检索结果-南通市图书馆

Anoctamin 4 defines glucose-inhibited neurons in the ventromedial hypothalamus

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2024年第6期19卷 1177-1178页

作者： Longlong Tu Yanlin He Yong Xu Children’s Nutrition Research Center Department of PediatricsBaylor College of MedicineOne Baylor PlazaHoustonTXUSA Brain Glycemic and Metabolism Control Department Pennington Biomedical Research CenterLouisiana State UniversityBaton RougeLAUSA Department of Molecular and Cellular Biology Section of EndocrinologyDiabetes and MetabolismDepartment of MedicineBaylor College of MedicineHoustonTXUSA

Glucose is the primary fuel source of the brain,and therefore glucose levels need to be tightly regulated and maintained within a small physiological ***,the body necessitates a stable supply of energy mainly provided by glucose for various bodily *** or low blood glucose levels would impair the physiological functions of various organs of the body.

关键词： inhibited medial organs

在线全文

学校读者我要写书评

暂无评论

基因组结构变异研究的前瞻性及临床应用

Science Bulletin 2024年第6期69卷 705-708页

作者：陈仲中 Richard H.Finnell 雷云平王红艳 Obstetrics and Gynecology Hospital State Key Laboratory of Genetic EngineeringInstitute of Reproduction and DevelopmentFudan UniversityShanghai 200011China Shanghai Children’s Hospital School of MedicineShanghai Jiao Tong UniversityShanghai 200062China Center for Precision Environmental Health Department of Molecular and Cellular BiologyBaylor College of MedicineHouston 77030USA Departments of Molecular and Human Genetics and Medicine Baylor College of MedicineOne Baylor PlazaHouston 77030USA Shanghai Key Laboratory of Metabolic Remodelling and Health Institute of Metabolism and Integrative BiologyFudan UniversityShanghai 200438China Children’s Hospital of Fudan University Shanghai 201102China

The challenges and breakthroughs in human genetics can largely depend on the depth of exploring the missing heritability[1]and understanding of genetic variants,which enabled scientists to better elucidate the underlying causes of diseases and apply this knowledge in clinical *** genomes differ from one individual to another in the form of single nucleotide variants(SNVs),small insertions and deletions(indels)(<50 base pairs(bp)),and structural variants(SVs)[2].

关键词： diseases breakthrough insertion

A developmental stage-dependent switch of the mechanisms for prostate epithelial maintenance

在线全文

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2013年第1期15卷 85-86页

作者： Li Xin Department of Molecular and Cellular Biology Baylor College of Medicine One Baylor Plaza Houston TX 77030 USA Department of Pathology and Immunology Baylor College of Medicine One Baylor Plaza Houston TX 77030 USA Dan L. Duncan Cancer Center Baylor College of Medicine One Baylor Plaza. Houston TX 77030 USA

Previous studies demonstrated that adult murine prostate basal and luminal cells are independently self-sustained, but prostate basal cells possess the potential to differentiate into multiple lineages upon induction by embryonic urogenital sinus mesenchyme. Nevertheless, it is unknown how prostate epithelia mature during the postnatal stage. Recently, Ousset et al.

关键词： MURINE PROSTATE STEM-CELLS UROGENITAL SINUS BASAL-CELLS CANCER SUBPOPULATION EXPRESSION DUCTS

Telomere regulation in pluripotent stem cells

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Protein & Cell 2014年第3期5卷 194-202页

作者： Yan Huang Puping Liang Dan Liu Junjiu Huang Zhou Songyang Key Laboratory of Reproductive Medicine of Guangdong Province the First Affiliated Hospital and Key Laboratory of Gene_ Engineering of the Ministry of Education School of Life Sciences Sun Yat-sen University Guangzhou 510275 China Cell-Based Assay Screening Core Baylor College of Medicine One Baylor Plaza Houston TX 77030 USA Dan L. Duncan Cancer Center Baylor'College of Medicine one Baylor'Plaza Houston TX 77030 uSA Verna and Marrs Mclean Department of Biochemistry and Molecular Biology Baylor College of Medicine One Baylor Plaza Houston TX 77030 USA

Pluripotent stem cells （PSCs） have the potential to pro- duce any types of cells from all three basic germ layers and the capacity to self-renew and proliferate indefinitely in vitro. The two main types of PSCs, embryonic stem cells （ESCs） and induced pluripotent stem cells （iPSCs）, share common features such as colony morphology, high expression of Oct4 and Nanog, and strong alkaline phosphatase activity. In recent years, increasing evi- dences suggest that telomere length represents another important internal factor in maintaining stem cell pluri- potency. Telomere length homeostasis and its structural integrity help to protect chromosome ends from recom- bination, end fusion, and DNA damage responses, ensuring the divisional ability of mammalian cells. PSCs generally exhibit high telomerase activity to maintain their extremely long and stable telomeres, and emerging data indicate the alternative lengthening of telomeres （ALT） pathway may play an important role in telomere functions too. Such characteristics are likely key to their abilities to differentiate into diverse cell types in v/vo. In this review, we will focus on the function and regulation of telomeres in ESCs and iPSCs, thereby shedding light on the importance of telomere length to pluripotency and the mechanisms that regulate telomeres in PSCs.

关键词： telomere pluripotent stem cells alternativelengthening of telomeres (ALT) regulators

LOX upregulates FAK phosphorylation to promote metastasis in osteosarcoma

在线全文

学校读者我要写书评

暂无评论

Genes & Diseases 2023年第1期10卷 254-266页

作者： Xiang Chen Margaret Clement MJohn Hicks Poonam Sarkar MWaleed Gaber Tsz-Kwong Man Department of Pediatrics Baylor College of MedicineOne Baylor PlazaHoustonTX 77030USA Department of Pathology Baylor College of MedicineOne Baylor PlazaHoustonTX 77030USA Dan L.Duncan Comprehensive Cancer Center 7200 Cambridge StreetHoustonTX 77054USA Texas Children's Cancer and Hematology Centers 1102 Bates StHoustonTX 77030USA

Osteosarcoma is a malignant bone tumor that commonly occurs in the pediatric *** the use of chemotherapy and surgery,metastasis remains to be the leading cause of death in patients with *** have previously reported that cytoplasmic mislocalization of p27 is associated with a poor outcome in *** this study,we further show that lysyl oxidase(LOx)expression was associated with p27 *** is an enigmatic molecule that acts as a tumor suppressor or a metastatic promoter;however,its role in osteosarcoma is still ***,we performed both in vitro and in vivo analyses to dissect the role of Lox in *** result of our survival analysis indicated that Lox expression significantly correlated with a poor outcome in osteosarcoma with or without controlling for the initial metastasis status(P<0.05).Functionally,we found that higher LoX expression promoted osteosarcoma cell proliferation,migration,and invasiveness in vitro and produced a higher number of mice with pulmonary metastases in an orthotopic xenograft mouse ***,phospho-FAK was increased in osteosarcoma cells with high LOX *** results further showed that FAK inhibition significantly reduced tumor cell proliferation and migration in vitro as well as LoX-mediated metastasis in ***,our findings suggest that there is a novel link between p27 mislocalization and LOX *** plays a pivotal role in osteosarcoma metastasis by upregulating FAK *** inhibition may constitute a promising therapeutic strategy to reduce the development of metastasis in osteosarcoma with Lox overexpression.

关键词： Focal adhesion kinase Lysyl oxidase Metastasis Osteosarcoma

内皮素-1促进猪冠状动脉再生内皮释放内皮衍生内过氧化物和血栓素A_2(英文)

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中国药理学报 1999年第10期20卷 872-878页

作者： Seung-Jung PARK John J LEE Paul M VANHOUTTE Center for Experimental Therapeutics Department of Medicine Baylor College of Medicine One Baylor Plaza Houston TX 77030 USACenter for Experimental Therapeutics Department of Medicine Baylor College of Medicine One Baylor Plaza Houston TX 77030 USACenter for Experimental Therapeutics Department of Medicine Baylor College of Medicine One Baylor Plaza Houston TX 77030 USA

AIM: To determine the role of endothelium-derivedcontracting factor (EDCF) in the response toendothelin-1 in arteries with regenerated ***: Rings of porcine coronary arteries, withand without endothelium of previously deendothelializedleft anterior descending coronary arteries and native leftcircumflex coronary arteries, were suspended inconventional organ chambers for the measurement ofisometric force. RESULTS: In quiescent rings of thepreviously deendothelialized left anterior

关键词：血管内皮药理冠状血管内皮素-1 吲哚美辛

Steroid responsive eosinophilic gastric outlet obstruction in a child

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2008年第14期14卷 2270-2271页

作者： Richard Kellermayer Nina Tatevian William Klish Robert J Shulman Section of Gastroenterology Hepatology and Nutrition Department of Pediatrics Baylor College of Medicine One Baylor Plaza Houston TX 77030 United States Department of Pathology Baylor College of Medicine One Baylor Plaza Houston TX 77030 United States Section of Gastroenterology Hepatology and Nutrition Department of Pediatrics Baylor College of Medicine One Baylor Plaza Houston TX 77030 United States Children’s Nutrition Research Center Department of Pediatrics Baylor College of Medicine One Baylor Plaza Houston TX 77030 United States

Gastric outlet obstruction is a rare complication of eosinophilic gastroenteritis, most commonly treated surgically. We report a case of eosinophilic gastric outlet obstruction in a child that responded to conservativ... 详细信息

关键词： Eosinophilic gastroenteritis Pylorus Gastric outlet obstruction Steroids

Executive Editor-in-Chief’s introduction for this Special Issue

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Reproductive and Developmental Medicine 2022年第1期6卷 65-66页

作者： Richard H.Finnell Center for Precision Environmental Health Baylor College of MedicineOne Baylor PlazaBCM 946HoustonTX 77030-411USA

Dear Colleagues,As an Executive Editor-in-Chief,I have edited this Special Issue(SI),entitled “Birth Defects:Issues and Advances in 2022”in the journal Reproductive and Developmental Medicine(RDM,ISSN:2096-2924,CN:10-1442/R),the first ever English journal in the field of reproductive medicine and developmental biology in China's *** its launch in 2017,RDM has been dedicated to providing a good platform for academic exchanges among scientists,both at home and abroad.

关键词： journal mainland Executive

Hyperpolarization caused by serotonin contributes to endothelium-dependent relaxations in the porcine coronary artery

在线全文

学校读者我要写书评

暂无评论

中国药理学报 1999年第12期20卷 1093-1096页

作者： Seung-Jung PARK Mikio NAKASHIMA Tetsuhiko NAGAO Paul M VANHOUTTE Center for Experimental Therapeutics Department of MedicineBaylor College of MedicineOne Baylor PlazaHoustonTX 77030USA

AIM:The present study was designed to investigate the contribution of membrane hyperpolarization to endothelium-dependent relaxations induced by serotonin in the porcine coronary ***:Rings with and without endothelium of porcine coronary arteries were suspended in conventional organ chambers for the measurement of isometric *** cell membrane potential of the vascular smooth muscle cells was measured using glass microelectrodes,in the presence of indometacin,ketanserin,and/or N^(ω)-***:Serotonin induced a transient endothelium-,and concentration-dependent relaxation in rings contracted with prostaglandin F_(2α)in the presence of N^(ω)-nitro-L-arginine(maximal relaxation;19%).The N^(ω)-nitro-L-arginine resistant relaxation was abolished by high K^(+)and tetrabutylammonium *** also caused an endothelium-,concentration-dependent membrane hyperpolarizations with a maximal amplitude *** nitro-L-arginine resistant relaxations and hyperpolarizations were abolished by methiothepin,but not by *** time course of the endothelium-dependent relaxations and hyperpolarizations was ***:These results suggest a contribution of cell membrane hyperpolarization to theendothelium-dependent relaxations induced by serotonin in the porcine coronary artery.

关键词： indomethacin ketanserin membrane potentials methiothepin nitric oxide potassium channels serotonin vascular endothelium