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Multimodal epidermal devices for hydration monitoring

Microsystems & Nanoengineering 2017年第1期3卷 267-277页

作者： Siddharth Krishnan Yunzhou Shi R.Chad Webb Yinji Ma Philippe Bastien Kaitlyn E.Crawford Ao Wang Xue Feng Megan Manco Jonas Kurniawan Edward Tir Yonggang Huang Guive Balooch Rafal M.Pielak John A.Rogers Department of Materials Science and Engineering Frederick Seitz Materials Research LaboratoryUniversity of Illinois at Urbana-ChampaignUrbanaIL 61801USA Department of Materials Science and Engineering Northwestern UniversityEvanstonIL 60208USA L’Oreal Tech Incubator California Research Center953 Indiana StreetSan FranciscoCA 94107USA Department of Civil and Environmental Engineering Mechanical EngineeringMaterials Science and EngineeringNorthwestern UniversityEvanstonIL 60208USA L’Oréal Research and Innovation 1 Avenue Eugène SchullerAulnay sous Bois 93601France Department of Engineering Mechanics Center for Mechanics and MaterialsTsinghua UniversityBeijing 100084China L’Oréal Early Clinical 133 Terminal AvenueClarkNJ 07066USA Departments of Materials Science and Engineering Biomedical EngineeringChemistryMechanical EngineeringElectrical Engineering and Computer Scienceand Neurological SurgeryCenter for Bio-Integrated ElectronicsSimpson Querrey Institute for Nano/biotechnologyNorthwestern UniversityEvanstonIL 60208USA

Precise,quantitative in vivo monitoring of hydration levels in the near surface regions of the skin can be useful in preventing skinbased pathologies,and regulating external *** we introduce multimodal sensors with important capabilities in this context,rendered in soft,ultrathin,‘skin-like’formats with numerous advantages over alternative technologies,including the ability to establish intimate,conformal contact without applied pressure,and to provide spatiotemporally resolved data on both electrical and thermal transport properties from sensitive regions of the *** in vitro studies and computational models establish the underlying measurement principles and associated approaches for determination of temperature,thermal conductivity,thermal diffusivity,volumetric heat capacity,and electrical impedance using simple analysis *** studies on 20 patients subjected to a variety of external stimuli validate the device operation and allow quantitative comparisons of measurement capabilities to those of existing state-of-the-art tools.

关键词： epidermal electronics hydration monitoring thermal characterization

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Engineering for Inclusion:Empowering Individuals with Physical and neurological Differences through Engineering Invention,Research,and Development

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Engineering 2021年第2期7卷 141-143页

作者： Peter T.Cummings Philippe M.Fauchet Michael Goldfarb Martha W.M.Jones Maithilee Kunda Jonathan B.Perlin Nilanjan Sarkar Keivan G.Stassun Zachary E.Warren Karl E.Zelik Department of Chemical and Biomolecular Engineering Vanderbilt UniversityNashvilleTN 37235-1604USA Department of Electrical Engineering and Computer Science Vanderbilt UniversityNashvilleTN 37235-1826USA Department of Mechanical Engineering Vanderbilt UniversityNashvilleTN 37235-1592USA Department of Medicine Healthand SocietyVanderbilt UniversityNashvilleTN 37235-1665USA The Frist Center for Autism and Innovation Vanderbilt UniversityNashvilleTN 37212USA Department of Physics and Astronomy Vanderbilt UniversityNashvilleTN 37235-1807USA Department of Biomedical Engineering Vanderbilt UniversityNashvilleTN 37235-1631USA HCA healthcare NashvilleTN 37203USA Department of Pediatrics Vanderbilt University Medical CenterNashvilleTN 37232USA Treatment and Research institute for Autism Spectrum Disorders Vanderbilt Kennedy CenterNashvilleTN 37203USA Department of Physical Medicine and Rehabilitation Vanderbilt University Medical CenterNashvilleTN 37212USA

*** The use of engineering tools,design,research,and thinking to create environments and capabilities whereby individuals who are currently under-employed or unemployed due to a physical disability(e.g.,amputation or spinal cord injury)or neurological difference(e.g.,autism)are enabled to become fully productive and employed members of society has been the implicit goal of decades of research at Vanderbilt University and *** Vanderbilt University,progress in these areas has been greatly facilitated by the proximity of the School of Engineering to the world-class Vanderbilt University Medical Center and the resulting close collaboration between engineering and medical researchers.

关键词： has environments power

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轻型缺血性卒中或短暂性脑缺血发作的早期双联抗血小板治疗

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英国医学杂志中文版 2019年第5期22卷 262-265页

作者：王拥军 S. Claiborne Johnston Philip M Bath James C. Grotta 潘岳松 Pierre Amarenco 王伊龙 Tabassome Simon Jong Sung Kim Jiann-Shing Jeng 刘丽萍林毅 Ka Sing Lawrence Wong David Wang 李昊首都医科大学附属北京天坛医院神经内科 l0Department of Clinical Pharmacology Sorbonne UniversityParisFrance FACT (French Alliance for Cardiovascular clinical Trials) ParisFrance Department of Neurology University of UlsanAsan Medical CenterSeoulSouth Korea Department of Neurology and Stroke Center National Taiwan University HospitalTaipeiTaiwan 福建医科大学第一附属医院神经内科 Division of Neurology Department of Medicine and Therapeuticsthe Chinese University of Hong KongPrince of Wales HospitalHong KongChina illinois neurological institute Stroke Network OSF Healthcare SystemPeoriaUSA Department of Neurology University of Illinois College of Medicine at PeoriaPeoriaUSA 国家神经系统疾病临床医学研究中心北京脑重大疾病研究院卒中研究中心北京市脑血管病转化医学重点实验室 Dean's Office Dell Medical SchoolUniversity of Texas at AustinAustinUSA Stroke Trials Unit Division of Clinical NeuroscienceUniversity of NottinghamNottinghamUK Clinical Innovation and Research institute Memorial Hermann HospitalHoustonUSA Department of Neurology and Stroke Center Bichat University Hospital and Paris-DiderotSorbonne UniversityParisFrance Department of Clinical Pharmacology and Clinical Research Platform of East of Paris (URCEST - CRC - CRB) Assistance Publique-Hopitaux de ParisParisFrance

王拥军及同事探讨了应用双联抗血小板治疗预防卒中复发或短暂性脑缺血发作的最新证据。轻型缺血性卒中和短暂性脑缺血发作(TIA)患者在头几周内有较高的卒中及其他血管事件的复发风险(5%~11.7%严。双联抗血小板治疗,包括氯吡格雷和阿司匹... 详细信息

王拥军及同事探讨了应用双联抗血小板治疗预防卒中复发或短暂性脑缺血发作的最新证据。轻型缺血性卒中和短暂性脑缺血发作(TIA)患者在头几周内有较高的卒中及其他血管事件的复发风险(5%~11.7%严。双联抗血小板治疗,包括氯吡格雷和阿司匹林,是减少卒中复发的有效治疗策略Magic Group的专家小组(http://***/)最近在The BMJ中发表了一个强烈的快速推荐建议,即对于轻型缺血性卒中和TIA患者应在症状出现24小时内开始双联抗血小板治疗,并持续10~21天3。

关键词：短暂性脑缺血发作抗血小板治疗缺血性卒中轻型早期复发风险阿司匹林有效治疗

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Stroke care during the COVID-19 outbreak in Spain: the experience of Spanish stroke units

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Stroke & Vascular Neurology 2021年第2期6卷 267-273页

作者： Maria Alonso de Lecinana Mar Castellanos Oscar Ayo-Martin Ana Morales the Stroke Group-Spanish Society of Neurology Department of Neurology and Stroke Center Hospital La Paz Institute for Health Research-IdiPAZ.La Paz University Hospital.Universidad Autonoma de MadridMadridSpain Department of Neurology Complexo Hospitalario Universitario A Coruna.Biomedical Research Institute of A CorunaA CorunaSpain Department of Neurology Complejo Hospitalario Universitario de AlbaceteAlbaceteSpain Department of Neurology University Clinic Hospital Virgen de la ArrixacaMurciaSpain 不详

Background and purpose Spain has been heavily affected by *** of resources for managing the outbreak might have caused a disruption in stroke *** study analyses the impact on stroke care of reorganising the healthcare system in response to the first COVID-19 outbreak peak in Spain and the strategies adopted by Spanish stroke units to deal with this *** and methods We obtained data from a structured survey sent to the responsible of stroke units across the *** recorded the number of strokes,stroke code activations,intravenous thrombolysis treatments and mechanical thrombectomies during February and March 2019 and *** also collected information on the impact on workflow metrics and on the availability of specialised neurological care and rehabilitation treatments,the characteristics of stroke care for patients with SARS-CoV-2 infection and the impact on human *** compared the activity data between 2019 and 2020 and the information on activity and impact on stroke care between regions classified according to the disease incidence *** Fifty-seven(75%)of all stroke units in Spain responded to the *** was an overall reduction in admissions for all stroke types during the outbreak’s peak and in the number of stroke code activations and intravenous thrombolysis treatments,results that were independent of the COVID-19 incidence *** reported a delay in workflow metrics and a reduction of admissions to stroke units,outpatient clinics and rehabilitation *** pathways and protocols for managing stroke patients with SARS-CoV-2 infection have been *** The COVID-19 outbreak has jeopardised all phases of stroke *** a consequence,some patients with stroke did not receive adequate treatment.

关键词： Spanish consequence outbreak

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Membrane-bound mucins and mucin terminal glycans expression in idiopathic or Helicobacter pylori, NSAID associated peptic ulcers

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World Journal of Gastroenterology 2014年第40期20卷 14913-14920页

作者： Yaron Niv Doron Boltin Marisa Halpern Miriam Cohen Zohar Levi Alex Vilkin Sara Morgenstern Vahig Manugian Erica St Lawrence Pascal Gagneux Sukhwinder Kaur Poonam Sharma Surinder K Batra Samuel B Ho Department of Gastroenterology Rabin Medical Center Tel Aviv University Beilinson Hospital Tel Aviv 49100 Israel Department of Pathology Rabin Medical Center Hasharon Hospital Tel Aviv 49100 Israel Department of Cellular andMolecular Medicine Glycobiology Research and Training Center University of California San Diego San Diego CA 92161 United States Department of Pathology Rabin Medical Center Beilinson Hospital Tel Aviv 49100 Israel Department of Medicine VA San Diego Healthcare System and University of California San Diego San Diego CA 92161 United States Department of Biochemistry and Molecular Biology University of Nebraska MedicaCenter Omaha NE 68198 United States Department of Pathology Creighton University Medical Center Omaha NE 68114 United States

AIM: To determine the expression of membrane-bound mucins and glycan side chain sialic acids in Helicobacter pylori (H. pylori)-associated, non-steroidal inflammatory drug (NSAID)-associated and idiopathic-gastric ulc... 详细信息

关键词： Mucin Idiopathic ulcer Helicobacter pylori Glycosylation Peptic ulcer disease Mucosal cytoprotection

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Erythropoietin therapy after out-of-hospital cardiac arrest:A systematic review and meta-analysis

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World Journal of Cardiology 2017年第12期9卷 830-837页

作者： Rahul Chaudhary Jalaj Garg Parasuram Krishnamoorthy Kevin Bliden Neeraj Shah Nayan Agarwal Rahul Gupta Abhishek Sharma Karl B Kern Nainesh C Patel Paul Gurbel Department of Medicine Sinai Hospital of BaltimoreBaltimoreMD 21215United States Division of Cardiology Lehigh Valley Health NetworkAllentownPA 18103United States Department of Medicine Division of CardiologyEinstein Healthcare NetworkPhiladelphiaPA 19141United States Inova Heart and Vascular institute Inova Medical CenterFairfaxVA 22042United States Division of Cardiovascular Medicine University of FloridaGainesvilleFL 32611United States Queens Cardiac Care QueensNY 11428United States Division of Cardiovascular Medicine State University of New YorkBrooklynNY 12246United States Division of Cardiology University of Arizona College of MedicineTucsonAZ 85721United States

AIM To assess safety and efficacy of early erythropoietin(Epo) administration in patients with out-of-hospital cardiac arrest(OHCA).METHODS A systematic literature search was performed using PubM ed,MEDLINE,EMBASE,EBSCO,CINAHL,Web of Science and Cochrane databases,of all studies published from the inception through October 10,*** criteria included:(1) Adult humans with OHCA and successful sustained return of spontaneous circulation;and(2) studies including mortality/brain death,acute thrombotic events as their end *** efficacyoutcome was "brain death or Cerebral Performance Category(CPC) score of 5".Secondary outcomes were "CPC score 1,and 2-4","overall thrombotic events" and "acute coronary stent thrombosis".RESULTS We analyzed a total of 606 participants(n = 276 received Epo and n = 330 with standard of care alone) who experienced OHCA enrolled in 3 clinical *** significant difference was observed between the Epo and no Epo group in brain death or CPC score 5(OR = 0.77;95%CI:0.42-1.39),CPC score 1(OR = 1.16,95%CI:0.82-1.64),and CPC score 2-4(OR = 0.77,95%CI:0.44-1.36).Epo group was associated with increased thrombotic complications(OR = 2.41,95%CI:1.26-4.62) and acute coronary stent thrombosis(OR = 8.16,95%CI:1.39-47.99).No publication bias was *** Our study demonstrates no improvement in neurological outcomes and increased incidence of thrombotic events and acute coronary stent thrombosis in OHCA patients who were treated with Epo in addition to standard therapy.

关键词： Erythropoietin Thrombosis Cardiac arrest Cardiopulmonary resuscitation

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隐源性卒中的心电监测策略：2015年卒中诊断和监测专题组的报告

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国际脑血管病杂志 2017年第7期25卷 592-600页

作者： Gregory W. Albers Richard A. Bernstein Johannes Brachmann John Camm J. Donald Easton Peter Fromm Shinya Goto Christopher B. Granger Stefan H. Hohnloser Elaine Hylek Amir K. Jaffer Derk W. Krieger Rod Passman Jesse M. Pines Shelby D. Reed Peter M. Rothwell Peter R. Kowey 地力木拉提·阿米提朱沂李红燕牛晓珊 Department of Neurology and neurological Sciences Stanford University Stanford CA Davee Department of Neurology Feinberg School of Medicine of Northwestern University Chicago IL Hospital Klinikum Coburg Teaching Hospital of the University of Wurzburg Coburg Germany Cardiovascular and Cell Sciences Research institute St. George's University of London and Imperial College London LK Department of Neurology University of California San Francisco Sandier Neurosciences Center San Francisco CA Center for Cardiovascular Health South Nassau Communities Hospital Oeeanside NY Department of Medicine Tokai University School of Medicine Isehara Japan Cardiac Care Unit Duke University Medical Center Durham NC Division of Clinical Electrophysiology Department of Cardiology J.W. Goethe University Frankfurt Germany Boston University School of Medicine Boston MA Department of Medicine Rush Lhiversity Medical Center Chicago IL Faculty of Health and Medical Science University of Copenhagen Denmark German Neuroscience Center Dubal Healthcare City Dubai UAE Bluhm Cardiovascular institute Northwestern University Feinberg School of Medicine Chicago IL Office for Clinical Practice Innovation George Washington Lhiversity Washington DC Duke Clinical Research institute Duke University Durham NC Stroke Prevention Research Unit Nuffield Department of Clinical Neurosciences University of Oxford UK Division of Cardiovascular Diseases Lankenau Heart Institute Wyrmewood PA Department of Medicine Jefferson Medical College Philadelphia PA 新疆维吾尔自治区人民医院神经内科乌鲁木齐830001

卒中是一个重要的全球性公共卫生问题。2010年全世界总共发生3300万例卒中，其中1690万为首发卒中。卒中是仅次于心脏病的第二大全球人口死亡原因，占全部死亡的10％以上。卒中是一类异质性疾病，其病因可以是血管破裂（出血性）或血管... 详细信息

卒中是一个重要的全球性公共卫生问题。2010年全世界总共发生3300万例卒中，其中1690万为首发卒中。卒中是仅次于心脏病的第二大全球人口死亡原因，占全部死亡的10％以上。卒中是一类异质性疾病，其病因可以是血管破裂（出血性）或血管闭塞（缺血性）。缺血性卒中约占全部卒中的85％，可根据发病机制进行分类。

关键词：缺血性卒中心电监测隐源性专题诊断公共卫生问题死亡原因异质性疾病

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Trial of Sodium Phenylbutyrate-Taurursodiol for Amyotrophic Lateral Sclerosis

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四川生理科学杂志 2021年第1期43卷 172-172页

作者： Sabrina Paganoni From the Sean M. Healey and AMG Center for ALS and the neurological Clinical Research institute Massachusetts General Hospital Harvard Medical School (S.P. J.D.B. S.B. M.C. D.D. M.M. J.O. L.P. A.V.S. E.T. P.V. J. Walker H.Y. R.E.T. M.E.C.) the Biostatistics Center Massachusetts General Hospital Harvard Medical School (E.A.M. J. Chan D.S.) and Spaulding Rehabilitation Hospital Harvard Medical School (S.P.) Boston the University of Massachusetts Memorial Medical Center Worcester (M.A.O.) and Amylyx Pharmaceuticals (J. Cohen J. Klee K.L. P.D.Y.) and Harvard University (W.G.) Cambridge — all in Massachusetts Pentara Millcreek UT (S.H. S.P.D. N.E. K.H.) Swedish Neuroscience institute Seattle (M.A.E.) Hennepin healthcare Minneapolis (S.M.) the Department of Neurology Oregon Health and Science University Portland (C.K.) the Department of Neurology Wake Forest School of Medicine Winston-Salem NC (J.B.C.) the Department of Neurology Ohio State University College of Medicine Columbus (A.Q.) the Department of Neurology University of Florida College of Medicine Gainesville (J. Wymer) the Department of Neurology University of Michigan Ann Arbor (S.A.G.) Texas Neurology Dallas (D.H.) the Department of Neurology Lewis Katz School of Medicine Temple University (T.H.-P.) and the Department of Neurology University of Pennsylvania Perelman School of Medicine (C.Q.) — both in Philadelphia Glenn Biggs institute for Alzheimer’s and Neurodegenerative Disease University of Texas Health Science Center at San Antonio San Antonio (C.E.J.) the Brain Science institute and Department of Neurology Johns Hopkins University Baltimore (J.D.R.) the Department of Neurology University of Kentucky College of Medicine Lexington (E.J.K.) California Pacific Medical Center and Forbes Norris MDA–ALS Research and Treatment Center San Francisco (J. Katz L.J.) Barrow neurological institute Phoenix AZ (S.L. M.H. G.K. R.R. J.M.S.) the Department of Neurology Washington University School of Me

Background:Sodium phenylbutyrate and taurursodiol have been found to reduce neuronal death in experimental *** efficacy and safety of a combination of the two compounds in persons with amyotrophic lateral sclerosis(ALS)are not ***:In this multicenter,randomized,double-blind trial,we enrolled participants with definite ALS who had had an onset of symptoms within the previous 18 months.

关键词： butyrate tau death

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颅外段颈动脉疾病筛查指南美国神经影像学学会多学科实践指南委员会向医疗卫生专业人员的声明血管和介入神经病学学会共同倡议

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中华脑血管病杂志（电子版） 2008年第2期2卷 94-117页

作者： Adnan I. Quresh Andrei V. Alexandrov Charles H. Tegeler Robert W. Hebson Ⅱ J. Dennis Baker L. Nelson Hopkins 陈红兵刘新峰 From the Zeenat Qureshi Stroke Research Center University of Minnescta Minneapolis Minnescta Neurosonology and Stroke Research Program Barrow Neurological Institute Phoenix Arizona Department of Neurology Bowman Gray School of Medicine Winston-Salem North Carolina CREST Administrative Center University of Medicine and Dentistry of New Jersey Newark New Jersey Division of Vascular Surgery David Geffen School of Medicine at University of California at Los Angeles Los Angeles California Department of neurological Surgery University at Buffalo State University of New York Buffalo New York 南京军区南京总医院神经内科 210002

这份新声明旨在普通人群和经过选择的患者亚群中针对无症状颈动脉狭窄的筛查提供全面和及时的循证推荐。这些推荐针对下列群体:普通人群中的高危者;接受心脏直视手术(包括冠状动脉旁路术)的患者;外周血管病、腹主动脉瘤和肾动脉狭窄患者... 详细信息

这份新声明旨在普通人群和经过选择的患者亚群中针对无症状颈动脉狭窄的筛查提供全面和及时的循证推荐。这些推荐针对下列群体:普通人群中的高危者;接受心脏直视手术(包括冠状动脉旁路术)的患者;外周血管病、腹主动脉瘤和肾动脉狭窄患者;头颈部恶性肿瘤放射治疗后患者;颈动脉内膜切除术或支架置入术后患者;视网膜缺血综合征患者;晕厥、头昏、眩晕或耳鸣患者;有血管病家族史和高同型半胱氨酸血症的患者。这些推荐是在患病率、预期益处和在经过选择的人群中来自其他专业组织的当前指南做出的。

关键词：颈动脉颈动脉狭窄指南筛查成像多普勒超声

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脊髓损伤后残存自主神经功能载录国际标准

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中华物理医学与康复杂志 2010年第4期32卷 310-315页

作者： MS Alexander AB Jackson W Donovan DE Graves SL Elliott A Krassioukov AW Sheel I Estoresl B Green A Gousse NL Braekett D Cardenas M Kennelly A-K Karlason F Biering-Sorensen K Krogh T Linsenmeyer R Marino J Ditunno CJ Mathias I Perkash G Creasey G Schilero J Wecht B Schurch V Dietz J Sonksen S Stiens D Bodner LA Wuermser J-J Wyndaele 周谋望刘楠 S Charlifue University of Alabama BirminghamALUSA Baylor College of Medicine HoustonTXUSA International Collaboration On Repair Discoveries (ICORD) University of British Columbia and Vancouver Coastal HealthVancouverBritish ColumbiaCanada James A Haley VA Hospital TampaFLUSA Shepherd Center AtlantaGAUSA University of Miami MiamiFLUSA McKay Urology Carolinas HealthcareCharlotteNCUSA Sahlgrenska University Hospital GothenburgSweden Rigshospitalet and University of Copenhagen CopenhagenDenmark Aarhus University Hospital AarhusDenmark Kessler institute for Rehabilitation West OrangeN JUSA Thomas Jefferson University PhiladelphiaPAUSA Imperial College St Mary's HospitalLondonUK Stanford Uni-versity Palo AltoCAUSA James J Peters Veterans Affairs Medical Center BronxNYUSA University Hospital Balgrist ZurichSwitzerland Herlev Hospi-tal University of CopenhagenCopenhagenDenmark Veterans Affairs Puget Sound Health Care SeattleWAUSA Case Western Re-serve University ClevelandOHUSA Mayo Clinic RochesterMSUSA and University Hospital Antwerp University AntwerpAntwerpBelgium 北京大学第三医院康复医学科 Craig Hospital EnglewoodCOUSA

近年来，脊髓损伤神经学分类园际标准（International Stand- ards for the neurological Classification of Spinal Cord Injury, ISNCSCI）被用来记载脊髓损伤后运动和感觉功能的损害，目前该标准已是第六版。1992年第一份国际认可的... 详细信息

近年来，脊髓损伤神经学分类园际标准（International Stand- ards for the neurological Classification of Spinal Cord Injury, ISNCSCI）被用来记载脊髓损伤后运动和感觉功能的损害，目前该标准已是第六版。1992年第一份国际认可的标准出版时，曾进行了较大的修订，修订内容包括完全性损伤与不完全性损伤的定义，

关键词：国际标准脊髓损伤自主神经功能不完全性损伤残存修订内容神经学分类 ards

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