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PEComa of the colon resistant to sirolimus but responsive to doxorubicin/ifosfamide

World Journal of Gastroenterology 2013年第10期19卷 1657-1660页

作者： Wolfgang Scheppach Nikolaus Reissmann Thomas Sprinz Ekkehard Schippers Bjoern Schoettker Justus G Mueller Department of Medicine Juliusspital WuerzburgD-97070 WuerzburgGermany Department of Surgery Juliusspital WuerzburgD-97070 WuerzburgGermany onkologische schwerpunktpraxis D-97070 WuerzburgGermany Department of Pathology University of Wuerzburg97070 WürzburgGermany

A 23-year-old male presented with a three-week-history of crampy abdominal pain and *** revealed a friable mass filling the entire lumen of the cecum;histologically,it was classified as perivascular epithelioid cell tumor(PEComa).An magnetic resonance imaging scan showed,in addition to the primary tumor,two large mesenteric lymph node metastases and four metastatic lesions in the *** patient underwent right hemicolectomy and left hemihepatectomy combined with wedge resections of metastases in the right lobe of the liver,the resection status was ***,the patient was treated with *** 4 mo of adjuvant mammalian target of rapamycin inhibition he developed two new liver metastases and a local pelvic *** visible tumor formations were again excised surgically,this time the resection status was R2 with regard to the pelvic *** patient was treated with 12 cycles of doxorubicin and ifosfamide under which the disease was stable for 9 *** clinical course was then determined by rapid tumor growth in the pelvic *** line chemotherapy with gemcitabine and docetaxel was ineffective,and the patient died 23 mo after the onset of *** case report adds evidence that,in malignant PEComa,the mainstay of treatment is curative *** not achievable,the effects of adjuvant or palliative chemotherapy are unpredictable.

关键词： Perivascular epithelioid cell tumor Colon Liver metastases Mammalian target of rapamycin inhibitor Sirolimus Chemotherapy Doxorubicin Ifosfamide

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Chemosensitivity Testing of Circulating Epithelial Tumor Cells (CETC) in <i>Vitro</i>: Correlation to in <i>Vivo</i>Sensitivity and Clinical Outcome

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Journal of Cancer Therapy 2013年第2期4卷 597-605页

作者： Nadine Rudiger Ernst-Ludwig Stein Erika Schill Gabriele Spitz Carola Rabenstein Martina Stauch Matthias Rengsberger Ingo B. Runnebaum Ulrich Pachmann Katharina Pachmann Clinic for Internal Medicine II University Hospital Friedrich Schiller University Jena Germany onkologische schwerpunktpraxis Kronach Germany Transfusionsmedizinisches Zentrum Bayreuth Germany Women’s Hospital University Hospital Friedrich Schiller University Jena Germany

Background: Chemotherapy is a mainstay of tumor therapy, however, it is predominantly applied according to empirically developed recommendations derived from statistical relapse rates occurring years after the treatment in the adjuvant situation and from progression-free interval data in the metastatic situation, without any possibility of individually determining the efficacy in the adjuvant situation and with loss of time and quality of life in the metastatic situation if the drugs chosen are not effective. Here, we present a method to determine the efficiency of chemotherapeutic drugs using tumor cells circulating in blood as the part of the tumor actually available in the patient’s body for chemosensitivity testing. Methodology/Principal Findings: After only red blood cell lysis, omitting any enrichment (analogous to other blood cell enumeration methods, including rare CD34 cells), the white cells comprising the circulating epithelial tumor cells (CETC) are exposed to the drugs in question in different concentrations and for different periods of time. Staining with a fluorescence-labeled anti-epithelial antibody detects both vital and dying tumor cells, distinguishing vital from dying cells through membrane permeability and nuclear staining with propidium iodide. Increasing percentages of dying tumor cells are observed dependent on time and concentration. The sensitivity can vary during therapy and was correlated with decrease or increase in CETC and clinical outcome. Conclusions/Significance: Thus, we are able to show that chemosensitivity testing of circulating tumor cells provides real-time information about the sensitivity of the tumor present in the patient, even at different times during therapy, and correlates with treatment success.

关键词： Circulating Epithelial Tumor Cells Chemosensitivity Testing Breast Cancer Ovarian Cancer

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Circulating cytokeratin-positive cells and tumor budding in colorectal cancer

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World Journal of Clinical Oncology 2016年第6期7卷 433-440页

作者： Bruno M?rkl Narjes Wilhelms Matthias Anthuber Gerhard Schenkirsch Günter Schlimok Daniel Oruzio Institute of Pathology Klinikum Augsburg Department of Visceral Surgery Klinikum Augsburg Clinical and Population-Based Cancer Registry Augsburg Hematology and Oncology Diakonissen-krankenhaus Augsburg onkologische Praxis MVZ

AIM To investigate whether circulating cytokeratin-positive(CK^+) cells in the mesenteric blood of resected colorectal specimens are prognostic and correlate with tumor *** Fifty-six colorectal specimens were collected between 9/2007 and 7/*** from the mesenteric vein was drawn immediately after receiving the fresh and unfixed specimens in the pathology *** separation of the mononuclear cells by Ficoll-Hypaquedensity-gradient centrifugation,cytological smears were immunocytochemically stained for *** budding was evaluated on slides stained for *** identification of ≥ 30 buds/1.3 mm2 was defined as high grade *** CK^+ cells and clusters were identified in 29(48%) and 14(25%) of the samples,*** cells were identified in one of three non-malignant *** were found exclusively in malignant *** occurrence of CK^+ cells or clusters was not associated with any of the evaluated clinicopathological factors,including surgical technique and tumor ***,the occurrence of CK^+ cells or clusters had no influence on the cancerspecific survival [75 mo(CI:61;88) vs 83 mo(CI:72;95) and 80 mo(CI:63;98) vs 79 mo(CI:69;89),respectively].CONCLUSION CK^+ cells and showed neither prognostic significance nor an association with tumor *** is very likely that CK18-staining is not specific enough to identify the relevant cells.

关键词： Colorectal cancer Circulating cells Tumor budding Peripheral blood Survival

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胸部CT应用静脉内造影剂注射的价值

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放射学实践 1989年第3期4卷 97-103页

作者： S.A.Beyer-Enke J.Grich M.Müller S.Tüngerthal G.van Kaick 张本固 Abteilung für onkologische Diagnostik und Therapie Institut für Radiologie und Pathophysiologie des Deutschen Krebsforschungszentrums Heidelberg 同济医科大学附属同济医院

胸部CT有较高诊断能力。在CT连续断层时应用造影剂(有时为附加应用)能明显减少对血管结构和肿瘤块影的分辨困难。

关键词：胸 CT诊断 X线造影剂静脉注射

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