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Neural Regeneration Research 2024年第1期19卷 226-232页

作者： Qian Tao Honglu Chao Dong Fang Dou Dou School of Medicine Jinan UniversityGuangzhouGuangdong ProvinceChina School of health and Life Science University of Health and Rehabilitation SciencesQingdaoShandong ProvinceChina Department of health Sciences National Natural Science Foundation of ChinaBeijingChina Department of Neurosurgery The First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu ProvinceChina

The National Natural Science foundation of China is one of the major funding agencies for neuro rehabilitation research in *** study reviews the frontier directions and achievements in the field of neurorehabilitation in China and wo *** used data from the Web of Science Core Collection(WoSCC) database to analyze the publications and data provided by the National Natural Science foundation of China to analyze funding *** addition,the prospects for neurorehabilitation research in China are *** 2010 to 2022,a total of 74,220 publications in neurorehabilitation were identified,with there being an overall upward *** this period,the National Natural Science foundation of China has funded 476 research projects with a total funding of 192.38 million RMB to support neuro rehabilitation research in *** the support of the National Natural Science foundation of China,China has made some achievements in neurorehabilitation *** related to neurorehabilitation is believed to be making steady and significant progress in China.

关键词： brain computer interface invasive neuromodulation National Natural Science foundation of China(NSFC) neuroreha bilitation non-invasive brain stimulation publication rehabilitation robotics virtual reality

Prospective randomized study correlating intra-operative urethral mucosal injury with early period after transurethral resection of the prostate stricture urethra: A novel concept

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Asian Journal of Urology 2024年第3期11卷 466-472页

作者： Suresh B.Patankar Mayur M.Narkhede Gururaj Padasalagi Kashinath Thakare Department of Urology Ace HospitalPuneASP Medical FoundationSripad Medisearch PVT LTDIndia

Objective:To investigate the incidence of urethral stricture during the early period after transurethral resection of the prostate(TURP)and correlate its incidence with intra-operative urethral mucosal injury during *** to compare the other established risk factors affecting the development of urethral stricture among patients undergoing monopolar or bipolar TURP over a period of 6 months follow-up as the prospective randomized ***:One hundred and fifty men older than 50 years with lower-urinary tract symptoms associated with benign prostatic hyperplasia were randomized to undergo either standard monopolar TURP with glycine as the irrigation fluid or bipolar TURP with normal saline as *** prostate size,operative time,intra-operative mucosal rupture,catheter time,catheter traction duration,uroflowmetry,and post-operative stricture rate were ***:A total of 150 patients underwent TURP,including 74 patients undergoing monopolar TURP(one patient was excluded as his post-operative histopathological examination report was of adenocarcinoma prostate)and 75 patients undergoing bipolar-TURP,all of which were performed using a 26 Fr sheath *** mean International Prostate Symptom Score and maximum urinary flow rate score at post-operative 3 months and 6 months were comparable between the *** of 149 patients,nine patients(6.0%)developed urethral *** severity of the injury(urethral mucosal injury)correlated with the likelihood of developing a subsequent complication(stricture urethra).Patients with stricture had significantly larger prostate volume than patients without stricture(65.0 mL vs.50.0 mL;p=0.030).Patients with stricture had longer operative time than patients without stricture(55.0 min vs.40.0 min;p=0.002).In both procedures,formation of post-operative stricture urethra was independently associated with intra-operative mucosal ***:Intra-operative recognition of urethral mucosal injury hel

关键词： Urethral stricture Transurethral resectionof the prostate Mucosal injury Risk factor

Higher intakes of lysine,threonine and valine are inversely associated with non-alcoholic fatty liver disease risk:a community-based case-control study in the Chinese elderly

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Food Science and Human Wellness 2024年第1期13卷 191-197页

作者： Xueqi Li Wenjun Ma Ting Yang Chong Wang Wei Zhang Hui Li Ting Zhao Xiaofei Guo Institute of Nutrition&health School of Public HealthQingdao UniversityQingdao 260071China Affiliated hospital of Qingdao University Qingdao 260071China

The associations of individual amino acid with non-alcoholic fatty liver disease(NAFLD)risk remained *** present study aimed to investigate the associations between the two in the Chinese ***:A community-based health check-up program was conducted in Qingdao,*** was diagnosed by ultrasonography accompanied by epidemiological *** dietary intakes of amino acids were investigated with 3-day,24-h dietary records and calculated by Nutrition Calculator *** cubic spline model was used to evaluate a nonlinear relationship between amino acid intake and NAFLD ***:400 NAFLD subjects were identified,and 400 participants were randomly selected as controls and matched by gender and age(±3 years)Dose-response analysis showed that 1000 mg increment of aromatic amino acids(AAAs)was associated with reduced 16%risk of *** increments of 750 mg/d threonine,950 mg/d valine,or 1700 mg/d lysine were associated with a 20%reduction in the NAFLD risk(all P for linearity<0.05).Conclusion:The present study demonstrated that the dietary increases in milk,eggs and deep-sea fish,which are rich in the amino acids,might contribute to protecting against NAFLD in the elderly.

关键词： Amino acid Non-alcoholic fatty liver disease Senior citizen Dose-response analysis

Molybdenum Concentration and the Risk of Spontaneous Preterm Birth: A Nested Case-Control Study — Beijing Municipality, China, 2018–2020

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China CDC weekly 2024年第13期6卷 261-266,I0005,I0006页

作者： Junhua Huang Wei Zheng Aili Wang Weiling Han Junxi Chen Hang An Lailai Yan Zhiwen Li Guanghui Li Division of Endocrinology and Metabolism Department of ObstetricsBeijing Obstetrics and Gynecology HospitalCapital Medical University.Beijing Maternal and Child Health Care HospitalBeijingChina Department of Obstetrics and Gynecology Beijing Luhe HospitalCapital Medical UniversityBeijingChina Institute of Reproductive and Child health National Health Commission Key Laboratory of Reproductive HealthPeking UniversityBeijingChina Department of Epidemiology and Biostatistics School of Public HealthPeking UniversityBeijingChina Department of Laboratorial Science and Technology School of Public HealthPeking UniversityBeijingChina

What is already known about this topic?The level of molybdenum(Mo)in a mother’s urine has been linked to the growth rate of the fetus and the blood pressure levels in *** is added by this report?We evaluated the variations in maternal plasma Mo concentrations throughout pregnancy and their potential association with the risk of spontaneous preterm birth(SPB).What are the implications for public health practice?Future research must determine the Mo levels in pregnant women across various regions in ***,particular attention needs to be given to the potential increase in Mo concentration throughout pregnancy and its possible adverse impacts on the health of both the mother and the fetus.

关键词： mother urine pregnancy

LncRNA IDH1-AS1 sponges miR-518c-5p to suppress proliferation of epithelial ovarian cancer cell by targeting RMB47

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The Journal of Biomedical Research 2024年第1期38卷 51-65页

作者： Juan Zhou Yiran Xu Luyao Wang Yu Cong Ke Huang Xinxing Pan Guangquan Liu Wenqu Li Chenchen Dai Pengfei Xu Xuemei Jia Department of Gynecology Women's Hospital of Nanjing Medical UniversityNanjing Maternity and Child Health Care HospitalNanjingJiangsu 210004China Nanjing Maternity and Child health Medical Institute Women's Hospital of Nanjing Medical UniversityNanjing Maternity and Child Health Care HospitalNanjingJiangsu 210004China.

Long noncoding RNA(lncRNA)IDH1 antisense RNA 1(IDH1-AS1)is involved in the progression of multiple cancers,but its role in epithelial ovarian cancer(EOC)is ***,we investigated the expression levels of IDH1-AS1 in EOC cells and normal ovarian epithelial cells by quantitative real-time PCR(qPCR).We first evaluated the effects of IDH1-AS1 on the proliferation,migration,and invasion of EOC cells through cell counting kit-8,colony formation,EdU,transwell,wound-healing,and xenograft *** then explored the downstream targets of IDH1-AS1 and verified the results by a dual-luciferase reporter,qPCR,rescue experiments,and Western *** found that the expression levels of IDH1-AS1 were lower in EOC cells than in normal ovarian epithelial *** IDH1-AS1 expression of EOC patients from the Gene Expression Profiling Interactive Analysis database indicated a favorable prognosis,because IDH1-AS1 inhibited cell proliferation and xenograft tumor growth of ***1-AS1 sponged miR-518c-5p whose overexpression promoted EOC cell *** miR-518c-5p mimic also reversed the proliferation-inhibiting effect induced by IDH1-AS1 ***,we found that RNA binding motif protein 47(RBM47)was the downstream target of miR-518c-5p,that upregulation of RBM47 inhibited EOC cell proliferation,and that RBM47 overexpressing plasmid counteracted the proliferation-promoting effect caused by the IDH1-AS1 *** together,IDH1-AS1 may suppress EOC cell proliferation and tumor growth via the miR-518c-5p/RBM47 axis.

关键词： lncRNA IDH1-AS1 epithelial ovarian cancer miR-518c-5p RBM47

Magnetic resonance imaging findings of radiation-induced breast angiosarcoma:A case report

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World Journal of Clinical Cases 2024年第13期12卷 2237-2242页

作者： Wen-Pei Wu Chih-Wei Lee Department of Medical Imaging Changhua Christian HospitalChanghua 50006Taiwan Department of Radiology Changhua Christian Medical Foundation Changhua Christian HospitalChanghua 50006Taiwan

BACKGROUND Breast conservation surgery(BCS)with adjuvant radiotherapy has become a gold standard in the treatment of early-stage breast cancer,significantly reducing the risk of tumor ***,this treatment is associated with adverse effects,including the rare but aggressive radiation-induced angiosarcoma(RIAS).Despite its rarity and nonspecific initial presentation,RIAS presents a challenging diagnosis,emphasizing the importance of imaging techniques for early detection and accurate *** SUMMARY We present a case of a 48-year-old post-menopausal woman who developed skin ecchymosis on the right breast seven years after receiving BCS and adjuvant radiotherapy for breast *** mammography and ultrasound were inconclusive,showing post-treatment changes but failing to identify the underlying ***-enhanced breast magnetic resonance imaging(MRI)revealed diffuse skin thickening and nodularity with distinctive enhan-cement kinetics,leading to the diagnosis of *** case highlights the crucial role of MRI in diagnosing and determining the extent of RIAS,facilitating timely and appropriate surgical *** Breast MRI is crucial for detecting RIAS,especially when mammography and ultrasound are inconclusive.

关键词： Radiation-induced angiosarcoma Radiotherapy Breast conserving surgery Breast cancer Magnetic resonance imaging Case report

Primary sclerosing cholangitis and cholangiocarcinoma:the 2023 practice guidance and future perspectives

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Hepatobiliary Surgery and Nutrition 2024年第1期13卷 172-175页

作者： Francesca Saffioti Vasileios K.Mavroeidis Department of Gastroenterology and Hepatology Oxford University Hospitals NHS Foundation TrustJohn Radcliffe HospitalOxfordUK UCL Institute for Liver and Digestive health University College LondonLondonUK Department of HPB Surgery University Hospitals Bristol&Weston NHS Foundation TrustBristol Royal InfirmaryBristolUK Department of Transplant Surgery North Bristol NHS TrustSouthmead HospitalBristolUK

The 2023 practice guidance on primary sclerosing cholangitis(PSC)and cholangiocarcinoma(CCA)of the American Association for the Study of Liver Diseases(AASLD)came as a needful update to the previous 2010 guidelines on PSC,with a first-time inclusion of dedicated guidance on the diagnosis and management of CCA(1,2).This data-supported approach developed by consensus of an expert panel,provides guidance statements based on analytical review of the relevant literature.

关键词： American Association for the Study of Liver Diseases(AASLD) guidelines primary sclerosing cholangitis(PSC) liver cancer biliary cancer

Trends in the Incidence of High-Risk Newborns Based on a New Conceptual Framework-Beijing Municipality,China,2013-2022

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China CDC weekly 2024年第31期6卷 767-771页

作者： Yongxian Zhao Zhaoxia Jia Lei Wang Qingqing Wu Moning Guo Dong Han Lili Huang Junhua Wang Di Zhang Zhao Wang Minghui Wu Beijing Obstetrics and Gynecology hospital Capital Medical UniversityBeijing Maternal and Child Health Care HospitalBeijingChina Beijing Municipal health Big Data and Policy Research Center BeijingChina

Summary What is already known on this topic?A new conceptual term,small and vulnerable newborns(SVN),bringing preterm birth,small for gestational age(SGA),or low birth weight(LBW)together is being advocated for assessing whether a child is at high *** is added by this report?According to the new conceptual term,the increasing incidence of high-risk newborns(from 9.82%to 10.96%)has been observed among 2,005,408 newborns over the period from 2013 to 2022,which is higher than using any of the three definitions of *** age≥35,primiparity,and multiple births are high risks for *** are the implications for public health practice?The new conceptual framework should be used to better assess the number of high-risk *** should be paid to multiple births to prevent preterm-related *** reduce term newborns who are SGA,we need to be concerned not only with multiple pregnancies but also with first-time mothers.

关键词： Beijing bringing mother

Machine learning-based comparison of factors influencing estimated glomerular filtration rate in Chinese women with or without nonalcoholic fatty liver

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World Journal of Clinical Cases 2024年第15期12卷 2506-2521页

作者： I-Chien Chen Lin-Ju Chou Shih-Chen Huang Ta-Wei Chu Shang-Sen Lee Department of Nursing Kaohsiung Armed Forces General HospitalKaohsiung 802Taiwan Department of Obstetrics and Gynecology Tri-Service General HospitalNational Defense Medical CenterTaipei 114Taiwan Chief Executive Officer's Office MJ Health Research FoundationTaipei 114Taiwan Department of Urology Taichung Tzu Chi HospitalBuddhist Tzu Chi Medical FoundationTaichung 427Taiwan School of Medicine Tzu Chi UniversityHualian 970Taiwan Department of Urology Tri-Service General HospitalNational Defense Medical CenterTaipei 114Taiwan

BACKGROUND The prevalence of non-alcoholic fatty liver(NAFLD)has increased *** with NAFLD are known to have higher chance for renal function *** past studies used traditional multiple linear regression(MLR)to identify risk factors for decreased estimated glomerular filtration rate(eGFR).However,medical research is increasingly relying on emerging machine learning(Mach-L)*** present study enrolled healthy women to identify factors affecting eGFR in subjects with and without NAFLD(NAFLD+,NAFLD-)and to rank their *** To uses three different Mach-L methods to identify key impact factors for eGFR in healthy women with and without *** A total of 65535 healthy female study participants were enrolled from the Taiwan MJ cohort,accounting for 32 independent variables including demographic,biochemistry and lifestyle parameters(independent variables),while eGFR was used as the dependent *** from MLR,three Mach-L methods were applied,including stochastic gradient boosting,eXtreme gradient boosting and elastic *** of estimation were used to define method accuracy,where smaller degree of error indicated better model *** Income,albumin,eGFR,High density lipoprotein-Cholesterol,phosphorus,forced expiratory volume in one second(FEV1),and sleep time were all lower in the NAFLD+group,while other factors were all significantly higher except for smoking ***-L had lower estimation errors,thus outperforming *** Model 1,age,uric acid(UA),FEV1,plasma calcium level(Ca),plasma albumin level(Alb)and T-bilirubin were the most important factors in the NAFLD+group,as opposed to age,UA,FEV1,Alb,lactic dehydrogenase(LDH)and Ca for the *** the importance percentage was much higher than the 2nd important factor,we built Model 2 by removing *** The eGFR were lower in the NAFLD+group compared to the NAFLD-group,with age being was the most important impact factor in both groups of he

关键词： Non-alcoholic fatty liver Estimated glomerular filtration rate Machine learning Chinese women

Gut flora in multiple sclerosis:implications for pathogenesis and treatment

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Neural Regeneration Research 2024年第7期19卷 1480-1488页

作者： Weiwei Zhang Ying Wang Mingqin Zhu Kangding Liu Hong-Liang Zhang Department of Neurology the First Hospital of Jilin UniversityJilin UniversityChangchunJilin ProvinceChina Department of Life Sciences National Natural Science Foundation of ChinaBeijingChina

Multiple sclerosis is an inflammatory disorder chara cterized by inflammation,demyelination,and neurodegeneration in the central nervous *** current first-line therapies can help manage symptoms and slow down disease progression,there is no cure for multiple *** gut-brain axis refers to complex communications between the gut flo ra and the immune,nervous,and endocrine systems,which bridges the functions of the gut and the *** in the gut flora,termed dys biosis,can lead to systemic inflammation,leaky gut syndrome,and increased susceptibility to *** pathogenesis of multiple sclerosis involves a combination of genetic and environmental factors,and gut flora may play a pivotal role in regulating immune responses related to multiple scle *** develop more effective therapies for multiple scle rosis,we should further uncover the disease processes involved in multiple sclerosis and gain a better understanding of the gut-brain *** review provides an overview of the role of the gut flora in multiple scle rosis.

关键词： gut flora gut-brain axis multiple sclerosis pathogenesis treatment