检索结果-南通市图书馆

Dosimetric Analysis of Prone Breast Treatment in Tomotherapy and Conventional Linear Accelerator

International Journal of medical Physics, Clinical Engineering and Radiation oncology 2013年第4期2卷 161-168页

作者： Ching Chong Jack Yang Zhihui Hu Yie Chen Jie Qiu Beijing Union Hospital Beijing China chinese Academy medical Science (CAMS) Beijing China Monmouth medical Center Long Branch USA

Purpose: To evaluate planning quality and dosimetric differences of clinically deliverable 3D conformal plans generated from Tomotherapy with TomoDirectTM (TD) and conventional field-in-field approach in prone breast treatment. Materials and methods: Total of twelve randomly selected early stage left breast patients who went through lumpectomy and were previously treated on traditional Linear Accelerator (LINAC) have been re-planned and tested on Tomotherapy TomoDirect module. Baseline prescription dose was chosen at 50.4 Gy (1.8 Gy × 28 fractions) to cover ≥95% of PTV for planning criteria with other critical structure dose constraints in the thoracic region. Planning outcomes such as D95 (95% of volume of PTV receiving the prescribed dose), D5 and D1, heart, both lungs as well as the contralateral breast were simultaneously evaluated. Conformity of the prescription isodose/volume to PTV was evaluated as conformity index (CI) and dose uniformity was also evaluated with homogeneity index (HI) in the same study series. All outcome parameters were analyzed and summarized to evaluate dosimetric impact of planning qualities between these two planning platforms. Results: The planning results indicate that CI, HI, D95, D5 and D1 of PTV, critical structures such as heart, ipsilateral and contralateral lungs as well as contralateral breast doses were comparable but with better overall statistical end points from TD plans. The D95, D5 and D1 of PTV for TD plans were superior in dosimetric analysis and more uniform than those plans generated from PinnacleTM field-in-field planning technique. Overall, TD plans have superior planning quality than the conventional method does, with straightforward and automated planning process once the beam delivery parameters were established. Conclusions: From the clinical treatment planning results, plans from TD in general achieved better uniform tumor coverage with fewer hot spots while sparing more critical structures were based upon isod

关键词： Field-In-Field Tomo Direct Prone Breast Modulation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Relationship of Toll-Like Receptors 2 and 4 Gene Polymorphisms with Essential Hypertension in chinese Han Population

引用

Journal of Biosciences and Medicines 2023年第2期11卷 53-63页

作者： Huabei Wu Shijie Yin School of General medical Guangxi Medical University Nanning China The First Affiliated Hospital of Guangxi University of Traditional chinese Medicine Nanning China

Objective: There are numerous studies suggesting that genetic polymor-phisms of inflammation factors Toll-like receptors 2 and 4 (TLR2, TLR4) might play a role in the pathophysiological process of hypertension. In this study, we evaluated the association in a sample of members of the chinese Han population. Method: We selected four single nucleotide polymor-phisms (SNP) of TLR2 (rs3804099, rs3804100, rs7656411) and TLR4 (rs1927906) genes, and measured the distributions of genotypic and allelic frequencies in 1063 participants, including 391 essential hypertension pa-tients and 672 controls. Result: No significant differences in the genotypic and allelic frequencies of the four SNPs were detected between cases and controls. However, three haplotypes, CCG, TTG and TTT of TLR2, were significantly associated with a decrease in the risk of essential hyperten-sion (OR: 0.512, 95% CI: 0.397 - 0.660, P P = 0.0038;OR: 0.797, 95% CI: 0.667 - 0.952, P = 0.0122, respectively). Inversely, the risk of essential hypertension increased sig-nificantly in patients with the CTG, TCG or TCT haplotypes (OR: 2.924, 95% CI: 2.157 - 3.963, P P P Conclusion: Our study suggested that haplotypes (CCG, TTG, TTT, CTG, TCG and TCT) of TLR2 might have profound effects on the development of essential hypertension in the chinese Han population.

关键词： Toll-Like Receptor 2 Toll-Like Receptor 4 Single-Nucleotide Polymor-phisms Essential Hypertension Inflammation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Capn3 depletion causes Chk1 and Wee1 accumulation and disrupts synchronization of cell cycle reentry during liver regeneration after partial hepatectomy

引用

Cell Regeneration 2020年第1期9卷 74-91页

作者： Feng Chen Delai Huang Hui Shi Ce Gao Yingchun Wang Jinrong Peng MOE Key Laboratory for Molecular Animal Nutrition College of Animal SciencesZhejiang UniversityHangzhou 310058China Present address:Department of Biology University of VirginiaCharlottesvilleVAUSA Present address:Department of Pediatric oncology Dana-Farber Cancer InstituteHarvard Medical SchoolBostonMAUSA State Key Laboratory of Molecular Developmental Biology Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China

Recovery of liver mass to a healthy liver donor by compensatory regeneration after partial hepatectomy(PH)is a prerequisite for liver *** cell cycle reentry of the existing hepatocytes after PH is seemingly a hallmark of liver compensatory *** the molecular control of the PH-triggered cell cycle reentry has been extensively studied,little is known about how the synchronization is achieved after *** nucleolus-localized protein cleavage complex formed by the nucleolar protein Digestive-organ expansion factor(Def)and cysteine proteinase Calpain 3(Capn3)has been implicated to control wounding healing during liver regeneration through selectively cleaving the tumor suppressor p53 in the ***,whether the Def-Capn3 complex participates in regulating the synchronization of cell cycle reentry after PH is *** this report,we generated a zebrafish capn3b null mutant(capn3b^(Δ19Δ14)).The homozygous mutant was viable and fertile,but suffered from a delayed liver regeneration after *** liver regeneration in capn3b^(Δ19Δ14)was due to disruption of synchronized cell proliferation after *** spectrometry(MS)analysis of nuclear proteins revealed that a number of negative regulators of cell cycle are accumulated in the capn3b^(Δ19Δ14)liver after ***,we demonstrated that Check-point kinase 1(Chk1)and Wee1,two key negative regulators of G2 to M transition,are substrates of *** also demonstrated that Chk1 and Wee1 were abnormally accumulated in the nucleoli of amputated capn3bΔ19Δ14 *** conclusion,our findings suggest that the nucleolar-localized Def-Capn3 complex acts as a novel regulatory pathway for the synchronization of cell cycle reentry,at least partially,through inactivating Chk1 and Wee1 during liver regeneration after PH.

关键词： Def Capn3 Chk1 Wee1 Nucleolus Cell cycle Liver regeneration Partial hepatectomy Zebrafish

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Construction of prognostic model of cervical cancer based on necroptosis-related lncRNAs

引用

medical Data Mining 2022年第3期5卷 23-35页

作者： Jin Cao Bu-Hai Wang Yi-Chen Liang J.Juan Gu Yu-Xiang Huang medical College Yangzhou UniversityYangzhou 225000China Institute of oncology Northern Jiangsu People's HospitalYangzhou 225000China Department of oncology Northern Jiangsu People's HospitalYangzhou 225000China

Background:Long non-coding RNAs(lncRNAs)can influence the necroptosis process,which is essential in malignant *** no studies have looked at the predictive value of necroptosis-related lncRNAs in cervical cancer(CC).Using necroptosis-related lncRNAs,we developed a prediction signature to predict the prognosis of CC ***:We gathered the RNA-seq and related clinical data for patients with CC from the Cancer Genome Atlas(TCGA)*** identify lncRNAs linked to necroptosis,we then conducted univariate and multivariate Cox regression ***-expression network analysis,least absolute shrinkage selection operator(LASSO)regression analysis and multivariate Cox regression analyses were subsequently used to further filter necroptosis-related lncRNAs signature and construct a predictive ***,we examined the medication sensitivity between the two risk *** performed a single-sample gene set enrichment analysis(ssGSEA)to investigate the association between the predictive signature and the tumor immune ***:Six necroptosis-related lncRNAs(AL021807.1,AC026803.2,AC015819.1,AC233728.1,AL158166.1,NKILA)that are independently connected to the overall survival(OS)time of CC patients make up the signature we *** predicting the 1-,3-,and 5-year survival rates,the areas under the receiver operating characteristic(ROC)curve(AUC)were 0.72,0.791,and *** was determined that the risk score model was a separate prognostic *** Kaplan-Meier analysis revealed that the prognosis for CC patients in the high-risk category was ***-risk CC patients had more active immune systems and responded better to PD1/L1 ***:The signature based on necroptosis-related lncRNAs is a reliable biomarker,which is more likely to independently predict the prognosis of patients with CC and offer a foundation for the pathogenesis of necroptosis-related lncRNAs in *** can also be utilized to direct the tailored ther

关键词： cervical cancer necroptosis long noncoding RNAs prognostic signature the cancer genome atlas

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Longest survival with primary intracranial malignant melanoma:A case report and literature review

引用

World Journal of Clinical Cases 2022年第30期10卷 11162-11171页

作者： Tang-Fai Wong Yin-Sheng Chen Xiang-Heng Zhang Wan-Ming Hu Xiao-Shi Zhang Yan-Chun Lv Dong-Cun Huang Mei-Ling Deng Zhong-Ping Chen Department of Neurosurgery Macao Kiang Wu HospitalMacao 999078Sichuan ProvinceChina Department of Neurosurgery/Neuro-oncology State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineSun Yat-Sen University Cancer CenterGuangzhou 510060Guangdong ProvinceChina Department of Pathology State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineSun Yat-Sen University Cancer CenterGuangzhou 510060Guangdong ProvinceChina Department of Biotherapy State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineSun Yat-Sen University Cancer CenterGuangzhou 510060Guangdong ProvinceChina Department of medical Imaging Sun Yat-sen University Cancer CenterCollaborative Innovation Center for Cancer MedicineGuangzhou 510060Guangdong ProvinceChina Department of Radiotherapy State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineSun Yat-Sen University Cancer CenterGuangzhou 510060Guangdong ProvinceChina

BACKGROUND Primary intracranial malignant melanoma(PIMM)is rare,and its prognosis is very *** is not clear what systematic treatment strategy can achieve long-term *** case study attempted to identify the optimal strategy for long-term survival outcomes by reviewing the PIMM patient with the longest survival following comprehensive treatment and by reviewing the related *** SUMMARY The patient is a 47-year-old chinese man who suffered from dizziness and gait *** underwent surgery for right cerebellum melanoma and was subsequently diagnosed by pathology in June *** the surgery,the patient received three cycles of chemotherapy but relapsed locally within 4 *** the second surgery for total tumor resection,the patient received an injection of Newcastle disease virus-modified tumor vaccine,interferon,andβ-elemene *** patient was tumor-free with a normal life for 21 years before the onset of the recurrence of melanoma without any symptoms in July 2021.A third gross-total resection with adjuvant radiotherapy and temozolomide therapy was *** magnetic resonance imaging showed no residual tumor or recurrence 3 mo after the 3rd operation,and the patient recovered well without neurological dysfunction until the last follow-up in June 2022,which was 22 years following the initial *** It is important for patients with PIMM to receive comprehensive treatment to enable the application of the most appropriate treatment ***-term survival is not impossible in patients with these malignancies.

关键词： Primary intracranial malignant melanoma Immunotherapy Newcastle disease virus-modified tumor vaccine β-elemene Long-term survival Case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The association of serum manganese concentrations with all-cause,cardiovascular disease and cancer mortality:A cohort study based on the 2011–2014 National Health and Nutrition Examination Survey(NHANES)

引用

Journal of Nutritional oncology 2024年第3期9卷 90-97页

作者： Jie Tang Li-Qun Zhu Xiao-Feng Chen Ke Jin Yong-Qian Shu Department of oncology Liyang People's HospitalKangda College of Nanjing Mdeical UniversityLiyang 213300JiangsuChina Department of oncology The First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029JiangsuChina

Objectives:There is a debate on the association between the circulating manganese(Mn)levels and *** aim of this study was to explore the nonlinear association between the serum Mn levels and all-cause or cause-specific ***:We included 8,145 adults from the United States(US)and their serum Mn concentrations obtained from the National Health and Nutrition Examination Survey(NHANES 2011–2014).We retrieved their survival information from baseline until 2019 using the national death *** Cox proportional hazards models were used to show the risk of all-cause or cause-specific mortality according to the baseline serum Mn *** curve fitting and threshold effect analyses were used to clarify the potential ***:During a median follow-up of 6.2 years,there were 716 deaths from all causes,224 of which were due to cardiovascular dis-ease(CVD)and 165 due to *** serum Mn levels exhibited a U-shaped relationship with all-cause or CVD-associated *** Mn levels lower than the threshold value(7.32μg/L)were negatively associated with all-cause(fully adjusted HR:0.86,95%CI:0.80–0.94)and CVD(fully adjusted HR:0.82,95%CI:0.71–0.94)*** contrast,serum Mn levels higher than the threshold value(7.32μg/L)were positively associated with all-cause(fully adjusted HR:1.04,95%CI:1.02–1.06)and CVD(fully adjusted HR:1.05,95%CI:1.02–1.08)***:The serum Mn concentrations showed a U-shaped relationship with all-cause and CVD-associated mortality among NHANES participants.

关键词： Serum manganese All-cause mortality CVD mortality Cancer mortality NHANES

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

我们对第四纪在地质年表中位置的意见(英文)

引用

第四纪研究 2005年第6期25卷 665-665页

作者：刘嘉麒 chinese association for Quaternary Research

此文为中国第四纪研究委员会给国际地层联合会2005年9月在比利时鲁汶(Leuven)特别会议(重点讨论第四纪在地层表中的位置问题)的发言稿。

关键词：第四纪研究地质年表中位地层表比利时委员会

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effect of modified ShengYangYiwei decoction on painless gastroscopy and gastrointestinal and immune function in gastric cancer patients

引用

World Journal of Gastrointestinal Endoscopy 2023年第5期15卷 376-385页

作者： Sui-Cai Mi Ling-Yan Wu Zheng-Jin Xu Li-Yan Zheng Jian-Wen Luo Department of oncology Xiamen Hospital of Traditional Chinese MedicineXiamen 361000Fujian ProvinceChina Department of Nephropathy Xiamen Hospital of Traditional Chinese MedicineXiamen 361000Fujian ProvinceChina Department of Anesthesiology Xiamen Hospital of Traditional Chinese MedicineXiamen 361000Fujian ProvinceChina

BACKGROUND Painless gastroenteroscopy is a widely developed diagnostic and treatment technology in clinical *** is of great significance in the clinical diagnosis,treatment,follow-up review and other aspects of gastric cancer *** application of anesthesia techniques during manipulation can be effective in reducing patient fear and *** clinical work,the adverse drug reactions of anesthesia regimens and the risk of serious adverse drug reactions are increased with the increase in propofol application dose application dose;the application of opioid drugs often causes gastrointestinal reactions,such as nausea,vomiting and delayed gastrointestinal function recovery,after *** adverse effects can seriously affect the quality of life of *** To observe the effect of modified ShengYangYiwei decoction on gastrointestinal function,related complications and immune function in patients with gastric cancer during and after painless *** A total of 106 patients with gastric cancer,who were selected from January 2022 to September 2022 in Xiamen Traditional chinese Medicine Hospital for painless gastroscopy,were randomly divided into a treatment group(n=56)and a control group(n=50).Before the examination,all patients fasted for 8 h,provided their health education,and confirmed if there were contraindications to anesthesia and *** the examination,the patients were placed in the left decubitus position,the patients were given oxygen through a nasal catheter(6 L/min),the welling needle was opened for the venous channel,and a multifunction detector was connected for monitoring electrocardiogram,oxygen saturation,blood pressure,*** and propofol propofol protocols were used for routine *** anesthesia administration,the patients underwent several deep breathing exercises,received intravenous nalbuphine[***(0.025 mg/kg)],followed by intravenous propofol[***(1.5 mg/kg)]until

关键词： Modified ShengYangYiwei decoction Gastric cancer patients Painless gastroscope Gastrointestinal function

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Fuzheng Kang'ai decoction(扶正抗癌方) inhibits cell proliferation,migration and invasion by modulating mir-21-5p/human phosphatase and tensin homology deleted on chromosome ten in lung cancer cells

引用

Journal of Traditional chinese Medicine 2022年第3期42卷 344-352页

作者： LI Jinhua LIU Chunping ZHAO Yueyang WU Wanyin SUN Pengtao LI Longmei YANG Xiaobing ZHOU Yushu Department of Ultrasound Guangdong Provincial Hospital of Chinese Medicinethe Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510120China Department of Ultrasound Institute of Ultrasound in Musculoskeletal Sports MedicineGuangdong Second Provincial General HospitalGuangzhou 510317China State Key Laboratory of Dampness Syndrome of chinese Medicine Guangdong Provincial Hospital of Chinese MedicineThe Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510120China Department of Hematology Guangdong Provincial Hospital of Chinese Medicinethe Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510120China Department of oncology Clinical and Basic Research Team of TCM Prevention and Treatment of NSCLCGuangdong Provincial Hospital of Chinese Medicinethe Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510120China

OBJECTIVE:To elucidate the potential molecular mechanism by which Fuzheng Kang’ai decoction(扶正抗癌方,FZKA)inhibits proliferation,migration,and invasion of lung cancer ***:Varying FZKA concentrations were used to manage lung cancer cells(A549 and PC9).We employed:cell counting kit-8(CCK-8)and plate clone formation assays to examine the cell viability;flow cytometry(FCM)to analyze the cycle arrest;transwell and woundhealing assays to assess the cell invasion and migration,***,a quantitative real-time polymerase chain reaction(q RT-PCR)assay was adopted to evaluate the miR-21-5p *** protein expression analysis,we employed the Western blot *** miR-21-5p overexpression adenovirus vector harboring GFP was constructed and transfected into A549 and PC9,after which we explored the effect of FZKA on miR-21-5p ***:Notably,treatment with FZKA inhibited viability,clone-formation ability,invasion,and migration of lung cancer ***,FZKA markedly suppressed miR-21-5p expression but elevated the human phosphatase and tensin homology deleted on chromosome ten(PTEN)protein level in both A549 and PC9 ***-expression of miR-21-5p lowered PTEN protein ***,overexpressed miR-21-5p levels with adenovirus antagonized FZKA-upregulated PTEN protein ***:The present study demonstrates how FZKA modulates cell biological behaviors,for instance,it impedes the proliferation by upregulating PTEN expression with miR-21-5p as the *** findings unveil the potential novel molecular mechanisms from the micro RNA aspect by which FZKA suppresses the growth of human lung cancer cells.

关键词： lung neoplasms miR-21-5p PTEN phosphohydrolase Fuzheng Kang’ai decoction

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The Inhibitory Effect of Oridonin on the Growth of Fifteen Human Cancer Cell Lines

引用

chinese Journal of Clinical oncology 2007年第1期4卷 16-20页

作者： Junhui Chen Shaobin Wang Dongyang Chen Guisheng Chang Qingfeng Xin Shoujun Yuan Zhongying Shen Department of oncology The First Affiliated Hospital of Shantou University Medical College Shantou 515041 China Pharmacology Laboratory Institute of Radiation Medicine Military Medical Sciences Academy of Chinese PLA Beijing 100270 China Department of Pathology Shantou University Medical College Shantou 515031 China

OBJECTIVE To study the inhibitory effect of oridonin on the growth of cancer cells. METHODS Fifteen human cancer cell lines were subjected to various concentrations of oridonin in culture medium. The inhibitory rate of cell growth was measured by the MTT assay, and compared with a negative control and 5-Fu-positive control. RESULTS The 50% inhibiting concentration （IC50） and maximal inhibition （Imax） of oridonin shown by studying the growth of the cancer cell lines were as follows： leukemias （HL60 cells： 3.9 μg/ml and 73.8%, K562 cells： 4.3 μg/ml and 76.2%）; esophageal cancers（SHEEC cells： 15.4 μg/ml and 99.2%, Eca109 cells： 15.1 μg/ml and 84.6%, TEl cells： 4.0 μg/ml and 70.2%）; gastric cancers （BGC823 cells： 7.6 μg/ml and 98.7%, SGC7901 cells： 12.3 μg/ml and 85.7%）; colon cancers （HT29 cells： 13.6 μg/ml and 97.2%, HCT cells： 14.5 μg/ml and 96.5%）; liver cancers （Bel7402 cells： 15.2 μg/ml and 89.2%, HepG2 cells： 7.1 μg/ml and 88.3%）; pancreatic cancer （PC3 cells： 11.3 μg/ml and 68.4%）; lung cancer （A549 cells： 18.6 μg/ml and 98.0% ）; breast cancer （MCF7 cells： 18.4 μg/ml and 84.7%）; uterine cervix cancer （Hela cells： 13.7 μg/ml and 98.5%）. CONCLUSION Oridonin had a relatively wide anti-tumor spectrum, and a relatively strong inhibitory effect on the growth of the 15 human cancer cells. Inhibitory effects were concentration dependent.

关键词： oridonin antitumor effect in vitro study.

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：