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Trends and outcomes of transarterial chemoembolization in hepatocellular carcinoma:a national survey

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Hepatobiliary & Pancreatic Diseases International 2017年第6期16卷 624-630页

作者： Khalid Mumtaz Nishi Patel Rohan M Modi Vihang Patel Alice Hinton James Hanje Sylvester M Black Somashaker Krishna Division of Gastroenterology Hepatology and NutritionThe Ohio State University Wexner Medical Center Columbus OHUSA Department of Internal Medicine The Ohio State University Wexner Medical Center Columbus OHUSA Department of Surgery The Ohio State University Wexner Medical Center Columbus OHUSA Division of Biostatistics College of Public Health The Ohio State University Columbus OH USA

BACKGROUND:Transarterial chemoembolization(TACE) is a palliative procedure frequently used in patients with advanced hepatocellular carcinoma(HCC). We examined the national inpatient trends of TACE and related outcomes in the United States over the last ***:We utilized the National Inpatient Sample(2002 to 2012) and performed trend analyses of TACE for HCC in all adult patients(age >18 years). Multivariate analyses for the outcomes of in-hospital "procedure-related complications"(PRCs) and "post-procedure complications"(PPCs) were performed. We also compared early(2002 to 2006) and late(2007 to 2012) eras by multivariate analyses to identify predictors of complications, healthcare resource utilization and ***:Overall, 19058 patients underwent TACE for HCC where PRCs and PPCs were seen in 24.2% and 17.6% of patients, respectively. The overall trends in the use of TACE(P<0.001) and associated PRCs(P=0.006) were observed to be increasing. There was less mortality [adjusted Odds ratio(a OR):0.58; 95% CI:0.41, 0.82], reduced length of hospital stay(-1.87 days; 95% CI:-2.77,-0.97) and increased hospital charges($19232; 95% CI:11013, 27451) in the late era. Additionally, there was increased mortality(a OR:4.07; 95% CI:2.96, 5.59), PRCs(a OR:3.21; 95% CI:2.56, 4.02), and PPCs(a OR:2.70; 95% CI:2.11, 3.46) among patients with ***:There is an increasing trend of TACE utilization in HCC. However, the outcomes are worse in patients with coagulopathy. Although PRCs have increased, mortality has decreased in recent years. These findings should be considered during TACE evaluation in patients with HCC.

关键词： transarterial chemoembolization hepatocellular carcinoma procedural complications mortality

Extended state observer-based pressure control for pneumatic actuator servo systems

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Control Theory and Technology 2021年第1期19卷 64-79页

作者： John Mohorcic Lili Dong Delta Systems Inc. StreetsboroOH 44241USA Department of Electrical Engineering and Computer Science Cleveland State UniversityClevelandOH 44115.USA

A pneumatic actuator is a fast and economical tool that converts compressed air into mechanical *** this paper,an extended state observer(ESO)-based sliding mode controller(SMC)is developed to adjust the air pressure of the actua-tor for accurate position control,Specifically,an impedance control module is established to produce desired air pressure based on the relationship between forces and desired ***,the ESO-based SMC is implemented to adjust the air pressure to the required level despite the presence of system uncertainties and *** a result,the position of the actuator is controlled to a setpoint through the regulation of *** performance of ESO-based SMC is compared with that of a classic active disturbance rciection controller(ADRC)and a *** results demonstrate that the:ESO-based SMC shows comparable performance to ADRC in terms of precise pressure *** addition,it requires the least control effort ncessary to excite valves among the three *** stability of ESO based SMC is theoretically justifed through Lyapunov approach.

关键词： Pneumatic actuator Pressure control ESO-based SMC ADRC Impedance control module Stability proof Lyapunov approach

ATP6AP2,a regulator of LRP6/β-catenin protein trafficking,promotes Wnt/β-catenin signaling and bone formation in a cell type dependent manner

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Bone Research 2024年第2期12卷 453-468页

作者： Lei Xiong Hao-Han Guo Jin-Xiu Pan Xiao Ren Daehoon Lee Li Chen Lin Mei Wen-Cheng Xiong Department of Neurosciences School of MedicineCase Western Reserve UniversityClevelandOH 44106USA Louis Stoke VA Medical Center ClevelandOH 44106USA

Wnt/β-catenin signaling is critical for various cellular processes in multiple cell types,including osteoblast(OB)differentiation and *** how Wnt/β-catenin signaling is regulated in OBs remain ***6AP2,an accessory subunit of V-ATPase,plays important roles in multiple cell types/organs and multiple signaling ***,little is known whether and how ATP6AP2 in OBs regulates Wnt/β-catenin signaling and bone *** we provide evidence for ATP6AP2 in the OB-lineage cells to promote OB-mediated bone formation and bone homeostasis selectively in the trabecular bone *** knocking out(CKO)ATP6AP2 in the OB-lineage cells(Atp6ap2^(Ocn-Cre))reduced trabecular,but not cortical,bone formation and bone *** and cellular biochemical studies revealed that LRP6 and N-cadherin were reduced in ATP6AP2-KO BMSCs and OBs,but not *** in vitro and in vivo studies revealed impairedβ-catenin signaling in ATP6AP2-KO BMSCs and OBs,but not osteocytes,under both basal and Wnt stimulated conditions,although LRP5 was decreased in ATP6AP2-KO osteocytes,but not *** cell biological studies uncovered that osteoblastic ATP6AP2 is not required for Wnt3a suppression ofβ-catenin phosphorylation,but necessary for LRP6/β-catenin and N-cadherin/β-catenin protein complex distribution at the cell membrane,thus preventing their *** of activeβ-catenin diminished the OB differentiation deficit in ATP6AP2-KO *** together,these results support the view for ATP6AP2 as a critical regulator of both LRP6 and N-cadherin protein trafficking and stability,and thus regulatingβ-catenin levels,demonstrating an un-recognized function of osteoblastic ATP6AP2 in promoting Wnt/LRP6/β-catenin signaling and trabecular bone formation.

关键词： LRP6 impaired organs

The Effect of Reaction Conditions on the Synthesis of Thermoplastic Elastomers Containing Polyalloocimene, Polyisobutylene and Tapered Blocks

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Chinese Journal of Polymer Science 2019年第9期37卷 884-890页

作者： Jozsef Kantor Judit E. Puskas Gabor Kaszas Department of Chemical and Biomolecular Engineering The University of Akron Akron OH 44325 USA Department of Food Agricultural and Biological Engineering (1/1/2019) The Ohio State University Wooster OH 44691 USA PolyFiberMatrix LLC 2295 W. Market St. Suite D. Akron OH 44313 USA

This work investigates the effect of reaction conditions on the copolymerization of isobutylene (IB) with alloocimene (Allo) in methyl chloride (MeCl) using AlCh and ethylaluminum dichloride (EtAlCh) as coinitiators and adventitious moisture as the initiator. Both AlCh and EtAlCb produced high molecular weight (Mn > 1.0 x 10^5 g/mol) thermoplastic elastomers (TPEs) with good mechanical properties in short reaction time (< 10 min). These unique TPEs have unsaturations in the end blocks, leading to easy functionalization and/or crosslinking.

关键词： Polyisobutylene Alloocimene Triblock copolymer Carbocationic polymerization

Extreme Weather Disruptions and Emergency Preparedness Among Older Adults in ohio: An Eight-County Assessment

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International Journal of Disaster Risk Science 2024年第2期15卷 213-225页

作者： Smitha Rao Fiona C.Doherty Anthony Traver Marisa Sheldon Emma Sakulich Holly Dabelko‑Schoeny College of Social Work The Ohio State UniversityColumbusOH 43210USA Age Friendly Innovation Center College of Social WorkThe Ohio State UniversityColumbusOH 43210USA College of Public Health The Ohio State UniversityColumbusOH 43210USA

The disproportionate risks and impacts of climate change and extreme weather on older adults are increasingly evident. While especially true in disaster-prone areas, human-caused climate change introduces an element of uncertainty even in previously identified “safe” regions such as the Midwestern United States. Using a cumulative disadvantage and vulnerability-informed framework and descriptive statistics from multiple data sources, this article provides an overview of climate impacts, vulnerabilities, and county-level characteristics, focusing on older adults living in Central ohio. A comparative multiple-case study methodology was used to triangulate regionally representative primary and secondary data sources to examine state and county-level measures of vulnerability, emergency preparedness, and disruptions caused by extreme weather among older adults across eight counties in Central ohio. Seventy-eight percent of older adults in the sample reported being prepared for emergencies per Federal Emergency Management Agency guidelines. Older adults in Union County reported the highest rates of preparedness, while those in Fayette County reported the lowest. County-level rates of disruption of life activities by extreme weather ranged widely. Among the most rural in the region, Fayette County emerged as uniquely disadvantaged, with the lowest median income, the most vulnerable across multiple social vulnerability dimensions, and the most reported disruptions to life activities from extreme weather. County profiles offer a snapshot of existing vulnerabilities, socioeconomic conditions, special needs, preparedness, and current disruptions among older adults in the region and can inform resource mobilization across community and policy contexts.

关键词： Disaster preparedness Extreme weather Midwestern United States Older adults Regional assessment Social vulnerability

Investigating Additional Cochlear Parameters: A follow-up systematic review and meta-analysis

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Journal of Otology 2024年第3期19卷 178-183页

作者： Deven P.Curtis Anthony N.Baumann Natasha Salmen Anita Jeyakumar Northeast ohio Medical University RootstownOHUSA Bon Secours Mercy Health YoungstownOHUSA

Objectives:The movement towards personalization of cochlear implantation has continued to generate interest about variabilities in cochlear *** a recent metaanalysis,Atalay et al.(2022)examined organ of corti length,cochlear lateral wall,and“A”value and found that most covariates,other than congenital sensorineural hearing loss,did not impact cochlear size via these ***,no meta-analysis exists on how patient-specific variables could impact other cochlear size measurements,such as cochlear height(CH),and“B”value(defined as the distance between opposite lateral walls and perpendicular to“A”value).The purpose of this systematic review and meta-analysis is to examine how patient-specific variables impact additional cochlear size measurements to assist clinical *** reviewed:A systematic review for cochlear size measurements using PRISMA methodology was performed using PubMed,CINAHL,and MEDLINE from database inception to October 1st,***:Search terms used included English,cochlea,size,histology,anatomy,and *** criteria were measurements for human cochlea,full-text articles,and articles in *** measurements were“B”value and CH,as these measurements differ from the recent meta-analysis on this *** duct length(CDL)was also included.A random-effects continuous model for meta-analysis was *** were stratified by gender(male/female)and disease type(sensorineural hearing loss(SNHL)/conductive hearing loss(CHL)).Results:A total of 7 articles met final inclusion criteria from a total of 674 articles received on initial search,resulting in 2263 total human *** was a statistical difference between male CDL(n=681 cochlea)compared to female CDL(n=657)from four articles(pohen’s d effect size(ES):0.421;95%confidence intervals(CI):0.171,0.671).The frequency weighted mean for male CDL was 33.5 mm±1.8 mm and the frequency weighted mean for female CDL was 32.4 mm±1.5 mm w

关键词： anatomy analysis walls

Multimodal single-cell omics analysis identifies epithelium-immune cell interactions and immune vulnerability associated with sex differences in COVID-19

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Signal Transduction and Targeted Therapy 2021年第8期6卷 2586-2599页

作者： Yuan Hou Yadi Zhou Michaela U.Gack Justin D.Lathia Asha Kallianpur Reena Mehra Timothy A.Chan Jae U.Jung Lara Jehi Charis Eng Feixiong Cheng Genomic Medicine Institute Lerner Research InstituteCleveland ClinicClevelandOHUSA Florida Research and Innovation Center Cleveland ClinicPort Saint LucieFLUSA Department of Cardiovascular and Metabolic Science Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Molecular Medicine Cleveland Clinic Lerner College of MedicineCase Western Reserve UniversityClevelandOHUSA Department of Population and Quantitative Health Sciences Case Western Reserve UniversityClevelandOHUSA Neurological Institute Cleveland ClinicClevelandOHUSA Center for Immunotherapy and Precision Immuno-Oncology Cleveland ClinicClevelandOHUSA Department of Cancer Biology Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Genetics and Genome Sciences Case Western Reserve University School of MedicineClevelandOHUSA Case Comprehensive Cancer Center Case Western Reserve University School of MedicineClevelandOHUSA

Sex differences in the susceptibility of SARS-CoV-2 infection and severity have been controversial,and the underlying mechanisms of COVID-19 in a sex-specific manner remain *** we inspected sex differences in SARS-CoV-2 infection,hospitalization,admission to the intensive care unit(ICU),sera inflammatory biomarker profiling,and single-cell RNA-sequencing(scRNA-seq)profiles across nasal,bronchoalveolar lavage fluid(BALF),and peripheral blood mononuclear cells(PBMCs)from COVID-19 patients with varying degrees of disease *** propensity score-matching observations revealed that male individuals have a 29%elevated likelihood of SARS-CoV-2 positivity,with a hazard ratio(HR)1.32(95%confidence interval[Cl]1.18-1.48)for hospitalization and HR 1.51(95%Cl 1.24-1.84)for admission to *** from male patients at hospital admission had elevated neutrophil-lymphocyte ratio and elevated expression of inflammatory markers(C-reactive protein and procalcitonin).We found that SARS-CoV-2 entry factors,including ACE2,TMPRSS2,FURIN,and NRP1,have elevated expression in nasal squamous cells from male individuals with moderate and severe *** observed male-biased transcriptional activation in SARS-CoV-2-infected macrophages from BALF and sputum samples,which offers potential molecular mechanism for sex-biased susceptibility to viral ***-cell interaction network analysis reveals potential epithelium-immune cell interactions and immune vulnerability underlying male-elevated disease severity and mortality in ***,monocyte-elevated expression of Toll-like receptor 7{TLR7)and Bruton tyrosine kinase{BTK)is associated with severe outcomes in males with *** summary,these findings provide basis to decipher immune responses underlying sex differences and designing sex-specific targeted interventions and patient care for COVID-19.

关键词： elevated epithelium analysis

Correlation of the Rutgeerts score and recurrence of Crohn’s disease in patients with end ileostomy

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Gastroenterology Report 2017年第4期5卷 271-276,I0001,I0002页

作者： Vasutakarn Chongthammakun Andre Fialho Andrea Fialho Rocio Lopez Bo Shen Department of Internal Medicine The Cleveland Clinic FoundationClevelandOHUSA Department of Quantitative Health Sciences The Cleveland Clinic FoundationClevelandOHUSA The Center for Inflammatory Bowel Diseases The Cleveland Clinic FoundationClevelandOHUSA

Background:Recurrence of Crohn’s disease(CD)can occur after surgery,including end ileostomy(EI).The Rutgeerts score(RS)was developed to predict postsurgical CD recurrence via ileocolonoscopy in patients having ileocolonic *** role of ileoscopic evaluation via stoma for assessing recurrence of CD has not been *** aim of this study was to evaluate the role of ileoscopy for predicting disease recurrence in CD patients after EI with the use of ***:A total of 73 eligible CD patients with at least two ileoscopies in our institution following EI were *** inflammation of the neo-terminal ileum was graded based on the *** primary outcomes were the need for endoscopic stricture dilation and subsequent surgery due to recurrence of *** secondary outcomes were CDrelated hospitalization and the need to escalate CD-associated ***:The median duration of CD until EI was 9 years(interquartile range:4-13 years),and themedian duration from EI to the first ileoscopy was 28months(interquartile range:11-93 months).The RSs in the neo-terminal ileum close to EI were calculated,and subjects were divided into two groups:the normal RS group with the score being zero(n=25)and the abnormal RS group with the RS score being(n=48).Patients in the abnormal RS group weremore likely to have recurrence of CD(92%vs 27%)and need endoscopic dilation of stricture(40%vs 10%),subsequent bowel surgery(68%vs 15%),disease-related hospitalizations(80%vs 23%)and escalation of CDmedications(64%vs 25%)than those in the normal RS ***-to-event analysis showed that patients in the abnormal RS group were at a higher risk of endoscopic dilation(odds ratio(OR)=1.5;95%CI:1.09–1.9),need of second bowel surgery(OR=1.5;95% CI:1.2–1.8)and disease-related hospitalizations(OR=1.3;95% CI:1.1–1.6)after adjusting for factors such as duration from surgery to sensor,duration of disease and the patient’s sex(all P<0.001).Further multivariable analysis showed

关键词： Crohn’s disease Rutgeerts score ileoscopy ileostomy recurrence

Autonomy in materials research: a case study in carbon nanotube growth

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npj Computational Materials 2016年第1期2卷 25-30页

作者： Pavel Nikolaev Daylond Hooper Frederick Webber Rahul Rao Kevin Decker Michael Krein Jason Poleski Rick Barto Benji Maruyama Air Force Research Laboratory Materials and Manufacturing DirectorateRXASWPAFBDaytonOHUSA UES Inc DaytonOHUSA Lockheed Martin Advanced Technology Laboratories Cherry HillNJUSA Present address:Air Force Research Laboratory RHCIWPAFBOH 45433 and Infoscitex IncDaytonOH 45431USA Present address:Air Force Research Laboratory 711 Human Performance WingHuman Effectiveness DirectorateRHASWPAFBDaytonOH 45433USA

Advances in materials are an important contributor to our technological progress,and yet the process of materials discovery and development itself is *** current research process is human-centred,where human researchers design,conduct,analyse and interpret experiments,and then decide what to do *** have built an Autonomous Research System(ARES)—an autonomous research robot capable of first-of-its-kind closed-loop iterative materials *** exploits advances in autonomous robotics,artificial intelligence,data sciences,and high-throughput and in situ techniques,and is able to design,execute and analyse its own experiments orders of magnitude faster than current research *** applied ARES to study the synthesis of singlewalled carbon nanotubes,and show that it successfully learned to grow them at targeted growth *** has broad implications for the future roles of humans and autonomous research robots,and for human-machine *** believe autonomous research robots like ARES constitute a disruptive advance in our ability to understand and develop complex materials at an unprecedented rate.

关键词： robot artificial autonomous