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Human induced pluripotent stem cell-derived therapies for regeneration after central nervous system injury

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Neural Regeneration Research 2025年第11期20卷 3063-3075页

作者： Stephen Vidman Yee Hang Ethan Ma Nolan Fullenkamp Giles W.Plant Department of Neuroscience Ohio State UniversityColumbusOHUSA

In recent years,the progression of stem cell therapies has shown great promise in advancing the nascent field of regenerative *** the non-regenerative nature of the mature central nervous system,the concept that“blank”cells could be reprogrammed and functionally integrated into host neural networks remained *** work has also demonstrated the ability of such cells to stimulate intrinsic growth programs in post-mitotic cells,such as *** embryonic stem cells demonstrated great potential in treating central nervous system pathologies,ethical and technical concerns *** barriers,along with the clear necessity for this type of treatment,ultimately prompted the advent of induced pluripotent stem *** advantage of pluripotent cells in central nervous system regeneration is multifaceted,permitting differentiation into neural stem cells,neural progenitor cells,glia,and various neuronal *** precise spatiotemporal application of extrinsic growth factors in vitro,in addition to microenvironmental signaling in vivo,influences the efficiency of this directed *** the pluri-or multipotency of these cells is appealing,it also poses the risk of unregulated differentiation and teratoma *** of the neuroectodermal lineage,such as neuronal subpopulations and glia,have been explored with varying degrees of *** the risk of cancer or teratoma formation is greatly reduced,each subpopulation varies in effectiveness and is influenced by a myriad of factors,such as the timing of the transplant,pathology type,and the ratio of accompanying progenitor ***,successful transplantation requires innovative approaches to develop delivery vectors that can mitigate cell death and support ***,host immune responses to allogeneic grafts must be thoroughly characterized and further developed to reduce the need for *** to a clinical setting wi

关键词： axon regeneration central nervous system regeneration induced pluripotent stem cells neurotrauma regenerative medicine spinal cord injury stem cell therapy

Tilting homeostatic and dyshomeostatic microglial balance in health and disease:transforming growth factor-beta1 as a critical protagonist

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Neural Regeneration Research 2025年第10期20卷 2895-2897页

作者： Nicolas Hugues Yu Luo Department of Molecular and Cellular Biosciences University of CincinnatiCincinnatiOHUSA Neuroscience Graduate Program University of CincinnatiCincinnatiOHUSA Division of Immunobiology Cincinnati Children’s Hospital Medical CenterUniversity of Cincinnati College of MedicineCincinnatiOHUSA

Adult microglia,by continuously sensing changes in their environment and communicating with nearly all brain cell types,are considered to be the immune sentinels of the *** the healthy central nervous system(CNS),microglia display a unique molecular homeostatic signature(i.e.,Tmem119,P2ry12,Sall1,Siglech,Gpr34,and Hexb)(Figure 1A).

关键词： Figure signature critical

Multiple sclerosis is at a checkpoint: advancing the program

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Neural Regeneration Research 2025年第3期20卷 811-812页

作者： Brandon C.Smith Jessica L.Williams Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Biological Geologicaland Environmental SciencesCleveland State UniversityClevelandOHUSA

Multiple sclerosis(MS) is a chronic inflammatory and demyelinating disease of the central nervous system(CNS). Patients with MS experience sensory and motor function loss due to myelin and/or axon damage perpetuated b... 详细信息

关键词： Hauser sclerosis damage

Generation of brain vascular heterogeneity:recent advances from the perspective of angiogenesis

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Neural Regeneration Research 2025年第7期20卷 2013-2014页

作者： Nathanael J.Lee Ryota L.Matsuoka Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Molecular Medicine Cleveland Clinic Lerner College of MedicineCase Western Reserve UniversityClevelandOHUSA

Heterogeneous proper t i es of vascular endothelial cells in the brain:The brain displays large energy dynamics and consumption,and this high level of metabolic demands is fulfilled by a continuous supply of glucose and oxygen through its vascular *** vasculature consists of highly divergent blood vessel branches,giving rise to a dense network of capillaries that supply blood to all cells across the *** elaborated vascular network is thought to develop via angiogenesis,a process in which new blood vessels grow from pre-existing *** capillaries exhibit organotypic features distinct from other tissues and are formed primarily by two major endothelial cell(EC)types:those that form the semi-permeable blood-brain barrier(BBB)and those that develop highly permeable pores known as fenestrae(Matsuoka et al.,2022).The structural and functional differences between BBB and fenestrated vascular ECs represent a fundamental feature of brain vasculature and form the foundation for both brain function and homeostasis.

关键词： angiogenesis homeostasis network

Apples to oranges:environmentally derived,dynamic regulation of serotonin neuron subpopulations in adulthood?

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Neural Regeneration Research 2025年第9期20卷 2596-2597页

作者： Christopher J.O’Connell Matthew J.Robson Department of Genetics College of MedicineHarvard UniversityBostonMAUSA James L.Winkle College of Pharmacy Division of Pharmaceutical SciencesUniversity of CincinnatiCincinnatiOHUSA Neuroscience Graduate Program College of MedicineUniversity of CincinnatiCincinnatiOHUSA

Traumatic brain injury(TBI)is a public health problem with an undue economic burden that impacts nearly every age,ethnic,and gender group across the globe(Capizzi et al.,2020).TBIs are often sustained during a dynamic range of exposures to energetic environmental forces and as such outcomes are typically heterogeneous regarding severity and pathology(Capizzi et al.,2020).

关键词： sustained orange dynamic

Temperature-water and competitive interactions in vitro of two toxic black molds,Fusarium oxysporum and Rhizopus stolonifer isolated from a shower setting

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Studies in Fungi 2018年第1期3卷 248-255页

作者： Yoder JA Klever LA Dobrotka CJ Department of Biology Wittenberg UniversitySpringfieldOH45504USA

We report differences in secondary resource capture and upper lethal temperature as survival attributes for Fusarium oxysporum(FOSC)and Rhizopus stolonifer,two medically important fungi that were co-isolated from a table shower *** of these two shower-associated fungi have been deposited at the University of Alberta Microfungus Collection and Herbarium,Centre for Global Microfungal Biodiversity(UAMH,Toronto,CAN)as *** UAMH 11965 and ***(FOSC)UAMH 11966;this paper provides growth characteristics for these two strains that can be used for further studies on black molds in bathrooms given the relevance to public *** *** UAMH 11965 and ***(FOSC)UAMH 11966 require contact with a wet surface substrate with water activity≥0.95 aw for growth and *** contrast to ***,*** has a 4-6x,faster radial growth rate,superior colonizing ability,and capacity for overgrowth(exploitative competition).This ***(FOSC)strain,however,is thermotolerant,as demonstrated by broader thermal growth range and higher optimum temperature,which puts fewer limitations on its growth compared to *** is a point of public awareness for mold-sensitive and immunocompromised people that wet,wood substrates in a shower can permit colonization and competitive interactions that can concentrate *** and *** spores.

关键词： Bathroom fungal ecology public health radial growth resource capture

Chemical Mechanical Pulping of Hardwoods

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Chemical Mechanical Pulping of Hardwoods

不同松厚度P-RC APMP与漂白麦草Soda-AQ纸浆共磨浆特性

2003中国造纸学会学术报告会

作者： Eric Chao Xu Andritz Inc. （Springfield Ohio USA 45504）

＜正＞In the first part of this paper, differences between chemical pulping and chemical mechanical pulping（CMP） technologies for hardwoods are compared in terms of their technical characteristics, commercial applicability and market conditions, which are all in favor of high yield chemical mechanical pulping, or pulps. Among the different CMP technologies, P-RC APMA and BCTMP were reviewed and compared based on results from the latest and extensive investigations. The results show that P-RC APMP in general uses less energy and less overall chemical cost, gives a better pulp intrinsic properties（which means higher bulk at the same tensile, or higher tensile at the same bulk）, has more efficient use of process equipment and water, and tends to have a lower effluent discharge and high pulp yield. It is also more flexible and able to reach higher brightness ceiling for certain hardwoods species.

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林业工程学报 2018年第6期3卷 62-67页

作者：陶文娟徐娜郭丽芳 XU Eric 翟华敏南京林业大学轻工与食品学院南京210037 Andritz Inc. SpringfieldOH 45504USA

为合理高效利用麦草纸浆和高得率纸浆,通过合理配浆及其共磨浆,以获得所需纸性。以漂白麦草Soda-AQ纸浆为主,添加不同比例、不同松厚度的P-RC APMP纸浆,形成系列混合纸浆,对混合浆进行共磨浆、抄造成纸;研究不同系列配浆的共磨浆特性,... 详细信息

为合理高效利用麦草纸浆和高得率纸浆,通过合理配浆及其共磨浆,以获得所需纸性。以漂白麦草Soda-AQ纸浆为主,添加不同比例、不同松厚度的P-RC APMP纸浆,形成系列混合纸浆,对混合浆进行共磨浆、抄造成纸;研究不同系列配浆的共磨浆特性,探讨了高得率浆的松厚度及配浆比例对磨浆能耗、成纸松厚度、强度以及光学性能的影响。研究结果表明:1)高松厚度P-RC APMP纸浆(HB)和中等松厚度P-RC APMP纸浆(MB)与麦草浆共磨浆均能显著降低磨浆能耗,而MB共磨浆的能耗略低于相应配比的HB共磨浆的能耗; 2) HB共磨浆与MB共磨浆均能明显改善共磨浆的松厚度,且HB作用效果更为明显; 3)高得率浆添加量在10%左右时,HB共磨浆的抗张指数、耐破指数与MB共磨浆的相近,并接近或高于纯麦草浆,随着配比量的提高,MB共磨浆的抗张指数、耐破指数略高于HB; 4) HB共磨浆与MB共磨浆均能显著改善撕裂度和脆裂度,且均明显优于3种单一纸浆的撕裂度和脆裂度; 5)共磨浆可以显著改变光散射系数。试验证明,高得率浆与麦草浆共磨浆两者之间具有良好的协同作用,其中,HB与麦草浆的共磨浆能更好地改善浆料松厚度、光学性能和物理强度,更具有应用价值。

关键词：麦草浆松厚度 P-RC APMP 混合磨浆强度性能光学性能

Using　Genetic　Algorithms　to　Improve　the　Search　of　the　Weight　Space　in　Cascade－Correlation　Neural　Network

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Journal of Systems Engineering and Electronics 1995年第2期6卷 9-21页

作者： E.A.Mayer, K. J. Cios, L. Berke & A. Vary(University of Toledo, Toledo, oh 43606, U. S. A.)(NASA Lewis Research Center, Cleveland, oh) University of Toledo OH 43606 U.S.A. NASA Lewis Research Center Cleveland OH

In this paper, we use the global search characteristics of genetic algorithms to help search the weight space of the neurons in the cascade-correlation architecture. The cascade-correlation learning architecture is a technique of training and building neural networks that starts with a simple network of neurons and adds additional neurons as they are needed to suit a particular problem. In our approach, instead ofmodifying the genetic algorithm to account for convergence problems, we search the weight-space using the genetic algorithm and then apply the gradient technique of Quickprop to optimize the weights. This hybrid algorithm which is a combination of genetic algorithms and cascade-correlation is applied to the two spirals problem. We also use our algorithm in the prediction of the cyclic oxidation resistance of Ni- and Co-base superalloys.

关键词： Genetic algorithm Cascade correlation Weight space search Neural network.