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Estimating the economic and social consequences for patients diagnosed with human African trypanosomiasis in Muchinga,Lusaka and Eastern Provinces of Zambia(2004-2014)

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Infectious Diseases of Poverty 2017年第1期6卷 1330-1342页

作者： Allan Mayaba Mwiinde Martin Simuunza Boniface Namangala Chitalu Miriam Chama-Chiliba Noreen Machila Neil Anderson Alexandra Shaw Susan C.Welburn School of Veterinary Medicine University of ZambiaLusakaZambia Department of Economics University of ZambiaLusakaZambia Division of Infection and Pathway Medicine and Centre for Infectious Diseases School of Biomedical SciencesCollege of Medicine and Veterinary MedicineThe University of EdinburghChancellor’s Building49 Little France CrescentEdinburghScotland EH164SBUK The Royal(Dick)School of Veterinary Studies and the Roslin Institute University of EdinburghRoslin EH259RGUK AP consultants Walworth Enterprise CentreAndover SP105APUK School of Veterinary Medicine Department of Disease Control University of ZambiaP.O Box 32379LusakaZambia

Background:Acute human African trypanosomiasis(rHAT)caused by Trypanosoma brucei rhodesiense is associated with high mortality and is fatal if left *** a few studies have examined the psychological,social and economic impacts of *** this study,mixed qualitative and quantitative research methods were used to evaluate the socio-economic impacts of rHAT in Mambwe,Rufunsa,Mpika and Chama Districts of ***:Individuals diagnosed with rHAT from 2004 to 2014 were traced using hospital records and discussions with *** they,or their families,were interviewed using a structured questionnaire and focus group discussions were conducted with affected *** burden of the disease was investigated using disability adjusted life years(DALYs),with and without discounting and *** impact of long-term disabilities on the rHAT burden was also ***:Sixty four cases were identified in the *** majority were identified in second stage,and the mortality rate was high(12.5%).The total number of DALYs was 285 without discounting or *** long-term disabilities were included this estimate increased by 50%to *** proportion of years lived with disability(YLD)increased from 6.4%to 37%of the undiscounted and un-age-weighted DALY *** a more active surveillance method was applied in 2013-2014 the cases identified increased dramatically,suggesting a high level of ***,the proportion of females increased substantially,indicating that passive surveillance may be especially failing this *** average of 4.9 months of productive time was lost per patient as a consequence of *** health consequences included pain,amnesia and physical *** social consequences included stigma,dropping out of education,loss of friends and *** obtained from focus group discussions revealed misconceptions among community members which could be attributed to lack o

关键词： Human African trypanosomiasis Hat Sleeping sickness T.B.Rhodesiense Social and economic burden DALYs Zambia

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TWENTY-FOUR HOUR DIURNAL CURVE COMPARISON OF COMMERCIALLY AVAILABLE BIMATOPROST 0.03% VERSUS TIMOLOL MALEATE 0.5%/OORZOLAMIDE 2% FIXED COMBINATION

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国际眼科杂志 2003年第1期3卷 98-98页

作者： D.G.Day E.D.Sharpe C.J.Beischel J.N.Leech J.A.Stewart W.C.Stewart Omni Eye Services GAOphthalmology Consultants SCWest Ashley Medical Center SCPharmaceutical Re-search Network LLC SCPharmaceutical Re-search Network LLC SCPharmaceutical Re-search Network LLC SC and Carolina Eye Institute At The University of South Carolina School of Medicine SC USA

Purpose: To evaluate the efficacy and safety of bimatoprost 0.03 percent given every evening versus timolol maleate 0.5 per-cent/dorzolamide 2 percent fixed combination (TDFC) given twice daily in open-angle glaucoma and ocular hypertensive patients. Design: A single-masked, two center, crossover comparison with two eight-week treatment periods following a four-week medicine free run-in period. Diurnal curve intraoc-

关键词：青光眼 Bimatoprost 疗效比较马来酸噻吗络尔/多佐胺昼夜IOP

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FAIR Principles:Interpretations and Implementation Considerations

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Data Intelligence 2020年第1期2卷 10-29,293-302,322页

作者： Annika Jacobsen Ricardo de Miranda Azevedo Nick Juty Dominique Batista Simon Coles Ronald Cornet Melanie Courtot Merce Crosas Michel Dumontier Chris T.Evelo Carole Goble Giancarlo Guizzardi Karsten Kryger Hansen Ali Hasnain Kristina Hettne Jaap Heringa Rob W.W.Hooft Melanie Imming Keith G.Jeffery Rajaram Kaliyaperumal Martijn GKersloot Christine R.Kirkpatrick Tobias Kuhn Ignasi Labastida Barbara Magagna PeterMcQuilton Natalie Meyers Annalisa Montesanti Mirjam van Reisen Philippe Rocca-Serra Robert Pergl Susanna-Assunta Sansone Luiz Olavo Bonino da Silva Santos Juliane Schneider George Strawn Mark Thompson Andra Waagmeester Tobias Weigel Mark D.Wilkinson Egon L.Willighagen Peter Wittenburg Marco Roos Barend Mons Erik Schultes Leiden University Medical Center Leiden2333 ZAThe Netherlands Institute of Data Science Maastricht UniversityUniversiteitssingel 60Maastricht 6229 ERThe Netherlands Department of Computer Science The University of ManchesterOxford RoadManchester M139PLUK Oxford e-Research Centre Department of Engineering SciencesUniversity of OxfordOxford OX13PJUK School of Chemistry Faculty of Engineering and Physical SciencesUniversity of SouthamptonSO171BJUK Amsterdam UMC University of AmsterdamAmsterdam 1000 GGThe Netherlands European Bioinformatics Institute(EMBL-EBI) HinxtonCambridgeCB101SDUK Harvard University CambridgeMassachusetts 02138USA Department of Bioinformatics–BiGCaT NUTRIMMaastricht UniversityMaastricht 6229 ERThe Netherlands Conceptual and Cognitive Modeling Research Group(CORE) Free University of Bozen-BolzanoBolzano 39100Italy Aalborg University Aalborg DK-9220Denmark Insight Centre for Data Analytics National University of Ireland GalwayH91 TK33Ireland Centre for Digital Scholarship Leiden University LibrariesLeiden2333 ZAThe Netherlands Department of Computer Science Vrije Universiteit AmsterdamDe Boelelaan 11051081 HV AmsterdamThe Netherlands Dutch Techcentre for Life Sciences(DTL) UtrechtThe Netherlands SURF Utrecht 3511 EPThe Netherlands Keith G Jeffery consultants FaringdonUK Castor EDC Paasheuvelweg 25Wing 5D1105 BPAmsterdamThe Netherlands San Diego Supercomputer Center University of California San DiegoLa JollaCalifornia 92093USA Learning and Research Resources Centre(CRAI) Universitat de Barcelona08007 BarcelonaSpain Environment Agency Austria A-1090 ViennaAustria University of Notre Dame 75004 ParisFrance Health Research Board(HRB) Dublin 2DO2 H638Ireland Liacs Institute of Advanced Computer Science Leiden University2311 GJ LeidenThe Netherlands Czech Technical University in Prague Faculty of Information Technology(FIT CTU)16000 Prague 6Czech Republic GO FAIR international Support&Coordination Office(GFISCO) LeidenThe Netherlands Harvard Catalys

The FAIR principles have been widely cited,endorsed and adopted by a broad range of stakeholders since their publication in *** intention,the 15 FAIR guiding principles do not dictate specific technological implementations,but provide guidance for improving Findability,Accessibility,Interoperability and Reusability of digital *** has likely contributed to the broad adoption of the FAIR principles,because individual stakeholder communities can implement their own FAIR ***,it has also resulted in inconsistent interpretations that carry the risk of leading to incompatible ***,while the FAIR principles are formulated on a high level and may be interpreted and implemented in different ways,for true interoperability we need to support convergence in implementation choices that are widely accessible and(re)-*** introduce the concept of FAIR implementation considerations to assist accelerated global participation and convergence towards accessible,robust,widespread and consistent FAIR *** self-identified stakeholder community may either choose to reuse solutions from existing implementations,or when they spot a gap,accept the challenge to create the needed solution,which,ideally,can be used again by other communities in the ***,we provide interpretations and implementation considerations(choices and challenges)for each FAIR principle.

关键词： FAIR guiding principles FAIR implementation FAIR convergence FAIR communities choices and challenges

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管线敷设与风机室布置对综合管廊通风阻力影响研究

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隧道建设（中英文） 2019年第9期39卷 1423-1430页

作者：闵绚张正维邹建明万磊 HATAYSAL Ertan 赵丽博中国电力科学研究院有限公司湖北武汉430074 奥雅纳工程咨询(上海)有限公司上海200031 国家电网公司华中分部湖北武汉430077 Ove Arup & Partners international Limited 伦敦B908AE 中国电力工程顾问集团中南电力设计院有限公司湖北武汉430000

为准确估算管线敷设与风机室内气流相互作用对压降损失的影响,基于武汉市江夏区谭鑫培路地下综合管廊项目建立典型数值分析模型与分析流程。通过建立典型管线布置的GIL舱、高压舱与综合舱的计算流体动力学三维模型,分别对入口段与稳定... 详细信息

为准确估算管线敷设与风机室内气流相互作用对压降损失的影响,基于武汉市江夏区谭鑫培路地下综合管廊项目建立典型数值分析模型与分析流程。通过建立典型管线布置的GIL舱、高压舱与综合舱的计算流体动力学三维模型,分别对入口段与稳定段进行分析,并使用循环边界条件来考虑稳定段流体的充分发展,得到阻力系数随流量的变化规律;通过建立GIL舱典型排风口三维模型,分析风机室中不同风机的压降损失,并与规范估算值进行比较。研究结果表明:管线敷设对压降损失的影响不可忽视;风机室风机相互作用显著,规范不能准确估算该相互作用导致的压降损失。

关键词：综合管廊 GIL舱高压舱综合舱阻力系数计算流体动力学三维模型

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在肺结核诊断中应用系列痰涂片的结果:系统综述

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国际结核病与肺部疾病杂志 2007年第3期2卷 71-80页

作者： S.R.Mase A.Ramsay V.Ng M.Henry P.C.Hopewell J.Cunningham R.Urbanczik M.D.Perkins M.A.Aziz M.Pai 张宗德张立兴 Division of Pulmonary and Critical Care Medicine San Francisco General HospitalUniversity of California Francis J Curry National Tuberculosis Center University of California United Nations Children's Fund/United Nations Development Programme/World Bank/World Health Organization(WHO)Special Programme for Research and Training in Tropical Diseases(TDR) WHO Albany Medical College County of Sacramento Department of Health and Human Services Sacramento WHO Tuberculosis Laboratory consultants Group Foundation for Innovative New Diagnostics(FIND) GenevaStop TB DepartmentWHO Stop TB Department WHO Department of Epidemiology & Biostatistics McGill University

目前的国际结核病(TB)指南推荐在对肺结核可疑患者评价时应用3次痰涂片镜检以寻找结核菌。我们对符合3次痰标本结果标准的研究进行了系统的评价。通过对多个数据库和资源的检索,我们确定了共37个合格的研究。第3份标本中涂阳结果的增加... 详细信息

目前的国际结核病(TB)指南推荐在对肺结核可疑患者评价时应用3次痰涂片镜检以寻找结核菌。我们对符合3次痰标本结果标准的研究进行了系统的评价。通过对多个数据库和资源的检索,我们确定了共37个合格的研究。第3份标本中涂阳结果的增加(所有培阳病例作为分母的研究)和敏感性的增高(所有培阳病例作为分母的研究)是我们关注的主要结果。虽然各研究的方法和结果不同对数据综合构成了挑战,但亚组的分析提示对第3份标本的检查使结果和/或敏感性平均增加了2%～ 5%。把推荐的标本检查数量从3份减至2份(特别是在同一天收集的2份标本)对结核控制项目有利。有很多理由可潜在增加病例检出;许多实施性研究问题需要强调。如果按照国际间协调和标准化的方法,在痰标本镜检时应用现行技术检验哪种方法最有效,这样的研究会是最有用的,既可以增加本国的数据,又可进行研究之间的对比。

关键词：结核痰显微镜检查结果增加抗酸菌系列痰标本

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