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Exploring the dynamic three-dimensional chromatin architecture and transcriptional landscape in goose liver tissues underlying metabolic adaptations induced by a high-fat diet

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Journal of Animal Science and Biotechnology 2024年第4期15卷 1494-1511页

作者： Guangliang Gao Rui Liu Silu Hu Mengnan He Jiaman Zhang Dengfeng Gao Jing Li Jiwei Hu Jiwen Wang Qigui Wang Mingzhou Li Long Jin Livestock and Poultry Multi‑omics Key Laboratory of Ministry of agriculture and Rural Affairs College of Animal Science and TechnologySichuan Agricultural UniversityChengdu 611130China Chongqing Engineering Research center of Goose Genetic Improvement Institute of Poultry ScienceChongqing Academy of Animal SciencesRongchang DistrictChongqing 402460China

Background Goose, descendants of migratory ancestors, have undergone extensive selective breeding, resulting in their remarkable ability to accumulate fat in the liver and exhibit a high tolerance for significant energy intake. As a result, goose offers an excellent model for studying obesity, metabolic disorders, and liver diseases in mammals. Although the impact of the three-dimensional arrangement of chromatin within the cell nucleus on gene expression and transcriptional regulation is widely acknowledged, the precise functions of chromatin architecture reorganization during fat deposition in goose liver tissues still need to be fully *** In this study, geese exhibited more pronounced changes in the liver index and triglyceride(TG) content following the consumption of the high-fat diet(HFD) than mice without significant signs of inflammation. Additionally, we performed comprehensive analyses on 10 goose liver tissues(5 HFD, 5 normal), including generating highresolution maps of chromatin architecture, conducting whole-genome gene expression profiling, and identifying H3K27ac peaks in the livers of geese and mice subjected to the HFD. Our results unveiled a multiscale restructuring of chromatin architecture, encompassing Compartment A/B, topologically associated domains, and interactions between promoters and enhancers. The dynamism of the three-dimensional genome architecture, prompted by the HFD, assumed a pivotal role in the transcriptional regulation of crucial genes. Furthermore, we identified genes that regulate chromatin conformation changes, contributing to the metabolic adaptation process of lipid deposition and hepatic fat changes in geese in response to excessive energy intake. Moreover, we conducted a cross-species analysis comparing geese and mice exposed to the HFD, revealing unique characteristics specific to the goose liver compared to a mouse. These chromatin conformation changes help elucidate the observed characteristics of fat

关键词： Compartment A/B Goose fatty liver Promoter-enhancer interactions Regulation of gene expression

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Microbiome-driven anticancer therapy:A step forward from natural products

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mLife 2024年第2期3卷 219-230页

作者： Yunxuan Guan Di Wu Hui Wang Ning-Ning Liu State Key Laboratory of Systems Medicine for Cancer Center for Single‐Cell OmicsSchool of Public HealthShanghai Jiao Tong University School of MedicineShanghaiChina

Human microbiomes,considered as a new emerging and enabling cancer hallmark,are increasingly recognized as critical effectors in cancer development and *** of microbiome revitalizing anticancer therapy from natural products shows promise toward improving cancer ***,we summarize our current understanding of the human microbiome‐driven molecular mechanisms impacting cancer progression and anticancer *** highlight the potential translational and clinical implications of natural products for cancer prevention and treatment by developing targeted therapeutic strategies as adjuvants for chemotherapy and immunotherapy against *** challenges and opportunities for future investigations using modulation of the microbiome for cancer treatment are further discussed in this review.

关键词： anticancer cancer chemotherapy immunotherapy microbiota

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Review of the detasseling techniques for maize(Zea mays L.)hybrid seed production

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International Journal of Agricultural and Biological Engineering 2024年第3期17卷 1-11页

作者： Ruirui Zhang Jiaxuan Yang Liping Chen Chenchen Ding Longlong Li Linhuan Zhang National Research center of Intelligent Equipment for agriculture Beijing Academy of Agriculture and Forestry SciencesBeijing 100097China National center of International Research on Agricultural Aerial Application Technology Beijing 100097China Research center of Intelligent Equipment Beijing Academy of Agriculture and Forestry SciencesBeijing 100097China

Maize(Zea mays L.)is a critical staple crop globally,integral to human consumption,food security,and agricultural product *** quality and purity of maize seeds,essential for hybrid seed production,are contingent upon effective *** study investigates the evolution of detasseling technologies and their application in Chinese maize hybrid seed production,with a comparative analysis against the United States.A comprehensive examination of the development and utilization of detasseling technology in Chinese maize hybrid seed production was undertaken,with a specific focus on key *** from the United States were included for comparative *** analysis encompassed various detasseling methods,including manual,semi-mechanized,and cytoplasmic male sterility,as well as more recent innovations such as detasseling machines,and the emerging field of intelligent detasseling driven by unmanned aerial vehicles(UAVs),computer vision,and mechanical *** detasseling methods were predominantly employed by *** the challenges of inflexible and occasionally overlooked,applying detasseling machines is efficient and *** present,China’s detasseling operations in hybrid maize seed production are mainly carried out by manual work,which is labor-intensive and *** order to address this issue,China is dedicated to developing intelligent detasseling *** study emphasizes the critical role of detasseling in hybrid maize seed *** United States has embraced mechanized *** application and development of manual and mechanized detasseling were applied later than those in the United States,but latest intelligent detasseling technologies first appeared in *** detasseling is expected to be the future direction,ensuring the quality and efficiency of hybrid maize seed production,with implications for global food security.

关键词： detasseling technique detasseling machine UAVs intelligent agriculture maize hybrid seed production

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Crystalline cyclic(alkyl)(amino)stannylene via transient stannyne

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Science China Chemistry 2024年

作者： Xinfeng Wang Chaopeng Hu Zhihao Lu Liu Leo Liu Department of Chemistry and Research center for Chemical Biology and omics Analysis College of Science Southern University of Science and Technology

We demonstrate that a bulky cyclic amino ligand, specifically 1,1,3,3-tetraphenylisoindolinyl, can facilitate the formation of a transient stannyne, endowed with adjacent ambiphilic carbon and tin centers. This stannyne, manifesting carbene-like behavior,engages in an unprecedented sequence of reactions, including Buchner ring expansion, [1,3]sigmatropic, and [1,5]-sigmatropic shifts, culminating in the synthesis of a stable cyclic(alkyl)(amino)stannylene. This compound represents the first tin analogue of the well-known cyclic(alkyl)(amino)carbenes. Both the bonding configuration and the formation process of this stannylene are thoroughly analyzed through quantum chemical computations. Our findings pave the way for further synthesis of unusual main group species using bulky isoindolinyl substituents, emphasizing their potential as a versatile tool in synthetic chemistry.

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Estimating wheat spike-leaf composite indicator(SLI)dynamics by coupling spectral indices and machine learning

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The Crop Journal 2024年第3期12卷 927-937页

作者： Haiyu Tao Ruiheng Zhou Yining Tang Wanyu Li Xia Yao Tao Cheng Yan Zhu Weixing Cao Yongchao Tian National Engineering and Technology center for Information agriculture Key Laboratory of Crop System Analysis and Decision MakingMinistry of Agriculture and Rural AffairsJiangsu Key Laboratory for Information AgricultureNanjing Agricultural UniversityNanjing 210095JiangsuChina

The contribution of spike photosynthesis to grain yield(GY)has been overlooked in the accurate spectral prediction of ***,it’s essential to construct and estimate a yield-related phenotypic trait considering spike *** on field and spectral reflectance data from 19 wheat cultivars under two nitrogen fertilization conditions in two years,our objectives were to(i)construct a yield-related phenotypic trait(spike–leaf composite indicator,SLI)accounting for the contribution of the spike to photosynthesis,(ii)develop a novel spectral index(enhanced triangle vegetation index,ETVI3)sensitive to SLI,and(iii)establish and evaluate SLI estimation models by integrating spectral indices and machine learning *** results showed that SLI was sensitive to nitrogen fertilizer and wheat cultivar variation as well as a better predictor of yield than the leaf area ***3 maintained a strong correlation with SLI throughout the growth stage,whereas the correlations of other spectral indices with SLI were poor after spike *** spectral indices and machine learning algorithms improved the estimation accuracy of SLI,with the most accurate estimates of SLI showing coefficient of determination,root mean square error(RMSE),and relative RMSE values of 0.71,0.047,and 26.93%,*** results provide new insights into the role of fruiting organs for the accurate spectral prediction of *** high-throughput SLI estimation approach can be applied for wheat yield prediction at whole growth stages and may be assisted with agronomical practices and variety selection.

关键词： Wheat spike photosynthesis Yield-related phenotypic trait Spectral indices Machine learning Estimation

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High expression circRALGPS2 in atretic follicle induces chicken granulosa cell apoptosis and autophagy via encoding a new protein

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Journal of Animal Science and Biotechnology 2024年第3期15卷 971-986页

作者： Haorong He Yuanhang Wei Yuqi Chen Xiyu Zhao Xiaoxu Shen Qing Zhu Huadong Yin Key Laboratory of Livestock and Poultry Multi‑omics Ministry of Agriculture and Rural AffairsCollege of Animal Science and TechnologySichuan Agricultural UniversityChengduSichuan 611130China Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province Sichuan Agricultural UniversityChengduSichuan 611130China

Background The reproductive performance of chickens mainly depends on the development of ***-mal follicle development can lead to decreased reproductive performance and even ovarian disease among *** is the only non-human animal with a high incidence of spontaneous ovarian *** recent years,the involvement of circRNAs in follicle development and atresia regulation has been *** In the present study,we used healthy and atretic chicken follicles for circRNA *** results showed differential expression of *** was then confirmed that circRALGPS2 can translate into a protein,named cir-cRALGPS2-212aa,which has IRES ***,we found that circRALGPS2-212aa promotes apoptosis and autophagy in chicken granulosa cells by forming a complex with PARP1 and *** Our results revealed that circRALGPS2 can regulate chicken granulosa cell apoptosis and autophagy through the circRALGPS2-212aa/PARP1/HMGB1 axis.

关键词： Apoptosis Autophagy Chicken CircRALGPS2 Follicle atresia PARP1 RNC-seq

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Mechanism of action of cordycepin in the treatment of hepatocellular carcinoma via regulation of the Hippo signaling pathway

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Food Science and Human Wellness 2024年第2期13卷 1040-1054页

作者： Xiaomin Li Qing Liu Songyu Xie Xiaoping Wu Junsheng Fu College of Life Sciences Mycological Research CenterFujian Agriculture and Forestry UniversityFuzhou 350002China

Hepatocellular carcinoma(HCC)is one of the common most malignant *** study aimed to determine the in vitro and in vivo anticancer activity of cordycepin and elucidate its mechanism of *** results of in vitro and in vivo studies revealed that cordycepin inhibited proliferation and migration in HepG-2 cells and inhibited the growth of HepG-2 xenograft-bearing nude mice by inducing *** sequencing analysis revealed a total of 403 differential genes,which revealed that cordycepin may play an anti-HCC role by regulating Hippo signaling *** regulatory effects of cordycepin on the Hippo signaling pathway was further investigated using a YAP1 *** results demonstrated that cordycepin upregulated the expression of MST1 and LAST1,and subsequently inhibited YAP1,which activated the Hippo signaling *** in turn downregulated the expression of GBP3 and ETV5,and subsequently inhibited cell proliferation and ***,YAP1 regulated the expression of Bax and Bcl-2,regulated the mitochondrial apoptotic pathway,and induced apoptosis by upregulating the expression of the caspase-3 *** summary,this study reveals that cordycepin exerts its anti-hepatocarcinoma effect through regulating Hippo signaling pathway,and GBP3 and ETV5 may be potential therapeutic targets for hepatocarcinoma.

关键词： Cordycepin Hepatocellular carcinoma Hippo signaling pathway GBP3 ETV5

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Development of a novel critical nitrogen concentration-cumulative transpiration curve for optimizing nitrogen management under varying irrigation conditions in winter wheat

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The Crop Journal 2024年第4期12卷 1242-1251页

作者： Tianyang Ye Yu Zhang Jingyan Xuan Xintian Wang Yang Li Junhao Xu Liujun Xiao Leilei Liu Liang Tang Weixing Cao Bing Liu Yan Zhu National Engineering and Technology center for Information agriculture Engineering Research Center of Smart AgricultureMinistry of EducationKey Laboratory for Crop System Analysis and Decision MakingMinistry of AgricultureJiangsu Key Laboratory for Information AgricultureJiangsu Collaborative Innovation Center for Modern Crop ProductionNanjing Agricultural UniversityNanjing 210095JiangsuChina Institute of Remote Sensing and Digital agriculture Sichuan Academy of Agricultural SciencesChengdu 610066SichuanChina

Accurate nitrogen(N)nutrition diagnosis is essential for improving N use efficiency in crop *** widely used critical N(Nc)dilution curve traditionally depends solely on agronomic variables,neglecting crop water *** three-year field experiments with winter wheat,encompassing two irrigation levels(rainfed and irrigation at jointing and anthesis)and three N levels(0,180,and 270 kg ha1),this study aims to establish a novel approach for determining the Nc dilution curve based on crop cumulative transpiration(T),providing a comprehensive analysis of the interaction between N and water *** Nc curves derived from both crop dry matter(DM)and T demonstrated N concentration dilution under different conditions with different *** equation Nc=6.43T0.24 established a consistent relationship across varying irrigation *** test results indicated that the nitrogen nutrition index(NNI),calculated from this curve,effectively identifies and quantifies the two sources of N deficiency:insufficient N supply in the soil and insufficient soil water concentration leading to decreased N availability for root ***,the NNI calculated from the Nc-DM and Nc-T curves exhibited a strong negative correlation with accumulated N deficit(Nand)and a positive correlation with relative grain yield(RGY).The NNI derived from the Nc-T curve outperformed the NNI derived from the Nc-DM curve concerning its relationship with Nand and RGY,as indicated by larger R2 values and smaller *** novel Nc curve based on T serves as an effective diagnostic tool for assessing winter wheat N status,predicting grain yield,and optimizing N fertilizer management across varying irrigation *** findings would provide new insights and methods to improve the simulations of water-N interaction relationship in crop growth models.

关键词： Crop dry matter Crop cumulative transpiration Bayesian statistical model Critical nitrogen dilution curve Nitrogen nutrition index

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Partnering crops with root-associated microbes for soil health and agricultural sustainability

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Pedosphere 2024年第1期34卷 26-29页

作者： Cunhu WANG Yongjia ZHONG Hong LIAO Root Biology center College of Resources and EnvironmentFujian Agriculture and Forestry UniversityFuzhou 350002China

Increasing global demand for food presents a significant challenge to maintaining soil health and sustainable production of agricultural crops. As plant root-associated microbial fitness is greatly impacted by community growth, development, and nutrient acquisition, the cultivation of functional assembly of root-associated microbes may provide solutions for achieving food security while maintaining healthy soils. Here, we propose a four-part strategy to promote soil health and agricultural productivity by partnering crops with root-associated microbes.

关键词： crops soil agricultural

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The AaBBX21–AaHY5 module mediates light-regulated artemisinin biosynthesis in Artemisia annua L.

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Journal of Integrative Plant Biology 2024年第8期66卷 1735-1751页

作者： Weizhi He Hang Liu Zhangkuanyu Wu Qing Miao Xinyi Hu Xin Yan Hangyu Wen Yaojie Zhang Xueqing Fu Li Ren Kexuan Tang Ling Li Frontiers Science center for Transformative Molecules Joint International ResearchLaboratory of Metabolic and Developmental SciencesKey Laboratory of Urban Agriculture(South)Ministry of AgriculturePlant Biotechnology Research CenterFudan-SJTU-Nottingham Plant Biotechnology R&D CenterSchool of Agriculture and BiologyShanghai Jiao Tong UniversityShanghai 200240China Institute for Agri-Food Standards and Testing Technology Shanghai Academy of Agricultural SciencesShanghai 201403China

The sesquiterpene lactone artemisinin is an important anti-malarial component produced by the glandular secretory trichomes of sweet wormwood(Artemisia annua L.).Light was previously shown to promote artemisinin production,but the underlying regulatory mechanism remains *** this study,we demonstrate that ELONGATED HYPOCOTYL5(HY5),a central transcription factor in the light signaling pathway,cannot promote artemisinin biosynthesis on its own,as the binding of AaHY5 to the promoters of artemisinin biosynthetic genes failed to activate their *** analysis and yeast two-hybrid screening revealed the B-box transcription factor AaBBX21 as a potential interactor with ***21 showed a trichome-specific expression ***,the AaBBX21–AaHY5 complex cooperatively activated transcription from the promoters of the downstream genes AaGSW1,AaMYB108,and AaORA,encoding positive regulators of artemisinin ***,AaHY5 and AaBBX21 physically interacted with the *** E3 ubiquitin ligase CONSTITUTIVELY PHOTOMORPHOGENIC 1(COP1).In the dark,AaCOP1 decreased the accumulation of AaHY5 and AaBBX21 and repressed the activation of genes downstream of the AaHY5–AaBBX21 complex,explaining the enhanced production of artemisinin upon light *** study provides insights into the central regulatory mechanism by which light governs terpenoid biosynthesis in the plant kingdom.

关键词： AaBBX21 AaHY5 AaCOP1 Artemisia annua L. artemisinin biosynthesis light

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