data mining “water-energy-food”nexus interaction mechanisms sustainability resources security

Intertidal area classification with generalized extreme value distribution and Markov random field in quad-polarimetric synthetic aperture radar imagery

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Frontiers of Information Technology & Electronic Engineering 2019年第2期20卷 253-264页

作者： Ting-ting JIN Xiao-qiang SHE Xiao-lan QIU Bin LEI Key Laboratory of Technology in Geo-spatial Information Processing and Application System Institute of ElectronicsChinese Academy of Sciences University of Chinese Academy of Sciences Huawei Software technologies Co. Ltd.

Classification of intertidal area in synthetic aperture radar(SAR) images is an important yet challenging issue when considering the complicatedly and dramatically changing features of tidal fluctuation. The difficulty of intertidal area classification is compounded because a high proportion of this area is frequently flooded by water, making statistical modeling methods with spatial contextual information often ineffective. Because polarimetric entropy and anisotropy play significant roles in characterizing intertidal areas, in this paper we propose a novel unsupervised contextual classification algorithm. The key point of the method is to combine the generalized extreme value(GEV) statistical model of the polarization features and the Markov random field(MRF) for contextual smoothing. A goodness-of-fit test is added to determine the significance of the components of the statistical model. The final classification results are obtained by effectively combining the results of polarimetric entropy and anisotropy. Experimental results of the polarimetric data obtained by the Chinese Gaofen-3 SAR satellite demonstrate the feasibility and superiority of the proposed classification algorithm.

关键词： Intertidal classification Polarimetric synthetic aperture radar Finite mixture model Markov random field Generalized extreme value model

Ultra-high spatio-temporal resolution imaging with parallel acquisition-readout structured illumination microscopy(PAR-SIM)

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Light(Science & Applications) 2024年第6期13卷 1140-1158页

作者： Xinzhu Xu Wenyi Wang Liang Qiao Yunzhe Fu Xichuan Ge Kun Zhao Karl Zhanghao Meiling Guan Xin Chen Meiqi Li Dayong Jin Peng Xi Department of Biomedical Engineering College of Future TechnologyPeking UniversityBeijing100871China Wallace H.Coulter Dept.of Biomedical Engineering Georgia Institute of Technology and Emory UniversityAtlanta30332GAUSA National Biomedical Imaging Center Peking UniversityBeijing100871China Department of Biomedical Engineering College of EngineeringSouthern University of Science and TechnologyShenzhen518055GuangdongChina Airy technologies Co. Ltd.Beijing100086China Eastern Institute for Advanced Study Eastern Institute of TechnologyNingboZhejiang315200China School of Life Science Peking UniversityBeijing100871China Institute for Biomedical Materials and Devices(IBMD) Faculty of ScienceUniversity of Technology SydneySydneyNSW2007Australia

Structured illumination microscopy(SIM)has emerged as a promising super-resolution fluorescence imaging technique,offering diverse configurations and computational strategies to mitigate phototoxicity during real-time imaging of biological *** efforts to enhance system frame rates have concentrated on processing algorithms,like rolling reconstruction or reduced frame reconstruction,or on investments in costly sCMOS cameras with accelerated row readout *** this article,we introduce an approach to elevate SIM frame rates and region of interest(ROI)coverage at the hardware level,without necessitating an upsurge in camera expenses or intricate ***,parallel acquisition-readout SIM(PAR-SIM)achieves the highest imaging speed for fluorescence imaging at currently available detector *** using the full frame-width of the detector through synchronizing the pattern generation and image exposure-readout process,we have achieved a fundamentally stupendous information spatial-temporal flux of 132.9 MPixels·s^(−1),9.6-fold that of the latest techniques,with the lowest SNR of−2.11 dB and 100 nm ***-SIM demonstrates its proficiency in successfully reconstructing diverse cellular organelles in dual excitations,even under conditions of low signal due to ultra-short exposure ***,mitochondrial dynamic tubulation and ongoing membrane fusion processes have been captured in live COS-7 cell,recorded with PAR-SIM at an impressive 408 *** posit that this novel parallel exposure-readout mode not only augments SIM pattern modulation for superior frame rates but also holds the potential to benefit other complex imaging systems with a strategic controlling approach.

关键词： hardware illumination resolution