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Advances in the treatment of autism spectrum disorder:Wharton jelly mesenchymal stem cell transplantation

World Journal of Methodology 2025年第1期15卷 72-79页

作者： Serdar Kabatas ErdinçCivelek Eyüp Can Savrunlu Umut Karaaslan Özlem Yıldız Erdal Karaöz Department of Neurosurgery University of Health Sciences TurkeyGaziosmanpaşa Training and Research HospitalIstanbul 34255Türkiye Department of Pediatric Allergy-Immunology Institute of Health Sciences Marmara UniversityIstanbul 34865Türkiye Center for Stem Cell&Gene Therapy research and Practice University of Health Sciences TurkeyIstanbul 34255Türkiye Department of Child and Adolescent Psychiatry University of Health SciencesGaziosmanpaşa Training and Research HospitalIstanbul 34255Türkiye Department of Child and Adolescent Psychiatry Kocaeli University Faculty of MedicineKocaeli 41001Türkiye Center for Regenerative Medicine and Stem Cell research&Manufacturing Liv HospitalIstanbul 34340Türkiye Department of Histology and Embryology Istinye UniversityFaculty of MedicineIstanbul 34010Türkiye Center for Stem Cell and Tissue Engineering research and Practice Istinye UniversityIstanbul 34340Türkiye

BACKGROUND Autism spectrum disorder(ASD)is a complex neurodevelopmental disorder with multifaceted *** recent studies,neuroinflammation and immune dysregulation have come to the forefront in its *** are studies suggesting that stem cell therapy may be effective in the treatment of *** To evolve the landscape of ASD treatment,focusing on the potential benefits and safety of stem cell *** A detailed case report is presented,displaying the positive outcomes observed in a child who underwent intrathecal and intravenous Wharton’s jelly-derived mesenchymal stem cells(WJ-MSCs)transplantation combined with *** The study demonstrates a significant improvement in the child’s functional outcomes(Childhood Autism Rating Scale,Denver 2 Developmental Screening Test),especially in language and gross motor *** serious side effects were encountered during the 2-year *** The findings support the safety and effectiveness of WJ-MSC transplantation in managing ASD.

关键词： Autism spectrum disorder Neurorehabilitation Stem cell transplantation Wharton jelly mesenchymal stem cells Inflammation

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Anterior mediastinal masses and thymic cysts

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World Journal of Clinical Cases 2025年第4期13卷 1-7页

作者： ÖnerÖzdemir Department of Pediatric Allergy and Immunology Sakarya Research and Training HospitalSakarya University Medical FacultyAdapazarı54100SakaryaTürkiye

Cystic lesions of the anterior mediastinum in children suggest a well-known group of benign lesions that are comparatively *** cysts(TCs)are mostly positioned in the anterior mediastinum and some patients in the *** TCs classified as congenital intra-thoracic mesothelial cysts are commonly asymptomatic and have slight clinical *** TC,which can mimic another anterior mediastinal cystic tumor and is seen in adults,is more clinically *** is a sporadic mediastinal lesion thought to arise in the course of acquired *** mediastinal cysts represent 3%-6%of all mediastinal tumors and 10%-18%of radiologically reported mediastinal *** TCs are uncommon and it is hard to know their true *** 60%of cases with mediastinal TCs are asymptomatic,and the remainder of patients complains of nonspecific symptoms(e.g.,chest pain,dyspnea,or cough).The literature suggests that most cysts are benign,but an indefinite percentage may have a neoplastic process and result in significant compressive symptoms over *** symptoms of TCs vary depending on the *** addition,frequent symptoms at the appearance of enlarged benign thymic and mediastinal cysts generally contain compressive symptoms(e.g.,respiratory distress,thymic pain,and symptoms related to Horner syndrome,hoarseness,dysphonia,dyspnea,orthopnea,wheezing,and fever).Many TCs have cystic density and a neat border and are simple to diagnose with radiological ***,some TCs are hard to identify before surgery and may be misidentified as thymomas depending on their site and computed tomography *** by thoracotomy,median sternotomy,or video-assisted techniques is essential for conclusive diagnosis,management,and abolition of relapse of anterior mediastinal masses and *** examination may be required after *** the extent of the mass and the preliminary inability to make a definitiv

关键词： Mediastinal mass Thymic cyst Malignant tumor Cysts Thymoma Computer tomography

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A functional tacrolimus-releasing nerve wrap for enhancing nerve regeneration following surgical nerve repair

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Neural Regeneration research 2025年第1期20卷 291-304页

作者： Simeon C.Daeschler Katelyn J.W.So Konstantin Feinberg Marina Manoraj Jenny Cheung Jennifer Zhang Kaveh Mirmoeini JPaul Santerre Tessa Gordon Gregory HBorschel SickKids research Institute Neuroscience and Mental Health ProgramTorontoONCanada Institute of Biomaterials and Biomedical Engineering University of TorontoTorontoONCanada Indiana University School of Medicine IndianapolisINUSA Division of Plastic and Reconstructive Surgery the Hospital for Sick ChildrenTorontoONCanada Translational Biology and Engineering Program Ted Rogers Centre for Heart ResearchInstitute of Biomedical EngineeringFaculty of DentistryUniversity of TorontoTorontoONCanada

Axonal regeneration following surgical nerve repair is slow and often incomplete,resulting in poor functional recovery which sometimes contributes to lifelong ***,there are no FDA-approved therapies available to promote nerve *** accelerates axonal regeneration,but systemic side effects presently outweigh its potential benefits for peripheral nerve *** authors describe herein a biodegradable polyurethane-based drug delivery system for the sustained local release of tacrolimus at the nerve repair site,with suitable properties for scalable production and clinical application,aiming to promote nerve regeneration and functional recovery with minimal systemic drug *** is encapsulated into co-axially electrospun polycarbonate-urethane nanofibers to generate an implantable nerve wrap that releases therapeutic doses of bioactive tacrolimus over 31 *** and drug loading are adjustable for applications in small and large caliber nerves,and the wrap degrades within 120 days into biocompatible *** released from the nerve wrap promotes axon elongation in vitro and accelerates nerve regeneration and functional recovery in preclinical nerve repair models while off-target systemic drug exposure is reduced by 80%compared with systemic *** its surgical suitability and preclinical efficacy and safety,this system may provide a readily translatable approach to support axonal regeneration and recovery in patients undergoing nerve surgery.

关键词： biodegradable local drug delivery nerve injury nerve regeneration nerve wrap tacrolimus

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Effects of fentanyl and sucrose on pain in retinopathy examinations with pain scale,near-infrared spectroscopy,and ultrasonography:a randomized trial

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World Journal of Pediatrics 2023年第9期19卷 873-882页

作者： Nursu Kara Didem Arman Zeynep Seymen Adem Gül Serdar Cömert Department of Pediatrics Division of NeonatologyUniversity of Health Sciences Istanbul Research and Training HospitalIstanbulTurkey Department of Opthalmology University of Health Sciences Istanbul Research and Training HospitalIstanbulTurkey

Background This study aimed to compare the efficacy of intravenous,intranasal fentanyl and oral sucrose in reducing the pain response during retinopathy of prematurity examinations using premature infant pain profile(PIPP)*** The study included 42 infants who underwent retinopathy screening *** infants were divided into three groups:oral sucrose,intranasal fentanyl,and intravenous *** signs(heart rate,arterial oxygen saturation,and mean arterial pressure)were *** PIPP was used to determine pain *** oxygenation and middle cerebral artery blood flow were evaluated using near-infrared spectroscopy and Doppler ultrasonography,*** data obtained were compared between *** There was no significant difference between the three groups regarding postconceptional and postnatal ages or birth weights and weight at the time of *** babies had moderate pain during the *** correlation was observed between analgesia method and pain scores(P=0.159).In all three groups,heart rate and mean arterial pressure increased,whereas oxygen saturation decreased during the exam compared with pre-examination ***,heart rate(HR),mean arterial pressure(MAP)and arterial oxygen saturation(sPO2)values did not differ between groups(HR,P=0.150;MAP,P=0.245;sPO2,P=0.140).The cerebral oxygenation(rSO2)values between the three groups were found to be similar[rSO2:P=0.545,P=0.247,P=0.803;fractional tissue oxygen extraction(FTOE):P=0.553,P=0.278].Regarding cerebral blood flow values,we also did not find any difference between the three groups[mean blood flow velocity(Vmean):P=0.569,P=0.975;maximum flow velocity(Vmax):P=0.820,P=0.997].Conclusions Intravenous and intranasal fentanyl and oral sucrose were not superior to each other in preventing pain during the examination for retinopathy of prematurity(ROP).Sucrose may be a good alternative for pain control during ROP *** findings suggest

关键词： Analgesia Cerebral blood flow Cerebral oxygenation Neonate Retinopathy of prematurity

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Investigation of corneal topographic and densitometric properties of Wilson's disease patients with or without a Kayser-Fleischer ring

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Eye and Vision 2021年第2期8卷 67-74页

作者： Mehmet Fuat Alakus Mehtap Caglayan Nazım Ekin Hasan Oncul Esref Arac Umut Dag Halit Diri Department of Ophthalmology University of Health SciencesDiyarbakir Gazi Yasargil Research and Training HospitalDiyarbakırTurkey Department of Internal Medicine University of Health SciencesDiyarbakir Gazi Yasargil Research and Training HospitalDiyarbakırTurkey

Background:To investigate the topographic measurements and densitometry of corneas in Wilson’s disease(WD)patients with or without a Kayser-Fleischer ring(KF-r)compared to healthy ***:This cross-sectional study included 20 WD patients without a KF-r(group I),18 WD patients with a KF-r(group II),and 20 age-matched controls(group III).The Pentacam high resolution imaging system is used to determine corneal topographic measurements and ***:Mean age for groups I,II and III was 25.40±6.43 years(14-36 years),25.38±6.96 years(16-39 years),23.60±6.56 years(17-35 years),respectively(P=0.623).There was no significant difference between the groups in terms of the anterior corneal densitometry values(P>0.05),while the 6-10mm and 10-12 mm mid stroma and the 2-6 mm,6-10 mm,and 10-12 mm posterior corneal densitometry values in group II were significantly higher than those in groups I and III(for all values,P<0.05).However,the 10-12mm posterior corneal densitometry values in group I were also significantly higher than those in group III(P=0.038).The central corneal thickness(CCT),thinnest corneal thickness(tCT),and corneal volume(CV)values in groups I and II were significantly lower than those in group III(for CCT values,P=0.011 and P=0.009;for tCT values,P=0.010 and P=0.005;for CV values,P=0.043 and P=0.029).Conclusion:In WD patients with a KF-r,corneal transparency decreased in the peripheral posterior and mid stromal corneal layers;for these patients,corneal transparency may be impaired not only in the peripheral cornea but also in the paracentral cornea.

关键词： Wilson Kayser-Fleischer ring Corneal densitometry

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Changes in human hepatic metabolism in steatosis and cirrhosis

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World Journal of Gastroenterology 2017年第15期23卷 2685-2695页

作者： Zoe Schofield Michelle AC Reed Philip N Newsome David H Adams Ulrich L Günther Patricia F Lalor Sci-Phy-4-health EPSRC Research and Training Centre in Physical Sciences for HealthCollege of Engineering and Physical Sciences School of Cancer Sciences at the University of Birmingham Centre for Liver research and National Institute for health research(NIHR)Birmingham Liver Biomedical research unit 不详

AIMTo understand the underlying metabolic changes in human liver disease we have applied nuclear magnetic resonance (NMR) metabolomics analysis to human liver *** have carried out pilot study using 1H-NMR to derive metabolomic signatures from human liver from patients with steatosis, nonalcoholic steatohepatitis (NASH) or alcohol-related liver damage (ARLD) to identify species that can predict outcome and discriminate between alcohol and metabolic-induced liver *** in branched chain amino acid homeostasis, tricarboxylic acid cycle and purine biosynthesis intermediates along with betaine were associated with the development of cirrhosis in both ARLD and nonalcoholic fatty liver disease. Species such as propylene glycol and as yet unidentified moieties that allowed discrimination between NASH and ARLD samples were also detected using our *** high throughput, non-destructive technique for multiple analyte quantification in human liver specimens has potential for identification of biomarkers with prognostic and diagnostic significance.

关键词： Human Liver Metabolomics Steatosis Nuclear magnetic resonance Alcohol

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Benefits of using an endotracheal tube introducer as an adjunct to a Macintosh laryngoscope for endotracheal intubation performed by inexperienced doctors during mechanical CPR:A randomized prospective crossover study

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World Journal of Emergency Medicine 2019年第3期10卷 182-186页

作者： Hüseyin Cahit Halhalli As?m Enes ?zbek Emrah ?el?k Yavuz Y???t Serkan Yilmaz Müge ?ardak Department of Emergency Medicine University of Health SciencesKocaeli Derince Training and Research Hospital

Dear editor, Out-of-hospital cardiac arrest survival rates vary between 7% and 46% and are lower than those for inhospital cardiac arrests (IHCA).[1,2] Therefore, efforts are being made to increase survival rates for out-ofhospital cardiac arrests (OHCA). According to advanced cardiac life support (ACLS) guidelines, out-of-hospital cardiac arrest survival rates may be increased by performing cardiopulmonary resuscitation (CPR) with minimal interruptions.[3] According to the latest ACLS, does the patient need an advanced airway.

关键词： Out-of-hospital cardiac inhospital cardiac advanced cardiac life support

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A 99-year old patient with takotsubo cardiomyopathy recovering from cardiogenic shock

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Journal of Geriatric Cardiology 2019年第7期16卷 578-579页

作者： Mustafa Yenercag Ugur Arslan Güney Erdogan Onur Osman Seker Osman Can Yontar Department of Cardiology University of Health Sciences Samsun Training and Research Hospital

Takotsubo syndrome(TTS)is a rare clinical entity commonly seen in post-menopausal women after an emotional or sometimes physical stress.[1,2]This syndrome is thought to be caused by increased circulation catecholamine levels secondary to an adrenergic stimulus resulting in transient coronary spasm and microvascular dysfunction.[3]TTS is characterized by acute and reversible left ventricular dysfunction with the typical ECG and clinical findings of an acute coronary syndrome but no significant coronary stenosis.[4]Typically,in TTS,antero-apical ballooning is observed in ventriculography,and segmentary wall motion abnormalities are observed in magnetic resonance imaging and *** heart failure,left ventricular outflow tract obstruction,mitral regurgitation and cardiogenic shock may complicate this syndrome.[5]Herein,we present a case who is the oldest one in the literature with TTS and cardiogenic shock.

关键词： Apical ballooning Levosimendan Takotsubo cardiomyopathy

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Evaluation of carotid intima-media thickness and carotid arterial stiffness in children with adenotonsillar hypertrophy

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World Journal of Pediatrics 2016年第1期12卷 103-108页

作者： MuratÇiftel Berrin Demir Günay Kozan Osman Yılmaz Hasan Kahveci Ömer Kılıç Department of Pediatric Cardiology Erzurum Training and Research HospitalErzurumTurkey Department of Radiology Erzurum Training and Research HospitalErzurumTurkey Department of Ear Noseand ThroatErzurum Training and Research HospitalErzurumTurkey Neonatal unit Erzurum Training and Research HospitalErzurumTurkey Department of Pediatric Infectious Diseases Erzurum Training and Research HospitalErzurumTurkey

Background:Adenotonsillar hypertrophy can produce cardiopulmonary disease in ***,it is unclear whether adenotonsillar hypertrophy causes *** study evaluated carotid intimamedia thickness and carotid arterial stiffness in children with adenotonsillar ***:The study included 40 children with adenotonsillar hypertrophy(age:5-10 years)and 36 healthy children with similar age and body mass *** blood pressure,diastolic blood pressure,and pulse pressure were measured in all *** intima-media thickness,carotid arterial systolic diameter,and carotid arterial diastolic diameter were measured using a high-resolution ultrasound *** on these measurements,carotid arterial strain,carotid artery distensibility,beta stiffness index,and elasticity modulus were ***:Carotid intima-media thickness was greater in children with adenotonsillar hypertrophy(0.36±0.05 mm vs.0.34±0.04 mm,P=0.02)compared to healthy *** stiffness index(3.01±1.22 vs.2.98±0.98,P=0.85),elasticity modulus(231.39±99.23 vs.226.46±83.20,P=0.88),carotid arterial strain(0.17±0.06 vs.0.17±0.04,P=0.95),and carotid artery distensibility(13.14±3.88 vs.12.92±3.84,P=0.75)were similar between children with adenotonsillar hypertrophy and the healthy ***:The present study revealed increased carotid intima-media thickness in children with adenotonsillar *** risk of subclinical atherosclerosis may be higher in children with adenotonsillar hypertrophy.

关键词： adenotonsillar hypertrophy carotid artery stiffness carotid intima media thickness subclinical atherosclerosis

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Carbon Monoxide and Respiratory Disorders in Professional Female Fish Smokers at 2 Artisanal Sites in Benin

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occupational Diseases and Environmental Medicine 2023年第4期11卷 175-186页

作者： Mênonli Adjobimey Ibrahim Mama Cissé Fintani Kaki Mariano Steven Sagbohan Perside Fabien Gounongbe Rose Mikponhoue Ayélo Paul Vikkey Hinson research and Teaching unit in occupational and Environmental health FSS Cotonou Cotonou Benin occupational health Service of the National University Hospital of Pneumo-Phtisiology of Cotonou Cotonou Benin Faculty of Medicine Occupational Health Training and Research Unit Parakou Benin Inter-Faculty Centre for Environmental training and research for Sustainable Development University of Abomey-Calavi Abomey Calavi Benin

Introduction: The use of biomass for cooking is a very common practice in Africa and Benin, and is associated with exposure to organic pollutants. The aim of this study was to assess carbon monoxide exposure and respiratory disorders in women at artisanal fish-smoking sites. Methods: This was a cross-sectional study of women fish smokers at two artisanal fish-smoking sites in Benin. Recruitment was exhaustive. An interview using a respiratory questionnaire inspired by the Union questionnaire, spirometry and carbon monoxide (CO) measurement were carried out. Descriptive analysis and comparison of means using Student’s t-test with a threshold of p = 0.05 were performed. Results: The median age of the 81 people surveyed was 40, with an interquartile range (IQT) of [25 to 75]. The median duration of daily exposure to smoke was 6 h IQT [4, 7]. Of those surveyed, 64 (79.01%) were illiterate and 39 (48.24%) had been working for 20 years. CO levels at the start of activity varied from 89 to 145 ppm in one case and from 40 to 89 ppm in the other. Respiratory symptoms were present in 19 (23.46%);18 (22.22%) had mild airway impairment on spirometry. There was a statistically significant decrease between the mean values of peak expiratory flow (PEF), mean expiratory volume in seconds (FEV1) and forced vital capacity (FVC) before and after exposure to smoke. Conclusion: CO levels are high on fish smoking sites and respiratory problems are common. Improved working conditions are important for these women.

关键词： Respiratory Symptoms Spirometry Carbon Monoxide Fish Smoking Women

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