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Revealing the role of honokiol in human glioma cells by RNA-seq analysis

BIOCELL 2024年第6期48卷 945-958页

作者： YUNBAO GUO XU LIU QI XU XIAOTONG ZHOU JIAWEI LIU YANYAN XU YAN LU HAIYAN LIU The Department of Neurosurgery First Hospital of Jilin UniversityChangchun130021China The Department of Anatomy College of Basic Medical SciencesJilin UniversityChangchun130021China The Third College of Clinical Medicine Jilin UniversityChangchun130021China

Background:Glioma is a kind of tumor that easily deteriorates and originates from glial cells in nerve *** is a bisphenol compound that is an essential monomeric compound extracted from the roots and bark of Magnoliaceae *** also has anti-infection,antitumor,and immunomodulatory *** this study,we found that honokiol induces cell apoptosis in the human glioma cell lines U87-MG and ***,the mechanism through which honokiol regulates glioma cell apoptosis is still ***:We performed RNA-seq analysis of U251-MG cells treated with honokiol and control ***-protein interaction(PPI)network analysis was performed,and the 10 top hub unigenes were examined via real-time quantitative ***,MAPK signaling and ferroptosis were detected via western ***:332 differentially expressed genes(DEGs)were found,comprising 163 increased and 169 decreased *** of the DEGs revealed that various biological processes were enriched,including‘response to hypoxia’,‘cerebellum development cellular response to hypoxia,’‘iron ion binding,’‘oxygen transporter activity,’‘oxygen binding,’‘ferric iron binding,’and‘structural constituent of cytoskeleton.’Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway analysis revealed that the DEGs were enriched in the following pathways:‘mitogen-activated protein kinases(MAPK)’,‘Hypoxia-inducible factor 1(HIF-1)’,‘ferroptosis,’‘Peroxisome proliferator-activated receptor(PPAR),’‘Phosphatidylinositol-4,5-bisphosphate 3-kinase(PI3K)-protein kinase B(Akt),’and‘phagosome.’Among these pathways,the MAPK signaling pathway and ferroptosis were veriﬁ***:This study revealed the potential mechanism by which honokiol induces apoptosis and provided a comprehensive analysis of DEGs in honokiol-treated U251-MG cells and the associated signaling *** data could lead to new ideas for future research and therapy for patients with glioma.

关键词： Human glioma Honokiol RNA-seq Apoptosis Ferroptosis MAPK

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The KAM theorem on the modulus of continuity about parameters

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Science China Mathematics 2024年第3期67卷 577-592页

作者： Zhicheng Tong Jiayin Du Yong Li School of Mathematics Jilin UniversityChangchun 130012China Institute of Mathematics Jilin UniversityChangchun 130012China School of Mathematics and Statistics Center for Mathematics and Interdisciplinary SciencesNortheast Normal UniversityChangchun 130024China

In this paper,we study the Hamiltonian systems H(y,x,ξ,ε)=〈ω(ξ),y〉+εP(y,x,ξ,ε),where ω and P are continuous about ξ.We prove that persistent invariant tori possess the same frequency as the unperturbed tori,under a certain transversality condition and a weak convexity condition for the frequency mapping ω.As a direct application,we prove a Kolmogorov-Arnold-Moser(KAM) theorem when the perturbation P holds arbitrary Holder continuity with respect to the parameter ξ.The infinite-dimensional case is also *** our knowledge,this is the first approach to the systems with the only continuity in the parameter beyond H?lder's type.

关键词： Hamiltonian systems invariant tori frequency-preserving weak regularity

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A reduced combustion mechanism of ammonia/diesel optimized with multi-objective genetic algorithm

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Defence Technology（防务技术） 2024年第4期34卷 187-200页

作者： Wanchen Sun Shaodian Lin Hao Zhang Liang Guo Wenpeng Zeng Genan Zhu Mengqi Jiang State Key Laboratory of Automotive Simulation and Control Jilin UniversityChangchun 130025China

For the deep understanding on combustion of ammonia/diesel,this study develops a reduced mechanism of ammonia/diesel with 227 species and 937 *** sub-mechanism on ammonia/interactions of N-based and C-based species(N—C)/NOx is optimized using the Non-dominated Sorting Genetic Algorithm II(NSGA-II)with 200 *** optimized mechanism(named as 937b)is validated against combustion characteristics of ammonia/methane(which is used to examine the accuracy of N—C interactions)and ammonia/diesel *** ignition delay times(IDTs),the laminar flame speeds and most of key intermediate species during the combustion of ammonia/methane blends can be accurately simulated by 937b under a wide range of *** for ammonia/diesel blends with various diesel energy fractions,reasonable predictions on the IDTs under pressures from 1.0 MPa to5.0 MPa as well as the laminar flame speeds are also achieved by *** particular,with regard to the IDT simulations of ammonia/diesel blends,937b makes progress in both aspects of overall accuracy and computational efficiency,compared to a detailed ammonia/diesel *** kinetic analysis reveals that the reaction pathway of ammonia during the combustion of ammonia/diesel blend mainly differs in the tendencies of oxygen additions to NH_2 and NH with different equivalence ratios.

关键词： Ammonia Diesel Combustion Kinetic mechanism Multi-objective optimization

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Exploration of the Path of Intelligent Development of Continuing Education in the Digital Age

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Journal of Contemporary Educational Research 2024年第8期8卷 8-13页

作者： Ronghan Bao jilin province Continuing Education Center Changchun 130022Jilin ProvinceChina

With the rapid development of big data and intelligent technology,opportunities and challenges coexist in continuing education work,and the integration of continuing education and intelligent education is ***,China’s continuing education should strengthen the construction of the education system,make long-term plans,strengthen overall management in system construction,promote the transformation of continuing education models,and accelerate the modernization process of *** on this,this article analyzes and studies the path of intelligent development of continuing education in the digital era,explores its inevitability,analyzes the main characteristics of intelligent continuing education,explores the problems of intelligent development of continuing education,and proposes strategies for the intelligent development of continuing education.

关键词： Digital age Continuing education Intelligence Modernization Integrated management

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A Selective‑Response Hypersensitive Bio‑Inspired Strain Sensor Enabled by Hysteresis Effect and Parallel Through‑Slits Structures

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Nano-Micro Letters 2024年第2期16卷 139-153页

作者： Qun Wang Zhongwen Yao Changchao Zhang Honglie Song Hanliang Ding Bo Li Shichao Niu Xinguan Huang Chuanhai Chen Zhiwu Han Luquan Ren Key Laboratory of Bionic Engineering(Ministry of Education) Jilin UniversityChangchunJilin 130022People’s Republic of China Liaoning Academy of Materials LiaoningShenyang 110167People’s Republic of China Key Laboratory of CNC Equipment Reliability(Ministry of Education) Jilin UniversityChangchunJilin 130022People’s Republic of China

Flexible strain sensors are promising in sensing minuscule mechanical signals,and thereby widely used in various advanced ***,the effective integration of hypersensitivity and highly selective response into one flexible strain sensor remains a huge ***,inspired by the hysteresis strategy of the scorpion slit receptor,a bio-inspired flexible strain sensor(BFSS)with parallel through-slit arrays is designed and ***,BFSS consists of conductive monolayer graphene and viscoelastic styrene–isoprene–styrene block *** the synergistic effect of the bio-inspired slit structures and flexible viscoelastic materials,BFSS can achieve both hypersensitivity and highly selective frequency ***,the BFSS exhibits a high gage factor of 657.36,and a precise identification of vibration frequencies at a resolution of 0.2 Hz through undergoing different morphological changes to high-frequency vibration and low-frequency ***,the BFSS possesses a wide frequency detection range(103 Hz)and stable durability(1000 cycles).It can sense and recognize vibration signals with different characteristics,including the frequency,amplitude,and *** work,which turns the hysteresis effect into a"treasure,"can provide new design ideas for sensors for potential applications including human–computer interaction and health monitoring of mechanical equipment.

关键词： Bio-inspired strain sensors Hysteresis effect Hypersensitivity Selective frequency response Health monitoring applications

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Graphene enables equiatomic FeNiCrCoCu high-entropy alloy with improved TWIP and TRIP effects under shock compression

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Journal of Materials Science & Technology 2024年第3期170卷 186-199页

作者： Hongcai Xie Zhichao Ma Wei Zhang Hongwei Zhao Luquan Ren School of Mechanical and Aerospace Engineering Jilin UniversityChangchun 130025China Key Laboratory of CNC Equipment Reliability Ministry of Education Jilin UniversityChangchun 130025China Key Laboratory of Bionic Engineering Ministry of Education Jilin UniversityChangchun 130025China Weihai Institute for Bionics-jilin University Weihai 264400China Institute of Structured and Architected Materials Liaoning Academy of MaterialsShenyang 110167China

Graphene(Gr)reinforced high-entropy alloy(HEA)matrix composites are expected as potential candidates for next-generation structural applications in light of outstanding mechanical properties.A deep comprehension of the underlying deformation mechanisms under extreme shock loading is of paramount importance,however,remains lacking due to experimentally technical limitations in *** the present study,by means of nonequilibrium molecular dynamics simulations,dynamic deformation behaviors and corresponding mechanisms in equiatomic FeNiCrCoCu HEA/Gr composite systems were investigated in terms of various shock *** resistance to dislocation propagation imparted by Gr was corroborated to encourage the elevated local stress level by increasing the likelihood of dislocation interplays,which facilitated the onset of twins and hexagonal close-packed(HCP)martensite ***,the advent of Gr was demonstrated to endow the HEA with an additional twinning pathway that induced a structural conversion from HCP to parent face-centered cubic(FCC)inside HCP martensite laths,different from the classical one that necessitated undergoing the intermediate procedure of extrinsic stacking fault(ESF)*** than that,by virtue of an increase in flow stress,the transformation-induced plasticity(TRIP)effect was validated to be additionally evoked as the predominant strain accommodation mechanism at higher strains on the one hand,but which only assisted plasticity in pure systems,and on the other hand,can also act as an auxiliary regulation mode together with the twinning-induced plasticity(TWIP)effect under intermediate strains,but with enhanced contributions relative to pure *** may expect that TRIP and TWIP effects promoted by introducing Gr would considerably inspire a synergistic effect between strength and ductility,contributing to the exceptional shock-resistant performance of FeNiCrCoCu HEAs under extreme regimes.

关键词： Molecular dynamics High-entropy alloy Graphene TRIP TWIP Shock

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Simultaneous photocatalytic degradation and SERS detection of tetracycline with self-sustainable and recyclable ternary PI/TiO_(2)/Ag flexible microfibers

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Microsystems & Nanoengineering 2024年第2期10卷 101-113页

作者： Donglai Han Boyang Guo Yanru Li Wei Feng Keyan Liu Tianna Wu Yuchun Wan Lili Wang Ming Gao Yang Liu Lili Yang Maobin Wei Shuo Yang School of Materials Science and Engineering Changchun University of Science and Technology130022ChangchunChina College of Science Changchun University130022ChangchunChina Key Laboratory of Functional Materials Physics and Chemistry of the Ministry of Education Jilin Normal University130103ChangchunChina

Facile and efficient photocatalysts using sunlight,as well as fast and sensitive surface-enhanced Raman spectroscopy(SERS)substrates,are urgently needed for practical degradation of tetracycline(TC).To meet these requirements,a new paradigm for PI/TiO_(2)/Ag organic‒inorganic ternary flexible microfibers based on semiconducting titanium dioxide(TiO_(2)),the noble metal silver(Ag)and the conjugated polymer polyimide(PI)was developed by engineering a simple *** sunlight,the photocatalytic characteristics of the PI/TiO_(2)/Ag flexible microfibers containing varying amounts of Ag quantum dots(QDs)were evaluated with photocatalytic degradation of TC in aqueous *** results demonstrated that the amount of Ag affected the photocatalytic *** the tested samples,PI/TiO_(2)/Ag-0.07(93.1%)exhibited a higher photocatalytic degradation rate than PI/TiO_(2)(25.7%),PI/TiO_(2)/Ag-0.05(77.7%),and PI/TiO_(2)/Ag-0.09(63.3%).This observation and evaluation conducted in the present work strongly indicated a charge transfer ***,the PI/TiO_(2)/Ag-0.07 flexible microfibers exhibited highly sensitive SERS detection,as demonstrated by the observation of the Raman peaks for TC even at an extremely low concentration of 10–10 moles per *** excellent photocatalytic performance and SERS detection capability of the PI/TiO_(2)/Ag flexible microfibers arose from the Schottky barrier formed between Ag and TiO_(2)and also from the outstanding plasmonic resonance and visible light absorptivity of Ag,along with immobilization by the *** successful synthesis of PI/TiO_(2)/Ag flexible microfibers holds significant promise for sensitive detection and efficient photocatalytic degradation of antibiotics.

关键词： mechanism. photocatalytic ternary

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B cell development and antibody responses in human immune system mice:current status and future perspective

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Science China(Life Sciences) 2024年第4期67卷 645-652页

作者： Tao Zhang Wentao Liu Yong-Guang Yang Key Laboratory of Organ Regeneration&Transplantation of the Ministry of Education The First Hospital of Jilin UniversityChangchun 130061China National-Local Joint Engineering Laboratory of Animal Models for Human Diseases Jilin UniversityChangchun 130061China International Center of Future Science Jilin UniversityChangchun 130061China

Humanized immune system(HIS)mice have been developed and used as a small surrogate model to study human immune function under normal or disease *** variations are found between models,most HIS mice show robust human T cell ***,there has been unsuccessful in constructing HIS mice that produce high-affinity human antibodies,primarily due to defects in terminal B cell differentiation,antibody affinity maturation,and development of primary follicles and germinal *** this review,we elaborate on the current knowledge about and previous attempts to improve human B cell development in HIS mice,and propose a potential strategy for constructing HIS mice with improved humoral immunity by transplantation of human follicular dendritic cells(FDCs)to facilitate the development of secondary follicles.

关键词： humanized immune system mouse humoral immunity germinal center B cell follicular dendritic cell

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Exploration of the Expression of Color Emotion in Oil Painting Sketch Creation

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Journal of Contemporary Educational Research 2024年第10期8卷 214-219页

作者： Qianwen Jin jilin University of Arts Changchun 130021Jilin ProvinceChina

This paper deeply analyzes the expression of color emotion in oil painting sketch *** with the three basic attributes of color theory(hue,lightness,and purity),this paper discusses its emotional symbolic significance and the relationship between contrast and *** interpreting the works of artists such as Van Gogh’s Sunflower,Monet’s Rouen Cathedral,and Cézanne’s Mont Sainte-Victoire,this paper shows the unique charm of different colors in conveying emotions,creating atmosphere,and expressing *** the same time,it is expounded that in the creation of an oil painting sketch,the effective expression of color emotion can be realized by observing nature,using subjective colors,and reasonable composition and layout of colors,so as to enhance the artistic value of the works.

关键词： Oil painting Writing and creation Emotional expression Art

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DeciLS-PBO: an effective local search method for pseudo-Boolean optimization

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Frontiers of Computer Science 2024年第2期18卷 239-241页

作者： Luyu JIANG Dantong OUYANG Qi ZHANG Liming ZHANG College of Computer Science and Technology Jilin UniversityChangchun 130012China Key Laboratory of Symbolic Computation and Knowledge Engineering(Ministry of Education) Jilin UniversityChangchun 130012China

1 Introduction Local search method is a rising star for solving combinatorial optimization problems in recent years,and the state-of-the-art local search-based incomplete Maximum Satisfiability(MaxSAT)solversshowpromi... 详细信息

关键词： Max optimization local

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