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World Journal of Pediatrics 2024年第3期20卷 287-293页

作者： Dinesh Babu Somasundaram Andrew Maher Sheeja Aravindan Zhongxin Yu Brian MBesch Natarajan Aravindan Department of Radiation Oncology University of Oklahoma Health Sciences CenterOklahoma CityOKUSA Stephenson Cancer Center Oklahoma CityOKUSA Department of Pathology University of Oklahoma Health Sciences CenterOklahoma CityOKUSA Radiation Biology Laboratory University of Oklahoma Health Sciences CenterBSEB 302F941 Stanton L.Young BoulevardOklahoma CityOK 73104USA

Progressive neuroblastomas(pNBs)that defy current intensive multimodal clinical therapy(IMCT)are a significant contributor to overall childhood cancer deaths[l].Neuroblastomas(NBs)that survive first-line IMCT actively evolve to acquire genetic and molecular rearrangements and display unparalleled plasticity and evolution,which causes frequent relapses in a rapidly accelerating timeline[2-4].

关键词： neuroblastoma clinical evolve

Impact of sex on the outcomes of deceased donor liver transplantation

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World Journal of Transplantation 2024年第1期14卷 120-129页

作者： Oya M Andacoglu Isabel S Dennahy Nicole C Mountz Luisa Wilschrey Arzu Oezcelik Division of Transplantation and Advanced Hepatobiliary Surgery University of UtahSalt Lake CityUT 84112United States Department of Surgery University of EssenEssen D-45122Germany Department of Surgery The University of Oklahoma Health Sciences CenterOklahoma CityOK 73117United States Department of Surgery University of Oklahoma College of MedicineOklahoma CityOK 73117United States

BACKGROUND Data examining the impact of sex on liver transplant(LT)outcomes are *** is clear that further research into sex-related differences in transplant patients is necessary to identify areas for *** of these differences may help to identify specific areas of focus to improve on the organ matching process,as well as the peri-and post-operative care of these *** To utilize data from a high-volume Eurotransplant center to compare characteristics of male and female patients undergoing liver transplant and assess association between sex-specific variables with short-and long-term post-transplant *** A retrospective review of the University of Essen’s transplant database was performed with collection of baseline patient characteristics,transplant-related data,and short-term *** of these data were made with Shapiro-Wilk,Mann-Whitney U,χ2 and Bonferroni tests applied where appropriate.A P value of<0.05 was accepted as statistically *** Of the total 779 LT recipients,261(33.5%)were *** patients suffered higher incidences of acute liver failure and lower incidences of alcohol-related or viremic liver disease(P=0.001).Female patients were more likely to have received an organ from a female donor with a higher donor risk index score,and as a high urgency offer(all P<0.05).Baseline characteristics of male and female recipients were also significantly *** multivariate hazard regression analysis,recipient lab-Model for End-Stage Liver Disease score and donor cause of death were associated with long-term outcomes in ***-operative diagnosis of hepatocellular carcinoma,age at time of listing,duration of surgery,and units transfused during surgery,were associated with long-term outcomes in *** of complications was associated with long-term outcomes in both *** survival was similar in both males and females;however,when stratified by age,females<50 y

关键词： Liver transplant Outcomes Survival Peri-and post-operative care

Emerging insights into the function of very long chain fatty acids at cerebellar synapses

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Neural Regeneration Research 2025年第6期20卷 1709-1710页

作者： Martin-Paul Agbaga Mohiuddin Ahmad Department of Cell Biology and Ophthalmology University of Oklahoma Health Sciences Centerand Dean McGee Eye InstituteOklahoma CityOKUSA

Very long chain-saturated and-polyunsaturated fatty acids(VLC-SFA and VLC-PUFA, respectively) are a functionally important class of fatty acids containing 28 carbons or more in their acyl chain. They are synthesized by the elongation of very long fatty acids-4(ELOVL4) enzyme, expressed mainly in the brain, retina, skin, testes, and meibomian gland, where these fatty acids are found(Agbaga et al., 2008). Further, these organs exhibit tissuespecific VLC-PUFA and VLC-SFA biosynthesis and incorporation into complex lipids for specific functions. In the brain, skin, and Meibomian glands, the ELOVL4 mainly makes VLC-SFA, which are incorporated into complex sphingolipids. In the retina, the ELOVL4 makes VLC-PUFA that are incorporated into phosphatidylcholine, that are critical for visual function, while in testes and sperm, the VLC-PUFA are incorporated into sphingolipids that are critical for fertility(Yeboah et al., 2021).

关键词： functions function insight

Assessment of the Respiratory Disease Mortality Risk from Single and Composite Exposures to PM_(2.5)and Ozone—Guangzhou city,Guangdong Province,China,2018-2021

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China CDC weekly 2024年第34期6卷 857-861,I0001-I0006页

作者： Hongwei Tu Yijun Hu Keqi Hu Peipei Dong Yue Wen Jing Jiang Xuedan Xu Jinxu Huang Jiemin Zhu Changyun He Qiuxia Chen Yongying Liu Guangdong Provincial Center for Disease Control and Prevention Guangzhou CityGuangdong ProvinceChina Jinan University Guangzhou CityGuangdong ProvinceChina Department of Science and Education Guangdong Second Provincial General HospitalGuangzhou CityGuangdong ProvinceChina Sun Yat-sen University Guangzhou CityGuangdong ProvinceChina

Summary What is already known about this topic?Fine particulate matter(PM_(2.5))and ozone(O_(3))are prevalent pollutants in the atmosphere,which threaten human health,especially the respiratory ***,people are exposed to a mixture of various pollutants in the ***,the single and combined effects of both pollutants need to be investigated.

关键词： environment. ozone Guangdong

Prevalence and outcomes of neonates with severe COVID-19:An observational study at Children’s Hospital 1 in Ho Chi Minh city,Vietnam

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Asian Pacific Journal of Tropical Medicine 2024年第9期17卷 392-399,I0001页

作者： Phung Nguyen The Nguyen Tran Thanh Thuc Nguyen Thanh Hung Ngo Ngoc Quang Minh Dang Quoc Duy Tran Minh Nhut Nguyen Hoang Dung Tran Nguyen Ai Nuong Dinh Nguyen Cam Tu Department of Pediatrics University of Medicine and Pharmacy at Ho Chi Minh cityHo Chi Minh CityVietnam Children’s Hospital 1 Ho Chi Minh CityVietnam Pediatric Department School of MedicineVietnam National University Ho Chi Minh CityVietnam

Objective:To evaluate the impact of the severe COVID-19 pandemic on neonates and develop strategies to improve their ***:We conducted an observational cross-sectional study at Children's Hospital 1(CH1)from July 25,2021,to May 31,*** neonates who had fever or respiratory symptoms or were born from mothers with COVID-19 and had a positive RT-PCR SARS-CoV-2 result would be *** classified neonates with COVID-19 into 2 groups:mild/moderate and severe for *** between groups were analyzed using Fisher's exact test/Chi-square test for categorical variables and Student's t-test/Wilcoxon Rank Sum test for continuous ***:This study included 88 newborns who had positive RT-PCR SARS-CoV-2 *** severity COVID-19 rate among neonatal cases was found to be 13.6%(12/88),with a corresponding mortality rate of 1.1%(1/88).All severe cases showed lung abnormalities as evident on chest X-ray *** addition to respiratory symptoms,a higher incidence of gastrointestinal manifestations,such as vomiting and diarrhea,was observed in the severe group,indicating a compelling *** administration of anticoagulant and anti-inflammatory drugs in the study group resulted in a satisfactory outcome with no significant ***:The COVID-19 pandemic has had a substantial impact on the well-being of *** management of COVID-19 in this population presents significant challenges.

关键词： COVID-19 Neonate Anti-inflammatory Anticoagulant

Technical efficiency of cocoa farms at varying elevation levels in Davao city, Philippines: implications to sustainable upland farming systems

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Journal of Mountain Science 2024年第1期21卷 33-48页

作者： Francis Levi A.DURANO Jon Marx SARMIENTO Larry N.DIGAL Pedro A.ALVIOLA IV School of Management University of the Philippines MindanaoDavao City 8000Philippines

Elevation is one of many components that influence agriculture, and this in turn affects the level of both inputs and outputs of farmers. This article focuses on the productivity and technical efficiency of 100 cocoa farms using cross-sectional data from areas ranging from 190 to 1021 m above sea level which were classified as low, medium, and high elevation in Davao city, considered as the chocolate capital of the Philippines. Using stochastic frontier analysis, the results showed that the cost of inputs per ha and the number of cocoa trees per ha significantly increase yield. Farms at high elevations were less technically efficient, as this entails lower temperatures and increased rainfall, and cocoa farming in those areas and conditions can be more challenging, especially with changes in farming practices, terrain, and distance to markets. Other significant variables were age of cocoa farms, married farmers, and age of the farmers. Older farms may be more developed, farmers who are married benefit from their spouses being able to readily contribute as farm labor, and lastly, older farmers' inefficiency may likely stem from nonadaptation of newer farming practices. With an average technical efficiency of 0.61, 0.63, and 0.26 in low, medium, and high elevation areas, respectively, farmers therefore have an incentive to improve farm practices and consider topographical variations found in high elevation areas. Recommendations for the improvement of technical efficiency of cocoa farms are better connectivity to markets, enhancing farm practices, and continuation and improvement of government programs on cocoa with an added emphasis on research. For farmers in high elevation areas, mitigating solutions such as sustainable agriculture practices and ecolabelling are key to improving efficiency and minimizing the potential negative impact on upland farming systems. Moreover, such adaptation measures may also contribute to sustainability of cocoa farming in high elevation

关键词： Cocoa farms Cobb-Douglas production function Elevation Philippines Stochastic frontier analysis Technical efficiency

Molecular Epidemiological Study of a Human Brucellosis Outbreak—Weihai city,Shandong Province,China,2022

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China CDC weekly 2024年第12期6卷 230-234页

作者： Yan Li Yifan Yu Jian Zhao Shujun Ding Guoying Zhang Xiaolin Yu Zengqiang Kou Shandong Provincial Center for Disease Control and Prevention Jinan CityShandong ProvinceChina Shandong First Medical University Shandong Academy of Medical SciencesJinan CityShandong ProvinceChina Weihai Municipal Center for Disease Control and Prevention Weihai CityShandong ProvinceChina

What is already known about this topic?Brucellosis,mainly caused by Brucella melitensis(***),is regarded as a significant zoonotic disease in *** Weihai,located at the eastern end of the Shandong Peninsula,brucellosis has been in a low epidemic phase for the past five *** is added by this report?This was the initial report of a brucellosis outbreak in the last five *** of *** bv.3 from Weihai and other cities showed a close genetic relationship,suggesting a potential common *** are the implications for public health practice?Epidemiological investigations depend on standardized and effective molecular typing methods and analysis tools for public health laboratories to identify and trace *** the circulation patterns of livestock in free-range households in heavily affected areas is essential for controlling the spread of brucellosis.

关键词： Shandong China. break

Antimicrobial Resistance Analysis and Whole-Genome Sequencing of Salmonella Isolates from Environmental Sewage — Guangzhou city, Guangdong Province, China, 2022–2023

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China CDC weekly 2024年第13期6卷 254-260页

作者： Bihui Su Guanghong Du Shuiping Hou Zongqiu Chen Xiaoying Wu Gang He Jun Yuan Chaojun Xie Tuberculosis Management and Treatment Department Guangzhou Chest HospitalGuangzhou CityGuangdong ProvinceChina School of Public Health Guangzhou Medical UniversityGuangzhou CityGuangdong ProvinceChina Guangzhou Center for Disease Control and Prevention Guangzhou CityGuangdong ProvinceChina Office of the Director Huadu District Center for Disease Control and PreventionGuangzhou CityGuangdong ProvinceChina

What is already known about this topic?S.1,4,[5],12:i:-and *** are emerging serotypes of Salmonella that require close monitoring for antimicrobial resistance and containment of their *** is added by this report?The study aimed to identify antimicrobial resistance genes(ARGs)in S.1,4,[5],12:i:-and *** strains isolated from environmental sewage in Guangzhou city,Guangdong Province,China.A phylogenetic tree was constructed using single nucleotide polymorphism data to assess genetic relatedness among strains,offering insights for Salmonella infection outbreak investigations in the *** are the implications for public health practice?It is crucial to implement strategies,such as integrating different networks,to control the spread of drugresistant *** technologies must be utilized to disinfect sewage and eliminate *** food safety and proper sewage disinfection are essential to curb the dissemination of Salmonella.

关键词： Whole offering integrating

The Combined Effects of High Temperatures and Ozone Pollution on Medical Emergency Calls—Jinan city,Shandong Province,China,2013–2019

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China CDC weekly 2024年第2期6卷 30-35,I0001-I0007页

作者： Huiyun Chang Chong Liu Xingyi Geng Xiumiao Peng Ke Huang Liheng Wang Liangliang Cui Department of Scientific Research and Education Jinan Municipal Center for Disease Control and PreventionJinan Municipal Center for Disease Control and Prevention Affiliated to Shandong UniversityJinan CityShandong ProvinceChina Jinan Health Well Development Center Jinan CityShandong ProvinceChina Department of Environmental Health Jinan Municipal Center for Disease Control and PreventionJinan CityShandong ProvinceChina Department of Emergency Jinan Medical Emergency CenterJinan CityShandong ProvinceChina

What is already known about this topic?Studies have extensively documented the separate and independent effects of extreme temperature and ozone on morbidity and mortality associated with respiratory and circulatory *** is added by this report?The study revealed a significant association between elevated temperature,ozone pollution,and the combined effect of high temperature and ozone pollution with an increased risk of all-cause medical emergency calls(MECs)and MECs specifically related to neurological *** are the implications for public health practice?Interventional measures should be implemented to mitigate exposure to high temperatures and ozone ***,during the warm season,it is crucial for relevant authorities to focus on disseminating scientific information regarding the health impacts of elevated temperatures and ozone ***,timely public health advisories should be issued to alert the public effectively.

关键词： ozone elevated pollution

Evaluation of Latent Tuberculosis Infection Using the ESAT6-CFP10 Skin Test Among International Freshmen With Diverse Skin Tones at a University—Nanjing city,Jiangsu Province,China,September 2023

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China CDC weekly 2024年第35期6卷 896-900,I0001页

作者： Peng Lu Rong Wang Jingjing Xu Jianming Wang Fangfang Du Guozhi Wang Shiming Cheng Limei Zhu Department of Chronic Communicable Disease Jiangsu Provincial Center for Disease Control and PreventionNanjing CityJiangsu ProvinceChina Department of Epidemiology School of Public HealthNanjing Medical UniversityNanjing CityJiangsu ProvinceChina Nanjing city Center for Disease Control and Prevention Nanjing CityJiangsu ProvinceChina Chinese Antituberculosis Association BeijingChina National Institutes for Food and Drug Control BeijingChina

Introduction:Newer skin tests,including the ESAT6-CFP10(EC)skin test,were recommended for diagnosing Mycobacterium tuberculosis(***)***,no data exist assessing the diagnostic performance of the EC skin test among foreign students with different skin ***:A cohort study at Nanjing Medical University screened incoming foreign *** EC skin test was used to assess for *** infection,and results were read at 24,48,72,and 96-hours ***:Among 96 participants,*** infection rates at 24,48,72,and 96-hours post-injection were 3.13%,7.29%,13.54%,and 9.38%,*** infection rates were lower among individuals with darker skin tones,the difference was not statistically significant(P=0.186),and variations were consistent across different measurement *** analysis revealed 5.3%in the continuousincreasing group,86.5%in the low-stable group,and 5.2%in the elevated-decreasing ***,participants in the elevated-decreasing group had lighter skin tones,with trajectory patterns consistent across different skin ***:The EC skin test is safe,and redness diameter is a more reliable indicator than *** should be collected within 48 to 72 hours,with verification at 72 hours crucial if initial results are ***,skin color does not affect EC skin test outcomes.

关键词： CFP10 Skin Nanjing