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Developing risk models and subtypes of autophagy-associated LncRNAs for enhanced prognostic prediction and precision in therapeutic approaches for liver cancer patients

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oncology Research 2024年第4期32卷 703-716页

作者： LU ZHANG JINGUO CHU YUSHAN YU Department of general practice The First Affiliated Hospital of Ningbo UniversityNingboChina

Background:Limited research has been conducted on the influence of autophagy-associated long non-coding RNAs(ARLncRNAs)on the prognosis of hepatocellular carcinoma(HCC).Methods:We analyzed 371 HCC samples from TCGA,identifying expression networks of ARLncRNAs using autophagy-related *** for prognostically relevant ARLncRNAs involved univariate Cox regression,Lasso regression,and multivariate Cox regression.A Nomogram was further employed to assess the reliability of Riskscore,calculated from the signatures of screened ARLncRNAs,in predicting ***,we compared drug sensitivities in patient groups with differing risk levels and investigated potential biological pathways through enrichment analysis,using consensus clustering to identify subgroups related to ***:The screening process identified 27 ARLncRNAs,with 13 being associated with HCC ***,a set of signatures comprising 8 ARLncRNAs was successfully constructed as independent prognostic factors for *** in the high-risk group showed very poor prognoses in most clinical *** Riskscore was closely related to immune cell scores,such as macrophages,and the DEGs between different groups were implicated in metabolism,cell cycle,and mitotic ***,high-risk group patients demonstrated a significantly lower IC50 for Paclitaxel,suggesting that Paclitaxel could be an ideal treatment for those at elevated risk for *** further identified C2 as the Paclitaxel subtype,where patients exhibited higher Riskscores,reduced survival rates,and more severe clinical ***:The 8 signatures based on ARLncRNAs present novel targets for prognostic prediction in *** drug candidate Paclitaxel may effectively treat HCC by impacting ARLncRNAs *** the identification of ARLncRNAsrelated isoforms,these results provide valuable insights for clinical exploration of autophagy mechanisms in HCC pathogenesis and offer potential av

关键词： Autophagy Hepatocellular carcinoma(HCC) Prognosis Precision medicine Paclitaxel

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Trends and hotspots in gastrointestinal neoplasms risk assessment: A bibliometric analysis from 1984 to 2022

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World Journal of Gastrointestinal oncology 2024年第6期16卷 2842-2861页

作者： Qiang-Qiang Fu Le Ma Xiao-Min Niu Hua-Xin Zhao Xu-Hua Ge Hua Jin De-Hua Yu Sen Yang Department of general practice Yangpu HospitalSchool of MedicineTongji UniversityShanghai 200090China Shanghai general practice and Community Health Development Research Center Shanghai 200090China Department of Shanghai Lung Cancer Center Shanghai Chest HospitalShanghai Jiao Tong University School of MedicineShanghai 200030China Department of oncology Shanghai Tenth People’s HospitalTongji University School of MedicineShanghai 200090China

BACKGROUND Gastrointestinal neoplasm(GN)significantly impact the global cancer burden and mortality,necessitating early detection and *** the evolution and current state of research in this field is *** To conducts a comprehensive bibliometric analysis of publications from 1984 to 2022 to elucidate the trends and hotspots in the GN risk assessment research,focusing on key contributors,institutions,and thematic *** This study conducted a bibliometric analysis of data from the Web of Science Core Collection database using the"bibliometrix"R package,VOSviewer,and *** analysis focused on the distribution of publications,contributions by institutions and countries,and trends in *** methods included data synthesis,network analysis,and visualization of international collaboration *** This analysis of 1371 articles on GN risk assessment revealed a notable evolution in terms of research focus and *** highlights the United States'critical role in advancing this field,with significant contributions from institutions such as Brigham and Women's Hospital and the National Cancer *** last five years,substantial advancements have been made,representing nearly 45%of the examined *** rates have dramatically increased,from 20 articles in 2002 to 112 in 2022,reflecting intensified research *** study underscores a growing trend toward interdisciplinary and international collaboration,with the Journal of Clinical oncology standing out as a key publication *** shift toward more comprehensive and collaborative research methods marks a significant step in addressing GN *** This study underscores advancements in GN risk assessment through genetic analyses and machine learning and reveals significant geographical disparities in research *** calls for enhanced global collaboration and integration of artificial intelligence to improve cancer p

关键词： Gastrointestinal neoplasms Bibliometric analysis Risk assessment Network analysis Research trends

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Mapping the intellectual structure and emerging trends for the application of nanomaterials in gastric cancer:A bibliometric study

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World Journal of Gastrointestinal oncology 2024年第5期16卷 2181-2199页

作者： Bo-Na Liu Xiao-Li Gao Ying Piao Department of oncology General Hospital of Northern Theater CommandShenyang 110015Liaoning ProvinceChina

BACKGROUND Recent reviews have outlined the main nanomaterials used in relation to gastrointestinal tumors and described the basic properties of these ***,the research hotspots and trends in the application of nanomaterials in gastric cancer(GC)remain *** To demonstrate the knowledge structure and evolutionary trends of research into the application of nanomaterials in *** Publications related to the application of nanomaterials in GC were retrieved from the Web of Science Core Collection for this systematic review and bibliometric *** and CiteSpace were used for bibliometric and visualization *** From 2000 to 2022,the application of nanomaterials in GC developed *** keyword co-occurrence analysis showed that the related research topics were divided into three clusters:(1)The application of nanomaterials in GC treatment;(2)The application and toxicity of nanomaterials in GC diagnosis;and(3)The effects of nanomaterials on the biological behavior of GC ***,silver nanoparticles,and green synthesis are the latest high-frequency keywords that represent promising future research *** The application of nanomaterials in GC diagnosis and treatment and the mechanisms of their effects on GC cells have been major themes in this field over the past 23 years.

关键词： Nanomaterials Gastric cancer Bibliometrics Drug delivery VOSviewer CiteSpace Systematic review

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Heterochronous multiple primary prostate cancer and lymphoma:A case report

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World Journal of Clinical Cases 2024年第7期12卷 1333-1338页

作者： Jin-Long Liang Yu-Qing Bu Li-Li Peng Hong-Zhen Zhang Department of oncology Hebei General HospitalShijiazhuang 050051Hebei ProvinceChina

BACKGROUND Multiple primary malignant tumors(MPMTs)are rare type of cancer,especially when solid tumors are the first and lymphoma is the second primary *** report a patient with heterochronous MPMTs consisting of prostate cancer and rectal diffuse large B-cell lymphoma(DLBCL).CASE SUMMARY We report a 77-year-old male patient diagnosed with prostate cancer who was treated with radiation therapy and one year of endocrine therapy with bicalutamide(50 mg per day)and an extended-release implant of goserelin(1/28 d).Seven years later,rectal DLBCL with lung metastases was *** Although rare,the possibility of prostate cancer combined with a double primary cancer of DLBCL can provide a deeper understanding.

关键词： Multiple primary malignant tumors Radiation therapy Diffuse large B-cell lymphoma Prostate cancer Non-Hodgkin lymphoma Case report

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Metabolic disorders and hepatitis: Insights from a Mendelian randomization study

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World Journal of Gastrointestinal Surgery 2024年第6期16卷 1775-1790页

作者： Ling-Bo Liang Xiang-Ping Liu Ting-Rui Mao Qiao-Li Su general practice Ward General Practice Medical CenterWest China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Primary Health Care The Fourth People’s Hospital of Dazhu CountyDazhou 635100Sichuan ProvinceChina

BACKGROUND Hepatitis is a systemic disease that often results in various ***-bolic disorders,the most common comorbidities in clinical practice,were selected for this *** To investigate the causal relationship between comorbidities and hepatitis trea-tment *** A total of 23583378 single nucleotide polymorphisms from 1248743 cases and related summaries of genome-wide association studies were obtained from online public databases.A two-sample Mendelian randomization(MR)was performed to investigate causality between exposure[type 2 diabetes mellitus(T2D),hyperlipidemia,and hypertension]and outcome(chronic hepatitis B or C in-fections).RESULTS The data supported the causal relationship between comorbidities and hepatitis infections,which will affect the severity of hepatitis progression and will also provide a reference for clinical *** three exposures showed a link with progression of both hepatitis B(T2D,P=0.851;hyperlipidemia,P=0.596;and hypertension,P=0.346)and hepatitis C(T2D,P=0.298;hyperlipidemia,P=0.141;and hypertension,P=0.035).CONCLUSION The results of MR support a possible causal relationship between different ex-posures(T2D,hyperlipidemia,and hypertension)and chronic hepatitis progression;however,the potential mechanisms still need to be elucidated.

关键词： Hepatitis Comorbidity Type 2 diabetes mellitus Hyperlipidemia Hypertension

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Nicotinamide adenine dinucleotide phosphate oxidase in pancreatic diseases:Mechanisms and future perspectives

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World Journal of Gastroenterology 2024年第5期30卷 429-439页

作者： Ya-Wei Bi Long-Song Li Nan Ru Bo Zhang Xiao Lei Department of Gastroenterology The First Medical Center of Chinese PLA General HospitalBeijing 100853China Department of Radiation oncology Chinese PLA General HospitalBeijing 100853China

Pancreatitis and pancreatic cancer(PC)stand as the most worrisome ailments affecting the *** have dedicated efforts to unraveling the mechanisms underlying these diseases,yet their true nature continues to elude their *** this realm,oxidative stress is often believed to play a causal and contributory role in the development of pancreatitis and *** accumulation of reactive oxygen species(ROS)can cause oxidative stress,and the key enzyme responsible for inducing ROS production in cells is nicotinamide adenine dinucleotide phosphate hydrogen oxides(NOX).NOX contribute to pancreatic fibrosis and inflammation by generating ROS that injure acinar cells,activate pancreatic stellate cells,and mediate macrophage *** ROS production occurs during malignant transformation and pancreatic carcinogenesis,creating an oxidative microenvironment that can cause abnormal apoptosis,epithelial to mesenchymal transition and genomic ***,understanding the role of NOX in pancreatic diseases contributes to a more in-depth exploration of the exact pathogenesis of these *** this review,we aim to summarize the potential roles of NOX and its mechanism in pancreatic disorders,aiming to provide novel insights into understanding the mechanisms underlying these diseases.

关键词： Nicotinamide adenine dinucleotide phosphate hydrogen oxides Pancreatitis Pancreatic cancer Reactive oxygen species Mechanism

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Predictive value of positive lymph node ratio in patients with locally advanced gastric remnant cancer

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World Journal of Gastrointestinal oncology 2024年第3期16卷 833-843页

作者： Meng Zhuo Lei Tian Ting Han Teng-Fei Liu Xiao-Lin Lin Xiu-Ying Xiao Department of oncology Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200127China Department of oncology Hebei General HospitalShijiazhuang 050051Hebei ProvinceChina

BACKGROUND Traditional lymph node stage(N stage)has limitations in advanced gastric remnant cancer(GRC)patients;therefore,establishing a new predictive stage is *** To explore the predictive value of positive lymph node ratio(LNR)according to clinicopathological characteristics and prognosis of locally advanced *** Seventy-four patients who underwent radical gastrectomy and lymphadenectomy for locally advanced GRC were retrospectively *** relationship between LNR and clinicopathological characteristics was *** survival analysis was performed using Kaplan-Meier survival curves and Cox regression *** Number of metastatic LNs,tumor diameter,depth of tumor invasion,Borrmann type,serum tumor biomarkers,and tumor-node-metastasis(TNM)stage were correlated with LNR stage and N *** analysis revealed that the factors affecting survival included tumor diameter,anemia,serum tumor biomarkers,vascular or neural invasion,combined resection,LNR stage,N stage,and TNM stage(all P<0.05).The median survival time for those with LNR0,LNR1,LNR2 and LNR3 stage were 61,31,23 and 17 mo,respectively,and the differences were significant(P=0.000).Anemia,tumor biomarkers and LNR stage were independent prognostic factors for survival in multivariable analysis(all P<0.05).CONCLUSION The new LNR stage is uniquely based on number of metastatic LNs,with significant prognostic value for locally advanced GRC,and could better differentiate overall survival,compared with N stage.

关键词： Gastric remnant cancer Positive lymph node ratio Clinicopathological characteristics Prognosis

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Cardiotoxicity induced by fluoropyrimidine drugs in the treatment of gastrointestinal tumors

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World Journal of Gastrointestinal oncology 2024年第2期16卷 251-254页

作者： Mo-Wei Kong Feng-Di Sun Zhen-Ying Pei Li Xu Ze-Bi Wang Yan Chen Shu-Qing Tang Ting-Fang Yang Guo-Xiang He Department of Cardiology Guiqian International General HospitalGuiyang 550018Guizhou ProvinceChina Department of oncology Guiqian International General HospitalGuiyang 550018Guizhou ProvinceChina

In this editorial,we review the article published in World J Gastrointest Oncol 2019,11:*** specifically focus on the occurrence,clinical characteristics,and risk factors of fluoropyrimidine drug-related cardiotoxicity in patients with gastrointestinal *** significant advancements in diagnostic and therapeutic techniques that have reduced mortality rates associated with digestive system tumors,the incidence and mortality rates of treatment-related car-diotoxicity have been increasing,severely impacting the survival and prognosis of cancer *** drugs are widely used as antimetabolites in the treatment of malignant tumors,including gastrointestinal tumors,and they represent the second largest class of drugs associated with ***,there is often a lack of awareness or understanding regarding their cardiotoxic effects and associated risks.

关键词： Cardiotoxicity Gastrointestinal tumors Risk factors Fluoropyrimidine Chest pain

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Application of exosomal miRNA mediated macrophage polarization in colorectal cancer:Current progress and challenges

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oncology Research 2024年第1期32卷 61-71页

作者： YUN ZHANG SHALING TANG YUBO GAO ZHONGTING LU YUAN YANG JING CHEN TAO LI Department of oncology School of Clinical MedicineNingxia Medical UniversityYinchuanChina general Hospital of Ningxia Medical University YinchuanChina School of Basic Medical Sciences Ningxia Medical UniversityYinchuanChina Department of Surgical oncology Tumor HospitalThe General Hospital of Ningxia Medical UniversityYinchuanChina

Colorectal cancer(CRC)is a major global health problem with high morbidity and mortality *** resection is the main treatment for early-stage CRC,but detecting it early is ***,effective therapeutic targets for advanced patients are still ***,tiny vesicles in body fluids,play a crucial role in tumor metastasis,immune regulation,and drug ***,they can even serve as a biomarker for cancer diagnosis and *** have shown that exosomes can carry miRNA,mediate the polarization of M1/M2 macrophages,promote the proliferation and metastasis of cancer cells,and affect the prognosis of *** the gastrointestinal tract has many macrophages,understanding the mechanism behind exosomal miRNA-mediated macrophage polarization in CRC treatment is *** article summarizes recent advancements in the study of exosomal miRNAs in CRC and their potential as diagnostic and prognostic markers.

关键词： Colorectal cancer Exosomes microRNA Macrophages Treatment

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Clinicopathological Features and Long-Term Prognostic Role of Human Epidermal Growth Factor Receptor-2 Low Expression in Chinese Patients with Early Breast Cancer:A Single-Institution Study

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Biomedical and Environmental Sciences 2024年第5期37卷 457-470页

作者： KONG Zi Qing LIU Li Qun HUANG De Qin WANG Yu Tong LI Jing Jie ZHANG Zheng WANG Xi Xi LIU Chuan Ling ZHANG Ya Di SHAO Jia Kang ZHU Yi Min CHEN Yi Meng LIU Mei ZHAO Wei Hong Medical School of Chinese PLA Beijing 100853China Department of Medical oncology the First Medical CenterGeneral Hospital of the Chinese People’s Liberation ArmyBeijing 100853China Nankai University School of Medicine Tianjin 300071China Department of Medical oncology the Fifth Medical CenterGeneral Hospital of the Chinese People’s Liberation ArmyBeijing 100039China Department of Medical oncology Xi'an Jiaotong UniversityXi’an 710061ShaanxiChina Department of Pathology the Sixth Medical CenterGeneral Hospital of the Chinese People’s Liberation ArmyBeijing 100037China

Objective This study aimed to comprehensively analyze and compare the clinicopathological features and prognosis of Chinese patients with human epidermal growth factor receptor 2(HER2)-low early breast cancer(BC)and HER2-IHC0 *** Patients diagnosed with HER2-negative BC(N=999)at our institution between January2011 and December 2015 formed our study *** characteristics,association between estrogen receptor(ER)expression and HER2-low,and evolution of HER2 immunohistochemical(IHC)score were ***-Meier method and log-rank test were used to compare the long-term survival outcomes(5-year follow-up)between the HER2-IHC0 and HER2-low *** HER2-low BC group tended to demonstrate high expression of ER and more progesterone receptor(PgR)positivity than HER2-IHC0 BC group(P<0.001).The rate of HER2-low status increased with increasing ER expression levels(Mantel-Haenszelχ^(2)test,P<0.001,Pearson’s R=0.159,P<0.001).Survival analysis revealed a significantly longer overall survival(OS)in HER2-low BC group than in HER2-IHC0 group(P=0.007)in the whole cohort and the hormone receptor(HR)-negative *** were no significant differences between the two groups in terms of disease-free survival(DFS).The discordance rate of HER2 IHC scores between primary and metastatic sites was 36.84%.Conclusion HER2-low BC may not be regarded as a unique BC group in this population-based study due to similar clinicopathological features and prognostic roles.

关键词： HER2 HER2-low Breast cancer Estrogen receptor Trastuzumab deruxtecan

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