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Can patients with mild non-neoplastic lesions diagnosed at baseline screening be safely exempt from surveillance: evidence from multicenter community-based cohorts

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Science China Life Sciences 2025年第1期 263-271页

作者： Siyi He Zhiyi Zhang Guohui Song Zhenhai Wang Chunyun Dai Shipeng Yan Kun Jiang Bingbing Song He Li Maomao Cao Dianqin Sun Fan Yang Xinxin Yan Shaoli Zhang Yi Teng Qianru Li Changfa Xia Wanqing Chen office of Cancer Screening National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical College Department of Gastroenterology Gansu Wuwei Tumor Hospital Cixian Cancer Institute Linzhou Cancer Hospital Center for Disease Control and Prevention of Sheyang County Department of Cancer Prevention and Control Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of MedicineCentral South University Luoshan Center for Disease Control and Prevention office for Cancer Control and Research Affiliated Cancer Hospital of Harbin Medical University

Surveillance recommendations for gastric cancer（GC） in current guidelines focused on advanced precancerous lesions and were based on precise diagnosis of severity/extent of baseline lesions. We aimed to develop a less endoscopy-related equipment-dependent risk-stratification tool, and assessed whether mild-precursor-lesion patients can be safely exempt from surveillance. In the multicenter communitybased cohort, 75,051 participants receiving baseline endoscopy were enrolled during 2015–2017 and followed-up until 2021. Cumulative incidence rates（CIRs） of GC for precancerous-conditions were calculated by Kaplan-Meier method and compared by Log-rank tests. Mixedeffects Cox regression models were used to detect potential factors for progression towards GC. A risk score was calculated as counts of selected factors. An independent cohort, including 26,586 participants was used for external validation. During a median follow-up of 6.25 years, CIRs of GC were 0.302%, 0.436%, and 4.756% for normal group, non-neoplastic（atrophic gastritis/intestinal metaplasia） and neoplastic lesions（low-grade/high-grade dysplasia）, respectively(Ptrend<0.001). Four predictors, including male, ≥60 years, smoking, and limited vegetable consumption, were selected for risk-stratification. High-risk patients（≥3 risk factors） with non-neoplastic lesions showed higher GC risks（adjusted HR=7.73, 95%CI: 4.29–13.92）, and their four-year CIR reached the one-year CIR of neoplastic lesions. Further categorizing non-neoplastic lesions by histological grade, both patients with moderate-to-severe lesions（aHR=3.07, 95%CI: 1.67–5.64） and high-risk patients with mild lesions（aHR=7.29, 95%CI: 3.58–14.86） showed higher risks. Consistent trends were observed in validation cohort. High-risk mild-precursor-lesion patients should receive surveillance within 3–5 years after baseline screening. Our study provides evidence on supplementing current guideline recommendations.

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A note from the Editorial office

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Chinese Science Bulletin 2011年第1期56卷 1-2页

作者： AN Rui, Ph.D. Executive director Editorial Office of Chinese Science Bulletin

从编辑部的编辑 A

关键词：编辑部编辑委员会公务员杂志科学

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The Role of Toxicology in Evaluating Marketing Applications for Prescription Drug Products in the United States

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毒理学杂志 2005年第A3期19卷 169-170页

作者： Kenneth L Hastings P.H. D.A.B.T. Associate director Office of New Drugs Center for Drug Evaluation and Research US Food and Drug Administration Associate Director Office of New Drugs Center for Drug Evaluation and Research US Food and Drug Administration Dr.Associate Director Office of New Drugs Center for Drug Evaluation and Research US Food and Drug Administration

In the United States, in order to market a prescription drug product studies need to be conducted to demonstrate safety and efficacy.

关键词：毒物学临床应用处方药代谢产物

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The Role of Toxicology in Evaluating Marketing Applications for Prescription Drug Products in the United States

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毒理学杂志 2005年第S1期 169-170页

作者： Kenneth L Hastings,P.H.,D.A.B.T. Associate director office of New Drugs Center for Drug Evaluation and Research US Food and Drug Administration Associate director office of New Drugs Center for Drug Evaluation and Research US Food and Drug Administration Dr. Associate director office of New Drugs Center for Drug Evaluation and Research US Food and Drug Administration

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IMPAIRED MEDICAL PROFESSIONALS IN THE UNITED STATES

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中国临床药理学杂志 1990年第1期 3-12页

作者： Yng-Shiuh SHEU Medical and International Affairs office of the director National Institute on Drug Abuse U.S.A Ph.D.

Drug Addiction Historically, drug addiction consists of psychologicaldependence, tolerance, and physical dependence. All three could be demon-strated as concurrent manifestations. It can also be a state of "An over-wh... 详细信息

关键词： IMPAIRED MEDICAL PROFESSIONALS IN THE UNITED STATES than

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Intestinal microbiota in various animals

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Integrative Zoology 2022年第3期17卷 331-332页

作者： Wenhua XIONG Executive Editor Integrative ZoologySenior EngineerInstitute of ZoologyChinese Academy of SciencesChinaand Executive DirectorOffice of the International Society of Zoological Sciences

Research on animal intestinal microbiota is one of the most cutting-edge topics in current zoological *** addition to getting involved in host animals’physiological functions or behaviors(Aagaard et al.2014;Woting&Blaut 2016;Schretter et al.2018;Dang&Marsland 2019),the gut microbiome has been shown to influence the relation between the hosts and their neighboring species,which would eventually affect the host’s fitness and evolution positively or negatively(Douglas 2015;Sherwin et al.2019;Xu et al.2019;Groussin et al.2020;Jang&Kikuchi 2020).

关键词： eventually neighboring

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Foster innovation and facilitate publications for zoology

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Integrative Zoology 2023年第3期18卷 397-398页

作者： Wenhua XIONG Associate Editor Integrative Zoology Senior EngineerInstitute of ZoologyChinese Academy of SciencesChina Executive DirectorOffice of the International Society of Zoological Sciences

Integrative Zoology(INZ)is the official journal of the International Society of Zoological Sciences(ISZS).The journal has made some remarkable gains in the past *** Impact Factor increases steadily and ranks top 25%in Journal Citation Reports(JCR)’s zoological journals for 7 *** journal has rallied zoologists from more than 80 *** number of submission and publication has almost doubled from 2020 to *** total downloads via Wiley Online Library increased 52.9%from 2020 to 2021,with a global *** the past year,6687 institutions offered access to our journal via Wiley license.

关键词： journal Foster doubled

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The promising role of poly（ADP-ribose） polymerase inhibitors in prostate cancer

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Asian Journal of Andrology 2016年第4期18卷 592-593页

作者： Jeanny B Aragon-Ching clinical Program director of Genitourinary Cancers INOVA Schar Cancer Institute 8505 Arlington Bird Suite 100 Faiffax VA USA

The TOPARP study showed the beneficial utility of olaparib in a heavily pretreatedpopulation of metastatic castration-resistant prostate cancer who were biomarker-positive for aberrations in DNA repair gene. A higher response rate to olaparib of 88% （14 out of 16 patients）, time to radiographic progression as well as overall survival, was seen in patients who were biomarker-positive compared to those who were not. This study showed a promising way of targeting prostate cancer with an enriched population of patients who harbor these deleterious genes. this paves the way for offering new therapeutic opportunities for men who have otherwise few remaining options.

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Use of early chemotherapy for hormone-sensitive prostate cancer： time for CHAARTED

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Asian Journal of Andrology 2016年第3期18卷 444-445页

作者： Jeanny B Aragon-Ching clinical Program director of Genitourinary Cancers INOVA Dwight and Martha gchar Cancer Institute8505 Arlington Boulevard Suite 100 Pairfax VAUSA.

CHAARTED was an ECOG-led phase III trial looking at early chemotherapy with the use of docetaxel in addition to androgen deprivation therapy （ADT） versus ADT alone in hormone-sensitive prostate cancer. The positive results of the trial showing marked improvement in overall survival in those who received chemotherapy with ADT have revolutionized the treatment of metastatic castration-sensitive prostate cancer.

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THE HEDGEHOG DILEMMA IN THE COURT-MEDIA RELATIONSHIP IN CHINA

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Frontiers of Law in China-Selected Publications from Chinese Universities 2014年第2期9卷 174-185页

作者： JIANG Huiling University of Montreal Canada Senior Judge and Deputy director-General of Judicial Reform office at the Supreme People's Court China

This paper explains why Schopenhauer＇s ＂Hedgehog Dilemma＂ may be the most apposite metaphor for the relationship between the courts and the media. Whatever they get from each other, the media＇s role representing the public and the court＇s role representing justice are both essential to modern democracy. Therefore, their relationship has attracted attention, not just in legal and media professions, but also in public and government debate. In the last two decades, China ＇s highest court has issued judicial interpretations and guidelines to regulate the activities of the media and the court, which has brought the topic to a new level of discussion. As a drafter of these official documents, the author will comment on development in this field and their interaction with values inherent to democracy.

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