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Determinant variables on the isotopic values of particulate organic matter in a neotropical floodplain

Journal of Oceanology and Limnology 2024年第4期42卷 1173-1185页

作者： Vinícius de ANDRADE URBANO Matheus MAXIMILIAN RATZ SCOARIZE Gustavo HENRIQUE ZAIA ALVES Driele DELANIRA-SANTOS Marcela da SILVA CAETANO Evanilde BENEDITO Departamento de Biologia(DBI) Laboratório de Ecologia EnergéticaUniversidade Estadual de Maringá(UEM)Maringá87020-900Brasil Programa de Pós-graduação em Ecologia de Ambientes Aquáticos Continentais(PEA) Universidade Estadual de Maringá(UEM)Maringá87020-900Brasil Departamento de Biologia Geral Universidade Estadual de Ponta Grossa(UEPG)Campus UvaranasPonta Grossa 84030-900Brasil Australian Rivers Institute(ARI) Griffith UniversityNathan QLD 4111Australia

Particulate organic matter(POM)is an important energy source for aquatic consumers,understanding its origin and composition is essential for understanding the energetic dynamics of aquatic *** aim of this study was to analyze the relationship between POM and phytoplankton(isotopic values and chlorophyll concentration)and abiotic variables during dry and rainy *** was conducted in rivers and lagoons in the floodplain of the Upper Paraná*** found a greater difference inδ13 C values of POM between sampling points than between seasons,indicating that the composition of regional sources influences the composition of POM more than dry and rainy *** addition,the concentration of chlorophyll during the dry season was positively correlated withδ13 C values during that rainy ***,we found a relationship between factors limiting the growth of phytoplankton andδ13 C values of POM,such as phosphate ions,indicating that variables that regulate phytoplankton growth tend to influence the composition of POM in river ***,maintaining the variables that regulate the phytoplankton community is of fundamental importance for the composition of POM,an important energy source in aquatic environments.

关键词： freshwater wetland stable isotopes food web subtropical environment

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Knowledge Is Invented: Addressing Invention and the Art of Saying in the Psychoanalytic Field

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Philosophy Study 2024年第3期14卷 97-105页

作者： Ana Lúcia Mandelli de Marsillac Universidade Federal de Santa Catarina FlorianópolisBrasil

In the Freudian-Lacanian field,there is an important distinction between knowledge and *** truth,of an unconscious nature,is something that inhabits us,directs us,but that escapes ***,in turn,is something to be invented,from the hole of the Real,the Unconscious truth,and the subjective *** relationships between playing,creating,and fantasizing;the dimension of the uncanny,fiction,and imagination in subjectivity;the invention of knowledge of oneself,derived from the pains and flavors of being who one is,are creative dimensions that inhabit the subject,permeate the analytical act,and transversalize *** the practice,we listen to and witness processes of analysis that awaken an invention/reinvention of oneself,in the process of remembering,repeating,and elaborating,but also in what the transference relationship *** of oneself,does not guarantee a life without mishaps,sadness,and illusions,but allows the invention and recognition of knowledge and a *** concept of Sinthome(2007),coined by Jacques Lacan,comes in the wake of the processes of self-invention and is a knowing-doing with the symptom,with the paradoxes of joyful suffering,producing,as a result,an art of ***,in this communication,I will articulate elements of theory,practice,and psychoanalytic experience that allow us to expand knowledge of the themes of invention and imagination articulated with the concept of sinthome,their relationships with subjectivity,and the direction of psychoanalytic treatment.

关键词： psychoanalysis invention imagination knowledge sinthome

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Development of a Ready-to-Use PSMA-11 Kit Formulation and Biological Evaluation of Binding Affinity

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Advances in Molecular Imaging 2024年第2期13卷 7-22页

作者： Maria Renata Valente Brandão Freire Natália Marchesan Bexiga Marco Antonio Stephano João Ezequiel Oliveira Carlos Roberto Jorge Soares Ana Cláudia Camargo Miranda Anna Carolina de Alcântara Barbosa Marycel Figols de Barboza Laura Fernanda Garcia Luiz Felipe S. Teixeira Maria Helena Marumo Bellini Natanael Gomes da Silva Luiza Mascarenhas Balieiro Joel Mendes Elaine Bortoleti de Araújo Centro de Radiofarmcia Instituto de Pesquisas Energticas e Nucleares (IPEN) Cidade Universitria So Paulo Brasil Departamento de Tecnologia Farmacutica Faculdade de Cincias Farmacuticas (USP) Cidade Universitria So Paulo Brasil Centro de Biotecnologia Instituto de Pesquisas Energticas e Nucleares (IPEN) Cidade Universitria So Paulo Brasil Departamento de Medicina Nuclear do Hospital Israelita Albert Einstein So Paulo/SP Brasil

Introduction: 68Ga-PSMA-11 is considered the gold standard in detection of micro and oligometastases in advanced prostate cancer, being used for therapeutic planning, as well as, potentially, for evaluating response to treatment. The development of ready-to-use lyophilized kit of PSMA-11 adds quality and safety to the routine use of this radiopharmaceutical and represents a pharmacotechnical challenge as it must preserve the integrity and specificity of the ligand. Methods: PSMA-11 kit formulation was proposed, considering radiolabeling parameters and the preservation of the peptide during the lyophilization process, using mannitol as an excipient. Critical temperature characterization studies were carried out using DSC equipment and the freeze-drying process was developed. The direct radiolabeling conditions were evaluated and standardized using 68Ge/68Ga generator eluate from two different manufacturers (ITG and Eckert & Ziegler). The radiochemical purity was evaluated by TLC and HPLC. Biological evaluation was carried out with lyophilized PSMA-11 to demonstrate the integrity of the peptide and preservation of biological activity after the lyophilization process. Results: Based on critical temperature characterization studies, the freeze-drying cycle was designed to reach a freezing temperature of around −40˚C and primary drying at 2˚C. Using 20 mg of mannitol, an intact and elegant lyophilized cake was obtained. PSMA-11 lyophilized kit was directly labeled with 68Ga eluate from 68Ge/68Ga GMP generators (ITG and Eckert & Ziegler) resulting in % RP > 95% at pH 4.0 to 4.5. The results obtained from in vitro and in vivo biological competition studies confirmed the preservation of PSMA-11 affinity for the receptor after lyophilization. Conclusion: A lyophilized formulation (Kit) of PSMA-11 was successfully obtained, which preserved the integrity and biological activity of the peptide and guaranteed radiolabeling efficiency.

关键词： 68Ga-PSMA-11 Prostate-Specific Membrane Antigen (PSMA) Ready-to-Use Kit GMP-Grade Generators Metastatic Prostate Cancer PET Imaging

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Analysis of Perinatal Outcomes of Twin Pregnancy in a Referral Hospital for High Risk

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Open Journal of Obstetrics and Gynecology 2024年第7期14卷 983-995页

作者： Eduarda Paim Pedro Lucas Carneiro Ferreira Luciano Selistre Fernanda Grossi José Mauro Madi Gabriela Françoes Rostirolla Mdica Residente do Programa de Residncia em Ginecologia e Obstetrcia Hospital Geral de Caxias do Sul Rio Grande do Sul Brasil Faculdade de Medicina Universidade de Caxias do Sul Rio Grande do Sul Brasil Programa de Ps-Graduao Universidade de Caxias do Sul Rio Grande do Sul Brasil Servio de Ginecologia e Obstetrcia Hospital Geral de Caxias do Sul Rio Grande do Sul Brasil

Introduction: The incidence of twin pregnancies has increased significantly in recent decades. These pregnancies require more attention due to their worse outcomes than singleton pregnancies. Objective: To analyze the characteristics and perinatal outcomes of twin pregnancies at the Caxias do Sul General Hospital. Methods: This is a descriptive and retrospective study that included all births related to twin pregnancies between March 1998 and June 2018. Maternal and perinatal variables were analyzed. Descriptive analyses were carried out using measures of central tendency and dispersion for continuous variables (mean and standard deviation or median and interquartile range), according to a prior assessment of distribution using the Shapiro-Wilk test, and absolute (n) and relative (n%) frequencies for categorical variables. Results: 172 pairs of twins/21,972 births (0.8%) were identified. There was a high percentage of interpartum interval of less than 12 months, adherence and prenatal visits, body mass index, and need for neonatal intensive care. Stillbirth and neomortality rates were within acceptable parameters. Conclusion: The sample studied showed a percentage similar to that in the literature, a high rate of maternal and perinatal complications, characterizing it as a high-risk fetal pregnancy.

关键词： Pregnancy Twin Pregnancy High Risk Pregnancy Morbidity Perinatal Mortality Perinatal Results

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Influence of Omega 3 Fatty Acid Supplementation on Phase Angle Values of People Living with HIV/AIDS with Lipodystrophy Secondary to Antiretroviral Therapy: A Randomized Clinical Trial

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Food and Nutrition Sciences 2024年第1期15卷 58-70页

作者： Thalita Bandeira Dantas Alline Peralta Castro Fernando de Souza Flexa Ribeiro Filho Rosana Maria Feio Libonati Núcleo de Medicina Tropical do Pará Programa de Pós gradua&ccedil&atildeo em Patologia das Doen&ccedilas Tropicais Universidade Federal do Pará Pará Brasil Instituto de Ciências Biológicas e da Saúde Faculdade de Medicina Universidade Federal do Pará Pará Brasil Centro de Ciências Biológicas e da Saúde Universidade Estadual do Pará Pará Brasil

Objective: The measurement of phase angles is an important monitoring parameter and supplementation with omega-3 could promote benefits by modulating the electrical potential of membranes and increasing body cell mass. This study aimed to evaluate the effectiveness of omega-3 fatty acid supplementation on the phase angle of people living with HIV/AIDS. Methods: In this study, 63 individuals of all genders who were undergoing outpatient follow-up and showed lipodystrophy due to highly active antiretroviral therapy were analyzed. Our sample consisted of two groups, one that received supplementation containing 2550 mg of omega-3/day (1080 mg of eicosapentaenoic acid and 720 mg of docosahexaenoic acid) for three months (n = 32) and another that underwent nutrition guidance (n = 31). Phase angle and body cell mass were assessed for both groups and compared at the beginning of research (T0) and after our intervention (T1) for each group separately. Results: Phase angle averaged 6.45° ± 1.06 SD. The comparison between T0 and T1 showed a significant increase in phase angle and body cell mass, whereas the guidance group showed a decrease in body cell mass at T1 in relation to T0, with a significant p-value. Variance in phase angle between moments showed significant values between T0 and T1 in the supplementation group for all genders. Conclusion: Omega-3 positively modulated patients phase angle and body cell mass, but we emphasize the need for other studies that can solidify knowledge about supplementation dosage and intervention time.

关键词： HIV Lipodystrophy Omega-3 Phase Angle

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Radical Prostatectomy by Laparotomy: Retrospective Study Comparing Separate and Continuous Stitches in the Performance of Vesicourethral Anastomosis at a Single Center in the Public Health Network

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Open Journal of Urology 2024年第6期14卷 368-379页

作者： Guilherme Canabrava Rodrigues Silva Tarcizo Afonso Nunes Rafael Calvão Barbuto Thiffany Quartarollo Lopes Beatriz Melo De Almeida Departamento de Cirurgia da FMUFMG e da PUC-MG Belo Horizonte Brazil Departamento de Cirurgia da FMUFMG Belo Horizonte Brazil Acadmica de Medicina da Universidade Federal de Minas Gerais (UFMG) Belo Horizonte Brasil Acadmica de Medicina da Pontifcia Universidade Catlica de Minas Gerais (PUC-MG) Betim Brasil

Background: Prostate cancer ranks as the second most prevalent malignancy in men, with treatment strategies ranging from observation to various interventions. Radical prostatectomy is a common approach, aiming for a cure, and the technique for vesico-urethral anastomosis varies, employing separate or continuous stitches. However, a consensus on the optimal technique is lacking. This study aims to compare vesico-urethral anastomosis techniques (separate vs. continuous stitches) in laparotomy-based radical prostatectomies, evaluating peri and postoperative outcomes. Materials and Method: A retrospective analysis of 140 patients’ medical records yielded 86 eligible cases, divided into two groups based on anastomosis technique. Both groups underwent surgery at the same urology center between 2016 and 2019, with a follow-up period exceeding 12 months. Pre-operative characteristics were statistically similar between groups. Results: Perioperative complication rates did not significantly differ between the two techniques (p > 0.99). However, the continuous stitch group experienced a 20-minute longer procedure time (p 0.05), patients with continuous stitches had 2.5 times higher diaper usage at twelve months (p Conclusion: This research suggests that vesico-urethral anastomosis with separate stitches yields superior results in laparotomy-based radical prostatectomies compared to continuous stitches, demonstrating benefits in surgical time, hospital stay, sentinel drain duration, stenosis rates, and long-term urinary incontinence outcomes.

关键词： Prostate Cancer Urinary Incontinence Urethrovesical Anastomosis

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Impact Containment Barriers with Geotextile Tubes

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Journal of Geoscience and Environment Protection 2024年第5期12卷 325-344页

作者： Flávio da Silva Ornelas Luís Fernando Martins Ribeiro Rafael Cerqueira Silva Instituto Federal de Educaç &#227o Ci&#234ncia e Tecnologia&#8212IFTO Palmas Brasil Departamento de Engenharia Civil e Ambiental Programa de p&#243s gradua&#231&#227o em Geotecnia Universidade de Bras&#237lia&#8212UnB/Campus Universit&#225rio Darcy Ribeiro Bras&#237lia Brasil

Recently, tragic tailings dam collapses in Brazil have caused deaths and major destruction and the need to develop technologies capable of preventing damage to people and the environment. Brazilian tailings dams are in a situation of uncertainty due to new legislation that even requires decommissioning, an activity that involves many problems and where the risk of failure is the main one. An impact containment structure downstream of these dams can be effective and geotextile tubes, in a new approach, have emerged as an option with advantages in terms of execution, costs and safety. The technology is versatile and can bring many benefits such as the reuse of tailings or filling with low-energy or reused materials. In this research, geotextile tubes were tested as free containment barriers, experiencing impacts in reduced models. The safety factor for the stability of the structure was constructed using an equation which is the ratio between the self-weight of the barrier structure and its coefficient of static friction and the impact pressure, where the data showed an adequate correlation which suggests the viability of mitigating risks.

关键词： Geotextile Tube Debris Flow Barriers Impact Mining

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Gravity Fault Subsidence and Beach Ridges Progradation in Quinta-Cassino (RS) Coastal Plain, Brazil

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Open Journal of Geology 2024年第2期14卷 177-195页

作者： Bruno Silva da Fontoura Adelir José Strieder Iran Carlos Stalliviere Corrêa Paulo Rogério Mendes Alexandre Felipe Bruch Angélica Cirolini Programa de Pós-Graduaç &#227o em Geoci&#234ncias (PPGeo) Instituto de Geoci&#234ncias UFRGS Porto Alegre Brazil Engenharia Geológica Centro de Engenharias UFPel Pra&#231a Domingos Rodrigues 2 Pelotas Brasil HIDROSERV-Serviç os Geológicos e Geofísicos Ltda. Rua Senegal 152 Porto Alegre Brazil Colégio Politécnico UFSM Santa Maria Brasil

Ground penetrating radar (GPR) surveys have being applied to investigate very near-surface stratification of sedimentary units in coastal plains and to define their depositional conditions. This paper presents, however, low-frequency GPR survey to investigate fault-related depositional systems at greater depths. The Quinta-Cassino area in the Rio Grande do Sul Coastal Plain (RGSCP, Brazil) shows a wide strandplain that is made off by very long, continuous, and linear geomorphic features (beach ridges). This strandplain extends for ~70 km southward. The beach ridges show low-angle truncations against the Quinta escarpment, and also truncations in the strandplain. The traditional approach points that RGSCP was developed by juxtaposition of four lagoons/barrier systems as consequence of sea level changes;previous model assumes that no deformational episode occurred in RGSCP. The geophysical and geological surveys carried out in this area showed the existence of listric fault controlling the beach ridges in the escarpments and hanging-wall blocks. The radargrams could distinguish Pleistocene basement unit anticlockwise rotation, thickening of beach ridges radarfacies close to listric normal faults, and horst structures. These deformational features indicate that the extensional zone of a large-scale gravity-driven structure controlled the mechanical subsidence, the Holocene sedimentation and its stratigraphic and geomorphic features in the Quinta-Cassino area to build up an asymmetric delta. The results point to a new approach in dealing with RGSCP Holocene evolution.

关键词： Gravity Tectonics Normal Faults Ground Penetrating Radar Survey Beach-Ridges Progradation

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Prediction of SARS-CoV-2 hosts among Brazilian mammals and new coronavirus transmission chain using evolutionary bioinformatics

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Animal Diseases 2022年第1期2卷 16-26页

作者： Luciano Rodrigo Lopes Giancarlo de Mattos Cardillo Natalia Carvalho de Lucca Pina Antonio Carlos da Silva Junior Silvana Kertzer Kasinski Paulo Bandiera-Paiva SPBrasil SPBrasil

Severe acute respiratory syndrome coronavirus(SARS-CoV)and SARS-CoV-2 are thought to transmit to humans via wild mammals,especially ***,evidence for direct bat-to-human transmission is *** of intermediate hosts is considered a reason for SARS-CoV-2 transmission to humans and emergence of *** biodiversity is found in tropical territories,such as *** the similar line,this study aimed to predict potential coronavirus hosts among Brazilian wild mammals based on angiotensin-converting enzyme 2(ACE2)sequences using evolutionary ***,maned wolf,and bush dogs were predicted as potential hosts for *** indigenous carnivores are philogenetically closer to the known SARS-CoV/SARS-CoV-2 hosts and presented low ACE2 divergence.A new coronavirus transmission chain was developed in which white-tailed deer,a susceptible SARS-CoV-2 host,have the central *** play an important role because of its low divergent ACE2 level in deer and *** discovery of these potential coronavirus hosts will be useful for epidemiological surveillance and discovery of interventions that can contribute to break the transmission chain.

关键词： SARS-CoV-2 Angiotensin-converting enzyme 2 Coronavirus Brazilian mammals White-tailed deer

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Gravity-Driven Listric Growth Fault and Sedimentation in the Lagoa do Peixe, Rio Grande do Sul Coastal Plain, Brazil

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Open Journal of Geology 2024年第4期14卷 594-616页

作者： Bruno Silva da Fontoura Adelir José Strieder Iran Carlos Stalliviere Corrêa Paulo Rogério Mendes Instituto de Geociê ncias UFRGS Porto Alegre Brazil Engenharia Geoló gica Centro de Engenharias UFPel Pelotas Brasil HIDROSERV— Servi&#231os Geol&#243gicos e Geof&#237sicos Ltda. Porto Alegre Brazil

High frequency, high resolution GPR surveys are successfully applied to investigate near-surface stratification architecture of sedimentary units in coastal plains and to define their depositional conditions. However, low frequency GPR surveys to investigate fault-related depositional systems at greater depths are scarce. This survey was designed investigate a > 100 km long linear escarpment that controls the northwest margin of the Lagoa do Peixe, an important lagoon in Rio Grande do Sul Coastal Plain (RGSCP, Brazil). The traditional approach points that RGSCP was developed by juxtaposition of four lagoons/barrier systems as consequence of sea level changes;no deformational structure is admitted to exist before. The low frequency GPR (50 MHz, RTA antenna) and geological surveys carried out in the RGSCP showed the existence of a large, gravity-driven listric growth fault controlling the Lagoa do Peixe escarpment and hangingwall sedimentation. The radargrams in four subareas along the Lagoa do Peixe Growth Fault could be interpreted following the seismic expression of rift-related depositional systems. The radargrams enabled to distinguish three main lagoonal deposition radarfacies. The lower lagoonal radarfacies is a convex upward unit, thicker close to growth fault;the radarfacies geometry indicates that fault displacement rate surpasses the sedimentation rate, and its upper stratum is aged ~3500 l4C years BP. The second lagoonal radarfacies is a triangular wedge restricted to the lagoon depocenter, whose geometry indicates that fault displacement and the sedimentation rates kept pace. The upper lagoonal radarfacies is being deposited since 1060 ± 70 l4C years BP, under sedimentation rate higher than fault displacement rate. The results indicate that low frequency GPR surveys can help in investigating fault-related depositional systems in coastal zones. They also point to a new approach in dealing with RGSCP stratigraphy.

关键词： GPR (Ground-Penetrating Radar) Growth Fault Sedimentation Radarfacies Coastal Plain

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