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Forensic Identification of Four Indian Snake Species Using Single Multiplex Polymerase Chain Reaction

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Journal of Forensic Science and Medicine 2022年第3期8卷 81-87页

作者： Ishani Mitra Soma Roy Ikramul Haque Division of Biology Central Forensic Science LaboratoryKolkataWest BengalIndia office of director Central Forensic Science LaboratoryChandigarhIndia

Among different endangered animal species,snakes are the most neglected creature looked at with apathy and therefore,are ruthlessly killed,illegally trafficked,and poached for their venom,lucrative skin,meat,and bones for manufacturing of medicines,accessories,and food *** the identity of the endangered snake species is important for punishing the offenders under Wildlife Protection Act(WPA)(1972)but morphological characters fail to establish identity as they are often *** technique of identification of snake species at molecular level holds very effective conclusion in punishing ***,we have constructed and demonstrated a novel multiplexing polymerase chain reaction technique,using 16S rRNA and C-mos gene for identification of four Indian snake species,namely Ptyas mucosa,Daboia russellii,Naja naja,and Xenochrophis *** are listed in Appendix-II and III of convention on international trade in endangered species of wild fauna and flora and Schedule II;Part II of Indian WPA,***,it may be considered a functional tool for establishing species-specific identity of four Indian snake species and promising to be useful for their conservation.

关键词： 16S rRNA C-mos forensic identification Indian snakes multiplex polymerase chain reaction amplification Wildlife Protection Act(1972)

ASEAN Regional Forum:Its Role in the Asian Pacific Security Cooperation

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Contemporary International Relations 1998年第7期8卷 14-27页

作者：丁奎松 director of the President's office previously Director of the Division for South & Southeast Asian StudiesCICIR.

Facing the turn of the century, Asia is unlucky to witness two crises successive-ly. One is the Southeast Asian financial crisis that started from Thailand in Ju-ly last year, which has swept almost all countries and regions in East Asia with dis-astrous struck to this“model student of the world”.Its impact has not onlyreached far to the United States, Europe, and Russia, but even led to serious polit-

关键词： Asia ARF

TMEM39A and TMEM131 facilitate bulk transport of ECM proteins through large COPII vesicle formation

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Journal of Genetics and Genomics 2025年第2期52卷 189-203页

作者： Jee Young Sung Ga-Eun Lim Jarim Goo Kyung Jin Jung Jeong Min Chung Hyun Suk Jung Yong-Nyun Kim Jaegal Shim Cancer Metastasis Branch Research InstituteNational Cancer Center323 Ilsan-roGoyang-siGyeonggi-do10408Republic of Korea Experimental clinical Research Center Biomedical Research InstituteSeoul National University Bundang HospitalSeongnamGyeonggi-do13620Republic of Korea Department of Biochemistry College of Natural SciencesKangwon National UniversityChuncheonKangwon-do24341Republic of Korea

The growth of Caenorhabditis elegans involves multiple molting processes,during which old cuticles are shed and new cuticles are rapidly *** process requires the regulated bulk secretion of cuticle *** transmembrane protein-39(TMEM-39)mutant exhibits distinct dumpy and ruptured phenotypes characterized by notably thin ***-39 primarily co-localizes with the coat protein II complex(COPII)in large vesicles rather than small COPII *** TMEM-39-associated large vesicles(TMEM-39-LVs)form robustly during the molting period and co-localize with various extracellular matrix components,including BLI-1 collagen,BLI-3 dual oxidase,and *** immunoprecipitation using TMEM39A-FLAG and proteomics analysis in human sarcoma cells,we identify TMEM39A-associated proteins,including *** of TMEM131 results in reduced TMEM39A-LV formation and collagen secretion in both *** and human sarcoma cells,indicating a cooperative role between TMEM39A and TMEM131 in the secretion of extracellular components through the formation of large COPII *** the conservation of TMEM39A and its associated proteins between *** and humans,TMEM39A-LVs may represent a fundamental machinery for rapid and extensive secretion across metazoans.

关键词： Bulk secretion Collagen COPII ECM TMEM39A TMEM131

Cancer statistics for young adults aged 20 to 49 years in China from 2000 to 2017:a population-based registry study

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Science China(Life Sciences) 2024年第4期67卷 711-719页

作者： Yi Teng Changfa Xia He Li Maomao Cao Fan Yang Xinxin Yan Siyi He Mengdi Cao Shaoli Zhang Qianru Li Wanqing Chen office of Cancer Screening National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

An increasing cancer incidence among adults younger than 50 years has been reported for several types of cancer in multiple *** aimed to report cancer profiles and trends among young adults in *** from the China Cancer Registry Annual Report were used to estimate incidence and mortality among young adults(ages 20–49 years)in China in 2017,and an age-period-cohort model was employed to estimate the average annual percent change(AAPC)in incidence and mortality from 2000 to *** 25 cancer types were grouped into obesity-or overweight-associated cancers(12 cancer types)and additional cancers(13 cancer types).In 2017,there were 681,178new cases and 214,591 cancer deaths among young adults in *** young adults,the most common cancers were thyroid,breast,cervical,liver,lung,and colorectal cancer,and the leading causes of cancer deaths were liver,lung,cervical,stomach,breast,and colorectal *** 2000 to 2017,the cancer incidence increased for all cancers combined among young adults,with the highest AAPC(1.46%)for adults aged 20–24 years,while cancer mortality decreased,with the highest AAPC(-1.63%)for those aged 35–39 *** conclusion,the cancer incidence in China has increased among young adults,while cancer mortality has decreased for nearly all *** control measures,such as obesity control and appropriate screening,may contribute to reducing the increasing cancer burden among young adults.

关键词： young adults incidence mortality trends China

Esophageal cancer global burden profiles, trends, and contributors

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Cancer Biology & Medicine 2024年第8期21卷 656-666页

作者： Yi Teng Changfa Xia Maomao Cao Fan Yang Xinxin Yan Siyi He Mengdi Cao Shaoli Zhang Qianru Li Nuopei Tan Jiachen Wang Wanqing Chen office of Cancer Screening National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

Objective:This study aimed to provide a comprehensive overview of the global burden of esophageal cancer(EC)and determine the temporal trends and factors influencing changes in the global ***:The latest incidence and mortality data for EC worldwide were obtained from GLOBALCAN *** mortality and disability-adjusted life years(DALYs)rates for EC from 1990±2019 were sourced from the 2019 Global Burden of *** in EC mortality and DALYs attributable to 11 risk factors or clusters of risk were analyzed using the joinpoint regression *** trends in age-related EC burden were assessed using a decomposition ***:An estimated 511,054 new cases of EC were diagnosed in 2022 with 445,391 deaths *** 75%of cases and deaths occurred in *** 50%of global EC deaths and DALYs were attributed to tobacco use in men in 2019,while 20%were attributed to high body mass index(BMI)in *** 1990±2019,EC deaths and DALYs attributable to almost all risk factors had declining trends,while EC deaths and DALYs attributed to high BMI in men had upward *** age-related EC burden exhibited an upward trend driven by population growth and aging,which contributed to 307.4 thousand deaths and 7.2 million DALYs due to ***:The EC burden remains substantial *** tobacco and obesity control measures are critical for addressing the risk-attributable burden of *** growth and aging pose challenges for EC prevention and control efforts.

关键词： Esophageal cancer incidence mortality disability-adjusted life years risk factors aging trends

Cancer statistics in Chinese older people,2022:current burden,time trends,and comparisons with the US,Japan,and the Republic of Korea

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Science China(Life Sciences) 2023年第5期66卷 1079-1091页

作者： Wen Ju Rongshou Zheng Siwei Zhang Hongmei Zeng Kexin Sun Shaoming Wang Ru Chen Li Li Wenqiang Wei Jie He office for Cancer Registry National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

Largely due to population ageing,the cancer burden from older people has been rising,which imposed considerable pressure on current Chinese healthcare *** provide comprehensive information about cancer burden of Chinese older people based on the most recent data from National Central Cancer Registry of *** logarithmic linear regression was used to project the current cancer burden in 2022,and Joinpoint regression was used for temporal trend analysis from 2000 to *** also estimated cancer statistics of older people in the US,Japan and the Republic of Korea for *** is estimated that 2.79 million cases and 1.94 million deaths occur for Chinese older people,representing 55.8%and 68.2%of cases and deaths in all population in *** overall cancer incidence rate gradually increased among older women,while the mortality rates declined for both ***,approximately 10.0%of all cases and 17.7%of all deaths are from people aged over 80 years,and cancer incidence and mortality in this age group showed upward trends for *** cancer and digestive cancers are the leading cancer types for Chinese older *** with other countries,China has lower incidence rates but higher mortality rates for older *** rapidly growing burden of prostate cancer,breast cancer,colorectal cancer,and declines in esophageal cancer,stomach cancer,and liver cancer among older people indicate the cancer pattern in China is being in a transition stage to that in developed *** findings imply that it should be the national health priority to meet the growing demands for cancer diagnosis,treatment and care services from the older people as the rapid population ageing in next few decades.

关键词： cancer burden older people temporal trend cancer pattern population ageing

Attributable liver cancer deaths and disability-adjusted life years in China and worldwide: profiles and changing trends

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Cancer Biology & Medicine 2024年第8期21卷 679-691页

作者： Mengdi Cao Changfa Xia Maomao Cao Fan Yang Xinxin Yan Siyi He Shaoli Zhang Yi Teng Qianru Li Nuopei Tan JiachenWang Wanqing Chen office of Cancer Screening National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

Objective: Liver cancer is a major health concern globally and in China. This analysis investigated deaths and disability-adjusted life years(DALYs) with respect to etiologies and risk factors for liver cancer in China and ***: Global and China-specific data were collected on liver cancer deaths, DALYs, and age-standardized rates(ASRs) from the Global Burden of Disease Study 2019 database. Liver cancer etiologies were classified into five groups and risk factors were categorized into three levels. Each proportion of liver cancer burden was calculated in different geographic regions. The joinpoint regression model were used to assess the trends from 1990±***: Liver cancer accounted for 484,577 deaths worldwide in 2019 with an ASR of 5.9 per 100,000 population. China had an elevated liver cancer death ASR in 2019 and males had an ASR 1.7 times the global rate. The global ASR for DALYs peaked at 75±79 years of age but peaked earlier in China. Hepatitis B virus was the prominent etiology globally(39.5%) and in China(62.5%), followed by hepatitis C virus and alcohol consumption. In high sociodemographic index countries, non-alcoholic steatohepatitis has gained an increasing contribution as an etiologic factor. The liver cancer burden due to various etiologies has decreased globally in both genders. However, metabolic risk factors, particularly obesity, have had a growing contribution to the liver cancer burden, especially among ***: Despite an overall decreasing trend in the liver cancer burden in China and worldwide, there has been a rising contribution from metabolic risk factors, highlighting the importance of implementing targeted prevention and control strategies that address regional and gender disparities.

关键词： Liver cancer deaths risk factors global China

Disparities in 36 cancers across 185 countries: secondary analysis of global cancer statistics

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Frontiers of Medicine 2024年第5期18卷 911-920页

作者： Qianru Li Changfa Xia He Li Xinxin Yan Fan Yang Mengdi Cao Shaoli Zhang Yi Teng Siyi He Maomao Cao Wanqing Chen office of Cancer Screening National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

Cancer is a major public health problem and represents substantial disparities *** study reported estimates for 36 cancers across 185 countries by incidence,mortality,5-year prevalence,mortality-toprevalence ratio(MPR),and mortality-to-incidence ratio(MIR)to examine its association with human development index(HDI)and gross national income(GNI).Data were collected from the GLOBOCAN *** and MIR were calculated by sex,age group,country,and cancer type and then summarized into ***’s population and global cancer spectrum were used to calculate age-and type-standardized *** analyses were conducted to assess *** showed that breast cancer was the most diagnosed cancer ***-and middle-income countries had high MPR and *** of esophagus,pancreas,and liver had the highest *** and the older population had the highest *** and GNI were positively correlated with incidence and mortality but negatively correlated with MPR/*** disparities in cancer burden were observed among 36 cancer types across 185 *** development may contribute to narrowing these disparities,and tailored strategies are crucial for regional-and country-specific cancer control.

关键词： cancer burden mortality-to-prevalence ratio mortality-to-incidence ratio disparities global

Cancer profiles in China and comparisons with the USA:a comprehensive analysis in the incidence,mortality,survival,staging,and attribution to risk factors

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Science China(Life Sciences) 2024年第1期67卷 122-131页

作者： Siyi He Changfa Xia He Li Maomao Cao Fan Yang Xinxin Yan Shaoli Zhang Yi Teng Qianru Li Wanqing Chen office of Cancer Screening National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

China faces a disproportionate cancer burden to the population size and is undergoing a transition in the cancer *** extracted data in five aspects of cancer incidence,mortality,survival,staging distributions,and attribution to risk factors in China,the USA and worldwide from open-source *** conducted a comprehensive secondary analysis of cancer profiles in China in the above aspects,and compared cancer statistics between China and the USA.A total of 4,546,400 new cancer cases and 2,992,600 deaths occurred in China in 2020,accounting for 25.1%and 30.2%of global cases,***-related cancers including lung cancer,colorectal cancer,and breast cancer showed an upward trend and have been the leading cancer types in China.41.6%of new cancer cases and 49.3%of cancer deaths occurred in digestive-system cancers in China,and the cancers of esophagus,nasopharynx,liver,and stomach in China accounted for over 40%of global ***-related cancers showed the highest population-attributable fractions among Chinese adults,and most cancers could be attributed to behavioral and metabolic *** proportions of stage I for most cancer types were much higher in the USA than in China,except for esophageal cancer(78.2%vs.41.1%).The 5-year relative survival rates in China have improved substantially during 2000–2014,whereas survival for most cancer types in the USA was significantly higher than in China,except for upper gastrointestinal *** findings suggest that although substantial progress has been made in cancer control,especially in digestive system cancers in China,there was still a considerable disparity in cancer burden between China and the *** robust policies on risk factors and standardized screening practices are urgently warranted to curb the cancer growth and improve the prognosis for cancer patients.

关键词： cancer burden survival rate neoplasm staging risk factors China